Leptidea sinapis (Wood White): 126975416 Help Entry 126975416         CDS       T09272                                  Name (RefSeq) ryanodine receptor isoform X1   KO K04962   ryanodine receptor 2 Organism lsin  Leptidea sinapis (Wood White) Brite KEGG Orthology (KO) [BR:lsin00001]  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:lsin04040]     126975416    04990 Domain-containing proteins not elsewhere classified [BR:lsin04990]     126975416 Ion channels [BR:lsin04040]  Voltage-gated cation channels   Ryanodine receptor    126975416 Domain-containing proteins not elsewhere classified [BR:lsin04990]  EF-hand domain-containing proteins   Other EF-hand domain-containing proteins    126975416 BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR SPRY Ins145_P3_rec MIR RR_TM4-6 RIH_assoc Ion_trans EF-hand_7 Serglycin Motif Other DBs NCBI-GeneID:  126975416 NCBI-ProteinID:  XP_050679264 LinkDB All DBs Position 2:complement(6259331..6448435) Genome browser AA seq 5111 aa AA seqDB search MAEAEGGASEQDDVSFLRTEDMVCLSCTATGERVCLAAEGFGNRHCFLENIADKNIPPDL SQCVFVIEQALSVRALQELVTAAGSETGKENLVGKGTGSGHRTLLYGNAILLRHLNSDMY LACLSTSSSQDKLAFDVGLQEHSQGEACWWTLHPASKQRSEGEKVRVGDDLILVSVATER YLHTTKENEVSIVNASFHVTHWSVQPYGTGISRMKYVGYVFGGDVLRFFHGGDECLTIPS TWTKEGGQNIVVYEGGSVMSQARSLWRLELARTKWAGGFINWYHPMRIRHITTGRYLGVN DQNELYLVSREEATTASCAFCLRQEKDDQKVVLEDKDLEVIGAPIIKYGDSTVIVQHSET GLWLSYKSYETKKKGVGKVEEKQAILHEEGKMDDGLDFSRSQEEESRTARVIRKCSSLFT KFINGLETLQENRRHSMFFASVNLAEMVMCLEDLINYFAQPDEDMEHEEKQNKFRALRNR QDLFQEEGILNLILEAIDKINVITSQGFLAGFLAGDESGQSWDMISVYLYQLLAAIIKGN HTNCAQFANSNRLNWLFSRLGSQASGEGTGMLDVLHCVLIDSPEALNMMRDEHIKVIISL LEKHGRDPKVLDVLCSLCVGNGVAVRSSQNNICDYLLPGKNLLLQTQLVDHVSSVRPNIF VGRVEGSAVYQKWYFEVTMDHIEQTTHMMPHLRIGWANTSGYVPYPGGGEKWGGNGVGDD LYSFGYDGAYLWSGGRKTAVNRTHAEEPFIRKGDVIGCALDLTVPIINFMFNGVRVTGSF TNFNLDGMFFPVISCSSKLSCRFLLGGEHGRLRYAAPEGYSPLVESLLPQQILSLEPCFY FGNLAKRALAGPPLVQDDTAFVPTPVDTVSITLATYIEQIRDKLAENIHEMWAMNKIEAG WMYGEQRDDLHKVHPCLVPFERLPPAEKRYDIQLAVQTLKTILALGYYISLDKPPARIRN VRLPNEPFMQSNGYKPAPLDLSAVTLTPKMDELVDQLAENTHNLWARERIQQGWTYGLNE EPEMHRSPHLVPYPKVDDAIKKANRDTASETVRTLLVYGYNLDPPTGEQHEALLAEASKQ KQADFRTYRAEKNYAVSSGKWYFEFEILTAGPMRVGWAHADMPPGMMLGQDENSWAFDGY NEEKVYSGSTESFGKQWAVGDVVGVFLDLIDKTISFSLNGELLMDALGGETTFADVQGDN FVPAFTLGVGQKARLSYGQDVNSLKYFTTCGLQEGYEPFCVNMKRDVTHWYTKDQPIFEN TDEMIDTKIDVTRIPAGSDTPPCLKISHNTFETMEKANWEFLRLSLPVICHAEFIDEAEK QRRWVEIKERQRMLMKEATEAQMPAHIDQIMRSGFTMNDIKGLHYEDGQEDLAARRRQPP RPPRRPSVTRTVTIHDYNLQPGQTNGMHRSTSEAEMSKYELGVQVPNEEKKDKRGRSPFK FFRSKRGESGDRGKSRKSKTPDPLSEPDVSPERGLRRPNPQIRISQANKRYSVAGRASGP NLYGSQTNLNTNLTVPSPQQERKQMTTTTLAANATETIGNEIFDADCLKLINEYFYGVRI FPGQDPTHVYIGWVTTQYHLHSKEFNQSKVTRSSVIITDDYDRVIESVNRHSCYMVRADE LYNEVMAEATAKGASQGMFIGCSVDTSTGSVAFTCEGKETSVRFKMEPETKLFPAIFVEA