Leptonychotes weddellii (Weddell seal): 102739535
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Entry
102739535 CDS
T08708
Symbol
LRRK2
Name
(RefSeq) leucine-rich repeat serine/threonine-protein kinase 2
KO
K08844
leucine-rich repeat kinase 2 [EC:
2.7.11.1
]
Organism
lww
Leptonychotes weddellii (Weddell seal)
Pathway
lww05012
Parkinson disease
lww05022
Pathways of neurodegeneration - multiple diseases
Brite
KEGG Orthology (KO) [BR:
lww00001
]
09160 Human Diseases
09164 Neurodegenerative disease
05012 Parkinson disease
102739535 (LRRK2)
05022 Pathways of neurodegeneration - multiple diseases
102739535 (LRRK2)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
lww01001
]
102739535 (LRRK2)
09182 Protein families: genetic information processing
04131 Membrane trafficking [BR:
lww04131
]
102739535 (LRRK2)
09183 Protein families: signaling and cellular processes
04147 Exosome [BR:
lww04147
]
102739535 (LRRK2)
Enzymes [BR:
lww01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.11 Protein-serine/threonine kinases
2.7.11.1 non-specific serine/threonine protein kinase
102739535 (LRRK2)
Protein kinases [BR:
lww01001
]
Serine/threonine kinases: TKL group
LRRK family
102739535 (LRRK2)
Membrane trafficking [BR:
lww04131
]
Exocytosis
Calcium ion-dependent exocytosis
Kinases and associated proteins
102739535 (LRRK2)
Exosome [BR:
lww04147
]
Exosomal proteins
Exosomal proteins of other body fluids (saliva and urine)
102739535 (LRRK2)
BRITE hierarchy
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
ARM_LRRK2
Beta-prop_LRRK2
Pkinase
PK_Tyr_Ser-Thr
Roc
COR
ANK_LRRK2
LRR_8
Ras
LRR_4
LRR_9
Beta-prop_EML_2
Arf
Beta-prop_RSE1_2nd
WD40_CDC20-Fz
LRR_NXF1-5
AAA_22
nSTAND3
PduV-EutP
ABC_tran
T2SSE
SRPRB
GTP_EFTU
MMR_HSR1
WDR55
G-alpha
AAA_7
Kdo
TsaE
Beta-prop_BBS7
WD40_WDHD1_1st
AAA_16
Beta-prop_WDR19_1st
MobB
Septin
cobW
AAA_29
NACHT
AAA_23
ARM_LIN_2nd
SRP54
Motif
Other DBs
NCBI-GeneID:
102739535
NCBI-ProteinID:
XP_006727769
UniProt:
A0A2U3X8F1
LinkDB
All DBs
Position
Unknown
AA seq
2150 aa
AA seq
DB search
MASGSCQGCEEEDEETLKKLIVRLNNVQEGKQIETLVQILEDMLVFTYADHASKLFQGKK
VHVPVLIVLDLYIRVASVQQVGWSLLCKLIEICPNTMQSLMGPQDIGHDWEVLGVHQLIL
KMLTVHNASVNLLTVGLKALDLLLTSGKITLLILDEESDIFLLIFDAMRTFSANDEVQKL
GCKALRVLFERVSEEQLTEFVENKDYMILLNALKNFKDEEEIVFHVLHCLHSLAIPCNNV
EVLMSGNVRCYNIVVEAMKAFPVNEKIQEVSCCLLHRLTLGNFFNILVLNEVHEFVVKAV
RRYSENATLQIAALSCLALLTETIFLNQDLEEKNENSETDDEEEDKLFWLEACYKALTWH
RKNKHVQEAACWALNNLLMYQNSLHEKIGDEDGQFPAHREVMLSMLMHSSSKEVFQASAN
ALSTLLEQNVNFRKILLSKGIYLNVLELMQKHIHSPEVAESGCKMLNHLFEGSNATLDTM
SAVAPKIITVMKSHEASLSVQLEALRAVLHFIVPVDRASYSFTFQKLFLHRPVCEKASSA
KLVELLLNGGSREQDVRKALTISIAKGDSQIISLLLRRLALDVANNSICLGGFCIGKIEP
SWLGPLFPDKTSNLRKETINIYLPLFYRLKIGSEGSFLVKRKSNSISVGEFYRDRALQRC
