KEGG   Mirounga angustirostris (Northern elephant seal): 123846017
Entry
123846017         CDS       T11530                                 
Symbol
ARAF
Name
(RefSeq) serine/threonine-protein kinase A-Raf
  KO
K08845  A-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
Organism
mano  Mirounga angustirostris (Northern elephant seal)
Pathway
mano01521  EGFR tyrosine kinase inhibitor resistance
mano01522  Endocrine resistance
mano04010  MAPK signaling pathway
mano04012  ErbB signaling pathway
mano04068  FoxO signaling pathway
mano04270  Vascular smooth muscle contraction
mano04650  Natural killer cell mediated cytotoxicity
mano04720  Long-term potentiation
mano04726  Serotonergic synapse
mano04730  Long-term depression
mano04810  Regulation of actin cytoskeleton
mano04910  Insulin signaling pathway
mano04914  Progesterone-mediated oocyte maturation
mano04928  Parathyroid hormone synthesis, secretion and action
mano05010  Alzheimer disease
mano05022  Pathways of neurodegeneration - multiple diseases
mano05034  Alcoholism
mano05160  Hepatitis C
mano05161  Hepatitis B
mano05200  Pathways in cancer
mano05205  Proteoglycans in cancer
mano05208  Chemical carcinogenesis - reactive oxygen species
mano05210  Colorectal cancer
mano05211  Renal cell carcinoma
mano05212  Pancreatic cancer
mano05213  Endometrial cancer
mano05214  Glioma
mano05215  Prostate cancer
mano05218  Melanoma
mano05219  Bladder cancer
mano05220  Chronic myeloid leukemia
mano05221  Acute myeloid leukemia
mano05223  Non-small cell lung cancer
mano05224  Breast cancer
mano05225  Hepatocellular carcinoma
mano05226  Gastric cancer
Brite
KEGG Orthology (KO) [BR:mano00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    123846017 (ARAF)
   04012 ErbB signaling pathway
    123846017 (ARAF)
   04068 FoxO signaling pathway
    123846017 (ARAF)
 09140 Cellular Processes
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    123846017 (ARAF)
 09150 Organismal Systems
  09151 Immune system
   04650 Natural killer cell mediated cytotoxicity
    123846017 (ARAF)
  09152 Endocrine system
   04910 Insulin signaling pathway
    123846017 (ARAF)
   04914 Progesterone-mediated oocyte maturation
    123846017 (ARAF)
   04928 Parathyroid hormone synthesis, secretion and action
    123846017 (ARAF)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    123846017 (ARAF)
  09156 Nervous system
   04726 Serotonergic synapse
    123846017 (ARAF)
   04720 Long-term potentiation
    123846017 (ARAF)
   04730 Long-term depression
    123846017 (ARAF)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    123846017 (ARAF)
   05205 Proteoglycans in cancer
    123846017 (ARAF)
   05208 Chemical carcinogenesis - reactive oxygen species
    123846017 (ARAF)
  09162 Cancer: specific types
   05210 Colorectal cancer
    123846017 (ARAF)
   05212 Pancreatic cancer
    123846017 (ARAF)
   05225 Hepatocellular carcinoma
    123846017 (ARAF)
   05226 Gastric cancer
    123846017 (ARAF)
   05214 Glioma
    123846017 (ARAF)
   05221 Acute myeloid leukemia
    123846017 (ARAF)
   05220 Chronic myeloid leukemia
    123846017 (ARAF)
   05218 Melanoma
    123846017 (ARAF)
   05211 Renal cell carcinoma
    123846017 (ARAF)
   05219 Bladder cancer
    123846017 (ARAF)
   05215 Prostate cancer
    123846017 (ARAF)
   05213 Endometrial cancer
    123846017 (ARAF)
   05224 Breast cancer
    123846017 (ARAF)
   05223 Non-small cell lung cancer
    123846017 (ARAF)
  09172 Infectious disease: viral
   05161 Hepatitis B
