KEGG   Lipotes vexillifer (Yangtze River dolphin): 103078639
Entry
103078639         CDS       T03090                                 
Symbol
PLCB4
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X1
  KO
K05858  phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
Organism
lve  Lipotes vexillifer (Yangtze River dolphin)
Pathway
lve00562  Inositol phosphate metabolism
lve01100  Metabolic pathways
lve04015  Rap1 signaling pathway
lve04020  Calcium signaling pathway
lve04022  cGMP-PKG signaling pathway
lve04062  Chemokine signaling pathway
lve04070  Phosphatidylinositol signaling system
lve04071  Sphingolipid signaling pathway
lve04072  Phospholipase D signaling pathway
lve04081  Hormone signaling
lve04082  Neuroactive ligand signaling
lve04261  Adrenergic signaling in cardiomyocytes
lve04270  Vascular smooth muscle contraction
lve04310  Wnt signaling pathway
lve04371  Apelin signaling pathway
lve04540  Gap junction
lve04611  Platelet activation
lve04613  Neutrophil extracellular trap formation
lve04621  NOD-like receptor signaling pathway
lve04713  Circadian entrainment
lve04720  Long-term potentiation
lve04723  Retrograde endocannabinoid signaling
lve04724  Glutamatergic synapse
lve04725  Cholinergic synapse
lve04726  Serotonergic synapse
lve04728  Dopaminergic synapse
lve04730  Long-term depression
lve04742  Taste transduction
lve04750  Inflammatory mediator regulation of TRP channels
lve04911  Insulin secretion
lve04912  GnRH signaling pathway
lve04915  Estrogen signaling pathway
lve04916  Melanogenesis
lve04918  Thyroid hormone synthesis
lve04919  Thyroid hormone signaling pathway
lve04921  Oxytocin signaling pathway
lve04922  Glucagon signaling pathway
lve04924  Renin secretion
lve04925  Aldosterone synthesis and secretion
lve04926  Relaxin signaling pathway
lve04927  Cortisol synthesis and secretion
lve04928  Parathyroid hormone synthesis, secretion and action
lve04929  GnRH secretion
lve04933  AGE-RAGE signaling pathway in diabetic complications
lve04934  Cushing syndrome
lve04935  Growth hormone synthesis, secretion and action
lve04961  Endocrine and other factor-regulated calcium reabsorption
lve04970  Salivary secretion
lve04971  Gastric acid secretion
lve04972  Pancreatic secretion
lve04973  Carbohydrate digestion and absorption
lve05010  Alzheimer disease
lve05016  Huntington disease
lve05017  Spinocerebellar ataxia
lve05022  Pathways of neurodegeneration - multiple diseases
lve05142  Chagas disease
lve05143  African trypanosomiasis
lve05146  Amoebiasis
lve05163  Human cytomegalovirus infection
lve05200  Pathways in cancer
lve05415  Diabetic cardiomyopathy
lve05417  Lipid and atherosclerosis
Module
lve_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:lve00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    103078639 (PLCB4)
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    103078639 (PLCB4)
   04310 Wnt signaling pathway
    103078639 (PLCB4)
