KEGG   Leptonychotes weddellii (Weddell seal): 102745822
Entry
102745822         CDS       T08708                                 
Symbol
SOS1
Name
(RefSeq) LOW QUALITY PROTEIN: son of sevenless homolog 1
  KO
K03099  son of sevenless
Organism
lww  Leptonychotes weddellii (Weddell seal)
Pathway
lww01521  EGFR tyrosine kinase inhibitor resistance
lww01522  Endocrine resistance
lww04010  MAPK signaling pathway
lww04012  ErbB signaling pathway
lww04014  Ras signaling pathway
lww04062  Chemokine signaling pathway
lww04068  FoxO signaling pathway
lww04072  Phospholipase D signaling pathway
lww04150  mTOR signaling pathway
lww04151  PI3K-Akt signaling pathway
lww04510  Focal adhesion
lww04540  Gap junction
lww04630  JAK-STAT signaling pathway
lww04650  Natural killer cell mediated cytotoxicity
lww04660  T cell receptor signaling pathway
lww04662  B cell receptor signaling pathway
lww04664  Fc epsilon RI signaling pathway
lww04714  Thermogenesis
lww04722  Neurotrophin signaling pathway
lww04810  Regulation of actin cytoskeleton
lww04910  Insulin signaling pathway
lww04912  GnRH signaling pathway
lww04915  Estrogen signaling pathway
lww04917  Prolactin signaling pathway
lww04926  Relaxin signaling pathway
lww04935  Growth hormone synthesis, secretion and action
lww05034  Alcoholism
lww05160  Hepatitis C
lww05161  Hepatitis B
lww05163  Human cytomegalovirus infection
lww05165  Human papillomavirus infection
lww05200  Pathways in cancer
lww05205  Proteoglycans in cancer
lww05206  MicroRNAs in cancer
lww05207  Chemical carcinogenesis - receptor activation
lww05208  Chemical carcinogenesis - reactive oxygen species
lww05210  Colorectal cancer
lww05211  Renal cell carcinoma
lww05213  Endometrial cancer
lww05214  Glioma
lww05215  Prostate cancer
lww05220  Chronic myeloid leukemia
lww05221  Acute myeloid leukemia
lww05223  Non-small cell lung cancer
lww05224  Breast cancer
lww05225  Hepatocellular carcinoma
lww05226  Gastric cancer
lww05231  Choline metabolism in cancer
Brite
KEGG Orthology (KO) [BR:lww00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    102745822 (SOS1)
   04012 ErbB signaling pathway
    102745822 (SOS1)
   04014 Ras signaling pathway
    102745822 (SOS1)
   04630 JAK-STAT signaling pathway
    102745822 (SOS1)
   04068 FoxO signaling pathway
    102745822 (SOS1)
   04072 Phospholipase D signaling pathway
    102745822 (SOS1)
   04151 PI3K-Akt signaling pathway
    102745822 (SOS1)
   04150 mTOR signaling pathway
    102745822 (SOS1)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    102745822 (SOS1)
   04540 Gap junction
    102745822 (SOS1)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    102745822 (SOS1)
 09150 Organismal Systems
  09151 Immune system
   04650 Natural killer cell mediated cytotoxicity
    102745822 (SOS1)
   04660 T cell receptor signaling pathway
    102745822 (SOS1)
   04662 B cell receptor signaling pathway
    102745822 (SOS1)
   04664 Fc epsilon RI signaling pathway
    102745822 (SOS1)
   04062 Chemokine signaling pathway
    102745822 (SOS1)
  09152 Endocrine system
   04910 Insulin signaling pathway
    102745822 (SOS1)
   04912 GnRH signaling pathway
    102745822 (SOS1)
   04915 Estrogen signaling pathway
    102745822 (SOS1)
   04917 Prolactin signaling pathway
    102745822 (SOS1)
