KEGG   Leptonychotes weddellii (Weddell seal): 102734291
Entry
102734291         CDS       T08708                                 
Symbol
AKT3
Name
(RefSeq) RAC-gamma serine/threonine-protein kinase isoform X1
  KO
K04456  RAC serine/threonine-protein kinase [EC:2.7.11.1]
Organism
lww  Leptonychotes weddellii (Weddell seal)
Pathway
lww01521  EGFR tyrosine kinase inhibitor resistance
lww01522  Endocrine resistance
lww01524  Platinum drug resistance
lww04010  MAPK signaling pathway
lww04012  ErbB signaling pathway
lww04014  Ras signaling pathway
lww04015  Rap1 signaling pathway
lww04022  cGMP-PKG signaling pathway
lww04024  cAMP signaling pathway
lww04062  Chemokine signaling pathway
lww04066  HIF-1 signaling pathway
lww04068  FoxO signaling pathway
lww04071  Sphingolipid signaling pathway
lww04072  Phospholipase D signaling pathway
lww04140  Autophagy - animal
lww04150  mTOR signaling pathway
lww04151  PI3K-Akt signaling pathway
lww04152  AMPK signaling pathway
lww04210  Apoptosis
lww04211  Longevity regulating pathway
lww04213  Longevity regulating pathway - multiple species
lww04218  Cellular senescence
lww04261  Adrenergic signaling in cardiomyocytes
lww04370  VEGF signaling pathway
lww04371  Apelin signaling pathway
lww04380  Osteoclast differentiation
lww04510  Focal adhesion
lww04517  IgSF CAM signaling
lww04518  Integrin signaling
lww04550  Signaling pathways regulating pluripotency of stem cells
lww04611  Platelet activation
lww04613  Neutrophil extracellular trap formation
lww04620  Toll-like receptor signaling pathway
lww04625  C-type lectin receptor signaling pathway
lww04630  JAK-STAT signaling pathway
lww04660  T cell receptor signaling pathway
lww04662  B cell receptor signaling pathway
lww04664  Fc epsilon RI signaling pathway
lww04666  Fc gamma R-mediated phagosome formation
lww04668  TNF signaling pathway
lww04722  Neurotrophin signaling pathway
lww04725  Cholinergic synapse
lww04728  Dopaminergic synapse
lww04810  Regulation of actin cytoskeleton
lww04910  Insulin signaling pathway
lww04914  Progesterone-mediated oocyte maturation
lww04915  Estrogen signaling pathway
lww04917  Prolactin signaling pathway
lww04919  Thyroid hormone signaling pathway
lww04920  Adipocytokine signaling pathway
lww04922  Glucagon signaling pathway
lww04923  Regulation of lipolysis in adipocytes
lww04926  Relaxin signaling pathway
lww04929  GnRH secretion
lww04931  Insulin resistance
lww04932  Non-alcoholic fatty liver disease
lww04933  AGE-RAGE signaling pathway in diabetic complications
lww04935  Growth hormone synthesis, secretion and action
lww04936  Alcoholic liver disease
lww04973  Carbohydrate digestion and absorption
lww05010  Alzheimer disease
lww05017  Spinocerebellar ataxia
lww05132  Salmonella infection
lww05135  Yersinia infection
lww05142  Chagas disease
lww05145  Toxoplasmosis
lww05152  Tuberculosis
lww05160  Hepatitis C
lww05161  Hepatitis B
lww05162  Measles
lww05163  Human cytomegalovirus infection
lww05164  Influenza A
lww05165  Human papillomavirus infection
lww05166  Human T-cell leukemia virus 1 infection
lww05167  Kaposi sarcoma-associated herpesvirus infection
lww05168  Herpes simplex virus 1 infection
lww05169  Epstein-Barr virus infection
lww05170  Human immunodeficiency virus 1 infection
lww05200  Pathways in cancer
lww05205  Proteoglycans in cancer
lww05207  Chemical carcinogenesis - receptor activation
lww05208  Chemical carcinogenesis - reactive oxygen species
lww05210  Colorectal cancer
lww05211  Renal cell carcinoma
lww05212  Pancreatic cancer
lww05213  Endometrial cancer
lww05214  Glioma
lww05215  Prostate cancer
lww05218  Melanoma
lww05220  Chronic myeloid leukemia
lww05221  Acute myeloid leukemia
lww05222  Small cell lung cancer
lww05223  Non-small cell lung cancer
lww05224  Breast cancer
lww05225  Hepatocellular carcinoma
lww05226  Gastric cancer
lww05230  Central carbon metabolism in cancer
lww05231  Choline metabolism in cancer
lww05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
lww05415  Diabetic cardiomyopathy
lww05417  Lipid and atherosclerosis
lww05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:lww00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    102734291 (AKT3)
   04012 ErbB signaling pathway