TSKEILQIELGRSSTSLPLSAAVLPTSDKHVNPQFPPRLKVQCLKPHQWARVPNQSLQVH ALKLSDIRGWSMLCEDAVSMLALHIPEEDRCIDILELIEMDKLLSFHSHTLTLYAALCYQ SNYRAAHALCQHVDQKQLLYAIQSQYLSGPLRQGFYDLLIALHLESHATTMEACKNEFVI PLGGELKSLYEDPEMRHSLRSLQTESVRPHMNMTNIAENISDISNLYSPHFPLEVVREFV MQALAEAVETNQVHNRDPVGGSNENLFLPLIKLVDRLLLVGMMRDEDVEKLLIMINPETW DPTFDKEGKDEHRKGLLHMKMAEGAKLQMCYLLQHLNDIQLRHRVEFIIAFAHDFVGDLQ SDQLRRYTEIKQSDLPSAVAAKKTREFRCPPREQMNAILSFKHMEEEDPDNCPCGEELIT RMNGFHESLMSHVSLNALQEPDSDATEPEVKSGPFGKIYNIINTVKELEEEPKALEEPPK KTPEEKFRKVLIQTIVNWAEESQIETPKLVREMFSLLVRQYDAIGELIRALEKTYVINAK TKLDVAEMWVGLSQIRALLPVQMSQEEEELMRKRLWKLVNNHTFFQHPDLIRVLRVHENV MAVMMNTLGRRAQAQSDAPTASPPTPEDKEKDTSHEMVVACCRFLCYFCRTGRQNQKAMF DHFDFLLENSNILLSRPSLRGSTPLDVAYSSLMENTELALALREHYLEKIAVYLSRCGLQ SNSELIEKGYPDLGWDPVEGERYLDFLRFCVWVNGESVEENANLVIRLLIRRPECLGPAL RGEGEGLLKAIVDANKMSERIADRRKLREMEQEGDVNFSHPLPESDDDEDYIDTGAAILN FYCTLVDLLGRCAPDAAVIALGKNESLRARAILRSLVPLEDLQGVLSLRFTLNNPAAGEE RPKSDMPSGLIPGHKQSVGLFLERVYGIETQELFYRLLEEAFLPDLRAATMLDRNDGCES DMALSMNRYIGNSILPLLIKHANFYNEAENYASLLDATLHTVYRLSKNRMLTKGQREAVS DFLVALTSAMQPSMLLKLLRKLTVDVSRLSEYTTVALRLLTLHYERCAKYYGSTGGQGAY GNSSDEEKRLTMMLFSNIFDSLSKMDYEPELFGKALPCLIAIGCALPPDYSLSKNYDDEF YGKENQGTGADNPQYDPQPINTSSVALNNDLNTIVQKFSEHYHDAWASRKIENGWVYGES WSDHQKTHPRLKPYNMLNDYEKERYKEPVRESLKALLAIGWSVEHSEVDIPSTNRSSMRR QSKSGIDSATPFNYNPHPVDMTNLTLSREMQNMAERLAENAHDIWAKKKKEELVTNGGGI HPQLVPYDLLTDKEKKKDRERSQEFLKYLQYQGYKLHRPSKATQGDTEQTTTGVAIELRF AYSLLEKLIQYIDRATINMKLLKPSTTFSRRSSFKTSTRDIKFFSKVVLPLMEKYFSTHR NYFIAVATATNNVGAASLKEKEMVAALFCKLASLLRSRLAAFGPDVRITVRCLQVLVKGI DAKSLVKNCPEFIRTSMLTFFNNLADDLGHTIMNLQDGKYAHLRGTHLKTSTSLGYINGV LLPVLTAMFDHLANCEYGADLLLDEIQVASYKMLGSLYTLGTDTQLTHDRKYLKTEIERH KPALGSCLGAFSSTFPVAFLEPHLNKHNQFSLLNRIADHSLEAQDIMAKMEQSMPTLETI LSEVDHFVESDKTYNEAPHIIDVVLPLLCSYLPFWWAQGPDNVTPTAGNHVTMVTAEHMN QLLKNVLKLIKKNIGNESAPWMTRIATYTQQIIINSSEELLRDAFLPLAERVRKRTDNMF HKEESLRGFIKSSTDDTSQVESQIQEDWQLLVRDIYSFYPLLIKYVDLQRNHWLRNNITE AEELYNHVAEIFNIWSKSQYFLKEEQNFISANEIDNMVLIMPTATRRVTTVVDGSQQGGG KKKKKHRDKKRDKDKEVQASLMVACLKRLLPVGLNLFAGREQELVQHCKDRFLKKMSEQD VAEFAKTQLTLPDKIDPADEMSWQHYLYSKLGSKSKASITMDTSDNKAKIIDDTVERIVA MSKVLFGLHMIDHPQQMSKNVYRSVVSIQRKRAVIACFRQTSLHSLPRHRACNIFARTYY ELWLEEENVGQEVMIEDLTQSFEDSELKKTDVVEEEGKPDPLTQLVTTFCRGAMTERSGA LQEDPLYMSYAHIIAKSCGEEEEEGGDEEEGGGEAEPEDEGRASIHEQEMEKQKLLFHQA RLANRGVAEMVLLHISASKGVPSDMVMGTLQLGISILRGGNIDIQMGMLNHLKDKKDVGF FTSIAGLMNSCSVLDLDAFERNTKAEGLGVGLEGAAGEKNMHDAEFTCALFRFIQLTCEG HNLEWQNYLRTQAGNTTTVNVVICTVDYLLRLQESIMDFYWHYSSKELIDPAGKANFFKA IGVASQVFNTLTEVIQGPCTQNQQALAHSRLWDAVGGFLFLFSHMQDKLSKHSSQVDLLK ELLNLQKDMITMMLSMLEGNVVNGTIGKQMVDTLVESASNVELILKYFDMFLKLKDLTSS ASFKEIDTNNDGWVLPKDFKEKMEQQKSYTPEEIEFLLACCETNHDGKLDYVGFCDRFHE PAKEIGFNLAVLLTNLSEHMPNEPRLARFLETAGSVLNYFEPFLGRIEIMGGSKRIERVY FEIKESNIEQWEKPQIKESKRAFFYSIVTEGGDKEKLEAFVNFCEDAIFEMTHASGLMAA