Leptonychotes weddellii (Weddell seal): 102729122 Help Entry 102729122         CDS       T08708                                  Symbol RYR2 Name (RefSeq) ryanodine receptor 2   KO K04962   ryanodine receptor 2 Organism lww  Leptonychotes weddellii (Weddell seal) Pathway lww04020   Calcium signaling pathway lww04024   cAMP signaling pathway lww04260   Cardiac muscle contraction lww04261   Adrenergic signaling in cardiomyocytes lww04371   Apelin signaling pathway lww04713   Circadian entrainment lww04911   Insulin secretion lww04921   Oxytocin signaling pathway lww04972   Pancreatic secretion lww05020   Prion disease lww05022   Pathways of neurodegeneration - multiple diseases lww05410   Hypertrophic cardiomyopathy lww05412   Arrhythmogenic right ventricular cardiomyopathy lww05414   Dilated cardiomyopathy lww05415   Diabetic cardiomyopathy Brite KEGG Orthology (KO) [BR:lww00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     102729122 (RYR2)    04020 Calcium signaling pathway     102729122 (RYR2)    04024 cAMP signaling pathway     102729122 (RYR2)  09150 Organismal Systems   09152 Endocrine system    04911 Insulin secretion     102729122 (RYR2)    04921 Oxytocin signaling pathway     102729122 (RYR2)   09153 Circulatory system    04260 Cardiac muscle contraction     102729122 (RYR2)    04261 Adrenergic signaling in cardiomyocytes     102729122 (RYR2)   09154 Digestive system    04972 Pancreatic secretion     102729122 (RYR2)   09159 Environmental adaptation    04713 Circadian entrainment     102729122 (RYR2)  09160 Human Diseases   09164 Neurodegenerative disease    05020 Prion disease     102729122 (RYR2)    05022 Pathways of neurodegeneration - multiple diseases     102729122 (RYR2)   09166 Cardiovascular disease    05410 Hypertrophic cardiomyopathy     102729122 (RYR2)    05412 Arrhythmogenic right ventricular cardiomyopathy     102729122 (RYR2)    05414 Dilated cardiomyopathy     102729122 (RYR2)    05415 Diabetic cardiomyopathy     102729122 (RYR2)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:lww04040]     102729122 (RYR2)    04990 Domain-containing proteins not elsewhere classified [BR:lww04990]     102729122 (RYR2) Ion channels [BR:lww04040]  Voltage-gated cation channels   Ryanodine receptor    102729122 (RYR2) Domain-containing proteins not elsewhere classified [BR:lww04990]  EF-hand domain-containing proteins   Other EF-hand domain-containing proteins    102729122 (RYR2) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  RR_TM4-6 RYDR_Jsol RyR RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_8 EF-hand_6 Motif Other DBs NCBI-GeneID:  102729122 NCBI-ProteinID:  XP_030883560 UniProt:  A0A7F8QR18 LinkDB All DBs Position Unknown AA seq 3019 aa AA seqDB search FIPVCSLGVAQVGRMNFGKDVSTLKYFTICGLQEGYEPFAVNTNRDITMWLSKRLPQFLQ VPPNHEHIEVTRIDGTIDSSPCLKVTQKSFGSQKSSTDIMFYRLSMPIECAEVFSKTVAG GLPGAGLFGPKNDLEDYDADSDFEVLMKTAHGHLVPDRVDKDKEATKPEFNNHKDYAQEK PSLAFVPVAAEEARMMCLLLQYLCDCQVRHRIEAIVAFSDDFVAKLQDNQRFRYNEVMQA LNMSAALTARKTKEFRSPPQEQINMLLNFKDDKSECPCPEEIRDQLLDFHEDLMTHCGIE LDEDGSLDGNSDLTIRGRLLSLVEKVTYLKKKQAEKPVESDSKKSSTLQQLISETMVRWA QESVIEDPELVRAMFVLLHRQYDGIGGLVRALPKTYTINGVSVEDTINLLASLGQIRSLL SVRMGKEEEKLMIRGLGHASFYCALLYCTSQIVCFYKLKLIHAGKGEAIRIRSILRSLIP LGDLVGVISIAFQMPTIAKDGNVVEPDMSAGFCPDHKAAMVLFLDRVYGIEVQDFLLHLL EVGFLPDLRAAASLDTAALSATDMALALNRYLCTAVLPLLTRCAPLFAGTEHHASLIDSL LHTVYRLSKGCSLTKAQRDSIEVCLLSICGQLRPSMMQHLLRRLVFDVPLLNEHAKMPLK LLTNHYERCWKYYCLPGGWGNFGAASEEELHLSRKLFWGIFDALSQKKYEQELFKLALPC LSAVAGALPPDYMESNYVSMMEKQSSMDSEGNFNPQPVDTSNITIPEKLEYFINKYAEHS HDKWSMDKLANGWIYGEIYSDSSKVQPLMKPYKLLSEKEKEIYRWPIKESLKTMLAWGWR IERTREGDSMALCNRTRRISQTSQVSVDAAHGYSPRAIDMSNVTLSRDLHAMAEMMAENY HNIWAKKKKLELESKGGGNHPLLVPYDTLTAKEKAKDREKAQDILKFLQINGYAVSRGFK DLELDTPSIEKRFAYSFLQQLIRYVDEAHQYILEFDGGSRSKGEHFPYEQEIKFFAKVVL PLIDQYFKNHRLYFLSAASRPLCSGGHASNKEKEMVTSLFCKLGVLVRHRISLFGNDATS IVNCLHILGQTLDARTVMKTGLESVKSALRAFLDNAAEDLEKTMENLKQGQFTHTRNQPR GVTQIINYTTVALLPMLSSLFEHIGQHQFGEDLILEDVQVSCYRILTSLYALGTSKSIYV ERQRSALGECLAAFAGAFPVAFLETHLDKHNIYSIYNTKSSRERAALNLPTNVEDVCPNI PSLEKLMEEIVELAESGIRYTQIPHVMEVILPMLCSYMSRWWEHGPENNPERAEMCCTAL NSEHMNTLLGNILKIIYNNLGIDEGAWMKRLAVFSQPIINKVKPQLLKTHFLPLMEKLKK KAAMVVSEEDHLKAEARGDMSEAELLILDEFTTLARDLYAFYPLLIRFVDYNRAKWLKEP NAEAEDLFRMVAEVFIYWSKSHNFKREEQNFVVQNEINNMSFLITDTKSKMSKAAVSDQE RKKMKRKGDRYSMQTSLIVAALKRLLPIGLNICAPGDQELIALAKNRFSMKDTEDEVRDI IRSNIHLQGKLEDPAIRWQMALYKDLPNRTEDTSDPEKTVERVLDIANVLFHLEQKSTCM RRRYYSLVEHPQRSKKAVWHKLLSKQRKRAVVACFRMAPLYNLPRHRAVNLFLQGYEKSW IETEEHYFEDKLIEDLAKPGANPPEEEEGTKRVDPLHQLILLFSRTALTEKCKLEEDFLY MAYADIMAKSCHDEEDDDGEEEVKSFEEKEMEKQKLLYQQARLHDRGAAEMVLQTISASK GDTGPMVAATLKLGIAILNGGNSTVQQKMLDYLKEKKDVGFFQSLAGLMQSCSVLDLNAF ERQNKAEGLGMVTEEGSGEKVLQDDEFTCDLFRFLQLLCEGHNSDFQNYLRTQTGNNTTV NIIISTVDYLLRVQESISDFYWYYSGKDVIDEQGQRNFSKAIQVAKQVFNTLTEYIQGPC TGNQQSLAHSRLWDAVVGFLHVFAHMQMKLSQDSSQIELLKELMDLQKDMVVMLLSMLEG NVVNGTIGKQMVDMLVESSNNVEMILKFFDMFLKLKDLTSSDTFKEYDPDGKGVISKRDF HKAMESHKHYTQSETEFLLSCAETDENETLDYEEFVKRFHEPAKDIGFNVAVLLTNLSEH MPNDTRLQTFLELAESVLNYFQPFLGRIEIMGSAKRIERVYFEISESSRTQWEKPQVKES KRQFIFDVVNEGGEKEKMELFVNFCEDTIFEMQLAAQISESDLNERSANKDESEKEKPEE