Legionella spiritensis: NCTC12082_00197 Help Entry NCTC12082_00197   CDS       T06800                                  Symbol lgrD Name (GenBank) non-ribosomal peptide synthase Organism lss  Legionella spiritensis SSDB OrthologParalogGene clusterGFIT Motif Pfam:  AMP-binding Condensation PP-binding AMP-binding_C Thioesterase GH3 Methyltransf_25 Methyltransf_18 PRMT5 DUF7080 Methyltransf_31 MTS Motif Other DBs NCBI-ProteinID:  VEG89787 LinkDB All DBs Position 1:complement(228925..249654) Genome browser AA seq 6909 aa AA seqDB search MDSIITSPKRSIIGYFNKQVSEHGNNVALITPQETISYQQLASRVTLLARHLQERGVGAE QFVTIALERSIEFVVSCLAVLKVGGAYIPVNTDNDMNHIRSIIKDSGSKVLLTRGTGYEQ LNDGSLTVMDLDALHEECCHASFSKPAYNPVAYAIYTSGSTGQPKGVNSTQEALLNRLEW VWQQYSFSRDDVCCLKAPVHFVDSVGEIFLPLLQGVPLAIVPPKMELEPELFLEFLATQQ VSRLVLVPSQLQVILDYSPFLKDRLPALKHLEISGEGLSTKLALRIQQALPQTTLINRYG SSEYTSCIFHEIGTIDTRETMIPVGKPIHNTRVYILDGDMKPVNPGEQGILWLSGKGLSP GYLNNDRLTRQKFKPNPFYEEHQESLWYSRIYNTGDLVRLNENKALIHLGRADTQVSIYG NRIELSSIEALLNNHPGVKQAVVVLNKHNDIEHLKAYVCFEDNIADFVQLREHLARSLPQ YQIPSIFKAVKTFKRLANGKIDRRALQSMDREVEKTTVTEENPITDYLISACQSLLPIGE IARNHTFFELGLNSLMLMTLVTMIQKHFGIHCQFSDLSRKNTVGRLSRFIAERLAKQEKI PSAHAVTLQSGKPTIAQMRFWLLENRINGDESPNHITITLRINGLPDVARLQRCLTAIIN DNPALSTNFKYLDNQLKAIAHTLDWHLDVISCDETRLGALLENHIKKRFKLENDYLLRGC LFEIEQDYSVLSIVAHHIIFDGWSQQQFLRLLFNRYNGAEDLAQVPYVEDKKLWPPDTSQ LSRFQENLAKISSVHLPVELQKPAVTSVSQYRFKIPADKVIAIGDLAKKNHSTVYLSLLS MFAVFLGRYTQNRDVSLGTVISLRDSNEMGCLINTLPMHIHLAFEQDFATLLADVQARFF DFYPVIEYALDPDSGLSQQQLKAESELNVFFIFEKIHDHQDGDLGGLDCELLYPDQSAPK SSLGLYIEEHQHELNGIFKFDPALFRTTTIQRIANNFLTLIDSILSARALPLYRHRILQT DDYHKLLYQWNDTSVPKKYKTLSRLLYEIASQRPSDTAVIDHDDSTYDYAWILQNAETMA GAFIQKKHTPGSVIAVAVDPGIDMIVTLFAILKSGSAFVPLDPRHPEKRLQHIVTDSKAG ILVTEEKYYTFFKKAAAQDVQVCTVNVLRNHPHPATTIDHAVIDDTACIIYTSGSTGRPK GVKISHYSICNRLSWMWDAFPFTATDKCSQKTALSFVDSLWEIFGPILGGVPLSIMSQQQ RDSIEKTVTKLIRDQSTRLVITPSLLKVILDYLSVNELKLESLRMCVISGENASGTLIPS IKAHLPNARLLNLYGSTEVTADASFYEVSDKDCDASSIPVGRPLDNMQMFVLDEYWQPLP IGVIGELFIAGDGVAGGYLDDALSADKFITREIEPGKPRRLFKTGDLAAWQEDGNVILAG RNDNQIKINGMRIDCHEVEYYLQKHHACVQAIVLPWHQPGFAVLIAFILSPDRHLEPDEL RDYLGLHLQDTFIPSYFYVLPSFPETITGKIDRTALLSHHERHISTPQNKPQAIDEMEQL ILNFFKDSLPDKNIDVNASFFEHGGSSLSAMALAHRVKSFFDIDVGLSDLFDNASARKFA RFISHAKTSTVDMPELLHTQRKGNQFPASGGQRAIWFAANASLDTPWLFNVPFVISLTGK LNIKALEAAINRIISENDCYQVNFSLQQGKLYQTISHNHLIIKHIRVSSKSELNQQLIEH AKHTFSLEQGLLIAVTLFQLNASRFELLVNHHHIITDACSIGKFLEKLGRYYNLAANDSC EYEHKKTRRIDYIDFSQWHNRLHEEGVFREQLDYWRTQLTINAASSLRPDRFDNHSVSSH EGARYHQSLSLKNTRALTVLAHDNHATPGLVLLTVFKLVLSRFCNSRTVLLGMPAAHRHW PELTDMLGYCINTLPVLTQFNNASHFSEAIAIVKKSMFEALKHQDISLGFVQETLGISSP YKIGFDFNSDNQNYHLDAQDLESKIRYLYLDTAQYDLTLFVNKTDSGLDYSFEYKTALYS EAFIHQLARYFNDLIQHVLRHGSSSPVLHYLPANEEKLLLQQGSIKGKHYPTTGRFFNDF IQVARQYPERIAIHSGQRDLTYAGLMKAIDEIAHRLCAQLPLASTKKQPVIATCLPQNTD WLTAILAIWKIGACYLPLNATFPTRRIAAMNQAVLPDLIITDSQLLNKHHEAFGDSPALV IDKAEEANQSALWNFASGKKKKPYAYIIFTSGTTGTPKAVPVFEEAFLNTAYAQIEAFRV NDQSRILQFANCSFDASLSEIATALLCGASLCVIPDPLRKDADALLDYINREGIDIATLP PVMLSMMPKDKSLGLKTLVVAGESCPADVFYHWSRERHFINAYGPTEVTICASLKEVDSQ TLPSCIGKPLNRIQLYVLDSRQNLVPRGAEGELYIGGPQLADGYLSQGEDNRHFCSVQIA GIKKKLYRSGDCIRWLMNGDLEFIGRVDRQMSYHGVRIEPREIEQRLEELSFVRQCVVSL EGNEHLVAFIEPNEPITEHHDGLEFWPSVAEFFIYDEFLYSVMTNDLKRNYFYQNALNDL AKDKLVLDIGTGKDAILARLALDAGAKKVYAIEYLQETYQAAKRTLENLNLTDSIILIHG DSRQASLPEPVDIIVSEIVGAIGGSEGAAVILDDAKKRHLKPGGVLIPDKAITKIAAVSL PDEFLNNPGFAPLAADYADKIINDHNVGFMPRICIKNIRPQHLISEATTFELLAFNQYPA SSGTHQAAIRVTRDAPFSGFIAWLNLYDHNNGSIDILQDTHCWLPVYFPAFEDNLILRKQ DLIDIRCEYRLCDNGLNPDYRIHAVIWRNHRKISTYSYDSLHFHPADSAHPFYKKLFVDN QAIISKALSATQYQSLIKHQLVLHFPDFMRPRHTILLDRFPLNASGKIDRHQLSKIFAEK CRDSRDYEAPVTALERQLQEVWSRLLSQKDIGRNVSFFHLGGDSITAISLVSELQGSGMN