KEGG   Lipotes vexillifer (Yangtze River dolphin): 103090984
Entry
103090984         CDS       T03090                                 
Symbol
MET
Name
(RefSeq) hepatocyte growth factor receptor isoform X1
  KO
K05099  proto-oncogene tyrosine-protein kinase Met [EC:2.7.10.1]
Organism
lve  Lipotes vexillifer (Yangtze River dolphin)
Pathway
lve01521  EGFR tyrosine kinase inhibitor resistance
lve04010  MAPK signaling pathway
lve04014  Ras signaling pathway
lve04015  Rap1 signaling pathway
lve04020  Calcium signaling pathway
lve04151  PI3K-Akt signaling pathway
lve04360  Axon guidance
lve04510  Focal adhesion
lve04520  Adherens junction
lve05100  Bacterial invasion of epithelial cells
lve05144  Malaria
lve05200  Pathways in cancer
lve05202  Transcriptional misregulation in cancer
lve05205  Proteoglycans in cancer
lve05206  MicroRNAs in cancer
lve05208  Chemical carcinogenesis - reactive oxygen species
lve05211  Renal cell carcinoma
lve05218  Melanoma
lve05223  Non-small cell lung cancer
lve05225  Hepatocellular carcinoma
lve05226  Gastric cancer
lve05230  Central carbon metabolism in cancer
Brite
KEGG Orthology (KO) [BR:lve00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    103090984 (MET)
   04014 Ras signaling pathway
    103090984 (MET)
   04015 Rap1 signaling pathway
    103090984 (MET)
   04020 Calcium signaling pathway
    103090984 (MET)
   04151 PI3K-Akt signaling pathway
    103090984 (MET)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    103090984 (MET)
   04520 Adherens junction
    103090984 (MET)
 09150 Organismal Systems
  09158 Development and regeneration
   04360 Axon guidance
    103090984 (MET)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    103090984 (MET)
   05202 Transcriptional misregulation in cancer
    103090984 (MET)
   05206 MicroRNAs in cancer
    103090984 (MET)
   05205 Proteoglycans in cancer
    103090984 (MET)
   05208 Chemical carcinogenesis - reactive oxygen species
    103090984 (MET)
   05230 Central carbon metabolism in cancer
    103090984 (MET)
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    103090984 (MET)
   05226 Gastric cancer
    103090984 (MET)
   05218 Melanoma
    103090984 (MET)
   05211 Renal cell carcinoma
    103090984 (MET)
   05223 Non-small cell lung cancer
    103090984 (MET)
  09171 Infectious disease: bacterial
   05100 Bacterial invasion of epithelial cells
    103090984 (MET)
  09174 Infectious disease: parasitic
   05144 Malaria
    103090984 (MET)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    103090984 (MET)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:lve01001]
    103090984 (MET)
Enzymes [BR:lve01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     103090984 (MET)
Protein kinases [BR:lve01001]
 Receptor tyrosine kinases (RTK)
  MET family
   103090984 (MET)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr TIG Pkinase Sema PSI Kinase-like Pkinase_fungal Linker_histone
Other DBs
NCBI-GeneID: 103090984
