Entry
Name
Metabolism of xenobiotics by cytochrome P450
Class
Metabolism; Xenobiotics biodegradation and metabolism
BRITE hierarchy
Pathway map
map00980 Metabolism of xenobiotics by cytochrome P450
Reference
Authors
Buckpitt A, Boland B, Isbell M, Morin D, Shultz M, Baldwin R, Chan K, Karlsson A, Lin C, Taff A, West J, Fanucchi M, Van Winkle L, Plopper C.
Title
Naphthalene-induced respiratory tract toxicity: metabolic mechanisms of toxicity.
Journal
Reference
Authors
Bolton JL, Trush MA, Penning TM, Dryhurst G, Monks TJ.
Title
Role of quinones in toxicology.
Journal
Reference
Authors
Halladay JS, Sauer JM, Sipes IG.
Title
Metabolism and disposition of [(14)C]1-nitronaphthalene in male Sprague-Dawley rats.
Journal
Drug Metab Dispos 27:1456-65 (1999)
Reference
Authors
Watt KC, Morin DM, Kurth MJ, Mercer RS, Plopper CG, Buckpitt AR.
Title
Glutathione conjugation of electrophilic metabolites of 1-nitronaphthalene in rat tracheobronchial airways and liver: identification by mass spectrometry and proton nuclear magnetic resonance spectroscopy.
Journal
Reference
Authors
Simmonds AC, Reilly CA, Baldwin RM, Ghanayem BI, Lanza DL, Yost GS, Collins KS, Forkert PG.
Title
Bioactivation of 1,1-dichloroethylene to its epoxide by CYP2E1 and CYP2F enzymes.
Journal
Drug Metab Dispos 32:1032-9 (2004)
Reference
Authors
Forkert PG, Baldwin RM, Millen B, Lash LH, Putt DA, Shultz MA, Collins KS.
Title
Pulmonary bioactivation of trichloroethylene to chloral hydrate: relative contributions of CYP2E1, CYP2F, and CYP2B1.
Journal
Reference
Authors
Wormhoudt LW, Commandeur JN, Ploemen JH, Abdoelgafoer RS, Makansi A, Van Bladeren PJ, Vermeulen NP.
Title
Urinary thiodiacetic acid. A selective biomarker for the cytochrome P450-catalyzed oxidation of 1,2-dibromoethane in the rat.
Journal
Drug Metab Dispos 25:508-15 (1997)
Reference
Authors
Brodie BB, Reid WD, Cho AK, Sipes G, Krishna G, Gillette JR.
Title
Possible mechanism of liver necrosis caused by aromatic organic compounds.
Journal
Reference
Authors
Lodovici M, Luceri C, Guglielmi F, Bacci C, Akpan V, Fonnesu ML, Boddi V, Dolara P.
Title
Benzo(a)pyrene diolepoxide (BPDE)-DNA adduct levels in leukocytes of smokers in relation to polymorphism of CYP1A1, GSTM1, GSTP1, GSTT1, and mEH.
Journal
Cancer Epidemiol Biomarkers Prev 13:1342-8 (2004)
Reference
Authors
Omura T, Ishimura Y, Fujii Y (eds).
Title
[Molecular Biology of P450] (In Japanese)
Journal
Kodansya (2003)
KO pathway