LSVRDLYAYPSIATLALKIEETSRHAKPGSGNVSAMYTSPESGLYPLNPLQQDMLTAYRW YPDSDLYINQVYWLTTIEDMDSYQQAWQILIAETECLRLSYVWDEQGICGQIINSAPMLN WDITDWSNLSEDKQQSRLKSCLAKDRKQGFDLALPGPMRVRCFLLGGQRAYVLWTHHHII LDGWSLPLLLKRLDEIYHDRLFSFERQRTSGPQFSRYLEWLRARDRDAAVTFWKSQLGEI SRATPLHFCRQSLSGYDITSSQSILSTRLPDVKTHEIEFFAKTHGITINTILQMAWAITL MYYSDEDVVMFGTTVSGRDIDLHQAAEIPGMMIGTVPILANTANYPSLLDGLYHLQKTIH NAQTHAHIGLGDIKRAIGWADSSPLFHSLFVFENYPSGINYGFHVDEKTNFPLVISLIHQ DCLQVELTYADNYFAPAIMNRLLARYCKTLGLITRSPNNSINELTLITDEEIALLKRWNT TRVKTPDTTIPHLFETACHHHPNRIALEHGELSLTYKVLNQRSDALCRRLCHQYKTIFGY SFTPETIIAVYLDRGVDLFISILAILKAGGCYLPLDKNYPRSRNEFIIKDSAPAFIMTNQ ALAPDVSEHTLLLVDLETDTEDASVKPPVITTNNLAYIIYTSGSTGTPNGVMIEHKGVVN LALNTAKALKVEGNSRLLQLNSPCFDTSVQEWSLALLNGATLVIPTKDEMPPSKKIGELI LEKFITHLNAPPYVISSTDYQRYPSLKVIISGGDICHPSLVDKWAGDYYFVNDYGPTETT ICVSMTRCLPGKKPTIGSPHPNTRFYVLNTRGQLAPIGTIGELYIAGVGMARGYLNRPHL NESRFLTNTFEDTDVNADYKTLYRTGDLVRWTDEGKLEYIGRIDSQLKIRGYRIEPVEIE NCLLTHKNIKNCVVIADGKESQRLSIFIERMDSNASTIEECRRYMQNRLPTFMLPNHFVM VDELPLLPNAKIDRKALLRQLNNIVPVDSHESTLNQEQKALMDAFTQALNYKEITPDSHF YTIGGDSINAIQVSAIMQQKGYHLTPNMLYEFPTIKALAQQLEKHKNSKALARIPQGNIE LSPIQHWFFERELANQHHYNQAVMLEYDGTFQKDCVLKTIKALEERYDSLRLRFKRCRNR WTQYYHQDVSGLSTITFHDLSDVSPEEQAKTIDKISARSHTMLNIEHGPMMSVLCFTGLH TPRDQLFWSCHHLLCDTVTWHLLLNDFKKIYLALSQGKTTANYPNRSSYADWVNALKKYA RENACPNQMPYWLEVVKSIQPIAYDYNACEFYQSDSRSLVTSLSHQETRELLTCANQYLG TRPQELIITALRLAVYQWRGLDELSITMEGHGREPICDTIDIHNIAGWFTTLFPVHFKQS PTQSALPLILDTKNHLRRIPDKGLGYGALLYLLPDNQTKKLRQANMPNLSFNYMGVMDNQ VHQDQFKIIETKSDDWVACENRSDYPLAINCYVINNQFKLQLGYSSKHFKKASIQTLLKK MAQGLKDVLSCAREQYKVVHAASDFPLLTLSQATVNVLSQDSEIESIYPLTPLQQGLYFH SRANVDPYVSQLCWQVRKGISLNLLKNAWAALVKNNPVLRTAFHQLSDGQLIQVVHRFKE LHWQVLDWSNLDENSYQYKLTELLTQDKGNGFDLTKAGCMRFFIIKARDGKHLCIWSHHH IILDGWSVGLLLQQLDDCYQTLAPGKSLHAARPQPVRFEDYVAWYINQPRQQALNYWKNL LKGYQEPATLLIHRYLGKAPITSHRALQFSQQITHACQAFCKQTTITMNTLLHSALGLIL AKYSRRKDIVFGMTISGRTIELQGAETITGLLINSIPVRMRLTDDVSVTDVIHSLHRQIH ESQKYACIGLTDIQHAINWQSEKPIFNYLSVLENYPHHESHLFEHCTVKEETHYPLSFVF EDQNDLKMTAIFDEHCFSGSLIESMLTHLQCCLMEMTRKPDAPIATIDILPRNERDKILH TFNQPIHDKIANEANIISTFERISKKYPHNLALCHQQMSLTYAQLSEQITRFSNYTLYCL QESGVVIDSGLPVPLLLNKGIQQIIAIFAVLKLGCAYVPVDPDLPQARINTILSDINSKL LIHDEANAQKASVTAKGCCINIDKEWHVSTRHNLKLPPPTKNNLAYIIFTSGTTGKPKGI MIEHRSVLNYVEWMANALSLNASDRFMQFANYGFDASVWEIFVPLLTGARLFIPGEKELQ DFRDLVAWMKIKDITIAQFVPSLFPVFLEIKEFSNLVNLRYLCAGGEKLSYDAVKSILKK LDLEIINLYGPTEVTIDATYKRINRDNFLELDHIPIGKPLANYQVIILDQYHQLCPPGVP GELCVSGLGLARGYYGQEQLTNNVFISNPYSGNTTGSGTRLYKTGDLASWSADGDIYYSG REDSQVKLRGYRIELDEIKERILEIRQIRQAEVLYMDKPDQSLVAFCSVRAHGGEDGLST QTLVQQHLATSLPSYMIPTKVIEIEHFPLNANDKIDYTKLKALYQSSSGVRQHSLRIHDQ FIAENLSLIWKRIFNVDEISPDSHFYHLGGHSLKAMQLVLGIEEQLGIFCHTSMILQNPK FIDLVAAVSAGKLLPGKTLNFDALNGNTSELSSEQKRIWFLSNISDNISRSYNMILSYQI IGELDIGRLEHAFRRLIKNHPILRARFSQIDGKIVQHSTQDIEPLLNVMPVKDAGEVDRQ IQKTINHPFDLTSRCWNVLLLKRTKKDHIMIITIHHILGDGWSLKLMMDDIACYYNKQQV DIAGNPYHYGHYIAWQKQFLESAEAKKQRQYWLEKLKNYERLSLPYDKNSPDFTGFSCNT FHFYLGNKRLKALHKLAEQEHCTPFMVVYGLLNILLYKITQQVDIVIGLPITQRVIPDTD KIIGCLLNTLVLRNQFSADDRFCDFLGTSRKVCLEAYENQLLPFEKIVTDVEHDRDPLRN PIFQVILNWFSDDEAVTLSLDGLDVKPYKIAHPYAKFDISFSFTHKEDRLGVTMDYNRSL FSYDFMREVKRSLLNIIDSALSNPDIRLADIPLLKDSQQSSLLPLHAPAPEFTLPAGDLF DVFQHQALKYPDKIAIVHNTASITYTELHEKSLALSANITIHDKIIAIVLERGTTLINAL LAVLASDNAFVIIDPHQMPVTRIDKIVQQCDINTIITSTEHLARLSSLKADPCRLINIDT CKTSDAPPPARGRRQSLSCEKMAYVISTSGTTSEPKMIAISHKNLLNHLLWRQTVFHLSA RDVVLQKTSATFDASIWEFFLPLFLGAKCVIADEQHMLQFETLFDIIEDNAVTIAQFSPS VLELLLQSPHAKRLNGLTHLCIGGEVFTRRLHAKCRAVYHGNLYNLYGPAETTIDASYQI VDTKKQNRDIPIGKAISNVALYIVDSNRKLLPKGYIGELAISGCAVGLGYVNDPKLSNEK FIDNPFYQSGQPEIFSRLYLSGDLARMNKDGTIQFIGRRDRQIKFHGIRIDLTQIEYYLT QHPTVCEARVIMFKQENSSHLAAFLMGYDGNMPAYDYWQRYLTNYLPAYMCPAYFLTIDE