NCBI-ProteinID: XP_007450843
UniProt: A0A340WMU0
LinkDB
Position
Unknown
AA seq 1412 aa
MLERWISGLSGAKEMRMQIWESSLYYKLLTMKAPAVLAPGILVLLFTLVQKSNGECKEAL
VKSKMNVNMQYQLPNFTAETPIQNVVSHKHHIYLGAINYLYVLNDKDLQKVAEYKTGPVL
EHPDCFPCQNCSHKANLSGGVWKDNINMALLVDTYYDDQLISCGSVHRGTCQRHVLPPDN
TANIQSEVHCMYSPQADEEPSQCPDCVVSALGTKVLLSEKDRFINFFVGNTINSSYLPDH
SLHSISVRRLKETQDGFKFLTDQSYIDVLPEFRDSYPIKYVHAFESNHFIYFLTVQRETL
DAQTFHTRIIRFCSVDSGLHSYMEMPLECILTEKRRKRSTREEVFNILQAAYVSKPGTQL
AKQIGANLNDDILYGVFAQSKPDSVEPMNRSAVCAFPVKYVNEFFNKIVNKNNVRCLQHF
YGPNHDHCFNRTLLRNSSGCEVRSDEYRTEFTTALQRVDLFMGQFNQVLLTSISTFIKGD
LTIANLGTSEGRFMQVVVSRSGSLTPHVNFLLDSHPVSPEAIVEDPLNQNGYTLVVTGKK
ITKIPLNGLGCEHFQSCSQCLSAPSFVQCGWCHDKCVRLEECPGGTWTQETCLPTIYKVF
PTSAPLEGGTTLTICGWDFGFKRNNKFDLKKTKVLLGNESCTLTLSESTINMLKCTVGPA
MNEHFNMSIVISNSRGTVHYSTFSYVDPIIKSISPSYGPKTGGTLLTLTGKHLNSGNSRH
ISIGGKTCTLKSVSDSILECYTPAQSTPTEFPIKLKIDLANREMNSFIYREDPIVYEIHP
TKSFVSGGSTITGVGKNLNSVSILTMVINVHEAGRNFTVACQHRSNSEIICCTTPSLQQL
NLQLPLKTKAFFMLDGIHSKYFDLIYVHNPVFKPFEKPVMISIGSENVLEIKGNDIDPEA
VKGEVLKVGNKSCENIHSHSEAVLCTVPNDLLKLNSELNIEWKQAISSTVLGKVIVQPDQ
NFTGLIVGVVSISIILLLLLGLFLWLKKRKQIKDLGSELVRYDARVHTPHLDRLVSARSV
SPTTEMVSNESVDYRATFPEDQFPNSSQNGSCRQVQYPLTDLSPILTSGDSDISSPLLQN
TVHIDLSALNPELVQAVQHVVIGPSSLIVHFNEVIGRGHFGCVYHGTLLDNDDKKIHCAV
KSLNRITDIGEVSQFLTEGIIMKDFSHPNVLSLLGICLRSEGSPLVVLPYMKHGDLRNFI
RNETHNPTVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLDEKFTVKVADFGLARDV
YDKEYYSVHNKTGAKLPVKWMALESLQTQKFTTKSDVWSFGVLLWELMTRGAPPYPDVNT
FDITVYLLQGRRLLQPEYCPDPLYEVMLKCWHPKAELRPSFSELVSRISAIFSTFIGEHY
VHVNATYVNVKCVAPYPSLLSSQDNVDGEGDT
NT seq 4239 nt   +upstreamnt  +downstreamnt
atgcttgagagatggatttctggactctctggagctaaagagatgaggatgcagatctgg
gagtcttcactctattataaacttctcaccatgaaggcccctgctgtgcttgcacctggc
atccttgtgcttctgtttaccttggtgcagaagagcaatggggagtgtaaagaggcacta
gtaaagtccaagatgaatgtgaacatgcagtatcagcttcctaacttcacagcagaaaca
cccattcagaatgtcgtttcgcacaagcatcacatttacctcggtgccattaactacctt
tacgttttaaatgacaaagaccttcagaaggttgctgagtacaagactgggcctgtgcta
gaacacccagattgtttcccatgtcagaactgcagccacaaagccaatttatcaggtggt
gtttggaaagataacatcaacatggctctgcttgttgacacgtactatgatgaccaactc
attagctgcggcagtgtccacagagggacctgccagcgacacgtccttccacctgacaat
actgctaacatacagtcggaggttcattgcatgtactctccacaggcagatgaagagccc
agccaatgtcctgactgtgtggtgagtgccctgggaaccaaagtactgctgtctgaaaag
gatcgattcatcaacttctttgtgggcaataccataaattcttcttaccttccagatcat
tcattgcattcgatatctgtgagaaggctaaaggaaacacaagatggttttaagtttttg
acagaccaatcctatattgatgttctacctgagttccgagattcctaccccattaagtat
gtccacgcctttgaaagcaaccattttatttactttctgacggtccaacgggaaactcta
gatgctcagacttttcacacaagaataatcaggttctgttctgtagactctggtttgcat
tcgtacatggaaatgcctctggagtgtattctcacagaaaagagaagaaagagatccaca
agggaggaagtgtttaatattctccaagctgcgtatgtcagtaagcctgggacccagctt
gctaagcaaataggtgccaacctgaatgatgatattctctacggggtgtttgcacaaagc
aaaccagattctgtcgaaccaatgaatcgctctgctgtctgtgcgttccctgtcaaatat
gtcaatgagttcttcaacaagatcgtcaacaaaaacaatgtgagatgtctccagcatttt
tatggccccaaccacgaccactgcttcaataggacacttttgagaaattcatcaggctgc
gaagtgcgcagtgatgaataccgaacggagtttaccacagctttgcagcgcgttgactta