QGPRMGFFSILTVKSALLALRYNILTLMRMLSLKSLKKQMKKVKKMTVKDMVTAAFSSYW SMFASLLHFVASVSRGFFRIICSLLLGGSLVEGAKKIRVAELLANMPDPTQDEVRGDGEE GDRKPMEATLPSEDLTDLKELTEESDLLSDIFGLDLKREGGQYKLIPHNPNAGLSDLMSN PVPIPDVQEKFQEQKAKEEEKEEKEENKSEPEKAEGEDGEKEEKAKEDKGKQKLRQLHTH RYGEPEIPESAFWKKIIAYQQKLLNYFARNFYNMRMLALFVAFAINFILLFYKVSTSSVV EGKELPTRSSSENAKVSSLDSGSPRIIAVHYVLEESSGYMEPTLRILAILHTVISFFCII GYYCLKVPLVIFKREKEVARKLEFDGLYITEQPSEDDIKGQWDRLVINTQSFPNNYWDKF VKRKVMDKYGEFYGRDRISELLGMDKAALDFSDAREKKKPKKDSSLSAVLNSIDVKYQMW KLGVVFTDNSFLYLAWYMTMSVLGHYNNFFFAAHLLDIAMGFKTLRTILSSVTHNGKQLV LTVGLLAVVVYLYTVVAFNFFRKFYNKSEDGDTPDMKCDDMLTCYMFHMYVGVRAGGGIG DEIEDPAGDEYEIYRIIFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVKEDMETKC FICGIGNDYFDTVPHGFETHTLQEHNLANYLFFLMYLINKDETEHTGQESYVWKMYQERC WEFFPAGDCFRKQYEDQLN NT seq 9062 nt NT seq  +upstreamnt  +downstreamnt gattcattcctgtctgtagtcttggagtggctcaagtgggcaggatgaactttggaaagg atgtcagcaccttgaaatatttcaccatctgtggcttacaagagggctatgagccatttg ctgttaacacaaacagggatattaccatgtggctaagcaagaggcttcctcagtttctcc aggtcccaccaaatcatgagcatatcgaggtgaccagaatagacggcaccatagacagtt ctccatgtttgaaggtgactcagaagtcctttggttctcagaagagcagcaccgatatca tgttctatcgcctgagcatgcctatcgagtgcgcagaagtcttctccaagacggtggcag gaggactcccaggcgccggcctctttgggcccaagaatgatcttgaggactatgatgcag attctgactttgaggttctaatgaagaccgctcatggccatctggtgccagatcgagttg acaaagacaaggaagccacaaaaccagaatttaataaccacaaagattatgctcaggaaa agccctctctcgcctttgtacctgtagctgcagaggaggccaggatgatgtgcctgctgc ttcagtacctctgtgactgccaggtccggcaccggatagaagccattgtggccttttcag atgactttgtagcaaagctccaagacaatcaacgcttccgatacaacgaagtgatgcaag ccttaaacatgtcagctgcactcactgccaggaaaacgaaggaatttagatcgccccctc aagagcagatcaatatgcttctcaattttaaggatgacaaaagtgaatgtccatgtcctg aagaaatccgtgaccaactcttagattttcatgaagatttgatgacacattgtggaattg agctggatgaagatgggtctttggatggaaacagtgacttaacaattaggggccgcctgc tatcccttgtagaaaaggtgacatacctgaagaagaaacaagctgaaaaaccagttgaga gtgactccaagaaatcctccactcttcagcagttgatttctgagaccatggtccgatggg cacaagagtctgtcattgaagaccccgaattggtgagggccatgtttgtgttgctccatc gacagtatgatggcattgggggtctggtccgggctctgccaaagacctacactataaatg gtgtctccgtggaggataccatcaacttgctggcatctcttggtcagattcgttctctgc tgagtgtaagaatgggcaaagaagaagagaagcttatgattcgtggattagggcatgcct cattttattgtgccttgctttattgcacttcgcagatagtgtgtttttacaaattgaagt tgattcatgctggtaagggggaagccatcagaatccggtccattttgagatccctaattc cgctgggagatttggtgggagtaatcagcattgcttttcagatgccaacgatagccaaag atgggaatgtggtggagcctgacatgtctgcggggttttgcccagatcacaaggcagcca tggttttgttccttgacagggtctatgggattgaggttcaagatttcctcctccaccttc tcgaggttggctttctgccagatctccgggctgcagcttctttagacacggctgctctga