Entry Name Serotonergic synapse
Description Serotonin (5-Hydroxytryptamine, 5-HT) is a monoamine neurotransmitter that plays important roles in physiological functions such as learning and memory, emotion, sleep, pain, motor function and endocrine secretion, as well as in pathological states including abnormal mood and cognition. Once released from presynaptic axonal terminals, 5-HT binds to receptors, which have been divided into 7 subfamilies on the basis of conserved structures and signaling mechanisms. These families include the ionotropic 5-HT3 receptors and G-protein-coupled 5-HT receptors, the 5-HT1 (Gi /Go -coupled), 5-HT2(Gq-coupled), 5-HT4/6/7 (Gs-coupled) and 5-HT5 receptors. Presynaptically localized 5-HT1B receptors are thought to be the autoreceptors that suppress excess 5-HT release. 5-HT's actions are terminated by transporter- mediated reuptake into neurons, leading to catabolism by monoamine oxidase.
Class Organismal Systems; Nervous systemBRITE hierarchy
Pathway map Other DBs Reference Authors Millan MJ, Marin P, Bockaert J, Mannoury la Cour C
Title Signaling at G-protein-coupled serotonin receptors: recent advances and future research directions.
Journal Reference Authors Bockaert J, Claeysen S, Becamel C, Dumuis A, Marin P
Title Neuronal 5-HT metabotropic receptors: fine-tuning of their structure, signaling, and roles in synaptic modulation.
Journal Reference Authors Raymond JR, Mukhin YV, Gelasco A, Turner J, Collinsworth G, Gettys TW, Grewal JS, Garnovskaya MN
Title Multiplicity of mechanisms of serotonin receptor signal transduction.
Journal Reference Authors Noda M, Higashida H, Aoki S, Wada K
Title Multiple signal transduction pathways mediated by 5-HT receptors.
Journal Reference Authors Daubert EA, Condron BG
Title Serotonin: a regulator of neuronal morphology and circuitry.
Journal Reference Authors Chameau P, van Hooft JA
Title Serotonin 5-HT(3) receptors in the central nervous system.
Journal Reference Authors Tournois C, Mutel V, Manivet P, Launay JM, Kellermann O
Title Cross-talk between 5-hydroxytryptamine receptors in a serotonergic cell line. Involvement of arachidonic acid metabolism.
Journal Reference Authors Iliff JJ, Jia J, Nelson J, Goyagi T, Klaus J, Alkayed NJ
Title Epoxyeicosanoid signaling in CNS function and disease.
Journal Reference Authors Adayev T, Ray I, Sondhi R, Sobocki T, Banerjee P
Title The G protein-coupled 5-HT1A receptor causes suppression of caspase-3 through MAPK and protein kinase Calpha.
Journal Reference Authors Albert PR, Tiberi M
Title Receptor signaling and structure: insights from serotonin-1 receptors.
Journal Reference Authors Durham PL, Russo AF
Title Serotonergic repression of mitogen-activated protein kinase control of the calcitonin gene-related peptide enhancer.
Journal Reference Authors Robert S, Maillet M, Morel E, Launay JM, Fischmeister R, Mercken L, Lezoualc'h F
Title Regulation of the amyloid precursor protein ectodomain shedding by the 5-HT4 receptor and Epac.
Journal Reference Authors Lezoualc'h F, Robert SJ
Title The serotonin 5-HT4 receptor and the amyloid precursor protein processing.
Journal Reference Authors Durham PL, Russo AF
Title Differential regulation of mitogen-activated protein kinase-responsive genes by the duration of a calcium signal.
Journal Reference Authors Hagberg GB, Blomstrand F, Nilsson M, Tamir H, Hansson E
Title Stimulation of 5-HT2A receptors on astrocytes in primary culture opens voltage-independent Ca2+ channels.
Journal Reference Authors Nestler EJ, Hyman SE, Malenka RC.
Title Molecular neuropharmacology: A foundation for clinical neuroscience
Journal The McGraw-Hill Companies, Inc. (2001)
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