SEESSGGPKNREASYMYMGDDDDERSGKDPFRRGLQSMKDGISAAFSSLSPSNIKSRIAD LQQMSPPELFLGFFKLFFYLFYYIGYGFVVVIRYIFGVLLGLMRGPQVEEAPPPEPTEEE KIGPSRHLPALPATDDTGQMQVSAFGLDITKEDNGQLQVKPHESPNASTPSSGEEAEVSL DESLEHSEETGGQPPSLIDILGGEQAKKQAAERMEAQAAQQAAMSAIEAESKKAVQVPAP SALSQVDLSQYTKRAVSFLARNFYNLKYVALVLAFCINFVLLFYKVSTPDVEKSEGSGLG DIISGSGSGHGSGSGDGSGEDADDSLEVVQIDEDFFYMEHVINIAAALHSIVSLAILIGY YHLKVPLAIFKREKDIARRLEFDGLYIAEQPEDDDLKSHWDKLVISAKSFPVNYWDKFIK KKVRAKYSETYDFDSISNMLGMERTSFSAQEDEGNKGLLNYIITIDWRYQVWKAGVTITD NSFLYSLWYFSFSVMGNFNNFFFAAHLLDVAVGFKTLRTILQSVTHNGKQLVLTVMLLTI IVYIYTVIAFNFFRKFYVQEEDDEINRNCHDMLTCFVFNLYKGVRAGGGIGDELEPPDGD DSEVYRIIFDISFFFFVIIILLAILQGLIIDAFGELRDQLESVKEDMESNCFICGINKDY FDKVPHGFDTHVQREHNLANYMFFLMHLINKPDTEYTGQETFVWNMYTQRCWDFFPVGDC FRKQYEDVMGE NT seq 15336 nt NT seq  +upstreamnt  +downstreamnt atggccgaagcggaggggggagcaagtgagcaggatgatgtctccttcttacgaacggaa gacatggtgtgtctgtcgtgcacggcgactggagagagggtgtgcctggcagcggagggc ttcggtaaccgacactgcttcctagagaacatcgctgacaagaacatcccgccagacctg tcacaatgtgtgttcgtcatcgagcaggcgctgtcggtgagagctcttcaagaactggtg acagccgcgggttccgaaactggcaaagagaacttagtaggtaaaggcaccggttccgga cacaggacactgctgtacggtaacgcgattctgctgcgacacctcaacagtgatatgtac ctcgcgtgtttgtcgacatcttcgtcgcaagacaagctggcgttcgacgtgggcttgcag gagcactcgcaaggagaggcctgctggtggaccttgcatccagccagcaagcagagatct gagggtgaaaaagtgcgtgtgggagatgatttgatcctggtgtctgtggctactgagaga tacttgcacacaacgaaggagaacgaggtgtcgatcgtgaacgcgtcgttccacgtgacg cactggtccgtgcagccgtacgggaccggcatctcccgcatgaagtacgtgggctacgtg ttcgggggcgacgtgctgcgcttcttccacgggggggatgagtgcctcaccatacccagc acctggactaaggagggcggacagaatatcgtagtgtacgagggcgggtcggtgatgtct caagcacgctcgctgtggcggctggagctggctcgcaccaagtgggctggtggcttcatc aactggtaccacccaatgcgcatccggcacatcaccaccggccgctacctgggcgtcaac gaccagaacgagctctacttggtcagcagagaggaagcgacaacagcatcgtgcgctttt tgtttgcgccaagagaaggatgaccagaaagtggtgctggaagacaaggacttggaggtg atcggagctcccatcatcaaatacggtgactccaccgtcatagtgcagcattcggaaact ggactttggctctcttataagtcatacgaaacgaaaaagaagggcgtaggcaaggtggaa gagaagcaggccattctccacgaggaaggcaagatggatgacggactggacttctcccgc tcgcaggaagaggagagccgaaccgcgcgcgttatcaggaaatgttcttcactcttcacc aagtttatcaatggtctggagacgctgcaggagaaccggcgccattccatgttcttcgcg tccgtcaacctggccgagatggtgatgtgtctcgaggatctcatcaactacttcgcacag cccgacgaagacatggagcatgaagagaaacagaataaattccgcgcgctgcggaaccgg caggacttgttccaggaagaaggtatcctgaacctgatcctggaagccatcgacaagatc aacgtgatcacgtcacaggggttcctggccggcttcctggccggagacgagtcgggccag agctgggacatgatttccgtctacttgtatcaattgttggcggccatcataaagggaaac catacgaactgcgctcagttcgcgaactccaaccgtctcaactggctgttctcgaggctc ggctcacaggcgtcgggcgagggcaccggaatgttggacgtattgcactgtgtgttgatt gactctcctgaggcgctcaacatgatgagggatgagcatatcaaggttatcatatcgttg ctggagaagcacggtcgagatccgaaggtactggatgtcctgtgctctctgtgcgtgggt aacggcgtggcggtccgctcctcccagaacaacatctgcgactatctgctgccggggaag