KEGG   Leptonychotes weddellii (Weddell seal): 102750302
Entry
102750302         CDS       T08708                                 
Symbol
MAP2K1
Name
(RefSeq) dual specificity mitogen-activated protein kinase kinase 1
  KO
K04368  mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
Organism
lww  Leptonychotes weddellii (Weddell seal)
Pathway
lww01521  EGFR tyrosine kinase inhibitor resistance
lww01522  Endocrine resistance
lww04010  MAPK signaling pathway
lww04012  ErbB signaling pathway
lww04014  Ras signaling pathway
lww04015  Rap1 signaling pathway
lww04022  cGMP-PKG signaling pathway
lww04024  cAMP signaling pathway
lww04062  Chemokine signaling pathway
lww04066  HIF-1 signaling pathway
lww04068  FoxO signaling pathway
lww04071  Sphingolipid signaling pathway
lww04072  Phospholipase D signaling pathway
lww04114  Oocyte meiosis
lww04140  Autophagy - animal
lww04148  Efferocytosis
lww04150  mTOR signaling pathway
lww04151  PI3K-Akt signaling pathway
lww04210  Apoptosis
lww04218  Cellular senescence
lww04270  Vascular smooth muscle contraction
lww04370  VEGF signaling pathway
lww04371  Apelin signaling pathway
lww04380  Osteoclast differentiation
lww04510  Focal adhesion
lww04540  Gap junction
lww04550  Signaling pathways regulating pluripotency of stem cells
lww04613  Neutrophil extracellular trap formation
lww04620  Toll-like receptor signaling pathway
lww04650  Natural killer cell mediated cytotoxicity
lww04660  T cell receptor signaling pathway
lww04662  B cell receptor signaling pathway
lww04664  Fc epsilon RI signaling pathway
lww04666  Fc gamma R-mediated phagocytosis
lww04668  TNF signaling pathway
lww04720  Long-term potentiation
lww04722  Neurotrophin signaling pathway
lww04725  Cholinergic synapse
lww04726  Serotonergic synapse
lww04730  Long-term depression
lww04810  Regulation of actin cytoskeleton
lww04910  Insulin signaling pathway
lww04912  GnRH signaling pathway
lww04914  Progesterone-mediated oocyte maturation
lww04915  Estrogen signaling pathway
lww04916  Melanogenesis
lww04917  Prolactin signaling pathway
lww04919  Thyroid hormone signaling pathway
lww04921  Oxytocin signaling pathway
lww04926  Relaxin signaling pathway
lww04928  Parathyroid hormone synthesis, secretion and action
lww04929  GnRH secretion
lww04934  Cushing syndrome
lww04935  Growth hormone synthesis, secretion and action
lww05010  Alzheimer disease
lww05022  Pathways of neurodegeneration - multiple diseases
lww05034  Alcoholism
lww05132  Salmonella infection
lww05135  Yersinia infection
lww05160  Hepatitis C
lww05161  Hepatitis B
lww05163  Human cytomegalovirus infection
lww05164  Influenza A
lww05165  Human papillomavirus infection
lww05166  Human T-cell leukemia virus 1 infection
lww05167  Kaposi sarcoma-associated herpesvirus infection
lww05170  Human immunodeficiency virus 1 infection
lww05200  Pathways in cancer
lww05205  Proteoglycans in cancer
lww05206  MicroRNAs in cancer
lww05207  Chemical carcinogenesis - receptor activation
lww05208  Chemical carcinogenesis - reactive oxygen species
lww05210  Colorectal cancer
lww05211  Renal cell carcinoma
lww05212  Pancreatic cancer
lww05213  Endometrial cancer
lww05214  Glioma
lww05215  Prostate cancer
lww05216  Thyroid cancer
lww05218  Melanoma
lww05219  Bladder cancer
lww05220  Chronic myeloid leukemia
lww05221  Acute myeloid leukemia
lww05223  Non-small cell lung cancer
lww05224  Breast cancer
lww05225  Hepatocellular carcinoma
lww05226  Gastric cancer
lww05230  Central carbon metabolism in cancer
lww05231  Choline metabolism in cancer
lww05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:lww00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    102750302 (MAP2K1)
   04012 ErbB signaling pathway
    102750302 (MAP2K1)
   04014 Ras signaling pathway
    102750302 (MAP2K1)
   04015 Rap1 signaling pathway