   04926 Relaxin signaling pathway
    102745822 (SOS1)
   04935 Growth hormone synthesis, secretion and action
    102745822 (SOS1)
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    102745822 (SOS1)
  09159 Environmental adaptation
   04714 Thermogenesis
    102745822 (SOS1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    102745822 (SOS1)
   05206 MicroRNAs in cancer
    102745822 (SOS1)
   05205 Proteoglycans in cancer
    102745822 (SOS1)
   05207 Chemical carcinogenesis - receptor activation
    102745822 (SOS1)
   05208 Chemical carcinogenesis - reactive oxygen species
    102745822 (SOS1)
   05231 Choline metabolism in cancer
    102745822 (SOS1)
  09162 Cancer: specific types
   05210 Colorectal cancer
    102745822 (SOS1)
   05225 Hepatocellular carcinoma
    102745822 (SOS1)
   05226 Gastric cancer
    102745822 (SOS1)
   05214 Glioma
    102745822 (SOS1)
   05221 Acute myeloid leukemia
    102745822 (SOS1)
   05220 Chronic myeloid leukemia
    102745822 (SOS1)
   05211 Renal cell carcinoma
    102745822 (SOS1)
   05215 Prostate cancer
    102745822 (SOS1)
   05213 Endometrial cancer
    102745822 (SOS1)
   05224 Breast cancer
    102745822 (SOS1)
   05223 Non-small cell lung cancer
    102745822 (SOS1)
  09172 Infectious disease: viral
   05161 Hepatitis B
    102745822 (SOS1)
   05160 Hepatitis C
    102745822 (SOS1)
   05163 Human cytomegalovirus infection
    102745822 (SOS1)
   05165 Human papillomavirus infection
    102745822 (SOS1)
  09165 Substance dependence
   05034 Alcoholism
    102745822 (SOS1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    102745822 (SOS1)
   01522 Endocrine resistance
    102745822 (SOS1)
SSDB
Motif
Pfam: RasGEF_N RhoGEF SOS1_NGEF_PH PH RasGEF PH_19 PH_10 IQ_SEC7_PH RHG20_PH
Other DBs
NCBI-GeneID: 102745822
NCBI-ProteinID: XP_030892546
UniProt: A0A7F8RH64
LinkDB
Position
Unknown
AA seq 1120 aa
MQAQQLPYEFFSEENAPKWRGLLVPALKKVQGQVHPTLESSDDALQYVEELILQLLNMLC
QAQPRSASDVEERVQKSFPHPIDKWAIADAQSAIEKRKRRNPLSLPVEKIHPLLKEVLGY
KIDHQVSVYIVAVLEYISADILKLVGNYVRNIRHYEITKQDIKVAMCADKVLMDMFHQDV
EDINILSLTDEEPSTSGEQTYYDLVKAFMAEIRQYIRELNLIIKVFREPFVSNSKLFSAN
DVENIFSRIVDIHELSVKLLGHIEDTVEMTDEGSPHPLVGSCFEDLAEELAFDPYESYAR
DILRPGFHDRFLSQLSKPGAALYLQSIGEGFKEAVQYVLPRLLLAPVYHCLHYFELLKQL
EEKSEDQEDKECLKQAITALLNVQSGMEKICSKSLAKRRLSESACRFYSQQMKGKQLAIK
KMNEIQKNIDGWEGKDIGQCCNEFIMEGTLTRVGAKHERHIFLFDGLMICCKSNHGQPRL
PGASNAEYRLKEKFFMRKVQINDKDDTSEYKHAFEIILKDENSVIFSAKSAEEKNNWMAA
LISLQYRSTLERMLDVTMLQEEKEEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPI
IKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADR
IAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDADLLQRMEEFIGT
VRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLH
PIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKXSF
HLVPFIIAVSFMSSSSYLPVLSKSHFLSFSSVNIFNNGYFEIFFFEFINERKTIYSFLFP
FTGSDTIFIQVSLPHGPRSASVSSISLTKGTDEVPLPPPVPPRRRPESAPAESSPSKIMS
KHLDSPPAIPPRQPTSKAYSPRYSISDRTSISDPPESPPLLPPREPVRTPDVFSSSPLHL
QPPPLGKKSDHGNAFFPNSPSPFTPPPPQTPSPHGTRRHLPSPPLTQEVDLPSITGPPVP
PRQSTSQHIPKLPPKTYKREHTHPSMHRDGPPLLENAHSS
NT seq 3363 nt   +upstreamnt  +downstreamnt
atgcaggcgcagcagctgccgtacgagtttttcagcgaggagaacgcacccaagtggcgg
gggctgctggtgccggcgctgaaaaaggtccaggggcaagttcatccgactcttgagtct
agtgatgatgctcttcaatatgttgaagaattaattttgcagttattaaatatgctatgc