    123846017 (ARAF)
   05160 Hepatitis C
    123846017 (ARAF)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    123846017 (ARAF)
   05022 Pathways of neurodegeneration - multiple diseases
    123846017 (ARAF)
  09165 Substance dependence
   05034 Alcoholism
    123846017 (ARAF)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    123846017 (ARAF)
   01522 Endocrine resistance
    123846017 (ARAF)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:mano01001]
    123846017 (ARAF)
Enzymes [BR:mano01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     123846017 (ARAF)
Protein kinases [BR:mano01001]
 Serine/threonine kinases: TKL group
  RAF family [OT]
   123846017 (ARAF)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Pkinase RBD C1_1 Kinase-like ABC1 Pkinase_fungal zf-RING-like TUG-UBL1 Kdo
Other DBs
NCBI-GeneID: 123846017
NCBI-ProteinID: XP_045732984
LinkDB
Position
Unknown
AA seq 606 aa
MEPPRGPPANGAEPSRAVGTVKVYLPNKQRTVVTVRDGMSVYDSLDKALKVRGLNQDCCV
VYRLIEGRKTVTAWDTAIAPLDGEELIVEVLEDVPLTMHNFVRKTFFSLAFCDFCLKFLF
HGFRCQTCGYKFHQHCSSKVPTVCVDMSTNCRQFYHSVQDLSGGSRQHEAPSHRPLNEPL
TPQGPSSCTQHREPEHFPFPATANAPLQRIRSTSTPNVHMVSTTAPMDSSLVQLTAPSFS
TDAAGSRGGGDGAPRGSPSPASVSSGRKSPHSKSPSEQRERKSVADDKKKVKNLGYRDSG
YYWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVAQPTAEQAQAFKNEMQVLRK
TRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYL
HAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRM
QDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGSRDQIIFMVGRGYLSPDLSKISSNCPK
AMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLS
AARLVP
NT seq 1821 nt   +upstreamnt  +downstreamnt
atggagccaccacggggcccccctgccaacggggccgagccatcccgggcagtgggcact
gtcaaagtatacctacccaacaagcaacgcacggtggtgactgtccgggatggcatgagt
gtctacgactctctagacaaggccctcaaggtacggggtctcaatcaggattgctgtgtg
gtctaccggctcatcgaggggcgaaagacagtcaccgcctgggacacggccattgcccca
ctggatggagaggagctcatcgtagaggtccttgaagatgtcccactgaccatgcacaat
tttgtacggaagacgttcttcagcctggcgttctgcgacttctgccttaagtttctgttc
cacggcttccgctgccaaacctgtggctacaagttccaccagcattgttcctccaaagtc
cccacagtctgtgttgacatgagcaccaactgccgacagttctaccacagtgtccaggat
ttgtccggaggctccagacagcacgaagctccctcacaccgccccctgaacgagccgtta
acccctcagggtcccagctcctgcacccagcaccgcgagcctgagcactttcccttcccc
gccactgccaacgcccctctccagcgcatccgctccacgtccactcccaacgtccacatg
gtcagcaccacagcccccatggactccagccttgtccagctcactgccccgagtttcagc
accgatgctgccggtagtagaggtggtggcgatggagccccccgggggagccccagcccg
gccagcgtgtcctcggggaggaagtctccccattccaagtccccatcagaacagcgggag
cggaagtccgtggccgatgacaagaagaaagtgaagaatctggggtaccgggactcgggc
tattactgggaggtgccgcccagtgaggtgcagctgctgaagaggatcgggacgggctcg
tttggcaccgtgtttcgcgggcggtggcatggcgatgtggccgtgaaggtgctcaaggtg
gcccaacccacagctgagcaggcccaggccttcaagaacgagatgcaggtgctcaggaag
acacggcacgtcaacatcctgctgttcatgggcttcatgacgcggccgggcttcgccatc
atcacgcagtggtgcgagggttccagcctctaccaccacctgcatgtggccgacacgcgc
ttcgacatggtccagctcattgacgtggcccggcagaccgcccagggcatggactacctc
catgccaagaacatcatccaccgagatctcaagtctaacaacatcttcctacacgagggg
ctcacggtgaagatcggtgacttcggcctggccacggtgaagacacggtggagtggggcc
cagcccttggaacagccctcaggctccgtgctgtggatggcggctgaggtgatccgtatg
caggacccgaacccctacagcttccagtcagatgtctacgcctatggggttgtgctctat
gagctcatgaccggctcgctgccctacagccacattggcagccgtgaccagattatcttc
atggtgggccgtggctatctgtccccggacctcagcaaaatctccagcaactgccccaag
gccatgcggcgcctgctgtctgactgcctcaagttccagcgggaggagcgtcccctcttc
ccccagatcctggccacgattgagctgctgcagcggtcactccccaagattgagcggagt
gcctccgaaccctccttgcatcgcacccaggccgatgagctgcctgcctgcctgctcagt
gcagcccgccttgtgccttag

DBGET integrated database retrieval system