IPLTSNGKTDEHALQQRISQYLSEKTPRQDQQEQENESVLQLRKIWQETLNHAQFGNEDN FFHVGGDSILSVQLVDRINQIFGTAFSITWTFTYNTIFRQAASIPLERHRSYMPVVRLNE IHCNKKLFFIHSGVGGAEVYMNLAKYLDSFEAYGIEPYNFYHSEAMIEDIGELADYYLGL IKKCQPIGPYQLAGWSLGGLLAFEVAYRLQKLGDEVEQVFLLDSFHYDKSSLQQITRFYS ENQSNNNLLSELLHESRLPDKYRQRLATLMLNNCKMLYGYTPGKISARVVLFKAMHNEYF DAGLYPQKYIDAIMNLYAKPDNGWHQKARHLDIHQLECTHKTMINKEHARNIARFIDATN QSTLAARIR NT seq 20730 nt NT seq  +upstreamnt  +downstreamnt atggattcaattattacttctccaaagcgttcaataatcggttattttaataaacaagtc agtgaacacggtaataacgtcgctctcataacaccccaggaaaccatttcttaccaacaa ctggcctcccgggtaacattactggcgcgacatttacaggagcgtggtgtcggagcggag caattcgttactattgcattggaaagaagtatcgagtttgtggtttcctgtttggccgta ctcaaagtaggtggtgcttatatccctgtcaatacggacaacgatatgaatcatatccga agtattattaaggatagcggcagtaaggtgctgttgaccaggggaaccggatacgaacaa ttaaacgatggttcactcacagtgatggatctcgatgccctccatgaagaatgttgccat gccagtttttccaaaccagcatataatcctgtcgcgtatgcaatctacacctcaggctca accggacaaccgaagggggttaacagcactcaggaagcgctgttaaatcgcctcgaatgg gtatggcagcaatattcattcagccgggatgatgtctgctgcctcaaggctccggtacac tttgtggattcagtcggagagatttttttaccgttgctgcaaggggtgccactagcaata gttccaccaaaaatggaactggaacctgagctttttctggaatttctagcaacccaacag gtctcacgcctggtcctcgttccttcccagttgcaggtgatcctggactatagtcccttc ctgaaagacaggttacccgcactcaaacacctggaaatcagtggcgaaggtttatcgaca aaactcgctttacggatacaacaagccctcccccaaacgacgcttatcaatagatatggg tcaagtgaatacacctcttgcatttttcatgagattggtactatcgataccagggaaacg atgatccctgttgggaagcctatacataatacccgtgtttatatcctggatggtgatatg aaaccggtgaatcccggtgagcagggaatattatggctgtccggcaagggtttgtcgccc ggttatctgaataatgaccgcctgaccaggcaaaagtttaaacccaatccattttatgaa gaacaccaagagtctctctggtattcacgcatttataacactggagacttggtgcgcttg aatgaaaataaggcgctcattcatctgggaagggctgatacccaggtcagtatttatggc aatcgtattgaattgtccagcattgaagccttgctcaataaccatccgggtgtcaaacaa gccgttgttgttttaaataaacataatgatatcgaacatttaaaagcctatgtatgcttc gaggataacattgcagattttgtccaacttcgggaacatcttgcccgttcattgccgcaa tatcagatcccaagcatctttaaagcagttaaaacattcaaacggcttgccaatggtaaa atagacaggcgcgccctgcaatcaatggatagagaggtcgagaagacaactgttaccgaa gaaaatccaatcaccgattacctgatttcagcatgccagtcgttattacccattggagaa atcgcacgaaaccacactttttttgaattaggcttaaactcattgatgttgatgacatta gtgaccatgattcaaaagcattttggaattcattgtcaattttccgatctgagccgcaaa aacacagtgggacggttgagccggttcatagccgagcgacttgccaaacaggaaaaaata ccgagtgcccatgccgttacattgcaaagcggcaaaccgacgatcgcgcaaatgagattc tggttactggaaaatagaatcaatggcgatgaaagtcccaatcatatcaccataacacta agaatcaatggtttgccggatgtagcaagattacagcggtgtctgacggcgattatcaac gacaatccggctttgtctacgaattttaaatacctggacaaccagttaaaagccatcgcg cataccctggattggcatttagacgttatcagctgtgatgaaaccagacttggtgcctta ttggaaaaccacatcaaaaagcgcttcaagcttgaaaatgattacttgttgcgaggttgc ctgttcgaaattgaacaggactattccgtgttgagtattgtcgcccaccacattattttt gatggctggtcgcagcagcaatttttaaggttattgttcaacaggtacaatggggcggaa gatctcgctcaagttccttacgtggaagataaaaaactttggccgcctgacaccagccag ctgtcacgttttcaagagaatctggcaaaaatttcctccgtccatttgcctgttgaactt caaaaaccggcggtgacttccgtatcgcaataccgcttcaaaatacctgccgataaagtc atcgctattggcgaccttgccaaaaaaaatcacagcacggtttatctcagtttattatca atgtttgcggtttttttaggccgttacactcaaaatcgtgatgtttcattaggaacggtc atttctctgcgtgacagtaatgaaatgggatgcctgataaacacccttcccatgcacatt catctggcgtttgaacaagacttcgctacgttactggccgacgtccaggcacgatttttt gatttttatccggttattgaatatgcccttgatccggattccggtttaagtcaacagcaa ctcaaggcagagtctgaattaaatgtctttttcatatttgaaaaaattcatgatcaccag gacggtgatttgggagggttggattgtgaattattatatcccgatcaatccgcccccaaa tcatccctcggtctttatattgaagaacatcagcatgaattaaacggcatcttcaagttt gatccggcgctcttcaggaccacgacgatccagcggatagcaaataactttctaacgctg atagattccattttgagtgcccgagccttgccactgtacaggcaccgcattttgcagacg gatgactaccacaaacttctttatcaatggaacgacacgtctgtaccaaaaaaatacaaa