SPNLQRHSNSLEPIFDHEDLLRQKRKILSSDDSLRSSKLQSHMRHSDSISSLASEREYIT
SLDLSANELRDIDALSQRCCISGHLEHLEKLELHQNALASFPQQLCETLKCLTHLDLHSN
KFTSFPSYLLKMNCIANLDVSRNDISPSVVLDPAVKCPTLKQFNLSYNQLSSFPENLGVV
VEKLEQLILEGNKIPEICSPLSLKELKILNLSKNHITSLSEDFLEACPKVESFSARMNYL
AVMPFLPSSLTSLKLSQNSFTCVPEAILNLPHLLFNFCLSNTRFLQQRLKKAVPYNRMKL
MIVGNTGSGKTTLLQQLTKTKKSDLGVQSSTVGIDVKDWPIQIRGKGKKDLILNVWDFAG
REEFYSTHPHFMTQRALYLAVYDLSKGQAEVDAMKPWLFNIKARASSSPVILVGTHLDVS
DEKQRKACISKITKELLNKRGFPAIRDYHFVNATEESDALAKLRKTIINESLNFKIRDQP
VVGQLIPDCYVELEKIILSERKNVPIEFPVIDRKRLLQLVKENQLQLDENELPHAVHFLN
ESGVLLHFQDPALQLSDLYFVEPKWLCKVMAQILTVKVEGYPKHPKGIISRRDVEKFLSK
KKRFPKNYMSQYFKLLEKFQIALPIGEEYLLVPSSLSDHRPVIELPHCENSEIIIRLYEM
PYFPMGFWSRLINRLLEISPYMLSGRERALRPNRMYWRQGIYLNWSPEAYCLVGSEVLDN
HPESFLKITVPSCRKGCILLGQVVDHIDSLMEEWFPGLLEIDICGEGETLLKKWALYSFN
DGEEHQKILLDDLTKKAEEGDLLINPDQPRLTIPISQIAPDLILADLPRNIMLNNDELEF
EQAPEFLLGDGSFGSVYRASYEGEEVAVKIFNKHTSLRLLRQELVVLCHLHHPSLISLLA
AGIRPRMLVMELASKGSLDRLLQQDKGSLTRTLQHRIALHVADGLRYLHSAMIIYRDLKP
HNVLLFTLYPNAGIIAKIADYGIAQYCCRMGIKTSEGTPGFRAPEVAKGNVIYNQQADVY
SFGLLLYDILTTGGRIAEGLKFPNEFDELAIQGKLPDPVKEYGCAPWPMVEKLIKKCLKE
NPQERPTSAQVFDTLNSAELICLMRHISIPKNFSVECMVATNHNSKNASIWLGCGHRDKG
QLLFLDLNTEKHTPEEVIDSRILCLALVPLPVEKESWIVCGTQSGMLLVINTEDGEKRHT
LEKMTDSVTCLYCSPFPKQSKQKNFLLVGTADGNLAIFEDKTVKCKGAAPLKILNIGNVS
TPLMCLSESMNSTEKNIMWGGCGTKLFSFSDDFTIQKLIETKTNQLFSYAAFSDSNIIAV
VVDTALYVAKKNSPFVEVRDKKTEKLFELIDCVHFLKEEMVKVNAESKHKLSYSGRVKTL
CLQKNTALWIGTGGGHILLLDLSTRRIIRIIHNFCDSVRVMMTAQLGSLKNVMLVLGYIR
KSTESTQYQKEIQSCLSVWDINLPHEVQNLEKHIEVRKELAEKMRRISVE
NT seq
6453 nt
NT seq
+upstream
nt +downstream
nt
atggccagtggcagctgtcaggggtgcgaggaggaggacgaggaaactctgaagaagttg
atagtcaggctgaacaatgtccaggaaggaaaacagatagagaccctggtccaaattctg
gaggatatgctggtgttcacgtacgccgaccacgcctccaagttatttcaaggcaaaaaa
gtccacgtgcctgtgttgatcgtcttggacttgtatataagagtcgctagcgtgcagcag
gtgggttggtcacttctttgcaaattgatagaaatctgtccaaatacaatgcaaagctta
atgggacctcaggatattggacatgattgggaagtacttggcgttcaccaactgattctt
aaaatgctaacagttcataatgccagtgtaaacctgttaacagttggactgaaggcctta
gatctccttctaacttcaggcaaaatcactttgctgatattggatgaagaaagtgatatt
ttcttgttaatttttgatgccatgcgcacattttcagccaatgacgaagtccagaaactt
ggatgcaaagctttacgtgtgctgtttgaaagagtttcagaggagcagctgactgaattt
gttgagaataaagattatatgatcttgctcaatgcattaaaaaattttaaagatgaagag
gaaattgtgtttcatgtcctgcactgtttacattccctagcaattccttgcaataatgtt
gaagtcctcatgagtggcaacgtcaggtgttacaacattgtggtagaagccatgaaagca
ttccctgtcaatgaaaaaattcaagaagtgagttgttgcttgctccataggcttacacta
ggtaatttttttaatattctggtattaaatgaggtacatgagtttgtggtgaaagccgtg
cggcgatattcagagaacgccacgttacagattgcagcactcagctgtttagcgctcctc
actgagaccattttcttaaatcaagatttagaggaaaagaatgagaattcggagactgat
gatgaggaagaagataaattgttctggttggaagcctgttacaaagcattaacatggcat
agaaagaataagcatgtgcaggaagctgcatgctgggcccttaacaatctccttatgtac
