Myxocyprinus asiaticus (Chinese sucker): 127423498 Help Entry 127423498         CDS       T08782                                  Name (RefSeq) ryanodine receptor 2   KO K04962   ryanodine receptor 2 Organism masi  Myxocyprinus asiaticus (Chinese sucker) Pathway masi04020   Calcium signaling pathway masi04260   Cardiac muscle contraction masi04261   Adrenergic signaling in cardiomyocytes masi04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:masi00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     127423498    04020 Calcium signaling pathway     127423498  09150 Organismal Systems   09153 Circulatory system    04260 Cardiac muscle contraction     127423498    04261 Adrenergic signaling in cardiomyocytes     127423498  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:masi04040]     127423498    04990 Domain-containing proteins not elsewhere classified [BR:masi04990]     127423498 Ion channels [BR:masi04040]  Voltage-gated cation channels   Ryanodine receptor    127423498 Domain-containing proteins not elsewhere classified [BR:masi04990]  EF-hand domain-containing proteins   Other EF-hand domain-containing proteins    127423498 BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 Ins145_P3_rec SPRY MIR RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_6 EF-hand_8 Motif Other DBs NCBI-GeneID:  127423498 NCBI-ProteinID:  XP_051523808 LinkDB All DBs Position 32:43704920..43912099 Genome browser AA seq 4964 aa AA seqDB search MTDGGEAEDEIQFLRTDDEVVLQCSAMVHKEQQKLCLAAEGFGNRLCFLESTSNSKNVPP DLSICTFVLEQSLSVRALQEMLANTEERVEGLIDMEKWTAQGGGHRTLLYGHAILLRHSY SGMYLCCLSTARSSTDKLAFDVGLQEDTTGEACWWTIHPASKQRSEGEKVRVGDDLILVS VSSERYLHLSYGNDSLHVDAAFQQTLWSVAPICSGSEVAQGFLIGGDVLRLLHGHMDECL TVPSGEHGEEHRRAVHYEGGAVSIHARSLWRLETLRVAWSGSHTRWGQPFRLRHVTTGKY LSMMDDQGLLLMDKEKADVKSTAFCFRSSKEKLDCGQRKEVDGMGVPDIKYGDSVCYIQH VDTGLWLTYQSVDAKCARMGGVQRKAIMHHEGHMDDGLTLSRSQHEESHTARVIRSTVFL FNRFIRGLDALSKKGKTSTLDLPIESVSLSLQDLIGYFQPPDEHLEHEDKQNRLRALKSR QNLFQEEGMINLVLECIDRLHVYSSAAHFADVAGKEAGESWKSILNSLYELLAALIRGNR KNCAQFSGSLDWLISRLERLEASSGILEVLHCVLVESPEALNIIKEGHIKSIISLLDKHG RNHKVLDVLCSLCVCHGVAVRSNQHLICDNLLPGRDLLLQTRLVNHVSSMRPNIFLGVSE GSAQYRKWYYELIVDHVVPFVTAEATHLRVGWASTQGYCPYPGGGEGWGGNGVGDDLYSY GFDGLHLWAGCVARSVSSPNQHLLRAEDVVSCCLDLSAPSISFRINGQPVQGMFENFNSD GLFFPVVSFSAGVKVRYLLGGRHGEFKFLPPSGYAPCFEAVLPREKLRVEHSQEYKHDHG KTRDLLGPTITLSQAAFTPTPVDTSQIILPPHLERIREKLAENIHELWVMNKIELGWTYG TVRDDNKRQHPCLVEFSKLPEQERSYNLQMSQETLKTLLALGCHVGVADERAAEKVKNLK LSAKYELSSSYKPAPMDLNHIKLASAQEAMVDKLAENAHNVWARDRIRQGWTYGIQQDIK SRRNPRLVPYALLDERTKKSNKDSLREAVRTLLGYGYNLEAPDQDHDRSDINNLSAERFR IYRAEKTYSVNGGKWYFEFEVVTSGEMRVGWARPGCLPDQELGSDEQAFVFDGFKAQRWH QGNEHFGRSWQCGDVVGCMVDMNERTMMFTLNGEVLLDDSGSELAFKDFEVWEGFIPVCS LGVCQVGRMNFGKDVSTLKYFTICGLQEGYEPFAVNMNRELTMWISKRLPQFIPVPPNHE