| Entry |
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| Name |
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
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| KO |
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| Organism |
lww Leptonychotes weddellii (Weddell seal)
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| Pathway |
| lww04070 | Phosphatidylinositol signaling system |
| lww04072 | Phospholipase D signaling pathway |
| lww04261 | Adrenergic signaling in cardiomyocytes |
| lww04270 | Vascular smooth muscle contraction |
| lww04613 | Neutrophil extracellular trap formation |
| lww04621 | NOD-like receptor signaling pathway |
| lww04723 | Retrograde endocannabinoid signaling |
| lww04750 | Inflammatory mediator regulation of TRP channels |
| lww04919 | Thyroid hormone signaling pathway |
| lww04925 | Aldosterone synthesis and secretion |
| lww04927 | Cortisol synthesis and secretion |
| lww04928 | Parathyroid hormone synthesis, secretion and action |
| lww04933 | AGE-RAGE signaling pathway in diabetic complications |
| lww04935 | Growth hormone synthesis, secretion and action |
| lww04961 | Endocrine and other factor-regulated calcium reabsorption |
| lww04973 | Carbohydrate digestion and absorption |
| lww05022 | Pathways of neurodegeneration - multiple diseases |
| lww05163 | Human cytomegalovirus infection |
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| Module |
| lww_M00130 | Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4 |
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| Brite |
KEGG Orthology (KO) [BR:lww00001]
09100 Metabolism
09101 Carbohydrate metabolism
00562 Inositol phosphate metabolism
102736489
09130 Environmental Information Processing
09132 Signal transduction
04015 Rap1 signaling pathway
102736489
04310 Wnt signaling pathway
102736489
04371 Apelin signaling pathway
102736489
04020 Calcium signaling pathway
102736489
04070 Phosphatidylinositol signaling system
102736489
04072 Phospholipase D signaling pathway
102736489
04071 Sphingolipid signaling pathway
102736489
04022 cGMP-PKG signaling pathway
102736489
09140 Cellular Processes
09144 Cellular community - eukaryotes
04540 Gap junction
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09150 Organismal Systems
09151 Immune system
04611 Platelet activation
102736489
04613 Neutrophil extracellular trap formation
102736489
04621 NOD-like receptor signaling pathway
102736489
04062 Chemokine signaling pathway
102736489
09152 Endocrine system
04911 Insulin secretion
102736489
04922 Glucagon signaling pathway
102736489
04929 GnRH secretion
102736489
04912 GnRH signaling pathway
102736489
04915 Estrogen signaling pathway
102736489
04921 Oxytocin signaling pathway
102736489
04926 Relaxin signaling pathway
102736489
04935 Growth hormone synthesis, secretion and action
102736489
04918 Thyroid hormone synthesis
102736489
04919 Thyroid hormone signaling pathway
102736489
04928 Parathyroid hormone synthesis, secretion and action
102736489
04916 Melanogenesis
102736489
04924 Renin secretion
102736489
04925 Aldosterone synthesis and secretion
102736489
04927 Cortisol synthesis and secretion
102736489
09153 Circulatory system
04261 Adrenergic signaling in cardiomyocytes
102736489
04270 Vascular smooth muscle contraction
102736489
09154 Digestive system
04970 Salivary secretion
102736489
04971 Gastric acid secretion
102736489
04972 Pancreatic secretion
102736489
04973 Carbohydrate digestion and absorption
102736489
09155 Excretory system
04961 Endocrine and other factor-regulated calcium reabsorption
102736489
09156 Nervous system
04724 Glutamatergic synapse
102736489
04725 Cholinergic synapse
102736489
04728 Dopaminergic synapse
102736489
04726 Serotonergic synapse
102736489
04720 Long-term potentiation
102736489
04730 Long-term depression
102736489
04723 Retrograde endocannabinoid signaling
102736489
09157 Sensory system
04742 Taste transduction
102736489
04750 Inflammatory mediator regulation of TRP channels
102736489
09159 Environmental adaptation
04713 Circadian entrainment
102736489
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
102736489
09172 Infectious disease: viral
05163 Human cytomegalovirus infection
102736489
09174 Infectious disease: parasitic
05146 Amoebiasis
102736489
05142 Chagas disease
102736489
05143 African trypanosomiasis
102736489
09164 Neurodegenerative disease
