Myxocyprinus asiaticus (Chinese sucker): 127426695 Help Entry 127426695         CDS       T08782                                  Name (RefSeq) ryanodine receptor 2   KO K04962   ryanodine receptor 2 Organism masi  Myxocyprinus asiaticus (Chinese sucker) Pathway masi04020   Calcium signaling pathway masi04260   Cardiac muscle contraction masi04261   Adrenergic signaling in cardiomyocytes masi04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:masi00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     127426695    04020 Calcium signaling pathway     127426695  09150 Organismal Systems   09153 Circulatory system    04260 Cardiac muscle contraction     127426695    04261 Adrenergic signaling in cardiomyocytes     127426695  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:masi04040]     127426695    04990 Domain-containing proteins not elsewhere classified [BR:masi04990]     127426695 Ion channels [BR:masi04040]  Voltage-gated cation channels   Ryanodine receptor    127426695 Domain-containing proteins not elsewhere classified [BR:masi04990]  EF-hand domain-containing proteins   Other EF-hand domain-containing proteins    127426695 BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 MIR SPRY Ins145_P3_rec RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_6 EF-hand_8 RNA_polI_A34 Motif Other DBs NCBI-GeneID:  127426695 NCBI-ProteinID:  XP_051529616 LinkDB All DBs Position 36:complement(998488..1203334) Genome browser AA seq 5054 aa AA seqDB search MTDGGEAEDEIQFLRTDDEVVLQCSAMVHKEQQKICLAAEGFGNRLCFLESTSNSKNVPP DLSICTFVLEQSLSVRALQEMLANTEERVEGHIDMEKWKFMMKTAQGGGHRTLLYGHAIL LRHSYSGMYLCCLSTARSSTDKLAFDVGLQEDTTGEACWWTIHPASKQRSEGEKVRVGDD LILVSVSSERYLHLSYGNGSLHVDAAFQQTLWSVAPICSGSEVAQGFLIGGDVLRLLHGH MDECLTVPSGEHGEEQRRAVHYEGGAVSIHARSLWRLETLRIAWSGSHIRWGQPFRLRHV TTGKYLSMMDDQGLLLMDKEKADVKSTAFCFRSSKEKLDCGQRKEVDGMGVPDIKYGDSV CYIQHVHTGLWLTYQSVDAKCARMGGVQRKAIMHHEGHMDDGLTLSRSQNEESRTARVIR STVFLFNRFIRGLDALSKKGKTSTIDLPIESVSLSLQDLIGYFQPPDEHLEHEDKQNRLR ALKSRQNLFQEEGMINLVLECIDRLHVYSSAAHFADVAGKEAGQSWKSILNSLYELLAAL IRGNRKNCAQFSSSLDWLISRLERLEASSGILEVLHCVLVESPEALNIIKEGHIKSIISL LDKHGRNHKVLDVLCSLCVCHGVAVRSNQHLICDNLLPGRDLLLQTRLVNQVSSMRPNIF LGVCEGSTQYRKWYYELIVDHVGPFVTAEATHLRLGWASTQGYCPYPGGGEGWGGNGVGD DLCSYGFDGLHLWAGCVARSVSSPNQHLLRAEDVVSCCLDLSAPSISFRINGQPVQGMFE NFNSDGLFFPVVSFSAGVKVRFLLGGRHGEFKFLPPSGYAPCFEAVLPREKLRVEHSQEY KQDCGKTRDLLGPTITLSQAAFTPTPVDTSQIVLPPHLERIREKLAENIHELWVMNKIEL GWTYGMVRDDNKRQHPCLVEFSKLPEQERSYNLQMSQETLKTLLALGCHVSVADERAAEK VRNLKLSSKYELSSGYKPAPMDLSHIKLASAQEAMVDKLAENAHNVWARDRIRQGWTYGI QQDIKNRRNPRLVPYVLLDERTKKSNKDSLREAVRTLLGYGYNLEAPDQDHAAQSDISNL SAERFRIFRTEKTYSVNGGKWYFEFEVVTAGEMRVGWARPGCLPDQELGSDELAFVFDGF KAQRWHQGNEHFGRPWQCGDVVGCMVDMNERTMMFTLNGEVLLDDSGSELAFKDFEVWEG