Leptonychotes weddellii (Weddell seal): 102736730 Help Entry 102736730         CDS       T08708                                  Symbol JAK1 Name (RefSeq) tyrosine-protein kinase JAK1   KO K11217   Janus kinase 1 [EC:2.7.10.2] Organism lww  Leptonychotes weddellii (Weddell seal) Pathway lww01521   EGFR tyrosine kinase inhibitor resistance lww04151   PI3K-Akt signaling pathway lww04217   Necroptosis lww04380   Osteoclast differentiation lww04550   Signaling pathways regulating pluripotency of stem cells lww04620   Toll-like receptor signaling pathway lww04621   NOD-like receptor signaling pathway lww04630   JAK-STAT signaling pathway lww04658   Th1 and Th2 cell differentiation lww04659   Th17 cell differentiation lww05140   Leishmaniasis lww05145   Toxoplasmosis lww05152   Tuberculosis lww05160   Hepatitis C lww05161   Hepatitis B lww05162   Measles lww05163   Human cytomegalovirus infection lww05164   Influenza A lww05165   Human papillomavirus infection lww05166   Human T-cell leukemia virus 1 infection lww05167   Kaposi sarcoma-associated herpesvirus infection lww05168   Herpes simplex virus 1 infection lww05169   Epstein-Barr virus infection lww05171   Coronavirus disease - COVID-19 lww05200   Pathways in cancer lww05203   Viral carcinogenesis lww05212   Pancreatic cancer lww05235   PD-L1 expression and PD-1 checkpoint pathway in cancer Brite KEGG Orthology (KO) [BR:lww00001]  09130 Environmental Information Processing   09132 Signal transduction    04630 JAK-STAT signaling pathway     102736730 (JAK1)    04151 PI3K-Akt signaling pathway     102736730 (JAK1)  09140 Cellular Processes   09143 Cell growth and death    04217 Necroptosis     102736730 (JAK1)   09144 Cellular community - eukaryotes    04550 Signaling pathways regulating pluripotency of stem cells     102736730 (JAK1)  09150 Organismal Systems   09151 Immune system    04620 Toll-like receptor signaling pathway     102736730 (JAK1)    04621 NOD-like receptor signaling pathway     102736730 (JAK1)    04658 Th1 and Th2 cell differentiation     102736730 (JAK1)    04659 Th17 cell differentiation     102736730 (JAK1)   09158 Development and regeneration    04380 Osteoclast differentiation     102736730 (JAK1)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     102736730 (JAK1)    05203 Viral carcinogenesis     102736730 (JAK1)    05235 PD-L1 expression and PD-1 checkpoint pathway in cancer     102736730 (JAK1)   09162 Cancer: specific types    05212 Pancreatic cancer     102736730 (JAK1)   09172 Infectious disease: viral    05166 Human T-cell leukemia virus 1 infection     102736730 (JAK1)    05161 Hepatitis B     102736730 (JAK1)    05160 Hepatitis C     102736730 (JAK1)    05171 Coronavirus disease - COVID-19     102736730 (JAK1)    05164 Influenza A     102736730 (JAK1)    05162 Measles     102736730 (JAK1)    05168 Herpes simplex virus 1 infection     102736730 (JAK1)    05163 Human cytomegalovirus infection     102736730 (JAK1)    05167 Kaposi sarcoma-associated herpesvirus infection     102736730 (JAK1)    05169 Epstein-Barr virus infection     102736730 (JAK1)    05165 Human papillomavirus infection     102736730 (JAK1)   09171 Infectious disease: bacterial    05152 Tuberculosis     102736730 (JAK1)   09174 Infectious disease: parasitic    05145 Toxoplasmosis     102736730 (JAK1)    05140 Leishmaniasis     102736730 (JAK1)   09176 Drug resistance: antineoplastic    01521 EGFR tyrosine kinase inhibitor resistance     102736730 (JAK1)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:lww01001]     102736730 (JAK1) Enzymes [BR:lww01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.10  Protein-tyrosine