caagctcagccccgaagtgcttcagatgtagaggaacgtgttcaaaaaagtttccctcat
ccaattgataagtgggcaatagctgatgcccaatcggctattgaaaagaggaagcgaaga
aaccctttatctctcccagtagaaaaaattcatcctttactaaaggaggtcctaggttat
aaaattgaccaccaggtttctgtttacatagtagctgtattagaatacatttctgcagac
attttaaagctggtggggaattatgtacgaaatatacggcattatgaaattacaaaacaa
gatattaaagtggcaatgtgtgctgataaggtattaatggacatgtttcatcaagatgta
gaagatataaatatattatctttaactgatgaagagccttccacctcaggagagcaaact
tattatgatttggtaaaagcatttatggcagaaattcgacagtacataagggaactaaat
ttaattataaaagtttttagagagccctttgtctccaactcaaaattgttttcagctaat
gatgtagaaaatatatttagtcgtatagtagatatacatgaacttagtgtaaagttactg
ggccatatagaagatactgtggaaatgactgatgaaggtagcccccatcccttagtagga
agctgctttgaagacttagctgaagaactggcatttgatccatatgaatcatatgctcga
gatattttacggcctggttttcatgatcgcttccttagtcagttatcaaagcctggagcg
gcactctatttacagtcaataggcgaaggtttcaaagaagctgttcagtatgttttaccc
aggctacttctagcccctgtttaccactgtctacattactttgaacttttgaagcagtta
gaagaaaagagtgaagatcaagaagacaaggaatgtttgaaacaagcaataacagctttg
cttaatgttcagagtggtatggaaaaaatatgttctaaaagtcttgcaaaacgaagactg
agtgaatctgcatgtcggttttatagtcagcaaatgaaggggaaacaactagcaatcaag
aaaatgaacgagattcaaaagaatattgatggttgggagggaaaggacattggacagtgt
tgcaatgaatttataatggaaggaactcttacacgtgtaggagccaaacatgagagacac
atatttctctttgatggcttaatgatttgctgtaaatcaaatcatgggcagccaagactt
cctggtgctagcaatgcagaatatcgtcttaaagaaaagtttttcatgcgaaaggtacaa
attaatgacaaagatgacaccagtgagtacaagcatgcttttgaaataattttaaaagat
gaaaacagtgttatattttctgccaagtcagctgaagagaaaaacaattggatggcagca
ttgatatctttacaataccggagtacactggaaaggatgcttgatgtgacgatgctgcag
gaagagaaggaggagcagatgaggctccctagtgctgatgtttatagatttgcagagcct
gactctgaagagaatataatatttgaagaaaacatgcagcccaaggctggaattccaatt
atcaaagcgggaactgttattaaacttatagagaggctcacgtaccatatgtacgcagat
cccaattttgttcggacatttcttacaacatacagatccttttgtaaacctcaagaacta
ctgagtcttataatagaaaggtttgaaattccagagcctgagccaacagaagctgatcgc
atagctatagagaatggagatcagcccttgagtgcagaactaaaaaggtttagaaaagaa
tacatacagcctgtacagctgcgagtattaaatgtatgtcggcattgggtagagcaccac
ttctatgattttgaaagggatgcagatcttttgcagcgaatggaagaatttattggaaca
gtgagaggtaaagcaatgaaaaaatgggttgaatccatcactaaaataatccaaaggaaa
aaaattgcaagagacaatggaccaggtcataatattacatttcagagttcacctcccaca
gttgagtggcatataagcaggcctgggcacatagagacttttgacctgctcaccttacac
ccaatagaaattgctcgacaactcactttacttgaatcagatctatatcgagctgtacag
ccatcagaattagttggaagtgtgtggacaaaagaagacaaagaaattaattctcctaat
cttctaaaaatgatccggcataccactaatctcactctgtggtttgagaagtaaagtttc
catttggttccttttatcattgctgtgtcttttatgtcatcgtcgtcctatcttcctgta
ctttctaaatcacactttctctcctttagttctgtgaacatattcaataatggctacttt
gaaatctttttctttgaatttatcaatgaaagaaaaacaatctactctttcttgtttcct
ttcacaggcagcgataccatctttatccaagtttcactgccccatggcccaagatctgct
tcagtatcgtctataagtttaaccaagggcactgatgaagtgcccctcccccctcctgtt
cctccacgaagacggccggaatctgcccccgccgaatcttcgccgtctaagattatgtct
aagcatttggacagccccccagcgattcctcctaggcagcccacatccaaagcctattca
ccacgatactcaatatcagaccggacctctatatcagaccctcctgagagccctccctta
ttaccaccgcgagagcctgtgaggacacctgatgttttctccagctccccgctacatctc
cagcctccccctttgggcaaaaaaagcgatcatggcaatgccttcttcccaaacagccct
tccccttttacaccacctcctcctcaaacaccgtctccccatggcacgagaaggcatctg
ccgtcgccaccattgacacaagaagtggaccttccttccatcactgggccgcctgttcct
ccacgacaaagcacttctcaacatatccctaaactccctccaaaaacttataaaagggag
cacacgcacccatccatgcacagagatggaccaccgctgttggagaacgcccactcctcc
tga

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