FIPVCSLGVCQVGRMNFGKDVSTLKYFTICGLQEGYEPFAVNMNRELTMWISKRLPQFIP VPPNHEHIEVTRIDGTVESPPCLKVTQRSFGSQNSSTDIMFFRLSMPIECSEAFVRSPSG TLAANGSFFSSKKDLDDFETVSDFEVLMKNSHGHMSANGPQRERDEFNNHKDHNQEKPSK IKQRFMLKRMKPDMNSSNSSARLSEEVLADEREDCENLIQTSVYFYSVRIFPGQDPSSIW VGWVTSDFHQHDPAFELNKVRTVTVTLGDEKGKVHESIKRCNCYMVWGGESSSPSQGRNN NGLEIGCLVDTANGLLTFTSNGKELSTYYQVEPSTKLFPAVFAQATSPNVFQFELGRIKS VMPLSAGLFKSERKNVVPQCPPRLHVQFLTPVLWSRVPNQFLRSEVTKVNERLGWMVQSS EPLQFMTLHIPEENRSLDILELMEQRDLLKFHYHTLRLYSAICALGNNRVALALCSHVDE AQLLYAIQNKYMPGLLRTGYYDLLIDIHLSGYATARLMMNSEYIVPMTPETKSITLFPNE KKKHGLPGIGLSTSLQPRMRFTSPSFVGAIGGNHGSGVVAGGDCFQYSPEFPLETLKSRT MEMLTEAVREGSLHVRDPVGGSTEFMFVPLIKLFYTLLIMGIFHNGDLKTILQLIEPSVF SQDSGAESGPGTLEAEESSGRGRLEVGGAVEHSLRGKLPKEGLLQMKLPEPVKLQMCHLL QYLCDCQVRHRIEAVVAFSDDFVANLQDNQRFRYNEVMQALNMSAALTARKTKEFRSPPQ EQINMLLNFKDEKQDCPCPEDIREQLLQFHEDLMTHCGIETDDDKSGDDSDFTIRARLMS LVEKVTYLKKKMADLPKKKKLKKPSTLQQLISETMVRWAQESVIEDPELVRAMFVLLHRQ YDGIGGQVRALPKTYTINAVSVEDTINLLASLGQIRSLLSVRMGREEEKLMIHGLSDIMN NKVFYQHPNLMRALGMHETVMEVMVNVLGGGETKEITFPKMVANCCRFLCYFCRISRQNQ KAMFDHLSYLLENSSVGLASPSMRGSTPLDVAAASVMDNNELALALREPDLEKVVQYLAG CGLQSCVMLMSKGYPDIGWNPVEGERYLDFLRFAVFCNGESVEENANVVVRLLIRRPECF GPALRGEGGNGLLAAMEEAIKISEDPSRDGPSPTTEENRTLNDVIEEEEEDDTIHMGNAI MTFYAALIDLLGRCAPEMHLIHAGKGEAIRIRAILRSLIPIEDLVGVISISFLMPTLAKD GSVIEPDMSGGFCPDHKAAMVLFLDRVYGIEDQNFLLHLLEVGFLPDLRAAASLDTAALS ATDMALALNRYLCTAVLPLLTKCAPLFAGTEPFASLIDSLLHTVYRLSKGCCLTKAQRDV IEECLLAVCGKLRPSMMQHLLRRLVFDVPVLNEHTKMPLKLLTNHYERCWKYYCLSGGWS SFGVASDEELHLSRKLFWGIFDALARKKYDVELFKLALPCLSAVGGALPPDYMESNYVAM MEKQSSMDAEGNFNPQPADASSVVVPEKLDHFINKYAEYSHEKWSMEKFAVGWVHGDQKC ESSKVHPLLKPYKCLSEKDKEAYRWPIRESLKTMLSWGWSIERTRESDASTLHNRTRRIS LSSQRSIEGAYGFSPQPVDMSNVTLSRDLHSMAELLAENYHNIWAQKKKLELESKGGGSH PLLVPYDTLTAKEKSKDREKAQDILKFFQINGYTVSRAVKEQDLDTPSIEKRFAYTFLQQ LITYVDEAHEHMLEFDVGIRSKGDKIPHEQQVKFFGKVVLPLVDQYFKNHRLYFLSTAVR PISSGGHASNKEKEMVTSLFCKLGVLVRHRISLFGNDATSIVNCLHILGQTLDARTVMKT GQDSVKAALWVFFGNAAEDLEKTMENLRQGQFTHTRTQPKGVTQIINYTTVALLPVLSSL FEHIGQNLFGEDLILDDVQVFCYRILNSLYSLGTSKSIYVERQRPALGECLAAFAGAFPV AFLEPSLNKHNTYSIYNCKSSRERAALGLPAQVEELCALVPSLERALEEIMELAESGMRY TQMPHVMEVLLPMLCSYMSHWWEHGPESDPERSESCCTSLTSDHMNTLLGNILKIIYNNL GIDEGAWMKRLAVFSQPIIGKAKSQLLKTHFLPLMEKLKKKAATVLQDEEHMKAEGRGEM AESELLILDEFTILVRDLYAFYPLLIRFVDYNRAKWLKEPNQEAEELFRMVAEVFIFWAK SHNFKREEQNFVVQNEINNMSFLITDTKSKMSKGAVSDQERKKMKKRGDRYSLQTSLIVA ALKRLLPVGLNICAPGDQELIALAKSRFTQKDTEDEVRETVRNNLHLQGKYRALHFKKLA KKLIIILKWVKSRQHKPAMAEILPRKWLLLRNRSATLDVTQRPPRMPPSQLKKASSVDFS CKQLKGTLEDPAIRWQMALYKDMPNRTEDTSDPEKTVERVLNIAHVLFHLDQVEHPQRSK KAVWHKLLSKQRKRAVVACFRMAPLYNLPRHRAVNLFLQGYEKSWIETEEHYFEDKLIED LAKAGGEEPSEEDETTKRIDPLHQLIQLFSRTALTEKCKLEEDHLYMAYADIMAKSCHDE EDEEEIKSFEEKEMEKQKLLYQQARLHDRGAAEMVLQTISASKGEMGPMVASTLKLGIAI LNGGNSTVQQKMLDYLKDKRDVGFFQSLAGLMQSCSVLDLNAFERQNKAEGLGMVTEEGS