acactgagtcgcctgctctacgaaatagccagtcaaagaccttctgataccgccgttatc gatcacgacgacagcacttatgactatgcctggatcttgcaaaatgctgaaacaatggcc ggtgcattcattcaaaaaaaacatacgccgggcagtgtcattgccgttgctgtcgatcct ggcatcgatatgatagtgacgctgtttgcaatattgaaatcaggttcggcctttgtaccg ctggatccacgccatcctgaaaaacggctgcaacatattgttacagatagtaaagccggg atactcgtcacggaagaaaaatattatacgtttttcaagaaggcggcggctcaggacgtt caggtttgtaccgtcaatgtattacgtaatcatccgcaccctgcgacaacgatagatcat gccgttatcgacgacaccgcatgcattatctacacatccggttctaccggccgtcccaaa ggcgtcaaaataagccattattcaatatgcaaccgtttgagctggatgtgggatgctttc ccctttacggcaacggacaaatgcagtcaaaaaaccgcactaagtttcgtggattccctg tgggaaattttcggaccgattcttggcggcgtaccgttgtctattatgagtcagcagcag cgcgattccattgaaaaaacagtgacaaagcttatcagggatcaatcgacaaggttagtg atcacgccctccctgttaaaggtgattctggattacctgagcgtcaatgaattaaaactt gaatcactgagaatgtgtgtgattagcggcgagaatgcaagcggtacgttaataccatca atcaaggcccatctccccaatgccagattattaaatctctacggctctacggaagtcacc gccgatgccagtttctatgaggttagcgataaagattgcgatgcgtcctcaattccggta ggccgccccctggataatatgcaaatgtttgtgcttgatgagtattggcaaccattaccc ataggggttatcggggaattgtttatagccggtgacggggttgccgggggctatctggat gacgcgttaagcgcggataaattcattacccgggagattgaaccgggcaaaccgagacga ttatttaaaaccggtgatttggccgcctggcaggaagacggcaacgtgattctcgccggc cgcaatgataatcagatcaaaataaatggcatgcgcatcgattgccatgaagttgagtat tacttacaaaaacatcacgcttgtgtccaggctatcgttctcccctggcatcaaccgggt tttgccgtactcattgcgtttattctaagtcccgaccgtcatttagaaccggatgaatta agagattaccttggacttcatctccaggatacctttatcccgtcgtatttctacgtgctt ccatcctttccggaaacgatcacgggcaaaattgacagaacagcgttgctctcgcaccat gagcggcacatcagcacgccacagaacaagcctcaagccattgatgaaatggaacaactc attttaaatttctttaaagacagcttgcctgacaaaaacattgatgtgaacgccagtttc tttgaacatggtggcagctctctttccgccatggccctggcccatcgcgtcaaatcattt tttgacattgacgttggactgtcggatttatttgataatgcaagcgccagaaaatttgca cgcttcattagtcacgccaaaaccagtactgttgatatgcctgaactgctgcacactcaa cgaaaaggaaatcagtttccggcgtccggtggacaacgtgcgatatggttcgcggccaat gccagccttgatacgccatggttatttaacgtgccattcgtgataagtctaaccggaaaa cttaatatcaaagccctggaagccgctatcaatcgaattatcagcgaaaatgattgctat caagtcaatttcagcctgcagcaaggaaaactgtatcaaacaatttcacataaccatttg attataaaacatattcgtgtgtcatcaaaatcggaacttaatcaacagttaatcgaacac gccaaacacaccttttcccttgagcaaggtttgttaatagcagtcaccctgtttcaattg aatgcctcgcgcttcgagttgcttgtcaatcatcatcatatcatcaccgatgcctgctca atcggcaaattcctggaaaaactgggtcgatattataacctcgctgccaatgactcctgt gaatacgaacataaaaaaacaaggcggatagactacattgatttctcgcagtggcataac cgcttgcatgaggaaggcgtttttcgagaacaactggattactggcgaacgcagttaacg attaacgcagcgtcttccctgcggcccgatcgatttgacaatcatagcgtctcttcgcat gaaggcgcgaggtatcatcaatcgctgtcattaaaaaatacccgggcattgaccgtacta gcccatgacaatcatgcgacgccaggcctcgtattactgaccgtgttcaaactggtatta tcgagattttgcaattccagaaccgttttactcggcatgcccgcagcccaccggcactgg ccggaattaaccgacatgcttgggtattgcatcaatacattgccggtacttacccaattc aacaacgcctctcatttcagcgaagcaatagccattgttaaaaaaagtatgtttgaagcc ttgaaacatcaggatatatcattgggatttgttcaggaaacacttggtatatcatccccc tacaagatagggtttgattttaacagtgacaatcagaactatcatttggatgcccaagac cttgaaagcaaaataagatatctgtatctcgatacggcacaatatgatttaacgctgttt gttaacaaaaccgattcaggtcttgattactcattcgaatacaagactgcgctatacagc gaagcgtttattcaccagctggcaaggtatttcaacgatttaattcaacatgtgcttcga catggttcatcgagtccggtcttacactatttgcccgcaaacgaggaaaaactattgctg caacaaggtagtataaaaggcaaacactacccaacgacgggtcgattttttaacgatttt atacaagtcgccaggcaataccccgagcgtattgcaatccattccgggcaacgcgatcta acctatgccggtcttatgaaggctattgatgaaatagctcatcgtctctgcgcgcaatta ccccttgcctcgactaaaaaacagcctgtcattgccacttgcctgccgcaaaataccgac tggcttacagcgattttagccatctggaagattggcgcgtgttatctgcctttgaatgcc acctttccgacaaggcgaatcgctgcgatgaatcaagccgttttacctgatctgattatc accgactcgcagctgctcaacaaacatcacgaggcttttggtgatagtccggctctggtt