   04070 Phosphatidylinositol signaling system
    103078639 (PLCB4)
   04072 Phospholipase D signaling pathway
    103078639 (PLCB4)
   04071 Sphingolipid signaling pathway
    103078639 (PLCB4)
   04022 cGMP-PKG signaling pathway
    103078639 (PLCB4)
  09133 Signaling molecules and interaction
   04082 Neuroactive ligand signaling
    103078639 (PLCB4)
   04081 Hormone signaling
    103078639 (PLCB4)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    103078639 (PLCB4)
   04613 Neutrophil extracellular trap formation
    103078639 (PLCB4)
   04062 Chemokine signaling pathway
    103078639 (PLCB4)
  09152 Endocrine system
   04911 Insulin secretion
    103078639 (PLCB4)
   04922 Glucagon signaling pathway
    103078639 (PLCB4)
   04929 GnRH secretion
    103078639 (PLCB4)
   04915 Estrogen signaling pathway
    103078639 (PLCB4)
   04921 Oxytocin signaling pathway
    103078639 (PLCB4)
   04926 Relaxin signaling pathway
    103078639 (PLCB4)
   04935 Growth hormone synthesis, secretion and action
    103078639 (PLCB4)
   04918 Thyroid hormone synthesis
    103078639 (PLCB4)
   04919 Thyroid hormone signaling pathway
    103078639 (PLCB4)
   04928 Parathyroid hormone synthesis, secretion and action
    103078639 (PLCB4)
   04924 Renin secretion
    103078639 (PLCB4)
   04925 Aldosterone synthesis and secretion
    103078639 (PLCB4)
   04927 Cortisol synthesis and secretion
    103078639 (PLCB4)
  09154 Digestive system
   04970 Salivary secretion
    103078639 (PLCB4)
   04971 Gastric acid secretion
    103078639 (PLCB4)
   04972 Pancreatic secretion
    103078639 (PLCB4)
   04973 Carbohydrate digestion and absorption
    103078639 (PLCB4)
  09155 Excretory system
   04961 Endocrine and other factor-regulated calcium reabsorption
    103078639 (PLCB4)
  09156 Nervous system
   04724 Glutamatergic synapse
    103078639 (PLCB4)
   04725 Cholinergic synapse
    103078639 (PLCB4)
   04728 Dopaminergic synapse
    103078639 (PLCB4)
   04726 Serotonergic synapse
    103078639 (PLCB4)
   04720 Long-term potentiation
    103078639 (PLCB4)
   04730 Long-term depression
    103078639 (PLCB4)
   04723 Retrograde endocannabinoid signaling
    103078639 (PLCB4)
  09157 Sensory system
   04742 Taste transduction
    103078639 (PLCB4)
   04750 Inflammatory mediator regulation of TRP channels
    103078639 (PLCB4)
  09159 Environmental adaptation
   04713 Circadian entrainment
    103078639 (PLCB4)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    103078639 (PLCB4)
  09172 Infectious disease: viral
   05163 Human cytomegalovirus infection
    103078639 (PLCB4)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    103078639 (PLCB4)
   05142 Chagas disease
    103078639 (PLCB4)
   05143 African trypanosomiasis
    103078639 (PLCB4)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    103078639 (PLCB4)
   05016 Huntington disease
    103078639 (PLCB4)
   05017 Spinocerebellar ataxia
    103078639 (PLCB4)