VNTHERGEKVMQDDEFTCDLFRFLQLLCEGHNSDFQNYLRTQTGNNTTVNIIISTVDYLL RVQESISDFYWYYSGKDVIDEQGQRNFSKAINVAKQVFNTLTEYIQGPCTGNQQSLAHSR LWDAVVGFLHVFAHMQMKLSQDSSQIELLKELMDLQKDMVVMLLSMLEGNVVNGTIGKQM VDMLVESSNNVEMILKFFDMFLKLKDLTSSDAFKEYDPDGKGVISKRDFHKAMESHKHYT QSETEFLLSCAETDENELLDYEEFVERFHEPAKDIGFNVAVLLTNLSEHMPHDSRLQTFL ELAESVLNYFQPFLGRIEIMGSAKRIERVYFEISESSRTQWEKPQVKESKRQFIFDVVNE GGEKEKMELFVNFCEDTIFEMQLAARMSDAGERSASKEDSEREKPEEENTEMGFFSVTTV RTALFALRYNVILLMKVLSMKSLKKQVKKVKKMTVKDMVTTLVSFYWSVLLGLLHFAFSV ARGFFRIIYNSFLGGSLVEGAKTMKVSELLANMPDPTQDEVRGETEEGEKKFADRTSPEE DLADLTVATDDTDLLSDIFGLDLKREGGQYKLMPHNPNASLTDLLNTPIPPAPTPSPELR RRHQTKGSSSSTENNEATVEAKSVPEKAEGENGEKAQKKKEETVKRKVRRHYCKSDEPDL QESAFWKKIIAYQRKLLNYFARNFYNMRMLALFVAFAINFILLFYKVSTSSAMTEGKEVL FSMSSDTSVRWDPLGGSSSRPVNVHFVLEESSGYMEPTLRILAILHTVISFFCIIGYYCL KVPLVIFKREKEVARKLEFDGLYITEQPSEDDIKGQWDRLVINTQSFPNNYWDKFVKRKV MDKYGEFYGHDRISELLGMDKAALDFSDAHEKKKPKRDSSLAAVLNSIDVKYQIWKLGVV FTDNSFLYLAWYMSMSILGHYNNFFFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGL LAVVVYLYTVVAFNFFRKFYNKSEDGESPDMKCDDMLTCYMFHMYVGVRAGGGIGDQIED PAGDEYEIYRIIFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVKEDMETKCFICGI GNDYFDTVPHGFETHTLQEHNLANYLFFFMYLINKDETEHTGQESYVWKMYQERCWEFFP AGDCFRKQYEDQLN NT seq 15165 nt NT seq  +upstreamnt  +downstreamnt atgacggacggcggagaagccgaagacgagatccagttcttaaggaccgatgatgaggtg gtgttacagtgttcagcaatggttcacaaggagcagcagaaaatctgtctggctgctgaa gggtttggaaacagactgtgtttcctggagtccacatccaactcaaagaatgttcctccg gatctgtccatatgtacgtttgtgttggagcagtcgctgtcagtacgagcgctgcaggag atgctcgcgaacacagaggagcgagtggaggggcacatagacatggagaaatggaaattc atgatgaagacagcacagggcggaggtcaccggacgctgctgtacggtcacgcaatctta ctgagacactcctacagcggaatgtatctgtgctgtctgtccacggctcgctcatccaca gataaactggcgtttgacgtggggcttcaggaagacacgacaggtgaggcgtgctggtgg accatacaccccgcgtccaagcagaggtcagagggcgagaaagtgcgagtgggcgacgac ctcatcctggtcagtgtgtcgtctgaacgatacctgcacttgtcttacggtaacggcagt ttacacgtggacgcagcgtttcaacagacgctctggagtgtcgcgccgatctgctccggg agtgaagtggctcaggggttcctgattggtggagatgttctccggctgcttcatggtcac atggacgagtgtctgaccgtcccgtcaggagaacatggagaggaacagcgcagggcggta cattacgagggtggagccgtgtccattcacgcgaggtctctctggagactggagacgctg cgaatagcgtggagcggtagtcatatccgctggggtcagccgttccggttacgtcatgtg accactgggaaatatctgagcatgatggatgatcaagggctgctgctaatggacaaagag aaagcagacgtcaaatcaacagctttctgcttccgttcctcaaaagagaagctggattgt ggtcagaggaaggaagtggatggaatgggtgttccggacatcaaatacggcgactctgtg tgttacatccagcatgtgcacactggactctggctcacctatcaatcagtggatgccaag tgtgcccgcatgggcggagtccagagaaaggccatcatgcatcatgaagggcacatggat gatggattaacattgtcgcgatcacaaaacgaagaatcgcgcacagctagagtcatacgc agcactgtcttcctctttaaccgctttatcaggggtctggatgctctgagtaaaaaagga aaaacctccacgattgatctgccaatcgaatcggtcagtctgagtcttcaggatctgatt ggctacttccagccacctgacgagcacctggagcacgaggacaaacagaaccgcctgcga