aacctcttactgcagacccaacttgtggaccatgtgtccagcgtccgtccgaatatattc gtgggtcgtgtggaaggatctgctgtgtatcagaagtggtattttgaggtcaccatggac cacatcgagcagaccacccacatgatgccacatttgaggatcggatgggctaatacctct ggctacgtaccgtacccgggaggtggggagaagtggggaggtaatggagtgggggatgac ctatactcatttggatatgacggagcgtacctttggtctgggggacggaagaccgctgtc aacagaactcacgctgaggagccctttatcaggaaaggggacgtgattgggtgcgcgctc gacctgacagtgccgattatcaacttcatgttcaacggggtgagggtcaccggatccttc acaaatttcaacctggacggcatgttcttcccggtcatcagctgctccagcaaactcagt tgtcgcttcctgctgggaggtgagcacggtcgcctccgctacgccgcacccgagggctac tccccgttggtggagtccctgctgccgcaacagatcctcagcctggagccgtgcttctac ttcggcaacctggccaagcgcgcgctcgccggtccccctctggtgcaagatgacaccgcc ttcgtgcctactcctgtcgatactgtttctatcaccctggcgacatatatcgaacaaatc cgagacaagctcgcggagaacattcatgagatgtgggccatgaacaagattgaggcgggc tggatgtacggcgagcagagggacgacctccacaaggtacatccgtgcctggtgccgttc gagcgactgcctcccgctgagaagagatacgacatccaactggctgtccagacgctcaaa acgatattggcgctcggctactacatcagcctggacaagccgccggctcgcatccggaac gtgaggctccccaatgaaccattcatgcagtctaacggctacaagccggccccgcttgac ctgagcgcggtgaccctcacgccaaagatggacgagctggtggaccagctggctgagaac acccacaacctgtgggcacgcgagcggatccaacaggggtggacatacggccttaacgag gagccggagatgcaccgctccccccacttggtgccgtaccccaaggtggatgacgccatc aagaaggcaaacagagacacggcctcggagaccgttcgcacgctactggtgtacggatac aacctggacccacccacgggcgaacaacacgaagcactgctggcggaagcatcgaagcag aagcaagccgatttccgcacgtaccgcgccgagaagaactacgccgtcagctcgggcaag tggtacttcgagtttgagatcctcaccgcaggacccatgcgggttggatgggcccacgct gacatgcccccgggtatgatgctgggacaggacgagaattcatgggcttttgatggatac aatgaggaaaaagtgtattccggtagcacggagtcgttcggaaagcaatgggcagtgggt gatgttgttggagtgttcctagatctcatagacaagacgataagtttttctctaaatggt gaacttcttatggatgcattgggaggtgaaactacatttgcagatgtgcaaggggacaat tttgtgcccgcttttactcttggtgttggacagaaagctaggctctcgtacggtcaggac gtgaactctctgaagtacttcacgacatgcggtctgcaggaaggctacgaaccgttctgt gttaacatgaagcgggatgtcactcactggtacaccaaggatcagccgatattcgagaac acggacgagatgattgacaccaagatagacgtcactagaataccggctggatccgacacg ccgccatgtctgaagatctctcacaacacgttcgagaccatggagaaagctaactgggag ttcctgcggctgtcgctgccggtcatctgccatgcggaattcatagatgaggcagagaaa caacgtcgttgggtggagatcaaggagaggcagagaatgctgatgaaggaggccactgag gctcagatgccagcacacatcgaccagatcatgaggagcgggttcaccatgaacgacatc aaaggtctgcactacgaggacgggcaggaggacttggcggcccgccggcggcagcccccg cgcccaccccgcaggccctctgtcacgcgaacagtcaccatccatgactataacctccaa ccaggtcaaacgaacgggatgcatcgatcaacgagtgaagctgaaatgagcaagtacgag cttggagttcaggtcccgaacgaagagaagaaagacaagaggggaagatccccattcaaa ttctttagaagtaagcgtggtgagagcggcgaccgcgggaagtcaagaaaatccaaaact cccgatccgctttctgagccagacgtttctccggagaggggattacggcgacccaatccg cagatacgaatctcacaggccaataagagatatagcgtggccggaagagctagcggtccc aatctgtacggcagccagactaatctgaacacaaacctcacggtaccgtcgccacaacag gaacggaaacagatgacaaccaccacgctcgctgctaacgctaccgagaccattggcaac