   05022 Pathways of neurodegeneration - multiple diseases
    103078639 (PLCB4)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    103078639 (PLCB4)
   05415 Diabetic cardiomyopathy
    103078639 (PLCB4)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    103078639 (PLCB4)
   04934 Cushing syndrome
    103078639 (PLCB4)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:lve04131]
    103078639 (PLCB4)
Enzymes [BR:lve01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     103078639 (PLCB4)
Membrane trafficking [BR:lve04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    103078639 (PLCB4)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    103078639 (PLCB4)
SSDB
Motif
Pfam: PI-PLC-X PH_14 PI-PLC-Y PLCB1-4-like_EFh EF-hand_like PLC-beta_C C2 EF-hand_7 EF-hand_6
Other DBs
NCBI-GeneID: 103078639
NCBI-ProteinID: XP_007452098
UniProt: A0A340WRF6
LinkDB
Position
Unknown
AA seq 1194 aa
MAKPYEFNWQKEVPSFLQEGAVFDRYEEESFVFEPNCLFKVDEFGFFLTWRSEGKEGQVL
ECSLINSVRLGATPKDPKILAALEAIGKSENDLEGRVVCVCSGTDLVNISFTYMVAENSE
VTKQWVEGLRSIIHNFRANNVSPMTCLKKHWMKLAFMTNTNGKIPVRSITRTFASGKTEK
VIFQALKELGLPSGKNDEIEPAAFTYEKFYELTQKICPRTDIEDLFKKINGDKTDYLTVD
QLVSFLNEHQRDPRLNEILFPFYDTKRAMQIIEMYEPDEDLKKKGQISSDGFCRYLMSDE
NAPVFLDRLELYQEMDHPLAHYFISSSHNTYLTGRQFGGKSSVEMYRQVLLAGCRCVELD
CWDGKGEDQEPIITHGKAMCTDILFKDVIQAIKETAFVTSEYPVILSFENHCSKYQQYKM
SKYCEDLFGDLLLKQALESHPLEPGRPLPSPNDLKRKILIKNKRLKPEVEKKQLEALKSM
MEAGESAAPVNILEDDNEEEIESAEQEEEAHPEYKYGNELSADDLGHKEAIANSVKKGLV
TIEDEQAWMASYKYVGATTNIHPYLSTMINYAQPVKFQGFHVAEERNIHYNMSSFNESVG
LGYLKTHAIEFVNYNKRQMSRIYPKGGRVDSSNYMPQIFWNAGCQMVSLNYQTPDLAMQL
NQGKFEYNGSCGYLLKPDFMRRPDRTFDPFSETPVDGVIAATCSVQVISGQFLSDKKIGT
YVEVDMYGLPTDTIRKEFRTRMVMNNGLNPVYNEESFVFRKVILPDLAVLRLAVYDDNNK
LIGQRILPLDGLQAGYRHISLRNEGNKPLSLPTIFCNIVLKTYVPDGFGDIVDALSDPKK
FLSITEKRADQMRAMGIETSDIADVPSDTSKNDKKGKANTAKASVTPQSSSELRPTTTAA
LGAGLEAKKGIELIPQVRIEDLKQMKAYLKHLKKQQKELNSLKKKHAKEHSTMQKLHCTQ
VDKIVAQYDKEKSTHEKILEKAMKKKGGSNCLEMKKETEIKIQTLTSDHKSKVKEIVAQH
TKEWSDMINTHSAEEQEIRDLHLSQQCELLKKLLINAHEQQTQQLKLSHDRESKEMRAHQ
AKISMENSKAISQDKSIKNKAERERRVRELNSSNTKKFLEERKRLAMKQSKEMDQLKKVQ
LEHLEFLEKQNEQLLKSCHAVSQTQGEGDAADGEIGSRDGPQTSNSCVKLQDTN
NT seq 3585 nt   +upstreamnt  +downstreamnt
atggccaaaccttatgaatttaattggcagaaggaagttccttcgtttttgcaagaagga
gcagtttttgacagatatgaagaggaatcctttgtgtttgaacccaactgcctcttcaag
gtggatgaatttggcttctttctgacctggagaagtgaaggcaaggaaggacaagttcta
gaatgttctctcatcaacagtgttcgactgggagccacaccaaaggatcccaaaattttg
gctgctcttgaagctattggaaagtcagaaaatgacctggaagggcgggtagtttgtgtc
tgcagtggtacagatctggtgaacatcagtttcacatacatggtggctgaaaattcagaa
gtaactaagcaatgggtcgaaggcctgagatccatcatacacaacttcagggccaacaat
gtcagtcccatgacatgcctcaagaaacactggatgaaattggcatttatgaccaacaca
aatgggaaaattccagttaggagtattaccagaacctttgcatcggggaaaacagaaaag
gtgatctttcaagcactcaaggagctaggtcttcccagtggaaagaatgatgaaattgaa
cctgcagcatttacttatgaaaagttctatgaactgacacaaaagatttgtcctcggaca
gatatagaggatctttttaaaaaaatcaatggagacaaaactgattatttaacggtagac