atcgataaggcggaggaggcaaatcagagcgcgttatggaactttgcaagcgggaaaaaa aagaaaccctacgcctatatcatttttacttccggaacaaccggtactccgaaagccgtt cctgttttcgaagaagcctttttgaacaccgcttatgctcaaatagaagccttccgggtt aatgaccaaagtcgtatattacaatttgcaaactgttccttcgatgcgtccctgtctgaa attgcaaccgccctgttgtgtggcgccagtctctgcgtcataccggatccgttgcgcaaa gatgctgacgcgttgctggattacatcaaccgggaaggtatcgatatagcgactttacca ccggttatgttgtccatgatgccaaaagataaatcacttggcttaaaaacgttagtcgtt gccggtgagtcctgtcccgcggacgttttttatcattggtcccgggaaagacatttcatt aatgcctatggaccaacagaggtaaccatatgtgcctccttgaaggaagtggacagtcag acgttaccatcctgtattggcaaacctttaaatcgcatacaactctacgttctggatagc aggcaaaatcttgttccccggggcgctgagggtgaattatatatcggtggccctcaactc gcagacggttatctgtctcaaggcgaagacaaccggcatttttgctctgtgcaaattgcc ggtatcaagaaaaaactctatcgcagtggtgattgcatacgctggcttatgaacggcgat ttggaattcattggccgggtagaccggcaaatgagctatcacggcgtacgaatcgagccc cgggaaatagagcaaagactggaagagctctcctttgtcaggcagtgtgtggtatcgctt gaaggtaatgagcacctcgtcgcattcattgaacccaatgaacctatcaccgaacatcac gatggactggagttttggccctccgtcgcggaatttttcatctatgatgaatttctttac agtgttatgaccaatgatttgaaaagaaattatttttaccagaatgccttgaatgatctg gcaaaagataagcttgttttagacataggcactggcaaagatgccattctggcacgactg gcgcttgatgccggtgcaaaaaaagtctatgccatcgaatacctgcaagaaacttatcaa gccgctaaaagaacgctggaaaatctcaacctgaccgacagtatcatattgattcatggt gattctcggcaggcatcactgcccgagcctgttgatatcatcgtatcggagattgttggt gcgatcggtggttctgaaggagcggcagtcattcttgatgatgcaaaaaaacgtcatctg aaaccaggcggggtattgattccggataaagccatcacaaaaatagccgccgtgtcgtta ccggatgagtttctgaataatcccggttttgcgccactagccgcagactatgccgacaag atcattaacgatcacaacgtgggttttatgccaaggatttgtattaaaaatatcaggccc caacatctgatttccgaggcaaccacatttgaattattagcgtttaaccagtatccggct tcctcagggacgcatcaagccgcaataagagtaacccgtgacgcccctttttccggattt atcgcatggcttaatttgtatgatcataacaacggaagtattgatattttacaggatacc cactgctggctaccggtttattttccagcgtttgaagacaacctgatcctgcgaaaacag gacttgattgatatcaggtgtgagtacaggttatgtgataatggattaaatcctgattat cgaatccatgcggtgatctggcgaaatcatcgaaagatcagcacctattcctatgactct ctgcattttcaccctgctgacagcgcccatccattttataaaaaattatttgtagacaac caggcaatcattagcaaggcgctttccgccacgcaataccagtcattaataaaacatcag ttagtacttcacttccccgatttcatgcggcccagacacaccattttgcttgacaggttc ccactcaatgcaagtggtaaaatagataggcatcaactgtcaaaaatatttgcggaaaag tgtcgtgatagtcgtgactatgaagcaccagtaacggcactggaacgtcaattgcaggaa gtctggtccagactgctgtcgcaaaaggatatcggtcgcaacgtcagtttttttcatctg ggaggtgattccatcacggctataagcctggtgtcagaactgcaaggttcaggaatgaat cttagtgtgcgggatttatacgcctatccaagcattgcgacgcttgcgcttaaaattgaa gaaaccagtcgccatgccaagcctggctcaggcaatgtctcagcgatgtacaccagcccc gaatcgggcttatacccgctaaatccgttgcaacaggatatgctcacagcgtaccggtgg tatccggactctgatttgtatatcaatcaagtgtattggctaacgaccatcgaggatatg gacagctatcagcaagcctggcaaatattaattgccgagacggaatgtttgcgacttagc tacgtatgggacgagcagggtatttgcgggcaaataattaattccgccccaatgctgaac tgggacattacagactggtcaaacctcagtgaagataaacaacagtcccgattgaagtcc tgtctggctaaagacagaaaacaaggatttgatcttgccctgcctggcccgatgagggtt cgatgctttttgcttggtggtcaacgtgcctatgtgctctggactcaccatcacatcatt ctggacggctggagcttgccgttattactcaaaagactcgatgaaatatatcacgaccgg cttttttcatttgagcggcaacgaacatccggcccccaattcagtcgatacctggaatgg cttcgcgcaagggacagggatgcggccgtcacattctggaaatctcagcttggggaaatt agccgggcaacgccattacatttctgccggcaatcgctaagcggttatgacatcacaagt tcccagtcgattctttcaacccggctccctgacgttaagacccatgagatagaatttttt gcaaaaacgcatgggattaccattaacactattttgcaaatggcctgggcaataacgctg atgtattatagcgatgaagacgtggttatgtttggtaccaccgtttcaggacgcgacatt gatcttcatcaggcggccgaaatacccggtatgatgataggcactgtccctatcctggcc aataccgccaactacccgagtctcctggacggtttatatcatttacaaaaaacaattcac aacgcacaaacccatgcccatattgggctcggcgacataaaaagggctatcggatgggct gactcatcccccctgtttcattcgttattcgtctttgagaattacccgtccggcatcaac