KEGG   PATHWAY: map00901
Entry
map00901                    Pathway                                
Name
Indole alkaloid biosynthesis
Class
Metabolism; Biosynthesis of other secondary metabolites
Pathway map
map00901  Indole alkaloid biosynthesis
map00901

Module
M00962  Psilocybin biosynthesis, tryptophan => psilocybin [PATH:map00901]
M00963  Chanoclavine aldehyde biosynthesis, tryptophan => chanoclavine-I aldehyde [PATH:map00901]
M00964  Fumigaclavine biosynthesis, chanoclavine-I aldehyde => fumigaclavine C [PATH:map00901]
M00965  Vinblastine biosynthesis, geissoschizine => vinblastine [PATH:map00901]
M00979  Ajmaline biosynthesis, geissoschizine => ajmaline [PATH:map00901]
M00980  Strychnine biosynthesis, geissoschizine => strychnine [PATH:map00901]
M00981  Geissoschizine biosynthesis, tryptophan => geissoschizine [PATH:map00901]
Other DBs
GO: 0009709
Reference
PMID:9622525
  Authors
Rijhwani SK, Shanks JV.
  Title
Effect of elicitor dosage and exposure time on biosynthesis of indole alkaloids by Catharanthus roseus hairy root cultures.
  Journal
Biotechnol Prog 14:442-9 (1998)
DOI:10.1021/bp980029v
Reference
PMID:4698228
  Authors
Madyastha KM, Guarnaccia R, Baxter C, Coscia CJ.
  Title
S-Adenosyl-L-methionine: loganic acid methyltransferase. A carboxyl-alkylating enzyme from Vinca rosea.
  Journal
J Biol Chem 248:2497-501 (1973)
Reference
PMID:510306
  Authors
Treimer JF, Zenk MH.
  Title
Purification and properties of strictosidine synthase, the key enzyme in indole alkaloid formation.
  Journal
Eur J Biochem 101:225-33 (1979)
DOI:10.1111/j.1432-1033.1979.tb04235.x
Reference
  Authors
Geerlings A, Ibanez MM, Memelink J, van Der Heijden R, Verpoorte R.
  Title
Molecular cloning and analysis of strictosidine beta-D-glucosidase, an enzyme in terpenoid indole alkaloid biosynthesis in Catharanthus roseus.
  Journal
J Biol Chem 275:3051-6 (2000)
DOI:10.1074/jbc.275.5.3051
Reference
PMID:11128
  Authors
Stockigt J, Treimer J, Zenk MH.
  Title
Synthesis of ajmalicine and related indole alkaloids by cell free extracts of Catharanthus roseus cell suspension cultures.
  Journal
FEBS Lett 70:267-70 (1976)
DOI:10.1016/0014-5793(76)80772-7
Reference
  Authors
St-Pierre B, De Luca V.
  Title
A Cytochrome P-450 Monooxygenase Catalyzes the First Step in the Conversion of Tabersonine to Vindoline in Catharanthus roseus.
  Journal
Plant Physiol 109:131-139 (1995)
DOI:10.1104/pp.109.1.131
Reference
  Authors
Schroder G, Unterbusch E, Kaltenbach M, Schmidt J, Strack D, De Luca V, Schroder J.
  Title
Light-induced cytochrome P450-dependent enzyme in indole alkaloid biosynthesis: tabersonine 16-hydroxylase.
  Journal
FEBS Lett 458:97-102 (1999)
DOI:10.1016/S0014-5793(99)01138-2
Reference
PMID:9654153
  Authors
Sottomayor M, Lopez-Serrano M, DiCosmo F, Ros Barcelo A.
  Title
Purification and characterization of alpha-3',4'-anhydrovinblastine synthase (peroxidase-like) from Catharanthus roseus (L.) G. Don.
  Journal
FEBS Lett 428:299-303 (1998)
DOI:10.1016/S0014-5793(98)00551-1
Reference
PMID:1368411
  Authors
Furuya T, Sakamoto K, Iida K, Asada Y, Yoshikawa T, Sakai S, Aimi N.
  Title
Biotransformation of tabersonine in cell suspension cultures of Catharanthus roseus.
  Journal
Phytochemistry 31:3065-8 (1992)
DOI:10.1016/0031-9422(92)83447-7
Reference
  Authors
Laflamme P, St-Pierre B, De Luca V.
  Title
Molecular and biochemical analysis of a madagascar periwinkle root-specific minovincinine-19-hydroxy-o-acetyltransferase.
  Journal
Plant Physiol 125:189-98 (2001)
DOI:10.1104/pp.125.1.189
Reference
  Authors
Jain S, Sinha A, Bhakuni DS.
  Title
The biosynthesis of beta-carboline and quinolizidine alkaloids of Alangium lamarckii.
  Journal
Phytochemistry 60:853-9 (2002)
DOI:10.1016/S0031-9422(02)00057-2
Reference
  Authors
Fricke J, Blei F, Hoffmeister D
  Title
Enzymatic Synthesis of Psilocybin.
  Journal
Angew Chem Int Ed Engl 56:12352-12355 (2017)
DOI:10.1002/anie.201705489
Related
pathway
map00400  Phenylalanine, tyrosine and tryptophan biosynthesis
map00902  Monoterpenoid biosynthesis
KO pathway
ko00901   
LinkDB

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