HIEVTRIDGTVESPPCLKVTQRSFGSQNSSTDIMFFRLSMPIECSEAFVRSPSGMLATNG SFFSPKKDLDDFETVSDFEVLMKSSHSHMSANGPERERDEFNNHKDHNQEKPSKIKQRFM LKRTKPDMNSSNSSARLSEEVLADERDDCENLIQTSTYFYSVRIFPGQEPSSVWVGWVTS DFHQHDPAFELNMVRVVTVTLGDEKGKVHESIKRSNCYMVWGGESSSPSQGRNNNGLEIG CLVDTANGLLTFTSNGKELSTYYQVEPSTKLFPAVFAQATSPNVFQFELGRIKSVMPLSA GLFKSERKNAIPQCPPRLHVQFLTPVLWSRVPNQFLRSEVTRVSERLGWMVQSSEPLQFM TLHIPEENRSLDILELTEQQDLLKFHYHTLRLYSAICALGNNRVAHALCSHVDEAQLLYA IQNKYMPGLLRTGYYDLLIDIHLSGYATARLMMNSEYIVPMTPETKSITLFPNEKKKHGL PGIGLSTSLQPRMRFSSPSFVGAVGGNHGSGAVAGGDCFQYSPEFPLETLKSRTMEMLTE AVREGSLHVRDPVGGSTEFLFVPLIKLFYTLLIMGIFHNGDLKTILQLIEPSVFSQDSGA ESGPGTPEAEESCGRGRLEEGGADEHSLRGKMPKEGLLQMKLPEPVKLQMCHLLQYLCDC QVRHRIEAVVAFSDDFVANLQDNQRFRYNEVMQALNMSAALTARKTKEFRSPPQEQINML LNFKDEKQDCPCPVDIREQLLEFHEDLMTHCGIEADDDKSDDSDFTIRGRLMSLVEKVTY LKKKMADLPKKKKLKKPSTLQQLISETMVRWAQESVIEDPELVRAMFVLLHRQYDGIGGQ VRALPKTYTINAVSVEDTINLLASLGQIRSLLSVRMGREEEKLMIHGLSDIMNNKVFYQH PNLMRALGMHETVMEVMVNVLGGGETKEITFPKMVANCCRFLCYFCRISRQNQKAMFDHL SYLLENSSVGLASPSMRGSTPLDVAAASVMDNNELALALREPDLEKVVQYLAGCGLQSCV MLMSKGYPDIGWNPVEGERYLDFLRFAVFCNGESVEENANVVVRLLIRRPECFGPALRGE GGNGLLAAMEEAIKISEDPSRDGPSPTTEENRTLNDVIEEEEEDDTIHMGNAIMTFYAAL IDLLGRCAPEMHLIHAGKGEAIRIRAILRSLIPIEDLVGVISIPFLMPTLAKDGSVIEPD MSGGFCPDHKAAMVLFLDRVYGIEDQNFLLHLLEVGFLPDLRAAASLDTAALSATDMALA LNRYLCTAVLPLLTKCAPLCAGTEPFASLIDSLLHTVYRLSKGCCLTKAQRDVIEECLLA VCGKLRPSMMQHLLRRLVFDVPVLNEHTKMPLKLLTNHYERCWKYYCLSSGWGSFGAASD EELHLSRKLFWGIFDALARKKYDVELFKLALPCLSAVGGALPPDYMESNYVAIMEKQSSM DAEGNFNPQPADTSSIVVPEKLDHFINKYAEYSHEKWSMEKFVVGWVHGDQMCESSKVHP LLKPYKCLSEKDKEVYRWPIRESLKTMLSWEWSIERTRESDASTLQNRTRRISLSSQRSI EGAHGFSPRPVDMSNVTLSRDLHSMAELLAENYHNIWAQKKKLELESKGGGSHPLLVPYD TLTAKEKSKDREKAQDILKFFQINGYTVSRAMKEQDLDTPSIEKRFAYTFLQQLIAYVDE AHEHMLEIDVGIRSKGEKIPHEQQVKFFGKVVLPLVDQYFKNHRLYFLSTAVRPISSGGH ASNKEKEMVTSLFCKLGVLVRHRISLFGNDATSIVNCLHILGQTLDARTVMKTGQDSVKA ALRAFFDNAAEDLEKTMENLRQGQFTHTRTQPKGVTQIINYTTVALLPVLSSLFEHIGQN LFGEDLILDDVQVSCYRILNSLYSLGTSKSIYVERQRPALGECLAAFSGAFPVAFLEPSL NKHNTYSIYNCKSSRERAVLGLPTQVEEVCALVPSLERALEEIMELAESGMRYTQMPHVM EVLLPMLCSYMSHWWEHGPESNPERSESCCTSLTSDHMNTLLGNILKIIYNNLGIDEGAW MKRLAVFSQPIIGKAKSQLLKTHFLPLMEKLKKKAATVLQDEEHMKAEGRGEMSESELLI LDEFTILVRDLYAFYPLLIRFVDYNRAIWLKEPNQEAEELFRMVAEVFIFWAKSHNFKRE EQNFVVQNEINNMSFLITDTKSKMSKGAVSDQERKKMKKRGDRYSLQTSLIVAALKRLLP VGLNICAPGDQELIALAKSRFTQKDTEDEVRETVRNNLHLQGKLEDPAIRWQMALYKDMP NRTEDTSDPNKTVERVLNIAHVLFHLDQVEHPQRSKKAVWHKLLSKQRKRAVVACFRMAP LYNLPRHRAVNLFLQGYEKSWIETEEHYFEDKLIEDLAKPGGEEPSEEDETTKRIDPLHQ LIQLFSRTALTEKCKLEEDHLYMAYADIMAKSCHDEEEEDEEEVKSFEEKEMEKQKLLYQ QARLHDRGAAEMVLQTISASKGEMGPMVASTLKLGIAILNGGNSTVQQKMLDYLKDKRDV GFFQSLAGLMQSCSVLDLNAFERQNKAEGLGMVTEEGSGEKVMQDDEFTCDLFRFLQLLC EGHNSDFQNYLRTQTGNNTTVNIIISTVDYLLRVQESISDFYWYYSGKDVIDEQGQRNFS