gtgctacagacatggccttggccctcaatcggtacctttgcacagccgtgctgcctttgt taacgagatgtgcccctctttttgcgggcacagagcaccacgcttctctcattgactcct tacttcacactgtgtacagactctctaagggctgctctcttaccaaagctcagcgggatt ccatagaagtttgtttactctctatttgtggccagttgagaccttctatgatgcagcact tactccgaagattagtatttgacgtgccattattaaatgaacatgcaaagatgcctctta agctgctgacaaatcattatgaaagatgctggaaatattactgtctgcccggagggtggg ggaactttggagctgcctccgaagaagagcttcatttatcaagaaagttgttttggggca tttttgacgccctatctcaaaagaaatacgaacaagaacttttcaaactggctctgcctt gcctgagtgcagttgcgggagctttgcctccagactacatggagtcaaattatgtcagta tgatggaaaaacagtcatcaatggattctgaagggaactttaacccacaacctgttgata cctcaaatattacaattcctgagaagttggaatacttcattaacaaatatgcggaacatt ctcatgacaaatggtcaatggacaagttggcaaatggatggatttatggagaaatatatt cagactcatctaaagttcaaccattaatgaagccatataaactattatctgaaaaggaaa aagaaatttatcgctggccaatcaaagagtctttaaaaaccatgctggcgtggggttgga ggattgagagaacgcgggagggagacagcatggcactctgtaaccgcactcgtcgaattt ctcagacaagtcaggtttctgtagatgctgcacatggttatagcccccgagccattgaca tgagcaatgtcacactgtccagagacctgcacgctatggcagaaatgatggctgaaaact accataatatatgggcaaagaaaaagaaactggaactggaatccaaaggaggtggaaacc atcccctgctggtgccctatgatacgctgacagccaaagagaaagccaaggatagggaaa aagcacaggacatcctcaaattcttgcagatcaatggctatgctgtatccaggggattca aggacctggagttggacacaccgtccattgagaaacgatttgcctatagcttccttcagc aactcattcgctatgtggatgaagcccatcagtatatcctggagtttgatggtggcagca gaagcaaaggagaacatttcccttacgaacaggaaatcaagttcttcgctaaagttgttc tccctttaattgatcagtatttcaaaaaccatcgtttatacttcttatctgcagcaagca gacctctctgttctggaggacatgcatcaaataaggagaaggaaatggtgactagcctat tctgcaaacttggagttcttgtcaggcataggatttcactatttggaaatgatgccacat caattgtcaactgccttcatattttgggtcagactttggatgccaggaccgtaatgaaga ctggcctagagagtgttaaaagcgcactccgagctttcctggacaacgccgcggaggatc tggagaagaccatggagaatctcaagcagggccagttcacccacacccgaaaccaaccca gaggtgtcactcagattatcaattacaccacagtggctctgttgccgatgctatcatcat tatttgagcatattggccagcatcagttcggagaagatctaatattggaagatgtacagg tgtcgtgttatagaattctgactagcttatatgctttgggaaccagcaaaagtatttatg tggaaaggcaacgttctgcattaggagaatgtcttgcggcttttgctggtgcctttcctg tagcatttttggaaactcatcttgacaaacataacatttactctatctacaatactaagt cctcaagagaaagagcagctctcaatttgccaactaatgtggaagatgtttgcccaaata taccgtctttggagaaactcatggaagaaattgtggaattagccgagtctggcattcgct acacacaaataccacatgtgatggaagtcatactgcccatgctttgcagctacatgtccc gctggtgggagcatggacctgaaaacaatccggaaagggctgaaatgtgctgcacagcac tgaactccgagcacatgaacacactcctggggaatatattgaaaatcatatataataact tgggaattgatgagggcgcctggatgaagaggttagcagttttctcccagcccattataa ataaagtgaaacctcagctcctgaaaactcatttcttgccattaatggagaaactcaaga