Indole diterpene alkaloids are a group of meroterpenoids consisting of a partial diterpene structure with four isoprene units and an indole moiety. The common cyclic diterpene skeleton is derived from geranylgeranyl diphosphate (GGPP) and an indole moiety is derived from tryptophan or a tryptophan precursor. They are combined in the initial step of biosynthetic reactions that generate paspaline, the first stable and less modified form required for other forms. Most indole diterpene alkaloids have potent mammalian tremorgenic activities, such as ryegrass staggers in livestock, and some have anti-insect properties. This map shows examples of indole diterpene alkaloids isolated from filamentous fungi.
Class
Metabolism; Biosynthesis of other secondary metabolites
Nicholson MJ, Koulman A, Monahan BJ, Pritchard BL, Payne GA, Scott B
Title
Identification of two aflatrem biosynthesis gene loci in Aspergillus flavus and metabolic engineering of Penicillium paxilli to elucidate their function.