05010 Alzheimer disease
102736489
05016 Huntington disease
102736489
05017 Spinocerebellar ataxia
102736489
05022 Pathways of neurodegeneration - multiple diseases
102736489
09166 Cardiovascular disease
05417 Lipid and atherosclerosis
102736489
05415 Diabetic cardiomyopathy
102736489
09167 Endocrine and metabolic disease
04933 AGE-RAGE signaling pathway in diabetic complications
102736489
04934 Cushing syndrome
102736489
09180 Brite Hierarchies
09182 Protein families: genetic information processing
04131 Membrane trafficking [BR:lww04131]
102736489
Enzymes [BR:lww01000]
3. Hydrolases
3.1 Acting on ester bonds
3.1.4 Phosphoric-diester hydrolases
3.1.4.11 phosphoinositide phospholipase C
102736489
Membrane trafficking [BR:lww04131]
Exocytosis
Calcium ion-dependent exocytosis
Phospholipases
102736489
Endocytosis
Macropinocytosis
Phospholipase C
102736489
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| SSDB |
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| Motif |
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| Other DBs |
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| LinkDB |
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| Position |
Unknown
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| AA seq |
726 aa
MWEACQSSQEYFPHRILSSIVTRFYSLLSVCLPKKDPKLRELLDVGNIGRLEHRMITVVY
GPDLVNISHLNLVAFQEEVAKEWTNEVFSLATNLLAQNMSRDAFLEKAYTKLKLQVTPEG
RIPLKNIYRLFSADRKRVETALEACSLPSSRNDSIPQEDFTPEVYRVFLNNLCPRPEIDN
IFSEFGAKSKPYLTVDQMMDFINLKQRDPRLNEILYPPLKQEQVQVLIEKYEPNSSLAKK
GQISVDGFMRYLSGEENGVVSPEKLDLNEDMSQPLSHYFINSSHNTYLTAGQLAGNSSVE
MYRQVLLSGCRCVELDCWKGRTAEEEPVITHGFTMTTEISFKEVIEAIAECAFKTSPFPI
LLSFENHVDSPKQQAKMAEYCRLIFGDALLMEPLEKYPLESGVPLPSPMDLMYKILVKNK
KKSHKSSEGSGKKKLSEQASNTYSDSSSVFESSSPGAGEADTESDDDDDDDDCKKSSMDE
VGISDLAMQINMGMYEYNGKSGYRLKPEFMRRPDKHFDPFTEGIVDGIVANTLSVKIISG
QFLSDKKVGTYVEVDMFGLPVDTRRKAFKTKTSQGNAVNPVWEEEPIVFKKVVLPSLACL
RIAVYEEGGKFIGHRILPVQAIRPGYHYICLRNERNQPLMLPAVFVYIEVKDYVPDTYAD
VIEALSNPIRYVNLMEQRAKQLAALTLEDEEEVKKEMRKLSTGRFDFSASVTQPVRSRVG
VEIQAI |
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| NT seq |
2181 nt +upstreamnt +downstreamnt
atgtgggaagcatgccaaagctcccaagaatacttcccacataggatattatcatctata
gttaccaggttttattctttgctttctgtctgcctcccaaagaaggaccccaaattacgt
gaacttttggatgtggggaacatcgggcgcctggagcatcgcatgataacagtggtatat
gggcctgacttggttaacatctcccatttgaatctcgtggctttccaagaagaagtggcc
aaggaatggacaaatgaggttttcagtttggcaacaaacctgctggcccaaaacatgtca
agagacgcatttctggaaaaagcctatactaagcttaagctgcaagtcactccagaaggg
cgcattcctctcaaaaacatataccgcttgttctcagcagaccggaagcgagtcgaaact
gctttagaggcttgtagtcttccatcttcaaggaacgattcaatacctcaagaagatttc
actccagaagtgtacagagttttcctgaacaacctttgccctcgacctgaaattgataac
atcttttccgaatttggtgccaaaagcaaaccataccttaccgtcgatcagatgatggac
tttatcaaccttaagcagcgagatccccggctaaatgaaatcctttacccacctttaaaa
caagaacaagtccaagtattgattgagaagtatgaacccaacagtagcctcgccaaaaaa
ggacagatatcagtggatggctttatgcgctatctgagtggagaagaaaatggagtcgtt
tcgcctgagaaactggatttgaatgaagatatgtctcagcccctttctcactatttcatc
aattcctcacacaacacctacctcacagctggccagttggctggaaactcctctgtcgag
atgtatcgccaagtgctcctgtctggttgtcgctgtgtggagttggactgctggaaggga
cggactgctgaagaggaaccagtcatcacccatgggttcaccatgacaactgaaatatcc
ttcaaggaagtgatagaagcaattgctgagtgtgcatttaagacgtcaccttttccaatt
ctgctttcatttgagaaccacgtagattccccaaagcagcaagccaagatggcggagtat
tgccgactgatctttggagatgctcttctcatggaaccactggaaaaatacccactggaa
tctggagttcctcttccaagccctatggacttaatgtacaaaattttggtgaaaaataag
aagaaatcgcacaagtcgtcggaaggaagtggcaaaaagaagctctccgaacaagcttcc
aacacgtacagcgactcttccagcgtgttcgagtcctcatctccaggagctggggaagct
gataccgagagtgacgacgacgatgatgatgatgactgtaaaaaatcttcaatggatgag
gtaggtatctcagacctggctatgcaaataaatatggggatgtacgaatacaatgggaaa
agtggctacagattaaagccagagttcatgaggagacctgacaagcattttgatccattc
accgaaggcatcgtggatgggatagtagccaatactttatctgtcaagattatatcaggt
cagtttctttctgataagaaagttgggacttacgtggaagtggatatgtttggtttgcct
gtggacacgaggaggaaggcatttaagaccaaaacatcacaaggaaatgctgtaaatcct
gtctgggaagaagagcccattgtgttcaaaaaggtggttcttccttctctggcctgtttg
aggatagcagtttatgaagaaggaggtaaattcatcggtcaccgaatcttgccagtacag
gcaattcggccaggctatcactatatctgtctgaggaatgagaggaaccagcctctgatg
ctcccagctgtctttgtctacatagaggtgaaagactatgtcccagatacatatgcagat
gtgattgaagctttgtcaaatccaatacgatatgtgaatctgatggagcaaagagctaaa
caattggctgcattgacactggaagatgaagaagaagtaaagaaagagatgaggaaactg
agtaccgggagattcgatttctcagccagtgtcacacaaccagtaaggagcagagtcggc
gttgaaattcaagccatctag |
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