KAINVAKQVFNTLTEYIQGPCTGNQQSLAHSRLWDAVVGFLHVFAHMQMKLSQDSSQIEL LKELMDLQKDMVVMLLSMLEGNVVNGTIGKQMVDMLVESSNNVEMILKFFDMFLKLKDLT SSDAFKEYDPDGKGVISKRDFHKAMESHKHYTQSETEFLLSCAETDENELLDYEEFVERF HEPAKDIGFNVAVLLTNLSEHMPHDSRLQTFLELAESVLNYFQPYLGRIEIMGSAKRIER VYFEISESSRTQWEKPQVKESKRQFIFDVVNEGGEKEKMELFVNFCEDTIFEMQLAAQMS DAGERSASKEDSEREKPEEENTEMGFFSVTTVRTALFALRYNVILLMRVLSMKSLKKQVK KAKKMTVKDMVTTLVSFYWSVLLGLLHFAFSVARGFFRIIYNSFLGGSLVEGAKTMKVSE LLANMPDPTQDEVRGETEEGEKKLVDRTSPEEDLADLTVATDDTDLLSDIFGLDLKREGG QYKLMPHNPNASLTDLLNTPLPPAPTPSPELHRRHQTKGSSSSTENNEATGETKSVPEKS EGENGEKAQKKKEETVKRKFRQHYCKSDEPDLQESAFWKKIIAYQRKLLNYFARNFYNMR MLALFVAFAINFILLFYKVSTSSAEGKEVLFSTSSDTSVRWDPLGSSSSRPVTVHFVLEE SSGYMEPTLRILAILHTVISFFCIIGYYCLKVPLVIFKREKEVARKLEFDGLYITEQPSE DDIKGQWDRLVINTQSFPNNYWDKFVKRKVMDKYGEFYGHDRISELLGMDKAALDFSDAH EKKKPKRDSSLAAVLNSIDVKYQIWKLGVVFTDNSFLYLAWYMSMSILGHYNNFFFAAHL LDIAMGFKTLRTILSSVTHNGKQLVLTVGLLAVVVYLYTVVAFNFFRKFYNKSEDGESPD MKCDDMLTCYMFHMYVGVRAGGGIGDQIEDPAGDEYEIYRIIFDITFFFFVIVILLAIIQ GLIIDAFGELRDQQEQVKEDMETKCFICGIGNDYFDTVPHGFETHTLQEHNLANYLFFFM YLINKDETEHTGQESYVWKMYQERCWEFFPAGDCFRKQYEDQLN NT seq 14895 nt NT seq  +upstreamnt  +downstreamnt atgacggacggcggagaagccgaagatgagatccagttcttacgaaccgatgatgaggtg gtgttacaatgttcagcgatggttcacaaggagcagcagaaactctgtctggctgctgaa gggtttggaaacagactgtgtttcctggagtccacatccaactcaaagaatgttcctccg gatctgtccatatgcacgtttgtgctggagcagtcgctgtcggtacgagcgttgcaggag atgctcgcgaacacagaggagcgagtggaggggctcatagacatggagaaatggacggca cagggcggaggtcaccggacacttctgtacggtcacgcgatcttactacgacactcctac agtggaatgtatctgtgctgtctgtccacggctcgctcgtccacagataaactggcgttt gatgtggggcttcaagaagacacgacaggtgaggcgtgctggtggaccatacatcccgcg tccaaacagaggtcagagggcgagaaagtgcgagtgggcgatgacctcatccttgtcagt gtgtcgtctgaacgatacctgcacttgtcgtacggtaacgacagtttacacgtggatgca gcatttcaacagacgctctggagtgtcgcgccgatctgctctggtagtgaagtggctcaa gggttcctgattggtggagatgttctacggcttcttcatggtcacatggacgagtgcctg accgtcccgtcaggagaacatggagaggaacaccgcagggcggtgcattacgaaggagga gccgtgtccatccatgcgagatctctctggagactggagacactgcgagtggcgtggagc ggtagtcatactcgctggggtcagccgttccggttgcgtcatgtgaccacagggaaatat ctgagcatgatggatgatcaagggctgctgctaatggacaaagagaaagcagacgtcaaa tcaacggctttctgcttccgttcctcgaaagagaagctggattgtggtcagaggaaggaa gtggatggaatgggtgttccggatatcaaatatggcgactctgtgtgctacatccagcat gtggacactggactctggctcacctaccaatcagtggatgccaagtgtgcccgcatgggc ggagtccagagaaaggccatcatgcatcatgaaggtcacatggatgatggattaacattg tcacgatcacaacacgaggagtcgcacacagctagagtcatacgcagcactgtcttcctc tttaaccgctttatcagaggtctggatgctctgagtaaaaaaggcaaaacctccacactt gatctaccgatcgaatcggtcagtctgagtcttcaggatctgattggctacttccagcca cctgacgagcacctggagcacgaggacaaacagaaccgcctgcgagcgctcaagagccga cagaacctgttccaggaggagggaatgataaacctggtgctggagtgtatcgatcgttta catgtgtacagcagcgcggctcattttgccgacgtggccgggaaggaagcgggagaatcc