caattagtgagctttctaaatgaacatcaacgagatcctcgattgaatgaaattttattc
ccattttatgatactaaaagggcaatgcagatcattgagatgtatgagcctgatgaagac
ttgaagaaaaaaggccaaatatcaagtgatgggttttgcagatacctgatgtcagatgaa
aatgccccagtcttcctagatcgcctagagctttaccaagaaatggaccaccctctggct
cactacttcatcagctcttcccacaacacctatctcactggcagacagtttggtggcaag
tcttcagtagaaatgtacagacaggtcctcctggctggttgcagatgtgttgaacttgac
tgttgggatggaaaaggtgaggaccaagaaccaataataactcatggaaaagcaatgtgc
acagatatcctttttaaggatgttattcaagccatcaaggaaactgcatttgtcacatct
gaatatcctgtaattctctcctttgaaaatcactgcagcaaatatcaacagtacaagatg
tccaaatattgcgaagatctatttggagatctcctgttgaaacaagcacttgaatcacat
ccactggaaccaggcaggcctttgccatccccaaatgacctcaaaagaaaaatactcatc
aaaaataaacggctgaaacctgaggttgaaaaaaaacagcttgaagctttgaaaagtatg
atggaagcaggagaatccgctgccccagtgaacatcttagaggatgacaatgaagaggaa
atagaaagtgctgagcaagaggaagaagctcaccctgaatacaaatatggaaatgaactt
tctgcggacgacttgggtcacaaggaagctattgccaatagtgttaagaagggcctggta
actatagaagatgagcaggcatggatggcatcttataaatatgtaggcgccaccactaat
atccatccatatttgtccacaatgatcaactatgcacagcccgtaaagtttcaaggtttc
cacgtggctgaagaacgcaatattcattataacatgtcttcttttaatgagtcagttggt
ctaggctacttgaagacacatgcgattgaatttgtgaattataacaaacggcaaatgagc
cgcatttaccccaagggaggccgagtcgattccagtaattacatgcctcagattttctgg
aacgctggctgccagatggtttcgctgaactatcaaaccccagatttagcgatgcaattg
aatcagggaaaatttgagtataatggatcgtgcgggtaccttctcaaaccagatttcatg
agacggcccgatagaacatttgatcccttctctgaaacgcctgttgatggggttattgca
gccacttgctcagtgcaggtcatatcaggtcagttcttatcagataaaaaaattggcaca
tatgtagaagtggatatgtatgggttgcccaccgacactatccggaaggaattccgaaca
cgcatggtgatgaacaatggactcaatccagtttacaatgaagaatcatttgtatttcgg
aaggtgatcctccctgacctggcagtcttgagacttgcagtgtatgatgacaacaacaag
ctgattggccagaggattctgccactggatggcctccaagcaggctatcgacacatttct
cttcgaaatgagggaaataaacctttatcactgccaacaattttctgcaatattgttctt
aaaacatatgtgcctgatggatttggagatattgtggatgctttatcagatccaaagaaa
tttctttccattacggaaaagagagcagaccaaatgagagctatgggcattgaaactagt
gacatcgccgacgtgcccagtgacacgtcaaagaatgacaagaaagggaaagccaacaca
gcgaaagcaagtgtgacccctcagagcagctcagagctcaggcccaccaccacggctgcc
ctgggagctggcctggaggccaagaaaggtattgaactgatccctcaagtgaggatagaa
gatttaaagcagatgaaggcttacttgaagcatttaaagaaacaacagaaggagctcaat
tctttaaagaagaaacatgcaaaggagcacagtaccatgcagaagctacattgcacacaa
gttgacaaaattgtggcacagtatgacaaggagaagtcaactcatgagaaaatcctagag
aaggcaatgaagaagaaggggggaagtaattgtcttgaaatgaagaaagaaacagaaatt
aaaattcagacgctgacatcagatcacaaatctaaggtcaaggagatcgtggcgcagcac
acaaaagagtggtcagacatgatcaacacccacagtgcagaggagcaggagatccgggat
ctgcacctcagccagcagtgcgagctgctcaaaaagctcctgatcaacgcccacgagcag
cagacccagcagttgaaactgtcccatgacagggaaagcaaggaaatgcgagcacaccag
gctaagatttctatggaaaatagcaaagccatcagccaagataaatctatcaagaataaa
gcagaacgggaaaggcgggtcagggagttaaacagcagcaacactaaaaagtttctggaa
gaaagaaagcgactcgcaatgaagcagtccaaagaaatggaccagttgaaaaaagtccag
cttgaacacctcgaattcctagagaaacagaacgagcagcttttgaaatcctgtcatgca
gtgtcccaaacgcaaggcgaaggagatgcagcagatggtgaaattggaagccgagatgga
ccgcagaccagcaacagttgtgtgaaactccaggacacaaactga

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