tatgggtttcatgtggatgaaaaaaccaattttccacttgtgataagtcttatacatcag gattgcttacaagtagaactgacctacgcggataactatttcgcacccgcgataatgaac cggctgctcgcccgatattgtaaaactcttggactcatcacccgatcacccaataactca ataaacgagttaacgcttattaccgatgaagagattgccttacttaaacgatggaataca acccgggttaaaacgccggatacgacaattccccatctttttgaaacggcctgtcatcat catccaaaccgcatagcgctggagcatggcgaactgagcctaacctacaaggtgttaaat caacgctcggatgcgttatgtcgacgtttatgtcatcaatacaaaaccatattcggatat tcatttacgcctgaaactattattgccgtctacctcgatagaggagtcgacctgtttatc agtatccttgcgatcctcaaggcgggaggatgttatcttcccctggataaaaactatccc aggtcgcgtaatgagtttatcatcaaagattccgcgcctgcctttatcatgaccaatcaa gcattagcgccggatgtatccgaacacacattattgctggttgatttggaaaccgatacg gaggatgcgtcggtaaaaccgcccgttataacgaccaataacctggcttatattatctac acatccggttcgaccggcacccctaacggcgtcatgatcgaacacaagggcgtggtcaat ctggcactgaatactgccaaagccttgaaagtagaaggcaacagtcgattgctgcaatta aattcaccctgttttgatacgtcggtacaggaatggtcgttggcgttactcaacggcgcc acccttgtgatcccaaccaaagacgagatgccgccctccaaaaaaatcggcgaattgatt ctggaaaagttcattacccatctcaacgcgccgccctatgttataagtagtaccgactac cagagataccccagcctgaaagtcatcatcagcggcggcgatatctgccacccttcactc gttgataaatgggccggtgattattactttgtcaatgattatggtccaactgaaaccacg atttgcgtatcaatgacccgatgccttcccggcaaaaaaccaaccattggcagccctcat cccaataccagattctatgttttaaatacccgtggacaattggcgccgattggtacaatt ggagagttgtatattgccggtgtcggtatggcacgagggtatttgaatcgcccccactta aatgagtcgcgctttcttacgaacacgtttgaagacaccgacgttaacgcggattacaaa acactctacaggacaggcgatctggttcgctggacagatgaaggaaaactcgaatacata ggaagaatcgattctcaattaaaaatcaggggatatcggatcgagcctgttgaaattgag aactgtctcctgacccataaaaatatcaaaaactgtgtcgttatagccgatggaaaagag agccagagactttccattttcatcgaaagaatggatagcaacgcatcgacaatcgaggaa tgtcgcaggtatatgcaaaacaggttaccaacgtttatgctgcctaatcattttgtcatg gttgatgaattgccgctgctgcctaatgccaaaatagacagaaaggctttactcaggcaa ttaaacaatatcgtacccgtagatagccatgagagtactttaaatcaagagcaaaaggct cttatggatgctttcacccaggctttaaactataaggaaattacccccgatagccatttt tatacgataggaggagattctatcaatgcgattcaagtgtctgccatcatgcaacaaaaa ggataccaccttacgcccaatatgttatatgaattcccgacaatcaaggcactggcgcaa caactggaaaagcataaaaacagcaaggctttggcgcgcataccccagggtaatattgaa ctcagcccgatccagcactggttttttgagagggagctggcgaatcagcatcattacaat caggccgtcatgcttgagtacgatggtacctttcaaaaagattgtgtcttaaaaaccata aaggcgctggaggaacgttatgatagtttgcgtttgcgtttcaagcgctgtcgcaaccgt tggacacaatactatcatcaggacgtctctggattatcaaccataacgtttcatgacttg agcgatgttagcccggaggagcaggcaaaaactatcgataaaataagcgcccggtctcat accatgctaaacattgagcatgggccaatgatgtctgttctatgttttaccggactacac accccccgtgatcaattattctggagttgccatcacctgttgtgtgatacggtaacatgg catttattgcttaacgatttcaaaaaaatctatctcgcgctgtcacagggtaagacaacc gccaattatcccaatcgatcgagttatgcggactgggtgaatgccttaaaaaaatatgcc agggagaatgcctgtcccaatcaaatgccatactggctggaggtagtaaaatccattcaa ccgatagcgtacgattacaatgcgtgcgaattttatcaatcagactccagatccctggtc acctcactctcgcatcaggaaaccagggagttgctaacctgcgccaatcaatatttaggc accaggcctcaagagttgataataaccgcattacgcctggctgtttatcaatggcgtgga ctggacgagttgtcgatcactatggaaggacatggccgtgaacccatttgcgataccata gatatccataatatcgcaggctggtttaccactcttttcccagtgcactttaaacaatcc cctacccaatctgccttgcctcttatccttgacaccaaaaaccatctgcgacgcataccg gataaaggattaggttatggtgcgttactatacctgcttcctgacaaccaaacgaagaaa ctgcgccaggcaaacatgccaaatctcagttttaattacatgggtgtaatggataatcag gtacaccaggatcaatttaaaattatagaaacgaaatccgacgactgggttgcttgcgag aaccgttctgattatccgctggcaatcaattgctatgtcattaataatcaatttaaacta caactaggctacagcagcaagcactttaaaaaagcatccatacaaaccttgttaaaaaaa atggcacagggactaaaagacgttttatcctgtgccagggaacaatataaagtcgttcat gcagcctcggactttcccctgctgaccttatcgcaagcaacggtcaatgtattaagccag gatagtgaaatagaatcgatttatcccctgactcctttgcaacaaggtttgtattttcat tccagggcaaacgttgacccttatgtttctcaactgtgctggcaggttcgcaaagggatt