    102734291 (AKT3)
   04014 Ras signaling pathway
    102734291 (AKT3)
   04015 Rap1 signaling pathway
    102734291 (AKT3)
   04370 VEGF signaling pathway
    102734291 (AKT3)
   04371 Apelin signaling pathway
    102734291 (AKT3)
   04630 JAK-STAT signaling pathway
    102734291 (AKT3)
   04668 TNF signaling pathway
    102734291 (AKT3)
   04066 HIF-1 signaling pathway
    102734291 (AKT3)
   04068 FoxO signaling pathway
    102734291 (AKT3)
   04072 Phospholipase D signaling pathway
    102734291 (AKT3)
   04071 Sphingolipid signaling pathway
    102734291 (AKT3)
   04024 cAMP signaling pathway
    102734291 (AKT3)
   04022 cGMP-PKG signaling pathway
    102734291 (AKT3)
   04151 PI3K-Akt signaling pathway
    102734291 (AKT3)
   04152 AMPK signaling pathway
    102734291 (AKT3)
   04150 mTOR signaling pathway
    102734291 (AKT3)
  09133 Signaling molecules and interaction
   04517 IgSF CAM signaling
    102734291 (AKT3)
   04518 Integrin signaling
    102734291 (AKT3)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    102734291 (AKT3)
  09143 Cell growth and death
   04210 Apoptosis
    102734291 (AKT3)
   04218 Cellular senescence
    102734291 (AKT3)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    102734291 (AKT3)
   04550 Signaling pathways regulating pluripotency of stem cells
    102734291 (AKT3)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    102734291 (AKT3)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    102734291 (AKT3)
   04613 Neutrophil extracellular trap formation
    102734291 (AKT3)
   04620 Toll-like receptor signaling pathway
    102734291 (AKT3)
   04625 C-type lectin receptor signaling pathway
    102734291 (AKT3)
   04660 T cell receptor signaling pathway
    102734291 (AKT3)
   04662 B cell receptor signaling pathway
    102734291 (AKT3)
   04664 Fc epsilon RI signaling pathway
    102734291 (AKT3)
   04666 Fc gamma R-mediated phagosome formation
    102734291 (AKT3)
   04062 Chemokine signaling pathway
    102734291 (AKT3)
  09152 Endocrine system
   04910 Insulin signaling pathway
    102734291 (AKT3)
   04922 Glucagon signaling pathway
    102734291 (AKT3)
   04923 Regulation of lipolysis in adipocytes
    102734291 (AKT3)
   04920 Adipocytokine signaling pathway
    102734291 (AKT3)
   04929 GnRH secretion
    102734291 (AKT3)
   04915 Estrogen signaling pathway
    102734291 (AKT3)
   04914 Progesterone-mediated oocyte maturation
    102734291 (AKT3)
   04917 Prolactin signaling pathway
    102734291 (AKT3)
   04926 Relaxin signaling pathway
    102734291 (AKT3)
   04935 Growth hormone synthesis, secretion and action
    102734291 (AKT3)
   04919 Thyroid hormone signaling pathway
    102734291 (AKT3)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    102734291 (AKT3)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    102734291 (AKT3)
  09156 Nervous system
   04725 Cholinergic synapse
    102734291 (AKT3)
   04728 Dopaminergic synapse
    102734291 (AKT3)
   04722 Neurotrophin signaling pathway
    102734291 (AKT3)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    102734291 (AKT3)
  09149 Aging
   04211 Longevity regulating pathway
    102734291 (AKT3)
   04213 Longevity regulating pathway - multiple species
    102734291 (AKT3)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    102734291 (AKT3)
   05205 Proteoglycans in cancer
    102734291 (AKT3)
   05207 Chemical carcinogenesis - receptor activation
    102734291 (AKT3)
   05208 Chemical carcinogenesis - reactive oxygen species
    102734291 (AKT3)
   05230 Central carbon metabolism in cancer
    102734291 (AKT3)
   05231 Choline metabolism in cancer
    102734291 (AKT3)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    102734291 (AKT3)
  09162 Cancer: specific types
   05210 Colorectal cancer
    102734291 (AKT3)
   05212 Pancreatic cancer
    102734291 (AKT3)
   05225 Hepatocellular carcinoma
    102734291 (AKT3)
   05226 Gastric cancer
    102734291 (AKT3)
   05214 Glioma
    102734291 (AKT3)
   05221 Acute myeloid leukemia
    102734291 (AKT3)
   05220 Chronic myeloid leukemia
    102734291 (AKT3)
   05218 Melanoma
    102734291 (AKT3)
   05211 Renal cell carcinoma
    102734291 (AKT3)