aaaaagcagcgatggtggtgtctgaggaggaccatctgaaggccgaggccaggggggata tgtctgaggcggaacttctcattctggatgagttcaccacactggccagagatctctatg ccttctacccactcttgattagatttgtggactacaacagggcaaagtggctaaaagagc ctaacgcggaagcagaggaccttttccgcatggtggccgaagtgtttatctactggtcga aatcccataatttcaagagggaagagcagaacttcgtggtacagaatgaaatcaacaata tgtctttccttatcactgacaccaagtcaaagatgtcaaaggcagctgtctctgatcagg aaaggaagaaaatgaagcgcaagggagatcgatattccatgcagacttctcttattgtgg cagctctgaagcgattgctgcccattgggttgaatatctgtgcccctggggaccaggagc tcattgctctggccaaaaaccgattcagtatgaaagacactgaggatgaagtacgagata taatccgcagtaatattcatttacaaggcaagttggaggatcctgctatcagatggcaaa tggctctttacaaagatttaccgaacaggactgaagatacatcagatccggagaagactg tggaaagagtattagatatagccaatgtgctttttcatcttgagcagaaatctacatgta tgcgccggagatattacagtctggtggagcatccacagagatcgaagaaggctgtatggc acaaactgttatccaaacagaggaaaagagcagtggtagcctgcttccggatggctccgt tatacaatctgccaaggcaccgggctgtcaatctctttcttcagggatatgaaaagtctt ggattgaaacagaagaacactactttgaagataagctgatagaagatttagcaaaacctg gagccaaccctccagaagaagaggaaggcacgaagagagttgatcccctccatcagctca tccttctgtttagtagaacagctttaacagagaaatgcaaactggaggaagattttttat atatggcttatgcagatattatggcaaagagttgtcatgatgaggaagatgatgatggtg aagaagaagtaaagagttttgaagaaaaagaaatggaaaagcaaaagcttctgtaccaac aagccaggctccatgaccgcggggcagctgagatggtgctgcagaccatcagtgccagca aaggtgatactggaccaatggtagctgcaactttgaaacttggaattgctatcttaaatg gtggcaactccacagtacagcagaaaatgcttgactacctcaaggagaaaaaggatgtgg gcttctttcagagtctggctggtctgatgcagtcatgtagtgtcctcgacctaaatgcat ttgagcgacaaaacaaagctgaaggacttggaatggtgaccgaggaaggatcaggagaaa aggttctccaggatgacgagttcacttgcgacctcttccgcttcctacaactgctttgtg agggacacaactcagattttcaaaattatctgagaactcagactggcaataatacaactg tcaacataatcatctctaccgtagactacctcctgagagtccaggaatccatcagtgatt tctattggtattactctgggaaagatgttattgatgaacaaggacaacggaatttctcta aagcaattcaagtagcaaagcaagtctttaacactctcacagagtatattcagggtcctt gtactgggaatcagcagagcttggcccacagcaggctgtgggatgcagttgtgggctttc ttcatgtatttgcccacatgcagatgaagctgtctcaggattccagtcaaattgagctat taaaagaattaatggatcttcagaaggacatggtggtcatgttgctgtccatgttagaag gtaatgttgttaatggaaccattggcaaacagatggtcgatatgctcgtggaatcttcca acaacgtggagatgattctcaagttttttgacatgttcttaaaactaaaggatttgactt cttctgacacatttaaggaatatgatcctgacggcaagggagtcatttccaagagggact tccataaagcgatggagagccataagcactacacgcagtcagaaaccgagtttcttctgt cctgtgcagagactgatgaaaacgagaccctcgactatgaagagtttgtcaaacggttcc acgagcccgcgaaggacatcggcttcaacgttgccgttctcctgaccaacctgtccgaac acatgcccaacgacactcgactgcagacgttcctggagttggcagagagcgtgctgaatt acttccagccctttctgggccgcatcgagatcatgggaagtgccaaacgcatcgaacggg tttatttcgaaatcagtgagtccagccgcacccagtgggagaaaccccaggtcaaggagt