tctctcaacctgttaaaaaatgcctgggccgctttggtaaaaaataatccggttctaaga accgcttttcatcagctttcagacggtcagcttatccaggtggttcaccgttttaaagaa ctccactggcaggtattggactggtcaaatttagatgaaaattcttaccagtacaaactg accgaattgcttactcaagataaagggaacgggtttgatctgactaaagcaggatgtatg cgcttctttattatcaaggcaagggatggcaaacacctgtgtatatggagccatcatcat atcatccttgatggctggagtgtcggcctcttattgcaacaactggacgactgttatcaa acacttgcccctggaaagtctttacatgccgctagaccgcaaccggtcaggttcgaagat tatgtagcctggtatatcaaccaaccgagacaacaagctctcaactattggaaaaattta ctgaaaggctatcaggaacctgccaccctgttaattcacaggtacttgggaaaagctccg attaccagtcatagagccttgcaattttcacagcagatcacccatgcctgccaagcgttt tgcaagcaaacaaccatcaccatgaatacccttttacattcagcattgggattaatcctg gcgaaatacagccgccggaaagatatcgtttttggtatgaccatctccgggcgaactata gaattgcaaggtgctgaaacaattaccggtctcttgataaacagcatccctgttagaatg cggctcacagatgacgtttctgtcacggatgtcattcacagcttgcaccgacagatccat gaatctcaaaaatacgcttgtatcggcctgactgacattcaacacgctattaactggcaa tcggaaaagccgatctttaactacctgtccgtattggaaaactaccctcaccatgagtcg catttatttgagcattgtacggtcaaagaagaaacacactacccgttgtcattcgtgttt gaggatcaaaatgatcttaaaatgaccgcaatttttgatgagcattgtttttcaggttca ctcatagaatcgatgctaacccacttgcaatgctgtctgatggaaatgacaaggaaaccg gatgcgcccattgcgaccatagatattttacctcggaatgaacgcgataaaattttacac acctttaatcaacccatacatgacaagattgcgaatgaggcaaatattatctcgacgttt gagcgtatcagcaaaaaatacccccataacctggccctttgccatcaacaaatgtcgttg acttacgcacaactttccgaacaaatcaccaggttttcaaattacaccctttattgtctg caagaatcgggggtggttattgatagcggattgccagtcccattactgttaaacaaaggg atccagcaaattattgcgatatttgccgtattgaagctgggttgtgcctacgtgcctgtc gacccggatctgccacaagcccggatcaacaccatcttatcggacatcaatagcaaactt ttgatccatgatgaggccaacgctcaaaaagcgtcggtcacagcgaaaggctgttgtatc aatatcgataaagaatggcatgtatcaacccggcataacctgaaactaccgccaccaacc aaaaataacctcgcgtatattatttttacctcaggaaccactggcaagcccaaaggcatc atgatagaacaccgcagtgttctcaattacgttgaatggatggctaacgccctgtcactg aacgcatcggatcgcttcatgcaatttgcaaactatggcttcgatgcgtcagtatgggaa atttttgtaccactattaacaggtgctcgcttatttatcccgggagagaaagaactccag gacttcagggatctggttgcctggatgaaaatcaaagacattaccatcgcccaattcgtc ccttccctgtttcctgtatttcttgagattaaggaattttcaaaccttgtgaatttacgc tatttatgcgccggtggtgaaaaattatcatatgatgccgtcaaatccatattgaagaaa ctcgatcttgagataataaacctctacgggcctacggaagtcaccatcgatgctacctat aaaagaataaatcgtgacaacttcctggaactggatcatattccaattggcaagccactc gccaattatcaggtcatcatcctcgatcagtatcatcaattatgtccgcccggagtgcct ggcgagctgtgcgtcagcggtctgggactggccagaggttattacggacaggaacaattg acgaataatgtttttattagcaatccttatagcggcaatacgacaggcagcggaacccga ctttataaaacaggcgatctggcaagctggtccgccgatggcgatatctattattcagga cgcgaagactcgcaggtcaaactacggggatatcgcatcgagcttgatgaaatcaaagaa cgcatattggaaatcaggcaaatccgtcaggcagaagtactgtatatggacaaacctgat caatcgctggtagcgttttgctccgtcagagcgcatggcggggaggatggcttgtctact caaactcttgtacaacaacacctggcaacgtctctgccatcgtacatgatcccgacaaaa gtcatcgagatagagcactttcccctaaatgcgaatgataagattgactataccaaactc aaagcgctgtatcagtcatcaagtggtgtacgtcaacatagtctcagaatacatgatcaa tttattgcagagaatttgagtcttatctggaaacggatttttaacgtcgatgaaatttct ccagacagtcatttctatcatctgggtggtcattctctgaaagccatgcaactggttttg gggatagaagagcaattagggattttttgccataccagtatgattttacaaaatcccaaa ttcatcgatttggtcgcggccgtaagtgctggaaagttactccccggtaaaacccttaat tttgacgcattaaatggcaataccagcgagctttcatccgagcagaaaagaatctggttc ttatcgaatatcagtgacaatatcagtcgaagttataacatgatcctgagctatcagatc attggcgaactggatatcggcagactcgaacatgccttccggcgtttaatcaagaaccat cccatactccgcgcccgtttttcacaaattgatggcaagattgtgcagcactcaacgcaa gacattgagccgttgctaaacgtcatgcctgtgaaagatgctggtgaggtggacagacaa atacaaaaaactataaaccatccttttgatttaacgtcccggtgctggaatgtcctgctc ttgaagcgaacgaagaaagatcacatcatgatcataaccatccaccatatcctgggtgac