gcgctcaagagccgacagaacctgttccaggaggagggaatgataaacctggtgctggag tgcatcgatcgtttgcatgtgtacagcagtgcggctcatttcgcagatgtggccgggaaa gaagcgggacaatcctggaaatccatcctgaactccctgtacgagctcctggcggctctg atcagaggaaacaggaagaattgtgcccagttttctagctctctggattggctgatcagt cgtctggagaggttggaagcctcatctggaattctggaggttcttcattgtgttctggtg gagagtccagaagctctgaacatcattaaagagggccacatcaaatccatcatctcttta ctggacaaacacggacgcaaccacaaggttctggatgtgttgtgttctctgtgtgtgtgt catggtgtggcagttcgctctaatcagcacctgatctgtgataacctgctgccggggaga gacctgctgctgcagacacgactcgtcaatcaagtcagcagtatgaggcccaatatcttc ctgggtgtgtgcgaaggctccacccagtacaggaagtggtattatgaactcatagtggat catgtgggtccatttgttactgctgaggccacacacctgcggttgggctgggcgtccact cagggctactgtccttacccgggcgggggagaaggctggggtggcaatggtgtcggggat gacctttgctcttatggatttgatgggctacacctgtgggcaggttgtgtggcgcgctct gtgagctctcccaatcagcacctgctgcgggcggaggacgtggtgagctgctgtctagat ctgagcgctccgagcatctcattccgtatcaatggccagcccgtccagggaatgtttgag aacttcaactcagatggactctttttccctgtcgtgtccttctctgctggagtcaaagtg cgcttcctgttgggcggtcgccatggagagtttaagttcctgcctccgtccggttacgct ccgtgtttcgaggctgttttaccacgagaaaaactgcgagtggaacacagtcaggagtat aaacaagattgcggaaaaacacgtgaccttctgggacccacgatcacactgtcacaagct gccttcacaccaacacctgtagataccagtcagattgtgttgccaccacatcttgagcga attcgagagaaactggcagaaaacatccatgagctgtgggtgatgaacaagattgagctc ggatggacctacgggatggttagagatgataataagcgacagcatccgtgtctggtggag ttctccaaacttcctgaacaagagcgcagctacaacctacagatgtctcaggagacacta aaaactcttctggctctgggctgtcatgtcagtgtggcggatgaacgagcagctgagaaa gtcagaaatctgaaactttcttccaaatacgagctgtccagtggttataaacccgcaccg atggatctgagccacatcaaactggcatctgctcaagaggccatggtggacaaactggcc gagaacgctcataatgtttgggccagagatcgcatacggcagggctggacctacggcata cagcaggacattaagaacaggaggaatcctcgtttggttccttacgttcttctggacgag agaacgaagaaatcaaacaaggacagtctgcgtgaagccgtgaggacattactggggtac ggctacaatctagaagcccccgatcaagatcatgcagctcagtcagacatcagtaatctc tccgcggagcgcttcaggattttccgaacggagaagacgtacagtgtgaacggggggaag tggtattttgagtttgaggtggtgacggcgggcgagatgcgggtgggctgggcaagaccc gggtgcctcccggatcaggagctgggatcagatgaactggcctttgtcttcgatggattc aaggctcagcgctggcaccagggtaacgagcactttgggcgtccgtggcagtgtggtgat gtcgtcggctgtatggtagacatgaatgaacgcaccatgatgttcacgctgaacggcgag gtgctgctcgatgactctggctctgaactcgctttcaaagactttgaggtttgggagggt ttcatccccgtgtgtagtctgggtgtgtgtcaggtcggccgtatgaacttcggtaaggac gtgagcactctgaagtatttcaccatctgtggtctgcaggaggggtacgaacccttcgcc gtcaacatgaaccgagagctgaccatgtggatcagcaaacgtctgccgcagtttattccc gtaccgcccaaccatgagcacatagaggtcacacggatcgatgggacagtggagagtcct ccgtgcctaaaagtcacccagagatcattcgggtcccagaacagcagcacagacatcatg ttctttcgactgagcatgcccatcgagtgctcggaggcgttcgtcagatctcccagtggt acgttggcagccaacggcagtttcttctcttcaaagaaagatctggatgattttgagacg gtgtcggactttgaggttctgatgaagaattcacacggtcacatgagtgccaacgggccg cagagagaacgagacgaattcaacaaccataaagatcataatcaagagaaaccatcgaaa