kinases     2.7.10.2  non-specific protein-tyrosine kinase      102736730 (JAK1) Protein kinases [BR:lww01001]  Non-receptor tyrosine kinases   JAK family [OT]    102736730 (JAK1) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  PK_Tyr_Ser-Thr Pkinase SH2_1 ABC1 RIO1 SH2 Haspin_kinase Motif Other DBs NCBI-GeneID:  102736730 NCBI-ProteinID:  XP_030874638 UniProt:  A0A7F8Q2P5 LinkDB All DBs Position Unknown AA seq 740 aa AA seqDB search DLSQLRDVDIPWALECSHWYEFFLPFPFSSSSTEYAINKLRQEGSEEGMYVLRWSCTDFD NILMTVTCFEKSEVLGGQKQFKNFQIEVQKGRYSLHGSDRSFPSLGDLMSHLKKQILRTD NISFVLKRCCQPKPREISNLLVATKKAQEWQPVYPMSQLSFDRILKKDIVQGEHLGRGTR THIYSGTLVDYKDDEGTSEEKRIKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLY GVCVRDVENIMVEEFVEGGPLDLFMHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGN VCTKNLLLAREGIDSECGPFIKLSDPGIPITVLSRQECIERIPWIAPECVEDSKNLSVAA DKWSFGTTLWEICYNGEIPLKDKTLIEKERFYESRCRPVTPSCKELADLMTRCMNYDPNQ RPFFRAIMRDINKLEEQNPDIVSERKPAIEVDPTHFEKRFLKRIRDLGEGHFGKVELCRY DPEGDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKL IMEFLPSGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESE HQVKIGDFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLIQCKFYIASDVWSFGVTLHEL LTYCDSDYSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPRHCPDEVYQLMRKCWEF QPSNRTTFQNLIEGFEALLK NT seq 2223 nt NT seq  +upstreamnt  +downstreamnt gacttgagccagctcagagacgtggatatcccgtgggctttagagtgttctcattggtat gagttctttctccctttccctttctcttcctctagcacagaatatgccatcaataagttg cggcaagaaggaagcgaggaggggatgtatgtgctgaggtggagctgtaccgactttgac aatatcctcatgactgtcacctgctttgaaaaatctgaggtgctgggtggccagaaacag ttcaagaactttcagatcgaggtgcagaagggccgctatagcctgcatggctcagaccgc agcttccccagcctgggggacctgatgagccacctcaagaagcagatcctgcgcacggac aacatcagctttgtgctgaagcgctgctgccagcccaagccccgagagatctccaatctt ctggtggctactaagaaagcccaggagtggcagcctgtctaccccatgagccagctgagt tttgaccggatcctcaagaaagatattgtgcaaggcgagcaccttgggagaggcacacgg acgcacatctactccggtaccctggtggattacaaggatgacgaaggaacttccgaagag aagagaataaaagtgatcctcaaagtcttagaccccagccacagggacatttctctggcc ttctttgaagcagccagcatgatgaggcaggtctcccacaaacacatcgtgtacctctat ggcgtctgtgtccgagacgtggagaatatcatggtggaggagtttgtggaaggcgggccc ctggatctcttcatgcaccggaaaagcgatgtcctcaccacaccatggaaattcaaagtt gccaaacagctggccagcgccctgagttacttggaggataaagacctggtccatggaaac gtgtgcacaaaaaaccttctcctggcccgcgagggtattgacagcgagtgcggcccgttc atcaagctcagtgaccctggcatccccatcacagtgctgtccaggcaggagtgcatagaa cgaatcccatggattgctcccgagtgtgttgaagactccaagaacctgagtgtggctgct gacaaatggagctttggaaccacactctgggagatctgctacaatggcgagatccctctg aaagacaagaccctgattgagaaagagagattctacgaaagccggtgccggccagtgaca ccatcttgtaaggagctggctgaccttatgacccgctgcatgaactatgaccccaaccag agacccttcttccgagccatcatgagagacatcaataaactggaagagcagaatccagac attgtttccgaaagaaagccggcaatcgaagtagatcccacacattttgaaaagcggttc ttgaagaggatccgtgacttgggggagggccactttgggaaggttgagctctgcaggtat gaccctgagggggacaataccggggagcaggtggcggtcaaatccctgaagcccgagagt ggaggcaaccacatagctgacctgaagaaggaaattgaaatcctaaggaacctctatcat gagaacattgtgaagtacaaaggcatctgtacagaagacggaggaaatggtattaagctc atcatggaatttctgccttcaggaagccttaaggaatatcttccaaagaataagaacaaa attaacctcaaacagcaattaaaatacgccgttcagatttgtaaggggatggactatttg ggttctcggcagtacgttcaccgggacttggcagcaagaaatgtcctcgttgagagtgag caccaagtgaaaattggagactttggtttgaccaaagcaattgaaactgacaaggagtac tacacagtcaaggatgatcgggacagccctgtgttttggtatgctcctgaatgtttaatt cagtgtaaattttatatcgcctctgatgtctggtcgtttggagtgactctgcatgagctg cttacttactgtgactcagattacagccccatggcgttgttcctgaaaatgataggccca actcatggccagatgacagtcacaagacttgtgaatacattaaaagaaggaaaacgtttg ccttgtccacgtcactgtccagatgaggtttatcaacttatgagaaaatgctgggaattc caaccatccaatcggacaacttttcagaaccttattgaaggatttgaagcacttttaaaa taa

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