tggaaatccatcctgaactccctgtacgagctcctggctgctctgatcagaggaaacagg aagaattgtgcccagttttctggctctctggattggcttatcagtcgtctggagaggttg gaagcctcatctggaattctggaagttcttcattgtgttctggtggagagtccagaagct ctgaacatcatcaaagagggccatatcaaatccatcatctctttactggacaaacacgga cgcaaccacaaggttctggatgtgttatgttctctctgtgtgtgtcatggtgtggcagtt cgctctaatcagcacctgatctgtgataacttgctgccagggagagacctgctgctgcag acacgacttgtcaatcacgtcagcagtatgaggcctaatatcttcctgggtgtgagtgaa ggctccgcccagtacaggaagtggtattatgagctcatagtggatcacgtggttccgttt gttacggctgaggccacacacctgcgggtgggctgggcgtccacacagggctactgtcct tacccgggcggaggagaaggatgggggggcaatggtgtaggggacgacctttactcttat ggctttgatgggctacacctgtgggcaggttgcgtggcacggtcggtgagctcacccaat cagcacctgctgcgggcagaggacgtggtgagctgctgtctagatctgagcgctccgagc atctcattccgtatcaacggccagcccgtccagggaatgtttgagaactttaattcagat ggactctttttccccgtcgtgtccttctctgctggagtcaaagtgcgctacctgctgggc ggtcgccacggagagttcaagttccttccgccttccggttacgctccgtgttttgaggcc gttttaccacgagaaaaactgcgagtggaacacagtcaagagtataaacatgatcacgga aaaacacgtgaccttctgggacccacgatcacactgtcacaagctgccttcacaccaaca cctgtagataccagtcagatcatcttgccaccacatcttgagcgaatccgagagaaactg gctgaaaacatccatgagctgtgggtgatgaacaagattgagcttggatggacctacggg acggtaagagacgataataagcgacagcatccgtgtctggtggagttctctaaacttcct gaacaagagcgcagctacaatctacagatgtctcaggagacgttgaaaactctactggct ctcggctgtcatgtcggtgtggcagatgaacgagcggccgagaaagtcaaaaatctgaaa ctttctgccaaatacgagctctccagcagttataaacctgcaccgatggatctgaaccac atcaaactggcatctgctcaagaggccatggtggacaaactggctgagaacgctcataat gtttgggctagagatcgcatccgtcagggctggacctacgggatacagcaggacattaag agcaggaggaatcctcgtctggttccttacgctcttctggatgagagaacgaagaaatca aacaaggacagtctgcgggaagccgtgaggacgttattgggttatggctacaatctagaa gcccccgatcaagatcacgatcggtcagacatcaataatctctccgctgagcgcttccgg atttacagagcggagaagacgtacagcgtgaacggaggaaagtggtactttgagtttgag gtggtgacgtcgggcgagatgcgggtgggctgggcgagacctgggtgcctgccggaccag gagctgggatcagacgaacaggccttcgtctttgatggattcaaggctcagcgctggcac cagggtaacgagcactttggccgttcgtggcagtgtggtgatgtcgtgggctgtatggtg gacatgaatgaacgcactatgatgttcacgctcaacggcgaagtgctgctcgatgactca ggctctgaactcgccttcaaagactttgaggtttgggaaggtttcatccccgtgtgtagt ctgggcgtgtgtcaggtcgggcgtatgaacttcggtaaggacgtgagcactctgaagtat ttcaccatctgcggtctgcaagaggggtacgaacccttcgccgtcaacatgaaccgagag ctgaccatgtggatcagtaaacgactgccgcagtttattcccgtgccacccaaccacgag cacatagaggtcacacggatcgatgggacagtggagagccctccgtgcctaaaggtcacc cagaggtcattcgggtcacagaacagcagcacagacatcatgttctttcgactgagcatg cccatcgagtgctcagaggcgttcgtcagatctcccagcgggatgttagcgaccaacggc agtttcttctctccaaagaaggatctggatgattttgagacggtgtcagactttgaggtt ctgatgaagagttcacacagtcacatgagtgcaaacgggccggagagagaacgagacgaa ttcaacaaccataaagatcataatcaagagaaaccatcgaaaatcaaacaaaggttcatg ttgaagagaacgaagccagacatgaacagcagtaactccagcgctcgtttatcagaggaa gttttggctgatgagagagatgattgtgagaatctcatacaaacatcaacgtatttctac