atcaaacaaaggttcatgttgaagagaatgaagccagacatgaacagcagtaactccagt gctcgtttatcagaggaagttttggctgatgagcgagaggattgtgagaatctcatacaa acttcagtgtatttctactcagtgaggatattccccggtcaggacccttccagcatttgg gttgggtgggtgacctctgactttcatcagcacgatccggcctttgaactcaacaaagtc agaacggtcaccgttaccctgggagacgagaagggcaaagttcacgagagtattaaacgc tgtaactgctacatggtttgggggggtgagagcagcagtcccagtcagggacgcaataat aacggactggagatcggatgtttggtggatacagccaacggcctcctcacgttcacctcc aacggcaaagagctcagtacatactatcaggtggagcccagcacgaaacttttccccgca gtgtttgcgcaggccacaagtccaaacgtcttccagttcgaactgggacgcatcaagagc gtgatgcctctctctgcagggctgtttaaaagcgagcggaagaatgtcgtccctcagtgt ccaccgcggttacatgtgcagttcctcacacctgtgttatggagtcgtgtgcccaatcag ttcttgaggtcagaagtcaccaaggtcaacgagagacttggctggatggttcagagttca gaacccctgcagttcatgaccttacatatacctgaagaaaacaggtcgctggatattctt gagttgatggagcagcgagacctgctgaagtttcactatcacacgctgcgtttatattcc gcgatctgtgctttggggaacaaccgagtagctctcgcgctctgcagtcacgtagatgag gcgcagctactgtacgctatccagaacaaatacatgccgggccttctgcgcaccggatat tatgacctgctcatcgacatccacctgagcggttacgccacggcccgacttatgatgaac tctgagtacattgttcccatgacacccgagaccaaaagcattacactgtttccaaacgag aagaagaaacacgggctgccgggaatcggactgagtacatcactgcaaccgcgtatgcgc tttacatcaccgagctttgtaggggctattggtggtaaccatggtagcggtgtggtcgcc gggggggactgttttcagtacagcccggagtttccgctggaaacgctgaagagtcgtacg atggagatgctgacggaagcagtgcgcgaaggtagtttacatgtgcgtgatcctgtaggg ggcagcactgagttcatgttcgttccgctcattaaactcttctacacgcttcttatcatg ggcatctttcataacggagatctgaagaccatcctgcagttgatcgagcctagcgtgttt tctcaggactctggggccgagagtggccccgggaccctagaggccgaggagagctctggg cggggccgattagaggtgggcggagctgtcgagcacagtctgagaggaaagctgcccaaa gaaggactgttacagatgaaacttcctgagcctgtcaaacttcagatgtgtcacctgctt cagtatctgtgtgactgtcaggtgcgtcatcgtatcgaggcagtggtcgcgttctctgat gactttgtggcaaatcttcaggataatcagcgtttccgctataatgaagtgatgcaggcg ttaaacatgtctgccgcgctcactgcacgcaaaaccaaagagttccgctcaccgccacag gaacagatcaacatgctgctgaattttaaggatgagaagcaggattgtccgtgtcctgaa gacatcagagaacaactgctgcagttccatgaagatctcatgactcactgcggcattgag acggatgatgataaatcaggagatgacagtgatttcactatcagagctcgtctgatgtca ctggtagagaaggtgacgtacctgaagaagaaaatggctgatttaccgaagaaaaagaaa ttaaagaagccgagcactctgcagcagttgatctcagagacgatggtccggtgggctcag gaatccgtcatcgaggaccctgagcttgtccgtgcgatgtttgtgttacttcaccgtcag tatgatgggatcggtggacaggtgcgagcgctgcctaaaacctacaccatcaacgccgtg tctgtggaggacaccattaacctgctggcgtctctgggtcagatcagatcgctgctcagc gtcaggatggggcgagaagaagagaaactcatgattcacggactcagtgacatcatgaac aataaggtgttttatcagcatccaaacctgatgcgagcgctcggcatgcacgagacagtg atggaggtgatggtgaatgtgctgggaggaggagaaaccaaagaaatcacatttcctaag atggtggcaaactgctgtcgtttcctgtgttacttctgtcgcatcagtcgtcagaatcag aaggccatgtttgatcatctgagctatctgctggagaacagtagcgtgggactcgcgtct ccctccatgcgaggttcaactcctctggatgtcgctgctgcatcagtgatggataataat gaactggcgctggcgctgagagaacccgacttggagaaggtggtccagtatctagcgggt