caaaacagtttacatgagaagattggagatgaagatggccagttcccagctcatagggaa
gtgatgctctccatgctgatgcattcttcatcaaaagaagtcttccaggcatctgcaaat
gcattgtcaactctgttagaacaaaatgttaatttcagaaaaatcctgttgtcaaaagga
atatacctgaatgtattggagttaatgcagaagcatatacattctcctgaagttgctgaa
agtggctgtaaaatgctaaatcatctctttgaaggaagcaacgcgaccctggatacgatg
tcagcagtggcccccaaaataataacagttatgaaaagtcacgaggcatccttatcagtg
cagctggaggcactaagagctgttttacattttatagttccagttgatagagcatcatat
tccttcacctttcagaagctgttcctgcacaggccagtatgtgagaaagccagtagtgcc
aaattggtggaactgttactgaatggtggttcccgtgaacaagatgtccggaaagcgctg
acgataagcattgcaaaaggtgacagccagatcatcagcttactcttaaggaggcttgcc
ctggatgtggccaataatagcatttgccttggaggattctgtataggaaaaattgaacct
tcatggcttggtcctttatttccggataagacatctaatttaagaaaagaaacaatcaac
atttacttgcctttattttatcgtttaaaaataggaagtgaaggctcatttcttgtgaaa
agaaaatccaattcaattagcgtaggagaattttaccgagatcgtgccttgcagcgttgc
tcaccaaatttgcaaaggcattccaactcattggaacccattttcgatcatgaagattta
ctgaggcaaaaaagaaaaatactgtcttcagatgactcactcagatcatcaaaacttcaa
tcccatatgaggcattcagacagcatttcttccctggcttctgagagagaatatattaca
tcattagacctttcagcaaatgaactaagagatattgatgccctaagccagaggtgctgt
atcagtggtcatttggagcatcttgaaaagctggagcttcaccagaatgcactcgcgagc
tttccacaacaactgtgtgaaaccctgaagtgtttgacacatttggatttgcacagtaat
aaatttacatcatttccctcttacttgttgaaaatgaattgtattgccaacctcgatgtc
tctcgaaacgacatcagcccttcagtggttttggatcctgcagtgaagtgcccaaccttg
aaacagtttaacttgtcatataatcagctgtcttcttttcctgagaaccttggcgttgtg
gtagagaaattggaacagctcattttagaaggaaataaaataccagaaatatgttccccc
ttaagcctgaaggaactgaagattttaaaccttagtaaaaaccacattacatccctatca
gaagacttccttgaggcatgtcctaaagtggagagtttcagtgccagaatgaattatctt
gctgttatgccttttttgccttcttctctgacaagcctaaaattatctcaaaacagcttt
acatgtgttccagaagcaattttaaatcttccacacttattatttaatttttgtctttca
aataccaggtttcttcaacagcggttaaaaaaggccgtaccttataaccgaatgaagcta
atgattgtgggaaatactgggagtggtaaaaccaccttactgcagcaattaacgaaaacc
aagaaatcagatcttggggtgcaaagctccacagttggtatagatgtgaaagactggcct
atccaaataagaggcaaagggaagaaagacctcattctaaatgtgtgggattttgcaggt
cgtgaggaattctacagcactcatccccacttcatgacccagcgagctctctaccttgcc
gtctatgacctcagcaaagggcaggctgaagtggacgccatgaagccttggctcttcaat
ataaaggctcgtgcttcttcttcccctgtgatactcgttggcacacatttagatgtttct
gatgagaagcagcgcaaagcctgcataagtaaaatcaccaaggaactcttgaacaagcga
gggtttcctgcaataagggattaccactttgtgaatgccactgaggaatccgacgctttg
gcaaagcttcggaaaaccatcataaatgagagtcttaatttcaagattcgagatcagcct
gttgttgggcagctgattccagactgctatgtagaacttgagaaaatcattttatcagag
cgtaaaaatgtgccaattgaatttcctgtaatcgaccggaaacgattattacaactcgta
aaagaaaatcagctgcagttggatgaaaatgagcttcctcatgcagttcacttcctaaat
gaatcaggggtccttcttcattttcaagacccagcactgcagttaagtgacttatatttt
gtggaacccaagtggctttgtaaagtcatggcacagattttgacagtgaaagtagaaggc
tatccaaaacatcctaaaggaatcatttcacgtagagatgtggaaaaatttctttcaaag
aagaagagatttccaaagaactacatgtcacagtactttaaactcctagaaaaattccag