gaaatattcgatgctgactgcttgaagcttatcaacgaatacttttacggcgtgagaata ttccctggacaagaccccacgcacgtgtacatcggctgggtcacgacacagtaccacctt cactccaaggagttcaaccagagcaaggtgaccaggtcttcggtcattatcaccgacgat tacgaccgggtcatagaaagtgtgaaccgtcactcgtgctacatggtacgcgctgatgag ctttacaacgaggtgatggcggaggccacagccaagggagcctcacagggaatgttcatc ggctgctctgtcgacacgtccaccggaagcgtcgccttcacctgcgaggggaaggaaacc agcgtgaggttcaagatggaaccagagaccaaactgttccccgcaatattcgtggaggct acctccaaggagatcctgcagatagagctgggcaggtcttccaccagtctcccgctgagc gcggcagtcctccccaccagcgacaagcacgtcaacccacagttcccgcccaggctcaaa gtacagtgcctcaaaccccaccagtgggctcgggtaccgaaccaatcgctgcaagtccac gccctcaagctgtcagacatcaggggttggtccatgctatgtgaagacgccgtgtccatg ttagcgctgcacattcctgaggaggaccgctgcatcgatatcctggagctgatcgagatg gacaagctgctcagcttccactctcatacgctcacgttgtacgccgctctctgctaccag agcaattacagagccgcgcacgcgttgtgtcaacacgtggaccagaagcagctgttgtac gcgatacagagccagtacctgtcagggccgctgcggcagggattctacgacctgctcatc gccttacatctggagtcgcacgccaccactatggaggcttgtaagaatgaattcgtcata ccactggggggtgagctgaagtctctctacgaagatccagagatgcggcacagtctccga tctcttcagactgagagcgttcgaccacatatgaacatgaccaatattgccgagaacata tctgacatcagtaacctgtactcgcctcacttcccactggaggtggtgcgggagttcgtg atgcaggccttggcggaggccgtggagaccaaccaggttcacaaccgggaccctgtcggc ggcagcaacgagaacctgttcctacccctgataaagctggtagaccggctgttgttggtt ggcatgatgagggatgaagacgtggagaagctactcataatgatcaaccctgagacttgg gatccaacttttgataaagagggcaaggacgagcacaggaagggtctgcttcacatgaag atggccgagggcgctaagctgcagatgtgctacctgctgcagcacctcaatgatatccag ctgcgacaccgcgtggagttcatcatcgccttcgcgcatgactttgttggggatttgcag agtgaccagcttagacgctacacagagatcaagcagtctgacctgcccagtgctgtggct gccaagaagaccagagagttccggtgtccaccgcgggaacagatgaacgctatattgagc ttcaagcacatggaagaagaggaccctgataactgcccgtgcggcgaggagctgatcacc aggatgaacggcttccacgagagtctcatgtcgcacgtgtcgctcaacgcgctccaggaa cccgactctgacgcaacggagccagaagtcaaatccggaccgtttggaaaaatttacaac atcatcaacactgtgaaagagctcgaagaggaacctaaggcactggaagaaccgccaaag aagactccagaagaaaagttccgtaaagtgctaattcagaccatcgtaaactgggcagag gaatcacagattgaaaccccgaaactcgtcagagaaatgtttagtttgttggttcggcaa tacgatgcgatcggtgaactgatccgagctctcgagaagacgtacgtgatcaacgcgaag acgaagctagacgtggctgagatgtgggtgggactgagccagatccgagcactgctgccc gtgcagatgagccaggaagaggaggagctcatgaggaagcgcctatggaaactggtgaac aatcacaccttcttccagcatcctgatttaatcagagttctccgcgtgcacgagaacgtc atggcagtgatgatgaacacgctgggaagacgggcgcaggcacagtctgacgctccaacc gcctcgccgcctacacccgaggacaaagaaaaggacactagtcacgagatggtggtggcg tgttgccggttcctgtgctacttctgccgcacgggccgacagaaccagaaggccatgttc gatcacttcgatttcttgctggagaactctaacatcttactatccagaccctcgctcaga gggtccaccccgctcgacgtggcctactctagtcttatggagaataccgagttggctttg gcattgcgggagcactatttagaaaagatagcggtatacctgtcgaggtgtggactgcag agtaactctgagcttatcgagaaaggctacccggacctggggtgggaccctgtggagggt gagcggtatctggacttcttgcggttctgtgtttgggtgaacggagaaagcgtcgaggag