tgtggtcttcagagttgtgtgatgctgatgtctaaaggctatccagacatcggctggaac ccggtagagggggagcgatacctcgacttcttgagatttgcagtcttctgtaacggagag agtgtggaggagaatgctaatgtggtggtgcggctcctgattcgccggccggagtgtttt ggccccgccctgcgcggtgagggcgggaatggactgcttgcggcgatggaggaggccata aagatctcagaagatcccagtagagatggaccatcacctaccacagaggagaacagaaca cttaatgatgtcattgaggaagaggaggaagatgacactattcacatgggaaatgccatc atgaccttctatgctgcactgatcgatctgttgggccgctgcgctccagagatgcatttg atccacgcagggaagggagaggccatccgtatccgagcaatcctgagatctctcattccc attgaagatctggttggggtgatcagtatttcattcctgatgccgaccctagctaaagat gggtctgtgattgagccggacatgtccggaggcttctgtccggatcataaagccgcaatg gttctgtttctggaccgagtttatggcatcgaggatcagaacttcctgctacatctgctg gaagtgggcttcctgcccgacctcagagctgccgcctcattggacacggctgccctgagc gctacagacatggcgttggctctgaaccggtatctgtgtacggccgttctgccgctgctg actaaatgtgctcctctgtttgcggggacggagccgtttgcgtctctcattgactctctg ctgcacactgtctacagactgtcgaaaggctgctgtctcaccaaagcacagagagatgtt atagaggagtgcctgctcgctgtgtgcggtaaactacggccttctatgatgcagcatcta ctgaggcgtctggtgtttgatgttcctgtgttgaatgaacacacaaagatgccgctgaag ctcttgaccaatcactatgagcgctgctggaagtattactgtctgtccggcgggtggagc agttttggtgtggcgtcagatgaggagcttcacctctccagaaaactcttctggggaatc tttgatgctctggccagaaagaaatatgatgtggagttgtttaagttggcattgccgtgt ctgagcgcggtgggcggagctttacctcctgattacatggagtcaaactatgtggcgatg atggagaaacagtcatcgatggacgccgaaggaaacttcaaccctcaaccagccgacgcc agcagcgttgttgttcctgagaaactcgatcatttcatcaataaatatgcagaatattct catgagaaatggtcaatggagaagtttgctgttggttgggttcatggagatcagaagtgt gaatcatctaaagttcatcctctgctgaagccctacaaatgtctctctgagaaggataag gaggcttaccgctggccaatcagagagagtctgaagacgatgctgtcgtggggatggagc atcgagagaacgagagagagcgacgcatccacattacacaaccgcacacgcagaatatct ctgtccagtcagcggtctatagaaggggcttacgggttcagcccgcagcctgttgacatg agcaacgtcacgctatccagagacctgcattcgatggcggagctgctggcggagaactat cacaacatctgggctcagaagaaaaaactggagctggaatctaaaggtggggggagtcac ccgttactggttccttacgacactttaaccgccaaagagaaatccaaagatcgggaaaaa gcacaagacatccttaaattctttcagatcaacggatacaccgtgtcaagggctgtgaaa gaacaggatctggacactccgtctatagagaagcgctttgcgtacacgtttctgcagcag ctgatcacgtatgtggatgaagcccatgaacacatgctggaattcgatgttggaatacga tctaaaggggacaaaatcccccacgagcagcaggtcaagttctttggaaaggttgtgttg ccgttggtggatcagtattttaaaaaccaccggctctacttcctgtctactgcagttcgg ccgatcagcagcggcggtcacgcctccaataaagagaaggagatggtgaccagtcttttc tgcaaactgggagttctggtcagacacaggatatctctgtttgggaatgatgccacctcc atagtgaactgtcttcacatactgggtcagacgctggatgccaggaccgtgatgaaaaca ggtcaggactccgtcaaagcggccctgtgggtattttttggtaatgcagcagaagatctg gagaagacgatggagaacctgcgacagggtcagttcacgcacacgcgcacgcaaccgaaa ggcgtcacacagatcataaactacacgaccgtcgcgctgctgcccgttctctcctcgctg tttgaacacatcggacaaaacctgtttggagaagacctgattttggatgacgtccaggtg ttctgctatcggattttaaacagtttgtactcacttggaaccagtaaaagtatttatgtt gagaggcaaagacccgctctgggtgagtgtctggctgcgtttgcgggtgcatttcctgtg