    102750302 (MAP2K1)
   04370 VEGF signaling pathway
    102750302 (MAP2K1)
   04371 Apelin signaling pathway
    102750302 (MAP2K1)
   04668 TNF signaling pathway
    102750302 (MAP2K1)
   04066 HIF-1 signaling pathway
    102750302 (MAP2K1)
   04068 FoxO signaling pathway
    102750302 (MAP2K1)
   04072 Phospholipase D signaling pathway
    102750302 (MAP2K1)
   04071 Sphingolipid signaling pathway
    102750302 (MAP2K1)
   04024 cAMP signaling pathway
    102750302 (MAP2K1)
   04022 cGMP-PKG signaling pathway
    102750302 (MAP2K1)
   04151 PI3K-Akt signaling pathway
    102750302 (MAP2K1)
   04150 mTOR signaling pathway
    102750302 (MAP2K1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    102750302 (MAP2K1)
   04148 Efferocytosis
    102750302 (MAP2K1)
  09143 Cell growth and death
   04114 Oocyte meiosis
    102750302 (MAP2K1)
   04210 Apoptosis
    102750302 (MAP2K1)
   04218 Cellular senescence
    102750302 (MAP2K1)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    102750302 (MAP2K1)
   04540 Gap junction
    102750302 (MAP2K1)
   04550 Signaling pathways regulating pluripotency of stem cells
    102750302 (MAP2K1)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    102750302 (MAP2K1)
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    102750302 (MAP2K1)
   04620 Toll-like receptor signaling pathway
    102750302 (MAP2K1)
   04650 Natural killer cell mediated cytotoxicity
    102750302 (MAP2K1)
   04660 T cell receptor signaling pathway
    102750302 (MAP2K1)
   04662 B cell receptor signaling pathway
    102750302 (MAP2K1)
   04664 Fc epsilon RI signaling pathway
    102750302 (MAP2K1)
   04666 Fc gamma R-mediated phagocytosis
    102750302 (MAP2K1)
   04062 Chemokine signaling pathway
    102750302 (MAP2K1)
  09152 Endocrine system
   04910 Insulin signaling pathway
    102750302 (MAP2K1)
   04929 GnRH secretion
    102750302 (MAP2K1)
   04912 GnRH signaling pathway
    102750302 (MAP2K1)
   04915 Estrogen signaling pathway
    102750302 (MAP2K1)
   04914 Progesterone-mediated oocyte maturation
    102750302 (MAP2K1)
   04917 Prolactin signaling pathway
    102750302 (MAP2K1)
   04921 Oxytocin signaling pathway
    102750302 (MAP2K1)
   04926 Relaxin signaling pathway
    102750302 (MAP2K1)
   04935 Growth hormone synthesis, secretion and action
    102750302 (MAP2K1)
   04919 Thyroid hormone signaling pathway
    102750302 (MAP2K1)
   04928 Parathyroid hormone synthesis, secretion and action
    102750302 (MAP2K1)
   04916 Melanogenesis
    102750302 (MAP2K1)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    102750302 (MAP2K1)
  09156 Nervous system
   04725 Cholinergic synapse
    102750302 (MAP2K1)
   04726 Serotonergic synapse
    102750302 (MAP2K1)
   04720 Long-term potentiation
    102750302 (MAP2K1)
   04730 Long-term depression
    102750302 (MAP2K1)
   04722 Neurotrophin signaling pathway
    102750302 (MAP2K1)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    102750302 (MAP2K1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    102750302 (MAP2K1)
   05206 MicroRNAs in cancer
    102750302 (MAP2K1)
   05205 Proteoglycans in cancer
    102750302 (MAP2K1)
   05207 Chemical carcinogenesis - receptor activation
    102750302 (MAP2K1)
   05208 Chemical carcinogenesis - reactive oxygen species
    102750302 (MAP2K1)
   05230 Central carbon metabolism in cancer
    102750302 (MAP2K1)
   05231 Choline metabolism in cancer
    102750302 (MAP2K1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    102750302 (MAP2K1)
  09162 Cancer: specific types
   05210 Colorectal cancer
    102750302 (MAP2K1)
   05212 Pancreatic cancer
    102750302 (MAP2K1)
   05225 Hepatocellular carcinoma
    102750302 (MAP2K1)
   05226 Gastric cancer
    102750302 (MAP2K1)
   05214 Glioma
    102750302 (MAP2K1)
   05216 Thyroid cancer
