Leptonychotes weddellii (Weddell seal): 102745262
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Entry
102745262 CDS
T08708
Symbol
JAK2
Name
(RefSeq) tyrosine-protein kinase JAK2 isoform X1
KO
K04447
Janus kinase 2 [EC:
2.7.10.2
]
Organism
lww
Leptonychotes weddellii (Weddell seal)
Pathway
lww01521
EGFR tyrosine kinase inhibitor resistance
lww04062
Chemokine signaling pathway
lww04081
Hormone signaling
lww04148
Efferocytosis
lww04151
PI3K-Akt signaling pathway
lww04217
Necroptosis
lww04550
Signaling pathways regulating pluripotency of stem cells
lww04630
JAK-STAT signaling pathway
lww04658
Th1 and Th2 cell differentiation
lww04659
Th17 cell differentiation
lww04725
Cholinergic synapse
lww04917
Prolactin signaling pathway
lww04920
Adipocytokine signaling pathway
lww04933
AGE-RAGE signaling pathway in diabetic complications
lww04935
Growth hormone synthesis, secretion and action
lww05140
Leishmaniasis
lww05145
Toxoplasmosis
lww05152
Tuberculosis
lww05161
Hepatitis B
lww05164
Influenza A
lww05167
Kaposi sarcoma-associated herpesvirus infection
lww05168
Herpes simplex virus 1 infection
lww05200
Pathways in cancer
lww05207
Chemical carcinogenesis - receptor activation
lww05235
PD-L1 expression and PD-1 checkpoint pathway in cancer
lww05417
Lipid and atherosclerosis
Brite
KEGG Orthology (KO) [BR:
lww00001
]
09130 Environmental Information Processing
09132 Signal transduction
04630 JAK-STAT signaling pathway
102745262 (JAK2)
04151 PI3K-Akt signaling pathway
102745262 (JAK2)
09133 Signaling molecules and interaction
04081 Hormone signaling
102745262 (JAK2)
09140 Cellular Processes
09141 Transport and catabolism
04148 Efferocytosis
102745262 (JAK2)
09143 Cell growth and death
04217 Necroptosis
102745262 (JAK2)
09144 Cellular community - eukaryotes
04550 Signaling pathways regulating pluripotency of stem cells
102745262 (JAK2)
09150 Organismal Systems
09151 Immune system
04658 Th1 and Th2 cell differentiation
102745262 (JAK2)
04659 Th17 cell differentiation
102745262 (JAK2)
04062 Chemokine signaling pathway
102745262 (JAK2)
09152 Endocrine system
04920 Adipocytokine signaling pathway
102745262 (JAK2)
04917 Prolactin signaling pathway
102745262 (JAK2)
04935 Growth hormone synthesis, secretion and action
102745262 (JAK2)
09156 Nervous system
04725 Cholinergic synapse
102745262 (JAK2)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
102745262 (JAK2)
05207 Chemical carcinogenesis - receptor activation
102745262 (JAK2)
05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
102745262 (JAK2)
09172 Infectious disease: viral
05161 Hepatitis B
102745262 (JAK2)
05164 Influenza A
102745262 (JAK2)
05168 Herpes simplex virus 1 infection
102745262 (JAK2)
05167 Kaposi sarcoma-associated herpesvirus infection
102745262 (JAK2)
09171 Infectious disease: bacterial
05152 Tuberculosis
102745262 (JAK2)
09174 Infectious disease: parasitic
05145 Toxoplasmosis
102745262 (JAK2)
05140 Leishmaniasis
102745262 (JAK2)
09166 Cardiovascular disease
05417 Lipid and atherosclerosis
102745262 (JAK2)
09167 Endocrine and metabolic disease
04933 AGE-RAGE signaling pathway in diabetic complications
102745262 (JAK2)
09176 Drug resistance: antineoplastic
01521 EGFR tyrosine kinase inhibitor resistance
102745262 (JAK2)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
lww01001
]
102745262 (JAK2)
Enzymes [BR:
lww01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.10 Protein-tyrosine kinases
2.7.10.2 non-specific protein-tyrosine kinase
102745262 (JAK2)
Protein kinases [BR:
lww01001
]
Non-receptor tyrosine kinases
JAK family [OT]
102745262 (JAK2)
BRITE hierarchy
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
PK_Tyr_Ser-Thr
Pkinase
SH2_1
FERM_F2
Jak1_Phl
SH2
ABC1
FERM_C_FAK1
RIO1
Kinase-like
Motif
Other DBs
NCBI-GeneID:
102745262
NCBI-ProteinID:
XP_006737323
UniProt:
A0A2U3Y110
LinkDB
All DBs
Position
Unknown
AA seq
952 aa
AA seq
DB search
MAVLDMMRLAKEKDQTPLDIYSSISYKTFLPKCVRAKIQDYHILTRKRIRYRFRRFIEQF