tcggtgaggatattccctggtcaggagccgtccagcgtttgggtcgggtgggtgacctct gactttcatcagcacgatccagcctttgaactcaacatggtcagagtagtcaccgttacc ctgggagacgagaagggcaaagttcatgagagtattaaacgcagtaactgctacatggtt tgggggggtgagagcagcagtcccagtcagggtcgcaataataacggactggaaatcgga tgtttggtggatacagccaacggcctcctcacgttcacatccaatggcaaagagcttagt acatactatcaggtggagcccagcacgaaacttttccccgcagtgtttgcacaggccaca agtccaaacgtcttccagttcgaactgggacgcatcaagagcgtgatgcctctttccgct gggctgtttaaaagcgagcggaagaacgccatccctcagtgtccgccgcggttacatgtg cagttcctcacgcctgtgttatggagtcgtgtgcccaatcagttcctgaggtcagaggtc accagggtcagtgagagactcggctggatggttcagagttcagaacccctgcagttcatg accttacatatacctgaagagaacaggtcgctggatattcttgagttgacggagcagcaa gacctgctgaagtttcactatcacacgctgcgtttatattctgcgatctgtgctttgggg aacaaccgcgttgctcacgcactctgcagtcacgtagatgaggcgcagctgctgtacgcc atccagaacaaatacatgccgggccttctgcgcactggatactacgacctgctcatcgac atccacctgagcggttacgccacggccaggctcatgatgaactctgagtacatcgttccc atgacgcctgagaccaaaagcatcacgctgtttcccaacgagaagaagaaacacgggctg cccggaatcggactgagtacatcactacaaccgcgcatgcgcttttcatccccaagcttt gtgggggctgttggtggtaaccacggcagcggtgcggtcgccgggggtgactgtttccag tacagcccggagtttccgttggagacgctgaagagtcgcacgatggagatgctgacggaa gcggtgcgcgagggtagtctacatgtgcgtgatcctgtaggtggcagcactgagttcctg tttgttccactcataaaactcttctacacacttcttatcatgggcatctttcataacgga gatctgaagaccatcctgcagctgatcgagcccagcgtgttttctcaggactctggggct gagagcggccccgggaccccagaggcagaggagagctgtgggcggggccgattagaggag ggcggagccgacgaacacagtctgagaggaaagatgcccaaagaaggactgttacagatg aaacttcctgaacctgtcaaacttcagatgtgtcacctgcttcagtatctatgtgactgt caggtgcgtcatcgtatcgaggcagtggtcgcgttctctgatgactttgtggcgaatctt caggataatcagcgtttccgctataatgaagtgatgcaggcgttaaacatgtcagccgcg ctcactgcacgcaaaaccaaagagtttcgctcgccgccacaggaacagatcaacatgctg ctgaattttaaggatgagaagcaggattgtccgtgtcctgtagacatcagagaacaactg ctggagtttcatgaagatctcatgactcattgtggcattgaggcagatgatgataaatca gatgacagtgatttcaccatcagaggtcgtctgatgtcactggtggagaaggtgacgtac ctgaagaagaaaatggctgatttaccaaagaaaaagaaactgaagaagccgagcactctg cagcagctgatatcggagacgatggtccggtgggctcaggaatcagtcatcgaggaccct gagcttgttcgtgcgatgtttgtgttacttcaccgtcagtacgatggtatcggtggacag gtgcgagcgctgcctaaaacttacaccatcaacgccgtgtctgtggaggacaccattaac ctgctggcgtctctgggtcagatcagatcgctgctcagcgtcaggatgggtcgagaggaa gagaaactcatgattcacggactcagtgacatcatgaataataaggtgttttatcagcat ccaaacctgatgcgagcgcttggcatgcacgagacagtgatggaggtgatggtgaatgtg ctgggaggaggagaaaccaaagaaatcacatttcctaagatggtggcgaactgctgtcgt ttcctgtgttacttctgtcgcatcagtcgtcagaatcagaaggccatgtttgatcatctg agctatctgctggagaacagtagcgtgggactcgcgtctccctccatgcgaggttcgact cctctggatgttgctgctgcatcagtgatggacaataatgaactggcgcttgcactgaga gaacccgacctggagaaggtggtccagtatctagcgggttgtggtcttcagagttgtgtg atgctcatgtctaaaggttatccagacattggctggaacccggtagagggagagcgatac