gccttcctggagcccagtctgaataaacacaacacttactccatatacaactgcaaaagc tccagagagagagcagcgttaggtctgcctgctcaggtggaggagttgtgtgcgctggtg ccatctctggagagggctctcgaggagatcatggagctggcggagtctggcatgcgttac acacagatgccccatgtgatggaggtcctgctgccgatgctctgcagttacatgtcgcac tggtgggaacacggacctgagagtgacccggagcgatcagagagctgctgcacctcactg acctctgaccacatgaacacactgctggggaacatcctcaaaatcatctacaacaacctg ggcatcgatgaaggagcctggatgaagagactcgcagtgttttctcagcccatcatcggt aaagcaaagtctcagctcctgaagactcacttcctgcctctgatggagaagctgaagaaa aaagcagcgacggttcttcaggatgaggagcacatgaaggccgagggcagaggagagatg gcagagtcagaacttctcatcctggatgagttcaccatcctcgtgagagatctgtacgcg ttctaccctctgctcattcgattcgtcgattacaacagagccaaatggctgaaagaaccg aatcaagaggctgaggaattattccgtatggtggcggaagtctttatattctgggccaaa tcacacaactttaagagagaggagcagaactttgtagttcagaatgaaatcaacaacatg tccttcctcatcactgacaccaaatccaaaatgtctaagggtgcagtatcagaccaggag aggaaaaagatgaagaaacgtggcgatcgatactcactgcagacgtcattgatcgtcgcc gctctcaagaggttacttcctgtcgggctgaatatctgtgcaccgggagatcaggagctg atcgcactcgccaagagccgctttacacagaaagacactgaagacgaggtacgagagacc gtcaggaacaacctgcacctgcaggggaagtaccgcgctttacacttcaaaaagctggcg aagaaactcattattatattgaagtgggtgaagagtcgtcagcataaacccgccatggca gaaatccttcctcgcaaatggctgctgttgcgcaatcgctccgcaaccctggacgtgacc cagagacccccgcgcatgcccccgtcccagctgaagaaggcatcttctgtggatttttcg tgtaaacaattgaaaggcactttggaggatcctgctatccgctggcagatggcgctctat aaagacatgcccaaccgcaccgaagacacctctgaccctgagaagactgtcgaaagggtg ctgaacattgctcatgtgctcttccacctggatcaggttgaacatcctcagaggagtaag aaagccgtgtggcacaagcttctttccaaacagaggaagagagctgtggttgcctgcttc aggatggcacctctttacaacctgcccaggcatcgtgctgtaaacctgttcctgcagggt tacgagaagtcctggatcgagacagaggaacattattttgaagacaagctgatagaggat ttggctaaagcaggtggtgaagagccatcagaggaagacgagaccaccaaacgcatagac ccattacaccagctcatacaactgttcagcagaactgcactgacagagaaatgtaaacta gaagaagatcatctctacatggcctatgctgatattatggccaagagttgtcatgatgaa gaggatgaggaagagatcaagagttttgaggagaaagagatggagaagcagaagctgttg tatcagcaggcgagacttcacgaccgcggagcggcagagatggtactgcagaccatcagc gccagcaaaggtgagatggggccgatggtggcctctaccctgaagctgggcatcgctata ctcaatggaggaaactcaactgtacagcagaaaatgctggactacctgaaagacaaaaga gacgtggggttctttcagagtcttgctggactcatgcagtcgtgcagtgttttggatctg aacgcatttgagagacagaataaagctgaaggtctcggtatggtgacagaggaaggatca gtcaacactcatgagcgtggtgaaaaggtcatgcaagatgacgaattcacctgtgacctc ttccgcttcctacagctgctctgtgagggtcacaactcagattttcagaactacctgaga acacagacgggcaacaacacaacggtcaacatcatcatctctacagtggattacctgctc agagtccaggagtccattagtgatttctactggtactactctgggaaagatgtgattgat gaacaaggccagcggaatttctccaaagctatcaatgtagccaaacaagtcttcaacact ctcacagagtacattcagggcccttgcacggggaaccagcagagtcttgctcacagtcgc ctgtgggatgcagttgttggtttcctgcatgtttttgcacatatgcagatgaagctgtct caggattcaagccaaatcgagctgttgaaggagctgatggatcttcagaaggacatggtt gtgatgctcttgtccatgttggagggaaatgttgtgaatggtaccattggaaagcagatg