Entry
Name
Lipoic acid metabolism
Class
Metabolism; Metabolism of cofactors and vitamins
BRITE hierarchy
Pathway map
Module
M00881 Lipoic acid biosynthesis, plants and bacteria, octanoyl-ACP => dihydrolipoyl-E2/H [PATH:map00785 ]
M00882 Lipoic acid biosynthesis, eukaryotes, octanoyl-ACP => dihydrolipoyl-H [PATH:map00785 ]
M00883 Lipoic acid biosynthesis, animals and bacteria, octanoyl-ACP => dihydrolipoyl-H => dihydrolipoyl-E2 [PATH:map00785 ]
M00884 Lipoic acid biosynthesis, octanoyl-CoA => dihydrolipoyl-E2 [PATH:map00785 ]
Other DBs
Reference
Authors
Gunther S, McMillan PJ, Wallace LJ, Muller S.
Title
Plasmodium falciparum possesses organelle-specific alpha-keto acid dehydrogenase complexes and lipoylation pathways.
Journal
Reference
Authors
Fujiwara K, Takeuchi S, Okamura-Ikeda K, Motokawa Y.
Title
Purification, characterization, and cDNA cloning of lipoate-activating enzyme from bovine liver.
Journal
Reference
Authors
Yasuno R, Wada H.
Title
Biosynthesis of lipoic acid in Arabidopsis: cloning and characterization of the cDNA for lipoic acid synthase.
Journal
Reference
Authors
Gueguen V, Macherel D, Jaquinod M, Douce R, Bourguignon J.
Title
Fatty acid and lipoic acid biosynthesis in higher plant mitochondria.
Journal
Reference
Authors
Wada M, Yasuno R, Jordan SW, Cronan JE Jr, Wada H.
Title
Lipoic acid metabolism in Arabidopsis thaliana: cloning and characterization of a cDNA encoding lipoyltransferase.
Journal
Reference
Authors
Morris TW, Reed KE, Cronan JE Jr.
Title
Identification of the gene encoding lipoate-protein ligase A of Escherichia coli. Molecular cloning and characterization of the lplA gene and gene product.
Journal
J Biol Chem 269:16091-100 (1994)
Reference
Authors
Zhao X, Miller JR, Jiang Y, Marletta MA, Cronan JE.
Title
Assembly of the covalent linkage between lipoic acid and its cognate enzymes.
Journal
Reference
Authors
Nesbitt NM, Baleanu-Gogonea C, Cicchillo RM, Goodson K, Iwig DF, Broadwater JA, Haas JA, Fox BG, Booker SJ.
Title
Expression, purification, and physical characterization of Escherichia coli lipoyl(octanoyl)transferase.
Journal
Reference
Authors
Solmonson A, DeBerardinis RJ
Title
Lipoic acid metabolism and mitochondrial redox regulation.
Journal
Reference
Authors
Cronan JE
Title
Assembly of Lipoic Acid on Its Cognate Enzymes: an Extraordinary and Essential Biosynthetic Pathway.
Journal
Reference
Authors
Mayr JA, Feichtinger RG, Tort F, Ribes A, Sperl W
Title
Lipoic acid biosynthesis defects.
Journal
Reference
Authors
Cao X, Zhu L, Song X, Hu Z, Cronan JE
Title
Protein moonlighting elucidates the essential human pathway catalyzing lipoic acid assembly on its cognate enzymes.
Journal
Reference
Authors
Soreze Y, Boutron A, Habarou F, Barnerias C, Nonnenmacher L, Delpech H, Mamoune A, Chretien D, Hubert L, Bole-Feysot C, Nitschke P, Correia I, Sardet C, Boddaert N, Hamel Y, Delahodde A, Ottolenghi C, de Lonlay P
Title
Mutations in human lipoyltransferase gene LIPT1 cause a Leigh disease with secondary deficiency for pyruvate and alpha-ketoglutarate dehydrogenase.
Journal
Reference
Authors
Habarou F, Hamel Y, Haack TB, Feichtinger RG, Lebigot E, Marquardt I, Busiah K, Laroche C, Madrange M, Grisel C, Pontoizeau C, Eisermann M, Boutron A, Chretien D, Chadefaux-Vekemans B, Barouki R, Bole-Feysot C, Nitschke P, Goudin N, Boddaert N, Nemazanyy I, Delahodde A, Kolker S, Rodenburg RJ, Korenke GC, Meitinger T, Strom TM, Prokisch H, Rotig A, Ottolenghi C, Mayr JA, de Lonlay P
Title
Biallelic Mutations in LIPT2 Cause a Mitochondrial Lipoylation Defect Associated with Severe Neonatal Encephalopathy.
Journal
Reference
Authors
Spalding MD, Prigge ST
Title
Lipoic acid metabolism in microbial pathogens.
Journal
Reference
Authors
Guerra AJ, Afanador GA, Prigge ST
Title
Crystal structure of lipoate-bound lipoate ligase 1, LipL1, from Plasmodium falciparum.
Journal
Reference
Authors
Afanador GA, Matthews KA, Bartee D, Gisselberg JE, Walters MS, Freel Meyers CL, Prigge ST
Title
Redox-dependent lipoylation of mitochondrial proteins in Plasmodium falciparum.
Journal
Reference
Authors
Afanador GA, Guerra AJ, Swift RP, Rodriguez RE, Bartee D, Matthews KA, Schon A, Freire E, Freel Meyers CL, Prigge ST
Title
A novel lipoate attachment enzyme is shared by Plasmodium and Chlamydia species.
Journal
Reference
Authors
Storm J, Muller S
Title
Lipoic acid metabolism of Plasmodium--a suitable drug target.
Journal
Reference
Authors
Gunther S, Wallace L, Patzewitz EM, McMillan PJ, Storm J, Wrenger C, Bissett R, Smith TK, Muller S
Title
Apicoplast lipoic acid protein ligase B is not essential for Plasmodium falciparum.
Journal
Reference
Authors
Wrenger C, Muller S
Title
The human malaria parasite Plasmodium falciparum has distinct organelle-specific lipoylation pathways.
Journal
Reference
Authors
Martin N, Christensen QH, Mansilla MC, Cronan JE, de Mendoza D
Title
A novel two-gene requirement for the octanoyltransfer reaction of Bacillus subtilis lipoic acid biosynthesis.
Journal
Reference
Authors
Christensen QH, Martin N, Mansilla MC, de Mendoza D, Cronan JE
Title
A novel amidotransferase required for lipoic acid cofactor assembly in Bacillus subtilis.
Journal
Related pathway
map00260 Glycine, serine and threonine metabolism
map00280 Valine, leucine and isoleucine degradation
KO pathway