aatgccaacctcgtgattcgtctcctgatcagacgtccagagtgtttgggaccggcgcta cgaggcgagggcgagggtctgctcaaggcgatcgtggacgcgaacaagatgagtgagagg atcgccgacaggaggaaactgagggagatggagcaggagggagacgttaacttcagtcac ccgctgcccgagtcggatgacgacgaagactacattgacacgggcgccgccatcttgaac ttctactgcacgctggtggacctgctcggacggtgcgcgcccgacgccgccgtcatcgct ctgggtaaaaacgaatcacttcgtgctcgagccatcttacgatctctggtccctcttgag gacctgcaaggtgtgctcagcctgaggttcacgttgaacaaccccgcggctggggaggag agacctaagtctgatatgccgtctggtctcatcccgggccacaagcagagcgtgggtttg ttcctcgagcgggtatatggcatcgagacccaggaactgttctaccgcctgctagaggag gcgttccttcctgacctgagagctgctactatgctggataggaacgacggttgcgaatcg gacatggcgctctcaatgaacagatacatcggcaactcgatcctgcccttgctcatcaag cacgccaacttctacaacgaggccgagaactacgccagcctgcttgacgccacactgcac actgtctacaggttgtcaaagaaccgcatgctgacgaagggtcagcgtgaggcggtgtca gacttcctggtcgcgctcacgtcagctatgcagccgtccatgttactgaagctgctccgg aaactgacggttgacgtgtcccgtctctcggagtacaccactgtagctctgaggttgctt acgctgcactacgagcgctgcgccaagtactacggcagcacgggcgggcagggcgcctac ggcaactcctccgatgaggagaagcgtctcaccatgatgctgttctccaacatcttcgac tccctcagcaagatggactacgagccggagttgttcgggaaggcgctgccttgtctcatc gctatcggttgcgctcttcctccggactattcactttccaagaactacgacgacgaattt tatggaaaagaaaaccaaggaacgggcgccgacaacccacagtatgacccgcagccgatc aacacgtcttcggtggcgcttaacaacgacctcaacactatcgtgcagaagttctccgag cactaccacgacgcctgggcttccagaaaaattgagaatggctgggtttacggtgagtca tggtccgaccaccagaagacacacccgcggctgaagccatacaacatgctcaacgactat gagaaagagcgctacaaggagccagtccgcgagtctctgaaggctctgctggccatcggc tggtcggtggagcactcggaggtggacatacccagcacaaaccgcagctccatgcggcgc cagtccaagtccggcatcgactcggcgacaccgttcaactacaacccacaccccgtggac atgacaaacctgacgctgtccagagagatgcagaacatggcggagaggctggctgagaac gcgcacgacatctgggctaagaagaagaaggaggaactcgtcaccaacggaggtggaatc catccccaactggttccgtacgatctcctcaccgacaaagaaaagaaaaaagaccgagaa cgttctcaggaattccttaagtacttacagtaccaaggttacaaactccacagacccagt aaggcaacacagggcgacacggaacagaccactaccggcgtggcaatagagctcagattc gcttactcgttgctcgagaaactaatccagtacatcgacagagcgactattaacatgaaa ctgctgaaaccatcgacaaccttcagcagaagatctagttttaagactagtacgagggat attaagttcttttccaaggtggtgctgcctctgatggagaagtacttctctactcaccgc aactacttcatcgcggtggcgaccgctaccaataacgtgggcgccgccagtctgaaggag aaggagatggtggcagcactcttctgtaaactggccagcttgttgagatccagattggcc gcgttcggtcctgatgtccgcatcacggtgcgctgtcttcaggtcctggtgaagggtatc gacgccaagtcgctcgtgaagaactgccccgagttcatccggacctccatgctcacgttc ttcaacaacctggctgacgatcttggacacaccattatgaacttacaggacggcaagtat gctcacctccgcggcactcacctgaagacgtccacctcgttaggctacatcaacggtgtc ctcctgcccgtgctcaccgcgatgtttgaccacctggctaactgcgagtacggcgctgat ttgttgctggatgagatacaagtggcgtcgtacaagatgctgggatctttgtacaccctg ggcaccgacactcaactcactcatgacaggaagtatctgaagactgagattgaaaggcat aagccggcattgggttcgtgcctgggcgccttcagttcaacattcccagtggcgttcctg gagccgcatctcaacaaacacaaccagttctctctgctcaaccgcattgccgaccactcg