ctcgacttcctgagatttgcagtcttctgtaatggagagagtgtagaggagaatgctaat gtggtggtacggctcttgattcgacggccggagtgttttggtcccgccctgcgcggtgag ggcgggaacggactgctggcggcgatggaggaggccataaagatctcagaagatcccagt agagacggaccatcacccaccacagaggagaacagaacacttaatgatgtcattgaggaa gaggaggaagatgacaccattcacatgggaaatgccatcatgaccttctacgctgcactg atcgacctgttgggccgctgcgctccagagatgcacctgatccacgcgggcaagggagag gccatccgtatccgagccatcttgagatctctcattcccattgaagatctggtcggtgtg atcagtattccattcctgatgcccactttagcgaaagacgggtctgtgatcgagccggac atgtccggaggcttctgtccggatcataaagccgccatggttctgtttctggaccgagtt tacggcatcgaggatcagaacttcctgctacatctgctggaggtgggcttcctgcccgac ctcagagctgccgcctcattggacacggctgccctgagcgctacagacatggcgttggct ctgaaccggtatctgtgtacggccgttctgccgctgctgactaaatgtgctcctctgtgt gcggggacggagccatttgcgtctctcatcgactctctgctgcacaccgtctacagactg tcgaaaggctgctgtctcaccaaagcacagagagatgttatagaggagtgtctgctcgct gtgtgcggtaaactacggccttctatgatgcagcatctactgcggcgtctggtgtttgat gttcctgtgctgaatgaacacacaaagatgcctctgaagctcttgaccaatcactatgag cgctgctggaagtattactgtctgtccagcgggtggggcagttttggtgcagcgtcagat gaggagcttcacctctccagaaaactcttctggggaatctttgacgctctggccagaaag aaatatgatgtggagttgtttaagttggctttgccatgtctgagcgcggtgggcggagct ttacctcctgattacatggagtcaaactatgtggctataatggagaaacagtcatcgatg gacgccgaaggaaacttcaaccctcagccagccgacaccagcagcattgtggttcccgag aaactcgatcatttcatcaataaatatgcagaatattctcatgagaaatggtcaatggag aagtttgttgttggttgggttcatggagatcagatgtgtgaatcatctaaagttcatcct ctgctgaagccctacaaatgtctctctgagaaggataaggaggtttaccgctggccaatc agagagagtctaaagacgatgttgtcgtgggaatggagcatcgagaggacgagagagagc gacgcatccacattacaaaaccgcacgcgcagaatatctctatccagtcagcggtctata gagggcgctcacgggttcagcccgcggcctgttgacatgagcaacgtcacgctgtccaga gacctgcattcaatggccgagctgctggcggagaactatcacaacatctgggctcagaag aaaaaactggagctggaatctaaaggtggggggagtcatccgttactggttccttacgac actttaactgccaaagagaaatccaaagatcgagaaaaagcacaagacatccttaaattc tttcagatcaacggatacactgtgtcaagggctatgaaagaacaagatctggacactccg tctatagagaagcgttttgcatatacatttctgcagcagttgatcgcgtatgtggatgaa gctcatgaacacatgctggagatcgatgttggaatacggtctaaaggggagaaaatccct catgagcagcaggtcaaattctttggaaaggttgtgttgcctctggtggatcaatacttt aagaaccatcggctctacttcctgtctactgctgttcgtccaatcagcagcggcggtcac gcctccaataaagagaaggagatggtgaccagtcttttctgcaaactgggagttctggtc agacacaggatatctctgtttgggaatgatgccacctccatagtgaactgtctacacata ctgggtcagacactggacgccaggaccgtgatgaaaacaggtcaggactctgtcaaagcg gctctgcgggcgttttttgataatgcagcagaagatctggagaagacgatggagaacctg cgacagggtcagttcacgcacacgcggacgcaaccgaaaggcgtcacacagatcataaac tacacgaccgtcgcactgctgcccgttctctcctcgctgtttgaacacatcggacaaaac ctgtttggagaagacctgattttggatgacgtccaggtgtcctgttatcggattttaaac agtttgtactcacttggaaccagtaaaagtatttatgtcgagaggcaaagacccgctctg ggtgagtgtctggccgcgttctcgggtgcatttcctgtggctttcctggagcccagtctg aataaacacaacacttactctatatacaactgcaaaagctccagagagagagcagtgcta