attgccttgccaataggagaagaatatttgctggttccaagcagtttgtctgaccacagg
cctgtgatagaacttccccattgtgagaactctgaaattatcattcgactatacgaaatg
ccttactttccaatgggattttggtccaggttaattaatcgattacttgaaatttcacct
tacatgctttcaggaagagaacgagcacttcgcccaaacagaatgtattggcgacaaggc
atctacttgaattggtctcctgaggcttattgtctggtaggatctgaagtcttagacaat
cacccagagagtttcttaaaaattacagttccttcttgtagaaaaggctgtattcttctg
ggccaagttgtggaccacattgattctcttatggaagaatggtttcctggattactggag
attgatatctgtggtgaaggagaaactctgttgaagaaatgggcattatatagttttaat
gatggtgaagagcatcaaaaaatcttacttgatgacttgacgaagaaagcagaagaagga
gaccttctgataaatccagatcaaccaaggctcaccattccaatatctcaaattgctcct
gacttaattttggctgacctgcctagaaatattatgttgaataatgatgaattggaattt
gaacaagctccagagtttctcctaggtgatggcagttttgggtctgtttatcgagcatcc
tatgaaggagaagaagtggctgtgaagattttcaataaacatacatcacttagactgtta
agacaagagctggtggtcctttgtcacctccaccaccccagcttaatatctttgctggcg
gctgggattcgtcctcgaatgttggtgatggagttggcctccaagggttcgctggaccgc
ttgcttcagcaggacaaaggaagtctcaccagaaccctgcagcacaggattgcactacat
gtggctgatggcttgagatacctccactcggccatgattatataccgtgacttgaagccc
cacaacgtgctgctcttcaccctgtatcccaatgctggcatcattgcaaagattgcggac
tacgggattgctcagtactgctgtagaatggggataaagacgtcagagggcacaccaggg
tttcgtgcacctgaagttgctaaaggaaatgttatttataaccagcaggctgatgtttat
tcatttggtttactactctatgacattttgacaactggaggtagaatagcagagggtttg
aagtttccaaatgagtttgatgaactggcaatacagggaaaattacctgatccagttaaa
gaatatggctgtgccccatggcccatggttgagaagttaattaaaaagtgtttgaaagaa
aatcctcaagaaaggcctacttctgcccaggtctttgacactttgaattcagctgagtta
atctgtctgatgagacatatatcaatacctaaaaactttagtgttgaatgcatggttgct
acaaatcataacagcaagaatgcaagcatctggctgggctgtgggcaccgtgataaagga
cagctcttatttctcgacttaaatacagaaaaacacactcctgaggaagttattgatagt
agaatactgtgcctggctttggtgcctcttcctgtggaaaaggaaagctggattgtgtgt
gggacacagtctggcatgctcctggtcatcaataccgaagatggggaaaagagacatacc
cttgaaaagatgactgattctgtgacttgcttgtattgcagtccctttcccaagcaaagc
aagcaaaaaaattttcttctggtgggaactgctgatggcaatttagcaatttttgaagat
aaaactgttaagtgtaaaggagccgctcctttgaagatactaaatataggaaatgtcagt
actccactgatgtgtttgagtgaatccatgaattcaactgaaaaaaacattatgtgggga
ggatgtggtacaaaacttttctcattttctgatgatttcaccattcagaagctcattgag
acaaagacaaatcagctgttttcttatgcagctttcagtgattccaacatcatagcggtg
gtggtagacacggctctctacgttgctaagaaaaatagcccatttgtggaagtacgggat
aagaaaactgaaaaactctttgaactaatagactgtgtgcactttttaaaggaggaaatg
gtcaaagtaaatgcagaatcaaaacacaaactgtcttattctgggagagtgaaaaccctc
tgcctccagaagaacactgctctctggataggaactggaggaggccatattttacttctt
gatctttcaactcgtcgaattatacgtataattcacaatttttgtgactctgtcagagtc
atgatgacagcacagttaggaagccttaaaaatgtcatgctggttttggggtatatccgg
aaaagtaccgaaagtacacaataccaaaaagagatacaatcttgtttgtctgtttgggac
atcaatcttccacatgaagtgcaaaatttagaaaaacatattgaagtgagaaaagaatta
gctgaaaaaatgagaagaatatctgttgaataa
DBGET
integrated database retrieval system