ctagaggctcaagatataatggcgaagatggaacagtccatgccaaccctggagacgatt ctgagtgaggtggatcacttcgtggagtcagacaagacgtacaacgaggcgccgcacatc atcgacgtggtcctgccactgctgtgctcgtacctacccttctggtgggcacaggggccg gacaacgtcacgcccactgcaggcaaccacgttaccatggtgacggcagaacacatgaac cagctccttaagaacgtgctgaaactgatcaagaagaacattggcaacgagagtgcgccc tggatgaccaggatcgcgacctacacacagcagattattatcaacagctctgaggagttg ttacgggacgccttcctgccactcgcagagagagtgcgcaagcggacagacaacatgttc cacaaggaggagagtttgagaggcttcattaagtcatcaacggatgacacttcgcaagtc gagtctcagatccaggaggactggcagctgctggtgcgtgacatctactccttttatcca ctcctcatcaagtacgtcgatctgcagaggaaccactggctcaggaataatataacagag gctgaagaactttacaaccacgtcgcggagatattcaacatttggtccaagagtcagtac ttcctcaaggaagaacagaacttcatatcggccaatgaaatcgacaacatggtgttgata atgcctaccgctaccagaagagtaaccaccgtggtcgatggctcgcaacaaggtggtgga aagaaaaagaagaagcatcgcgacaagaagcgtgataaggacaaggaagttcaggcgtcg ctgatggtcgcctgtctcaagcggttgcttcccgtgggactcaacttgttcgcgggaagg gaacaggagctggtgcaacattgcaaggatcgcttcctgaagaaaatgtcggagcaagat gttgcagaattcgctaaaactcagctcacgctaccagacaagattgaccctgcggatgaa atgtcttggcagcactatctgtacagtaagctgggctcgaagagtaaggcgtctatcacg atggatacatccgacaataaggccaagatcatagacgatactgtcgagaggattgtcgct atgagtaaagtgctgttcggattgcatatgatcgaccatccacaacaaatgagcaagaat gtataccgttccgttgtgtcgatacaacggaagagagcggtcatcgcttgcttcagacag acgtcgctccactcgttgcccaggcatcgggcgtgtaatatattcgcgaggacatactat gagctgtggttggaagaagaaaacgtcggccaagaagtaatgattgaagacctgacgcaa tcgtttgaggattcagaactgaagaagaccgatgtggtagaagaggaaggcaagccagat cctctcactcagctggtgaccactttctgtagaggcgccatgacggagagatccggagcg cttcaagaggatcccctgtacatgtcgtacgctcacatcatagcgaagtcttgtggtgag gaggaagaggagggaggcgacgaggaggaggggggaggagaggctgagccagaggatgag gggagggcgagtatacacgaacaagaaatggagaaacagaagctgctgttccatcaagca cggttggctaatcgtggagtggcagagatggtactcctgcacatatccgcttccaaggga gtgcccagcgatatggtaatgggcactctgcagctgggcatctctattctcaggggtggc aacattgatatacagatgggcatgttgaatcacctcaaagacaaaaaggatgtcggtttc ttcacgtcgatagctggtcttatgaactcctgctccgtgctcgacttggacgcgttcgaa cggaacactaaagctgaaggtttgggagtgggcttggaaggtgctgcaggtgagaagaat atgcacgatgcagagttcacctgcgccctgttcaggttcattcagctgacttgcgagggt cacaacctggaatggcagaactacctccgcacccaagccggcaacactaccaccgtcaat gtggtcatctgcaccgtcgactatctgctgcggctgcaggagtccatcatggacttctac tggcattactcaagcaaggaattgatagacccggctggaaaggcgaacttcttcaaagcc atcggcgtcgcgtctcaggtgttcaacacactcactgaggtgatacagggcccgtgtaca cagaaccaacaggctttggcgcattccaggttgtgggacgcggtgggcgggttcctcttt ctgttctcacacatgcaagacaagctgtcgaagcactcctcgcaggtggatctgctaaag gagctccttaaccttcagaaggacatgatcacaatgatgctttccatgcttgaaggaaac gtggttaatggtacgatcggtaagcagatggttgacacgttggtagagtctgcctccaat gtcgagctgatcctcaagtacttcgacatgttcctcaagctaaaggacctgacgtccagt gccagcttcaaggagatcgacaccaacaacgacggctgggtgctgcctaaagacttcaag gagaagatggaacagcagaaaagttatacaccggaagagatagagtttctacttgcttgc