   05215 Prostate cancer
    102734291 (AKT3)
   05213 Endometrial cancer
    102734291 (AKT3)
   05224 Breast cancer
    102734291 (AKT3)
   05222 Small cell lung cancer
    102734291 (AKT3)
   05223 Non-small cell lung cancer
    102734291 (AKT3)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    102734291 (AKT3)
   05170 Human immunodeficiency virus 1 infection
    102734291 (AKT3)
   05161 Hepatitis B
    102734291 (AKT3)
   05160 Hepatitis C
    102734291 (AKT3)
   05164 Influenza A
    102734291 (AKT3)
   05162 Measles
    102734291 (AKT3)
   05168 Herpes simplex virus 1 infection
    102734291 (AKT3)
   05163 Human cytomegalovirus infection
    102734291 (AKT3)
   05167 Kaposi sarcoma-associated herpesvirus infection
    102734291 (AKT3)
   05169 Epstein-Barr virus infection
    102734291 (AKT3)
   05165 Human papillomavirus infection
    102734291 (AKT3)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    102734291 (AKT3)
   05135 Yersinia infection
    102734291 (AKT3)
   05152 Tuberculosis
    102734291 (AKT3)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    102734291 (AKT3)
   05142 Chagas disease
    102734291 (AKT3)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    102734291 (AKT3)
   05017 Spinocerebellar ataxia
    102734291 (AKT3)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    102734291 (AKT3)
   05418 Fluid shear stress and atherosclerosis
    102734291 (AKT3)
   05415 Diabetic cardiomyopathy
    102734291 (AKT3)
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    102734291 (AKT3)
   04932 Non-alcoholic fatty liver disease
    102734291 (AKT3)
   04931 Insulin resistance
    102734291 (AKT3)
   04933 AGE-RAGE signaling pathway in diabetic complications
    102734291 (AKT3)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    102734291 (AKT3)
   01524 Platinum drug resistance
    102734291 (AKT3)
   01522 Endocrine resistance
    102734291 (AKT3)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:lww01001]
    102734291 (AKT3)
Enzymes [BR:lww01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     102734291 (AKT3)
Protein kinases [BR:lww01001]
 Serine/threonine kinases: AGC group
  AKT/PKB family
   102734291 (AKT3)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr Pkinase_C Kinase-like PH ABC1
Other DBs
NCBI-GeneID: 102734291
NCBI-ProteinID: XP_006740067
UniProt: A0A2U3Y8K7
LinkDB
Position
Unknown
AA seq 418 aa
MKTERPKPNTFIIRCLQWTTVIERTFHVDTPEEREEWTEAIQAVADRLQRQEEERMNCSP
TSQIDNIGEEEMDASTTHHKRKTMNDFDYLKLLGKGTFGKVILVREKASGKYYAMKILKK
EVIIAKDEVAHTLTESRVLKNTRHPFLTSLKYSFQTKDRLCFVMEYVNGGELFFHLSRER
VFSEDRTRFYGAEIVSALDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITDAA
TMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILME
DIKFPRTLSSDAKSLLSGLLIKDPNKRLGGGPDDAKEIMRHSFFSGVNWQDVYDKKLVPP
FKPQVTSETDTRYFDEEFTAQTITITPPEKYDEDGMDCVDNERRPHFPQFSYSASGRE
NT seq 1257 nt   +upstreamnt  +downstreamnt
atgaaaacagaacgaccaaagccaaacacatttattatcagatgtctccagtggaccact
gttatagaaagaacatttcatgtagatactccagaggaaagggaagagtggacagaagct
attcaggctgtagcagacagacttcagagacaagaagaggagagaatgaattgtagtcca
acttcacaaattgataatataggggaggaggagatggatgcttccacaacccatcataaa
agaaagacaatgaatgattttgactatttgaaactactaggtaaaggcacttttgggaaa
gttattttggttcgagagaaggcaagtgggaaatactatgctatgaagattctgaagaaa
gaagttattattgcaaaggatgaagtggcgcatactctgactgagagcagagtattaaag
aacaccagacacccctttttaacatccttgaaatattccttccagacaaaagaccgtttg
tgttttgtgatggaatatgtaaatgggggagagctgtttttccatttgtcgagagagcgg
gtgttctccgaggaccgcacacgtttctatggtgcagaaattgtctctgctttggactat
ctacattccggaaagattgtgtaccgtgatctcaagttggagaatttaatgctggataaa
gatggccacataaaaattacagattttggactttgcaaagaagggatcacagatgcagcc
accatgaagacattctgtggcacaccagaatatctggcaccagaggtgttagaagacaat
gactatggccgagccgtggattggtggggcctgggggtcgtcatgtatgagatgatgtgt
gggaggctacctttctacaaccaggatcatgagaaactttttgaactaatactaatggaa
gacattaaatttcctcgaacactctcttcagatgcaaaatcactgctttcagggctcttg
ataaaggatccaaataaacgccttggcgggggcccagatgatgcaaaagaaattatgagg
cacagtttcttctctggagtcaactggcaagatgtttatgataaaaagcttgtacctcct
tttaagcctcaagttacatctgagacagataccagatattttgatgaagaatttacagct
cagactattacaataactccacctgaaaaatatgacgaggacggcatggactgcgtggac
aacgagcggcggccgcacttccctcagttctcctactctgccagcggccgcgagtaa

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