ggatggtcattaaaattaatgatggacgacatagcttgctactataataaacaacaagtc gatattgctggcaacccataccattatggacattatatcgcctggcaaaaacaatttctt gaatctgccgaagcgaaaaaacaacgccagtactggttggaaaaactgaaaaattatgaa cgcctttcgctgccctatgataagaactcaccggactttaccggattttcatgcaacacc ttccatttttatttaggaaataaaagactaaaagcactccataaacttgccgaacaggaa cactgcacgccattcatggtggtgtatggtctgctcaatatcctgctctataaaatcacc caacaggtggacattgtgattggcttgccaatcacacaacgggtgatccctgataccgac aagatcattggatgcctgctcaatacattagtcttgaggaatcaattttcagccgatgac cgtttttgtgattttctgggcacgtccagaaaggtttgtcttgaagcttatgaaaatcaa ctattgccgtttgaaaagatagtgaccgacgtcgagcatgatcgtgatccccttcgcaat ccaatttttcaggttatactcaattggtttagcgatgatgaagccgtcacactgagtctt gatggtttggatgttaaaccgtacaagatagctcacccctatgccaaatttgatatcagt ttttcgttcacccataaagaagataggctcggtgttacgatggactataaccgatcattg ttttcctatgatttcatgcgcgaagtcaaacgcagtttactgaatatcatcgattcggcg ttatcaaatccggatattcgccttgccgacattccattattaaaagattcacagcagtca tctctattaccattacatgctccggcaccggagtttaccttgccagccggtgatctcttt gatgtatttcaacaccaggctttgaaatacccggataaaattgccattgtacataatacc gcgtccataacctatactgaactccatgaaaaaagtctggcactttcggcaaacatcacc atccatgacaaaatcatcgccattgtccttgaacgcggtacaacacttatcaatgccctg ttggcggtactggcctccgataacgcgttcgttattatcgacccccatcaaatgcctgtg acgcgtatagacaagatcgttcaacaatgcgatatcaatacaatcattacatcgaccgaa catcttgcaaggctttcttcattaaaagcggatccctgtcgattgataaacatcgatacc tgcaagacttccgatgcaccacctccagccaggggcagacgtcagagtctgtcctgcgaa aaaatggcttacgtgatttcaacgtcagggactaccagtgaacccaagatgatagcaata agccataaaaatctcttgaatcatctattatggcgtcaaacggtatttcatctttcagcc cgggatgttgtcctgcaaaaaaccagtgcaaccttcgatgcctcaatctgggaatttttc ttaccactgtttttgggtgccaagtgcgtcatcgcagatgaacaacacatgcttcagttt gaaacacttttcgatatcattgaagacaacgcggttactatcgctcaattttcaccttcc gtgctggaattgttattacaatcaccgcacgccaaacgattgaatggccttacccatctt tgtatcggtggcgaagtattcacacgccgcctgcatgcaaaatgccgcgccgtttatcac ggaaacttatacaatttgtacggccctgcggaaacgaccattgatgcctcttaccagatt gtcgataccaaaaaacaaaatcgggatataccaattggtaaagcaatcagcaatgtggct ttgtatatcgttgacagcaatcgcaagttgctgcccaaaggttacattggagagttagcc ataagcggttgcgccgttggtttgggttatgtcaatgatccaaagctaagcaatgaaaaa tttatagataaccctttctatcaatcaggacaacccgaaattttttccaggctatatctg agcggcgatttggcgagaatgaataaagacggaaccattcagttcatcggacgccgggac cggcaaataaaatttcatgggatcagaatagacctgactcaaattgaatattatttgact cagcacccgaccgtgtgtgaagcacgcgttatcatgttcaaacaggaaaacagctcccac ctggccgcattcttaatggggtatgatggaaacatgccggcgtatgactattggcaacgt tatttaaccaattatctgcccgcatacatgtgtcccgcctattttctgacaatagacgaa atacctttgaccagcaatggcaaaacggatgaacatgccttgcagcagcgcatcagtcaa tacctctctgaaaaaacaccgaggcaagaccaacaggaacaggaaaatgaatccgtcttg caattaagaaaaatctggcaggaaacactcaatcatgcccagtttggaaacgaagacaat ttctttcacgttggtggtgactccatcttatcggtacaattagtcgatcgaatcaatcaa atttttggcaccgcgttttcgattacatggaccttcacttacaataccatcttcaggcaa gccgccagcatacccctcgaacgccatcgctcttatatgcctgttgtccgattgaacgag attcattgtaataaaaaattgttctttatacattcgggtgtcggcggtgctgaggtatat atgaatctggcaaaatatcttgattcttttgaagcgtatggtattgagccttacaatttt tatcattccgaagcgatgatagaggatatcggtgaacttgccgactattatcttggtctg ataaaaaaatgccaaccaatcggaccttatcaactggccggatggtctctaggcggactt cttgcctttgaggttgcttatcgattacaaaagcttggcgatgaggtggaacaagtattt ttactggacagttttcactacgataagtcatcgctgcagcaaatcacccgattttattcc gagaatcagtcgaataataatttattgtccgaattattgcatgaatcaagattgcctgat aaataccgacaacgactggcaactctgatgttgaataactgtaaaatgttgtatggctac acgccagggaaaatatcggcacgggtagtcctgttcaaggccatgcacaatgaatatttt gacgccggactctatccgcaaaaatatatagacgccattatgaatttatatgcaaaaccc gataatggctggcaccagaaagcacgtcatcttgacattcatcaattagagtgcacccac aaaacgatgataaataaagaacatgcgcgtaatatcgcgcgattcattgacgccactaac caatccacactggctgcgaggatccgatga

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