tgcgagacgaatcatgatggcaagttggactacgttggcttctgtgaccgtttccacgag ccagcgaaagaaattggattcaatctggccgtgctgctaaccaacttgtcagagcacatg cctaacgaacccagacttgcccgtttcctggagacagctggctcagttctgaactacttc gagccgttcctcggccgtatcgaaatcatgggcgggtcgaagcgtatcgagcgcgtgtac ttcgagatcaaggagtccaacatcgagcagtgggagaagccgcagatcaaggagtcgaaa cgcgcgttcttctacagcatcgtaactgagggtggagataaagagaaattggaagcgttc gtgaacttctgtgaggacgccatctttgagatgacccacgcgtcaggtctgatggcagct tcggaggagtcttccggaggccccaagaacagggaagccagctatatgtatatgggagat gatgatgacgagagatcgggtaaagatccattccgacgtggtctgcagtccatgaaggac ggtatttctgcggcattctcgtccttatctccatccaacataaagtcgaggattgctgat ctgcagcagatgtcaccaccggagctgttcctcggatttttcaagctattcttttacctg ttctactatatcggttacggatttgttgttgttataaggtatatatttggagtgctgctc ggactgatgagaggcccacaggtggaggaggcaccgcccccggagcccacggaagaggag aaaatcggcccgtctcgacatctgccagcattgccggccactgacgacacgggacagatg caagtctctgcattcggactcgacatcaccaaagaggacaatggacagctgcaagtgaaa ccccacgagtctcccaacgcgtccactccatcatcaggtgaagaggccgaggtgtctctt gacgagagcctggagcacagtgaggagacaggcgggcagcccccctcgctcattgatata ctaggaggtgagcaagctaaaaaacaagcagccgagcgaatggaggcacaagctgcgcaa caagctgccatgtctgctatagaggctgaaagcaaaaaggcagttcaagtccccgcaccg tcagctctctctcaagtggatctgtctcagtacacaaagcgcgctgtatcgttcctggct cgcaacttctacaacctcaaatacgtcgctctcgttctggccttctgcatcaactttgtg cttctcttttacaaggtatcaactcccgatgtagagaagagcgagggttcaggacttgga gatattatcagcggttcggggtctggacacggttctggtagtggagatggcagtggcgag gatgctgacgacagcctggaggtggttcagatcgacgaggacttcttctatatggagcat gtcatcaatatcgcggccgcactgcactccatcgtgtcgctcgccatcctcatcggctac taccatctcaaggtgccgctggctatattcaaacgtgaaaaggacatagcacgcagactg gagtttgatggactttacattgctgagcaacctgaagatgatgacctcaagagccactgg gacaaacttgttatttctgccaaatcgttcccggtcaactactgggacaagttcattaag aagaaagtgcgcgccaagtactcagagacttatgacttcgactcgatctccaacatgttg ggtatggagcggacctcgttctcagcccaggaggatgagggcaacaaaggactgctgaac tacatcatcacgatcgactggcgctaccaggtttggaaggccggcgtcaccatcaccgat aactcgttcctgtactcactgtggtacttcagcttctccgttatgggcaacttcaataac ttcttcttcgctgcacatctgctcgacgtggctgtgggcttcaagacgctcagaactatc ctgcagtccgtcacgcataatgggaaacagttggtgctgacggtgatgctgctcacgata atagtgtacatctacacggtgatcgcgttcaacttcttccgcaagttctacgtacaagaa gaggatgatgagatcaataggaactgccatgacatgcttacgtgcttcgtgttcaacttg tacaagggagtccgcgctggcggtggtatcggtgatgagctggagccgcccgacggtgat gactccgaggtgtaccgcatcatcttcgacatctccttcttcttcttcgtcatcattatt cttctcgccattctgcagggtttgattatcgacgcattcggagaactgcgtgaccagctc gagtcggtgaaggaagacatggagtcgaactgcttcatctgtggcatcaataaggattac tttgataaggtgccgcatgggtttgacacgcacgtgcagcgcgagcataatcttgccaat tacatgttcttcctcatgcacctcataaacaaacccgacaccgaatacactggtcaagag acatttgtctggaatatgtacacccagcgctgttgggacttcttcccggtcggagactgc ttcaggaaacaatatgaagacgtcatgggagaatag

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