    102750302 (MAP2K1)
   05221 Acute myeloid leukemia
    102750302 (MAP2K1)
   05220 Chronic myeloid leukemia
    102750302 (MAP2K1)
   05218 Melanoma
    102750302 (MAP2K1)
   05211 Renal cell carcinoma
    102750302 (MAP2K1)
   05219 Bladder cancer
    102750302 (MAP2K1)
   05215 Prostate cancer
    102750302 (MAP2K1)
   05213 Endometrial cancer
    102750302 (MAP2K1)
   05224 Breast cancer
    102750302 (MAP2K1)
   05223 Non-small cell lung cancer
    102750302 (MAP2K1)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    102750302 (MAP2K1)
   05170 Human immunodeficiency virus 1 infection
    102750302 (MAP2K1)
   05161 Hepatitis B
    102750302 (MAP2K1)
   05160 Hepatitis C
    102750302 (MAP2K1)
   05164 Influenza A
    102750302 (MAP2K1)
   05163 Human cytomegalovirus infection
    102750302 (MAP2K1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    102750302 (MAP2K1)
   05165 Human papillomavirus infection
    102750302 (MAP2K1)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    102750302 (MAP2K1)
   05135 Yersinia infection
    102750302 (MAP2K1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    102750302 (MAP2K1)
   05022 Pathways of neurodegeneration - multiple diseases
    102750302 (MAP2K1)
  09165 Substance dependence
   05034 Alcoholism
    102750302 (MAP2K1)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    102750302 (MAP2K1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    102750302 (MAP2K1)
   01522 Endocrine resistance
    102750302 (MAP2K1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:lww01001]
    102750302 (MAP2K1)
Enzymes [BR:lww01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.12  Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
    2.7.12.2  mitogen-activated protein kinase kinase
     102750302 (MAP2K1)
Protein kinases [BR:lww01001]
 Serine/threonine kinases: STE group
  STE7 family
   102750302 (MAP2K1)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr ABC1 Pkinase_fungal Kinase-like Haspin_kinase Seadorna_VP7
Other DBs
NCBI-GeneID: 102750302
NCBI-ProteinID: XP_006729698
UniProt: A0A2U3XED8
LinkDB
Position
Unknown
AA seq 393 aa
MPKKKPTPIQLNPAPDGSAVNGTSSAETNLEALQKKLEELELDEQQRKRLEAFLTQKQKV
GELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHE
CNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYL
REKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHY
SVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSY
GMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAF
IKRSDGEEVDFAGWLCSTIGLNQPSTPTHAAGV
NT seq 1182 nt   +upstreamnt  +downstreamnt
atgcccaagaagaagccgacgcccatccagctgaacccggctcccgacggctccgcggtt
aacgggaccagctcggcggagaccaacctggaggccttgcagaagaagctggaggagttg
gagcttgatgagcagcagcggaagcgccttgaggcctttctcacccagaagcagaaggtc
ggggaattgaaggatgacgacttcgagaagatcagtgagctgggcgccggcaacggtggt
gtggtgttcaaggtctcgcacaagccctccggcctggtcatggccagaaagctaattcac
ctggagatcaaacctgcaatccggaaccagatcatacgggagctgcaggttctacatgag
tgcaactccccctacatcgtgggcttctatggtgcgttctacagcgatggcgagatcagt
atctgcatggagcacatggatggtggttccttggatcaagtcctgaagaaagctggaaga
attcctgaacaaattttaggaaaagttagcattgctgtaataaaaggtctgacatacctg
agggagaagcacaagataatgcacagagatgtcaagccttccaacatcctcgtgaactcc
cgtggggagatcaagctctgtgactttggggtcagcgggcagctcattgactccatggcc
aactccttcgtgggcacacggtcctacatgtcgccagaaagactccaggggactcattac
tcggtgcagtcggacatctggagcatggggctctctctggttgagatggcggttgggagg
tatcccatccctcctccagatgctaaggagctggagctgatgtttgggtgccaagtggag
ggagatgcggctgagacgccacccagaccaaggacccctggaaggcccctcagctcttat
ggaatggacagccgacctcccatggcaatttttgagttgttggattacatagtcaacgag
ccgcctccaaaactgcccagtggagtattcagtctggaatttcaagattttgtgaataag
tgcttaataaaaaacccagcagagagagcagatctgaagcaactcatggttcatgccttt
atcaagagatcggacggggaggaagtggattttgcaggttggctctgctccaccattggc
cttaaccagcccagcacaccgacccacgcagccggcgtctaa

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