Entry Name Osteoclast differentiation
Description The osteoclasts, multinucleared cells originating from the hematopoietic monocyte-macrophage lineage, are responsible for bone resorption. Osteoclastogenesis is mainly regulated by signaling pathways activated by RANK and immune receptors, whose ligands are expressed on the surface of osteoblasts. Signaling from RANK changes gene expression patterns through transcription factors like NFATc1 and characterizes the active osteoclast.
Class Organismal Systems; Development and regenerationBRITE hierarchy
Pathway map Other DBs Reference Authors Takayanagi H, Sato K, Takaoka A, Taniguchi T
Title Interplay between interferon and other cytokine systems in bone metabolism.
Journal Reference Authors Takayanagi H
Title New immune connections in osteoclast formation.
Journal Reference Authors Nakashima T, Takayanagi H
Title Osteoimmunology: crosstalk between the immune and bone systems.
Journal Reference Authors Caetano-Lopes J, Canhao H, Fonseca JE
Title Osteoimmunology--the hidden immune regulation of bone.
Journal Reference Authors Lorenzo J, Horowitz M, Choi Y
Title Osteoimmunology: interactions of the bone and immune system.
Journal Reference Authors David JP
Title Osteoimmunology: a view from the bone.
Journal Reference Authors Jimi E, Ghosh S
Title Role of nuclear factor-kappaB in the immune system and bone.
Journal Reference Authors Boyle WJ, Simonet WS, Lacey DL
Title Osteoclast differentiation and activation.
Journal Reference Authors Darnay BG, Besse A, Poblenz AT, Lamothe B, Jacoby JJ
Title TRAFs in RANK signaling.
Journal Reference Authors Baron R
Title Arming the osteoclast.
Journal Reference Authors Takayanagi H
Title Osteoimmunology: shared mechanisms and crosstalk between the immune and bone systems.
Journal Reference Authors Krum SA, Chang J, Miranda-Carboni G, Wang CY
Title Novel functions for NFkappaB: inhibition of bone formation.
Journal Reference Authors Lee NK, Choi YG, Baik JY, Han SY, Jeong DW, Bae YS, Kim N, Lee SY
Title A crucial role for reactive oxygen species in RANKL-induced osteoclast differentiation.
Journal Reference Authors Shinohara M, Koga T, Okamoto K, Sakaguchi S, Arai K, Yasuda H, Takai T, Kodama T, Morio T, Geha RS, Kitamura D, Kurosaki T, Ellmeier W, Takayanagi H
Title Tyrosine kinases Btk and Tec regulate osteoclast differentiation by linking RANK and ITAM signals.
Journal Reference Authors Takayanagi H, Kim S, Koga T, Taniguchi T
Title Stat1-mediated cytoplasmic attenuation in osteoimmunology.
Journal Reference Authors Jin W, Chang M, Paul EM, Babu G, Lee AJ, Reiley W, Wright A, Zhang M, You J, Sun SC
Title Deubiquitinating enzyme CYLD negatively regulates RANK signaling and osteoclastogenesis in mice.
Journal Reference Authors Bai S, Kitaura H, Zhao H, Chen J, Muller JM, Schule R, Darnay B, Novack DV, Ross FP, Teitelbaum SL
Title FHL2 inhibits the activated osteoclast in a TRAF6-dependent manner.
Journal Reference Authors Takayanagi H, Kim S, Taniguchi T
Title Signaling crosstalk between RANKL and interferons in osteoclast differentiation.
Journal Related KO pathway