ccaaacggcagttcatctttgacgtggtcaacgaagggggagaaaaggagaagatggagc ttttcgtcaacttctgcgaggacaccatatttgaaatgcaactggcggcgcagatctctg agtcggatctgaatgagaggtcggcaaataaggacgaaagtgagaaggagaagcccgaag agcaggggcccagaatgggtttcttttccattctgacggtcaagtcggccctgctggctc tcaggtacaatatcttgaccctcatgcgaatgctcagcctgaagagcctgaagaaacaga tgaagaaggtgaagaagatgactgtgaaggatatggtcacagccgccttttcatcctatt ggagtatgttcgcgagcctcctgcacttcgtggccagcgtttccagaggctttttccgca tcatttgcagcctgctgctggggggcagcctggtagaaggagcgaagaagatcagagtgg cagagctcttagccaacatgccggaccccactcaggatgaggtgaggggggacggcgaag aaggggacaggaaacccatggaagccaccctgccctcggaagatctgacagacctgaagg aactgacagaggaaagcgaccttctttcagacatatttggcttggatctgaagagagaag gaggacagtacaaactcattccccataatccaaacgccggcctcagtgacctcatgagca acccggtccccatccccgacgtgcaagaaaaattccaggaacagaaggcaaaagaggaag aaaaggaggaaaaagaagaaaacaaatctgaacccgaaaaggccgagggagaagacgggg aaaaagaagaaaaagccaaagaagataagggtaaacagaagttgagacagctccacacac acagatacggagagccggaaattcccgagtctgcgttctggaagaaaatcatagcatatc aacagaaacttctaaactattttgctcgcaacttttacaacatgagaatgttagccttat ttgtcgcatttgcaatcaatttcatcttgctcttttataaggtctccacttcttctgtgg ttgaaggaaaggagctccccactcgcagttcgagtgaaaatgccaaagttagcagcctag acagcggctcacccagaatcatcgcagttcactacgtcctggaggagagcagcgggtata tggagcccacgctgaggatcttagctattctccacacagtcatttctttcttctgcatca tcggatactactgcttgaaagtcccattggttatttttaagcgagaaaaggaagtagctc gaaaattggaatttgatgggctttatattacagaacagccttcagaagatgatattaaag gccagtgggatagacttgtaatcaacacacagtcatttcccaacaactactgggacaaat ttgttaaaagaaaggttatggataagtacggagagttctatggccgggacagaatcagcg agctcctcggtatggacaaagccgctctggacttcagcgatgcccgggagaagaagaagc caaagaaagacagctccctatcggccgtactgaactctatcgatgtgaagtatcagatgt ggaaactaggagtcgtcttcactgacaactccttcctctacctggcctggtatatgacta tgtccgttcttggacactataacaactttttttttgctgctcatcttcttgacattgcta tgggattcaagacgctaagaaccatcttgtcatcagtaactcacaacggcaagcagcttg tattaaccgttggcttactagctgttgtcgtatacctatatacggttgtggcattcaatt ttttccgaaaattctacaataaaagtgaagatggtgatactccagatatgaaatgtgatg atatgctaacgtgctatatgttccacatgtatgttggggtacgtgccggagggggtatcg gtgatgaaatcgaagacccagcaggcgatgaatatgaaatctatcgaatcatctttgaca tcaccttcttcttcttcgtgattgtcattctcttggccataatacaaggtttaattattg atgcttttggagaactaagagaccaacaggagcaagtcaaagaagacatggagaccaaat gcttcatctgtgggataggcaacgattacttcgacacggtgccacatggctttgaaactc acactttacaggaacacaacctggccaattacctgttttttctgatgtatctcataaaca aagatgaaacagagcacacagggcaggaatcttatgtctggaagatgtatcaagaaaggt gctgggaatttttcccagcaggggactgtttccggaaacagtatgaggaccagctaaatt ag

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