ggtctacctactcaggtggaggaggtgtgtgcactggtgccatctctggagcgggctctc gaggagatcatggagctggcggagtctggcatgcgttacacacagatgcctcacgtgatg gaggtcctgctgccgatgctctgcagttacatgtcgcactggtgggaacacggacctgag agcaacccggagcgatcggagagctgctgcacatctctgacctctgaccacatgaacaca ctgctgggaaacatcctcaaaataatttacaacaacctgggcatcgatgaaggagcctgg atgaagagactcgcagtgttttctcaacccatcatcggtaaagcaaagtctcagctgctg aagactcacttcctgcctctgatggagaagctgaagaagaaagcagcgacggttcttcag gatgaggagcacatgaaggctgagggtcgaggagagatgtctgaatcagaacttctcatc ctggacgagttcaccatcctcgtgagagatctgtacgcgttctacccactgctcattcga ttcgtcgattacaacagggcaatatggttgaaagaaccgaatcaagaggctgaggaatta tttcgtatggtggcagaagtctttatattctgggccaaatcacacaacttcaagagagag gagcagaactttgtagttcagaatgaaatcaacaacatgtccttcctcatcactgacacc aaatcaaaaatgtctaagggtgcagtatcagaccaggagaggaaaaagatgaagaaacgc ggcgatcgatactcacttcagacgtcactgatcgttgccgctctcaagaggttacttcct gtcgggttgaatatctgtgcgccgggagatcaggagctgatcgcactcgccaagagccgc ttcacacagaaagacactgaagatgaggtgcgagagaccgtcaggaataacctccacctg caggggaagttggaggatcctgctatccgctggcagatggcgctctataaagacatgccc aaccgcaccgaagacacctctgatcctaataagactgtcgaaagagtgctgaacatcgct catgtgctcttccacctggatcaggttgaacatcctcagaggagtaaaaaagccgtgtgg cacaagcttctgtccaaacagaggaagagagccgtggtggcctgcttcaggatggcacct ctttacaacctgcccaggcatcgtgcagtaaacctgttcctgcagggttatgagaagtcc tggatcgagacagaggaacattattttgaagacaaactgatagaggatttggctaaacca ggtggagaagagccgtcagaggaggacgagaccaccaaacgcatcgatccgttacaccag ctcatacaactgttcagcagaaccgcactgacagagaaatgtaaactagaggaagatcat ctctacatggcctacgctgatattatggccaagagttgtcatgatgaagaggaagaggat gaggaagaggtcaagagttttgaggagaaagagatggagaagcagaagttgttgtatcag caggcaagacttcatgaccgcggagccgctgagatggtgctgcagaccatcagcgccagc aaaggtgagatggggccgatggtggcctctacactgaagttgggcatcgctatactcaat ggaggaaactcaactgtacagcagaaaatgctggactacctgaaagacaaaagagacgtg ggattctttcagagtctagctggactgatgcagtcgtgcagtgttttggatctgaatgca tttgagagacagaataaagctgaaggtctcggtatggtgacagaggaaggatcaggtgaa aaggtcatgcaagatgacgaattcacctgtgacctcttccgcttcctacagctgctctgt gagggtcacaactcagattttcagaactacctgagaacacagacgggtaacaacacaacg gtcaacatcatcatctctacagtggattacctgctcagagtccaggagtcgatcagtgat ttctactggtattattctggtaaagatgtgattgatgaacaaggccagcggaatttctcc aaagccattaatgtagccaaacaagtcttcaacactctcacagagtacattcagggccct tgcacggggaaccagcagagtcttgctcacagtcgtttgtgggatgcagttgttggtttc ctgcatgtttttgcacatatgcagatgaagctgtctcaggattcgagccagatcgagctg ttgaaggagctgatggatcttcagaaggacatggttgtgatgctcttgtccatgttggag ggaaatgttgtgaatggcacaattggaaagcagatggtggacatgttagtggagtcctcc aacaatgtcgagatgattctcaagttctttgacatgttcctcaaactgaaggacttgaca tcgtcagatgccttcaaagagtacgaccctgatgggaagggagtcatatccaagagggat ttccataaggccatggagagccataaacactacacccaatccgaaacggagttcctcctt tcctgcgcagaaacagatgaaaacgagctcttggactatgaagagtttgtcgaacgcttc cacgagccggcgaaggacatcggcttcaatgttgctgttctcctgaccaatctctctgaa