SHCKATARNLKLKYLINLETLQSAFYTEQFEVKEPGRGPSGEEIFATIIITGNGGIQWSR
GKHKESETLTEQDLQLYCDFPDIIDVTIKQASQEGSNESRIVTIHKQDGKNLEIELSSLR
EALSFVSLIDGYYRLTADAHHYLCKEVAPPMVLENIQSNCHGPILMDFAISKLKKAGNQT
GLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENGEYNLSGTKKNFSNLKDLLNC
YQMETVRSDSIIFQFTKCCPPKLKDKSNLLVFRTNGVSDVPTSPTLQRHNNVNQMVFHKI
RNEDLMFNESLGQGTFTKIFKGIRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASM
MSQLSHKHLVLNYGVCVCGEENILVQEFVKFGSLDTYLKKNKNSINILWKLEVAKQLAWA
MHFLEEKALIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVP
PECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWTEL
ANLINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRD
PTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIE
ILKSLQHDNIVKYKGVCYSAGRRNLRLIMEYLPYGSLRDYLQKHKERIDHKKLLQYTSQI
CKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFW
YAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIE
LLKNNGRLPRPDGCPDEIYLIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG
NT seq
2859 nt
NT seq
+upstream
nt +downstream
nt
atggctgtgttagatatgatgagactagccaaagagaaggatcagaccccactggacatc
tatagctctatcagctacaagacattcttaccaaaatgtgttcgagcaaagatccaagac
tatcatattttgacaaggaaacgaataaggtacagatttcgcagatttattgagcaattc
agccattgcaaagccactgccagaaacttgaaacttaagtatcttataaatctggaaact
cttcagtctgccttctacacagagcagtttgaagtaaaagaacctggaagaggtccttca
ggtgaggagatttttgcaaccattataataactggaaacggtggaattcagtggtcaaga
gggaaacataaagaaagtgagacactgacagaacaggatttacagttatattgtgacttt
cctgatattattgatgttactattaagcaagcaagccaagaaggctcaaatgaaagtaga
attgtaactatccataagcaagatggtaaaaatctggaaattgaacttagctcattaaga
gaagctttgtcctttgtgtcattaattgatggctattatagattaactgcagatgcacat
cattacctctgtaaagaagtagcacctccaatggtccttgaaaatatacaaagcaactgt
catggcccaattttaatggattttgccatcagtaaactgaagaaagcaggtaatcagact
ggactctatgtacttcgatgcagtcctaaggactttaataagtattttctgacttttgct
gtagagcgagaaaatgtcatcgaatataagcactgtttgattacaaaaaatgagaatgga
gaatacaacctcagtgggaccaagaagaacttcagtaatcttaaagatcttttgaattgc
tatcaaatggaaactgttcgctcagacagtataattttccagtttactaaatgctgtccc
ccaaagttgaaagataaatcaaaccttctagtcttcagaaccaatggcgtttctgatgtt
ccaacatcaccaacattacagaggcataataatgtgaaccaaatggtgtttcacaaaatc
agaaatgaagatttgatgtttaatgaaagccttggtcaaggcacttttacaaaaattttt
aaaggtataagaagagaagtaggagactatggtcaactacatgaaacagaagttctgtta
aaagttctggataaagcgcacagaaactattcagagtctttctttgaagcagcaagcatg
atgagccagctttctcacaagcatctagttttaaattacggagtatgtgtctgtggggaa
gagaatattctggttcaagagtttgtaaaatttggatcactagatacatatctgaaaaag
aataaaaattctataaatatattatggaaacttgaagtggctaaacaattggcatgggcc
atgcattttctagaagaaaaagcacttattcatgggaatgtgtgtgccaaaaatattctg
cttatcagagaagaagacaggaaaacaggaaatcctcctttcatcaaacttagtgatcct
ggcattagtattacagttttgccaaaggacattcttcaggagagaataccatgggtacca
cctgaatgcatcgaaaatcctaaaaatctaaatttggcaacagacaaatggagttttggt
accactttgtgggaaatctgcagtggaggagataagcctctgagtgctttggattctcaa
agaaagctacagttttatgaagataggcaccagcttcctgcaccaaagtggacagaatta
gcaaatcttattaataattgtatggattatgaaccagattttagaccttctttcagagcc
atcatacgagatcttaatagtttgtttactccagattatgaactattaacagagaatgac
atgttaccaaatatgagaataggtgccctagggttttctggtgcttttgaagaccgagac
cctacacagtttgaagagagacacttgaaatttctacagcaacttggtaagggtaatttt
ggcagtgtggagatgtgccggtatgaccctctacaagacaacactggggaggtggtggct
gtgaagaagctccagcacagcactgaggagcacctgagagactttgagagggaaatcgaa
atccttaaatccctgcagcatgacaacattgtgaagtacaagggagtgtgctacagtgct
ggtcggcgtaatctaagattaattatggaatatttaccatatggaagtttacgagactat
ctccaaaaacataaagaacggatagatcataaaaaacttctgcagtatacatctcagata
tgcaagggcatggagtatcttggtacaaaaaggtatatccacagggatctggcaacaagg
aatatactggtggaaaacgaaaacagggttaaaattggagattttgggttaaccaaagtc
ttgccacaagacaaagaatactacaaagtgaaagaacctggtgaaagtcccatattctgg
tatgctccagaatcactgacagagagcaagttttctgtggcttcagatgtttggagcttt
ggagtggttctgtatgaacttttcacatatattgagaagagtaaaagtcccccagcggaa
tttatgcgtatgattggcaatgacaaacaaggacagatgattgtgtttcatttgatagaa
ctcctaaagaataatggaagattaccaagaccagatggatgtccagatgagatttatttg
atcatgacagaatgctggaacaataatgtcaatcaacgcccctcttttagagacctagct
cttcgagttgatcaaataagggacaacatggctggatga
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