ttcatgggccagttcaaccaagtcctcttaacatctatatccacctttattaaaggagac
ctcaccatcgctaatcttggaacatcagagggtcgattcatgcaggttgtggtttctcga
tcaggatcattaaccccacacgtgaatttcctcctggattcccaccctgtgtctccagaa
gcaattgtggaggacccgctaaaccaaaatggctatacactcgttgtcactgggaagaag
atcaccaagatcccgctgaatggcttaggctgtgaacatttccagtcctgcagtcagtgc
ctctccgccccttcctttgtgcagtgtggctggtgccatgataaatgtgtgcgattggag
gaatgccctggtggaacatggactcaagagacctgtctgcctacaatctacaaggttttc
ccaactagtgccccccttgaaggagggacaacgctgaccatatgtggctgggactttgga
ttcaagaggaataataaatttgacttgaagaaaaccaaagttctccttggaaatgagagc
tgcaccttgaccttaagtgagagcacgataaacatgttgaaatgcacagttggtcctgca
atgaatgaacatttcaatatgtccatagttatttcaaacagtcgagggaccgtacattat
agtacattttcctatgtggatcctataataaaaagtatttctccaagttatggtcctaaa
actggtggcactttacttacattaactggaaagcacctaaacagtggaaattctagacac
atttcaattggtggaaaaacatgtactttaaaaagcgtttcagatagtattctcgaatgt
tataccccagcccaaagcactccaactgagtttcctattaaattgaaaattgacttagcc
aaccgagagatgaacagcttcatttaccgggaagaccccattgtctatgaaatacatccc
accaaatcttttgttagtggtgggagcacaataacaggtgttggaaaaaacctgaattca
gttagtatcctgacgatggtaataaatgtgcatgaagcaggaaggaactttacagtggca
tgtcagcatcgctctaattcggagataatctgctgtacaactccttcactacaacagctg
aacctacaactccccctgaaaaccaaagcctttttcatgttagatgggatccattccaaa
tactttgatctcatttatgtacataatcctgtgtttaagccttttgaaaagccagtgatg
atctcaataggcagtgaaaatgtactggaaattaagggaaatgatattgaccctgaagca
gtaaaaggtgaagtgttaaaagttggaaataagagctgtgagaatatacactcacattct
gaagccgttttatgtacggtccccaatgacctgctgaaattgaacagcgaactaaatata
gagtggaagcaagcaatttcttcaaccgtccttggaaaagtgatagttcaaccagatcag
aatttcacaggactgattgttggtgttgtctcaatatcaataatactcttattattactt
gggcttttcctgtggctgaaaaagagaaagcaaattaaagatctgggcagtgaattagtt
cgctatgatgcaagagtacacactcctcatttggataggcttgtaagtgcccgaagtgta
agcccaactacagaaatggtttcaaatgaatctgtagactaccgagctacttttccagaa
gaccagtttcctaactcatctcagaatgggtcatgcagacaagtgcagtatcctctgaca
gacctatcccccatcctaactagtggggactctgatatatccagtccattactgcaaaat
actgtccacattgacctcagtgctctaaatccagagcttgtccaggcagttcagcacgta
gtgattgggccaagcagcctgattgtgcatttcaatgaagtcataggaagaggacatttc
gggtgtgtatatcatgggactttgttggacaacgatgataaaaaaattcactgtgctgtg
aaatccttgaatagaatcactgacataggagaagtttcccaatttctgaccgagggaatc
atcatgaaagattttagtcatcccaatgttctctcgctcttgggaatctgccttcgaagt
gaggggtctccactggtggtcctaccatacatgaaacatggggatcttcgaaatttcatt
agaaatgagactcacaaccccactgtaaaagatcttattggctttggtcttcaagtagcc
aaaggcatgaaatatcttgcaagcaaaaagtttgtccacagagacttggctgcaagaaac
tgtatgctggatgaaaaattcactgtcaaagttgctgattttggccttgccagagacgtg
tatgataaggaatactatagcgtacacaacaaaacaggtgcaaaactgccggtgaagtgg
atggctttagagagcctgcaaactcagaaatttaccaccaagtcagatgtgtggtccttt
ggcgtgctcctctgggaactgatgacaagaggagcaccaccttatcctgatgtcaacacc
tttgatataacagtatatttgttgcaaggcagaaggctcctacaacctgaatactgccca
gatcccttgtatgaagtgatgctgaaatgctggcaccctaaagctgaactgcgcccatcc
ttttctgaactggtctccaggatatcagcgatattctctactttcattggggaacactat
gtccatgtgaacgctacatacgtgaatgtcaaatgtgtcgctccatatccttctctgttg
tcatcacaagataatgttgacggcgagggggatacatga

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