catatgccccacgattctcgcctccaaaccttcctggagcttgcagagagcgttctgaac tatttccagccatatctgggccgcatcgagatcatgggcagtgccaagcggattgagcgc gtgtacttcgagattagcgagtcgagtcgcacccagtgggagaagccgcaggtcaaggag tccaaacggcagttcatctttgatgttgtaaacgagggtggtgagaaagagaaaatggag cttttcgtgaacttttgtgaggacaccatctttgagatgcagctggctgcgcagatgtcg gacgccggcgagcgctcggctagcaaagaggacagcgagagggaaaagccagaagaggag aacactgagatgggtttcttctctgtcaccactgtacggacagccctatttgccctacga tacaacgtgattcttctgatgagggtgctttccatgaagagcctgaagaagcaggtgaag aaagcgaagaagatgacagttaaggacatggtgaccacgctcgtgtccttctactggagc gtcctgctgggtctgctgcacttcgccttcagcgtcgctcgaggattcttccgaatcatc tacaacagctttttaggagggagtctggtggagggagccaagaccatgaaggtgtccgag ctcctggccaacatgcccgacccaacacaggacgaagtgagaggagagacggaagagggc gagaagaagcttgtggacagaacctcaccagaggaagatctggctgatctgacggtggcc acagacgacactgatcttctgtctgatatatttggtttggatctgaagagagaaggagga caatataaactgatgcctcataatccaaacgccagcctcactgatcttctcaacacaccc ctcccacctgctcctacgccatcacctgaactccacagaagacaccagacaaaggggtct tcatcatcaacagagaacaatgaagctacaggggagaccaaatcagtgcctgaaaaatct gaaggggaaaatggcgagaaagcacagaaaaagaaagaagagacggtgaaacggaaattc agacagcattactgtaaatctgatgagcctgatctgcaggagtcggccttctggaagaag atcatcgcttaccaacgcaagctgctgaactattttgcacgaaatttctacaacatgaga atgttggctttgtttgtggcctttgcaatcaactttattctgctgttttacaaggtgtcc acatcgtcagccgaagggaaggaagtgttgttcagcacatcctcagacaccagcgtgcgg tgggacccgctgggcagctcaagcagtcgccccgtcactgtgcactttgtcctggaggag agcagcgggtacatggagcccacactgaggattctggccattctacacaccgtcatctca ttcttctgtatcatcggatactactgcttgaaggttcctctggtgatatttaagcgtgag aaggaagtggcgagaaagctggagtttgacggtctttacatcaccgaacagccgtcagag gacgatattaaaggtcaatgggatcgactagtcatcaatacacagtccttcccaaacaat tactgggataaatttgtcaagagaaaggtgatggataaatatggagagttttatggccat gatcggatcagtgagctactcgggatggataaagcagcgctggacttcagtgacgcacac gagaaaaagaaaccaaagagggacagttcactagccgcagtactgaactcgattgatgtc aagtatcagatatggaagttgggagtcgtgttcacagacaactcgttcctgtatctggcc tggtacatgagtatgtccattctcggccactacaataatttcttctttgccgctcatctg ttggacatcgccatgggctttaaaacacttagaactattctgtcttcagtcacacacaat ggcaaacagctggtcctgactgtaggtctgctggcggtcgtcgtgtatctctacacagtt gtggcttttaacttcttccgtaagttctacaataagagtgaagatggagaatcaccggat atgaagtgtgacgacatgctgacgtgctatatgttccacatgtatgttggcgttcgcgct ggcggtggaatcggcgatcaaattgaggatccggcgggtgacgaatatgagatctatcgc atcatcttcgacatcaccttcttcttctttgtcatcgtcatcctcctcgccatcattcag ggtctgattattgatgcatttggtgagctgagagaccaacaagaacaagtgaaagaagac atggagaccaagtgtttcatctgtggaattggaaatgattatttcgacacggttcctcat ggctttgagacgcacacgctacaggaacacaacctggccaactatctatttttctttatg tatctcatcaataaagatgaaacggagcacacgggccaggagtcttacgtttggaaaatg taccaggaaagatgctgggaattctttcctgctggtgactgtttccgcaaacaatatgag gatcagctcaattaa

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