gtggacatgttagtggagtcctccaacaatgttgagatgattctcaagttctttgacatg ttcctcaaattgaaagacttgacgtcgtcagatgccttcaaagagtacgaccctgatggc aaaggggtcatatccaagagggatttccacaaggccatggagagccataaacactacacc caatctgagacggagttcctcctgtcctgcgcagaaacagatgaaaatgagctgttggac tacgaagagtttgtcgaacgcttccacgagccagcgaaggacatcggcttcaacgttgct gttctcctgactaatctctctgaacatatgccccacgattctcgcctccaaaccttcctg gagctcgcagagagcgttctgaactatttccaaccgtttctgggccgcatcgagatcatg ggcagtgccaagcggatcgagcgcgtgtactttgagattagcgagtcaagtcgcacccaa tgggagaagccgcaggttaaggagtccaaacggcagttcatctttgatgttgtaaacgag ggtggtgagaaagagaaaatggagctctttgtgaacttctgtgaggacaccatctttgag atgcagctggctgcgcggatgtcggacgccggcgaacgctcggctagcaaagaggacagt gagagggaaaagccagaagaagagaacactgagatgggtttcttctccgtcaccactgta cggacagccctgtttgccctccgatacaacgtgattcttctgatgaaggtgctttccatg aagagcctgaagaagcaggtgaagaaagtgaagaagatgacggttaaggacatggtgacc acactcgtgtccttctactggagcgtcctgctgggtctgctgcactttgccttcagcgtc gctcgaggattcttccggatcatctacaacagctttctcggagggagtctggtggaggga gccaagaccatgaaggtgtccgagctcctggccaacatgcccgacccaacacaggatgaa gttagaggagagacggaagagggcgagaagaagtttgcggacagaacctcaccagaggaa gatctggctgatctgacggtggccacagatgacactgatctcctgtctgatatatttggt ttggatctgaagagagaaggaggacaatataaactgatgcctcataatccaaacgccagc ctcactgatcttctcaatacacccatcccacctgctcctacgccatcacctgaactccgc agaagacaccagacaaaggggtcttcgtcttcaacagagaacaatgaagctacagtggag gccaaatcagtgcccgagaaagctgaaggggaaaatggcgagaaagcacagaaaaagaaa gaagagacggtgaaacggaaggtcagacggcattactgtaaatcagatgagcctgatctg caggagtcggccttctggaagaagatcatcgcttaccaacgcaagctgctgaactatttt gcacgaaatttctacaacatgagaatgttggctctgtttgtggcctttgcaatcaacttt attctgttattttataaggtgtccacatcgtcagccatgacagaggggaaagaagtgttg ttcagcatgtcctccgacaccagcgttcggtgggacccgctgggcggctctagcagtcgc cccgtcaatgtgcactttgttctggaggagagcagtgggtacatggagcccacactgagg attctggccattctacacaccgtcatctcattcttctgtattattggatactactgcctg aaggttcctctggtgatatttaagcgtgagaaggaagtagcgagaaagctggagtttgat ggtttgtacatcactgaacaaccatcagaggacgatattaaagggcaatgggatcgactg gtcatcaatacacagtccttcccaaacaattactgggataaatttgtcaagagaaaggtg atggataaatatggagagttttatggccatgatcgtatcagtgagcttctcgggatggat aaagccgcgctggacttcagtgacgcacacgagaaaaagaaacccaagagagacagttca ctagccgcagtactgaactcgatcgatgtcaagtatcagatatggaagttgggagtcgtg ttcacagacaactcgttcctctatctggcctggtacatgagcatgtccattctcggccac tacaacaatttcttctttgccgctcatctcttggacatcgccatgggctttaaaacgctc aggactattctgtcttcagtcacacacaacggcaaacagctggtcctgactgtaggtctg ctggcggtcgtcgtgtatctgtacacagttgtggcttttaacttctttcgtaagttctac aataagagtgaagacggagaatcgccggatatgaagtgtgacgacatgctgacgtgctat atgttccacatgtatgttggcgttcgtgctggtggtggaatcggtgatcaaatcgaggat ccggcgggtgacgagtacgagatctatcgcatcatcttcgacatcaccttcttcttcttc gtcatcgtcatcctcctcgccatcattcagggtctgatcattgatgcatttggtgagcta agagaccaacaagagcaagtgaaagaagacatggagacgaaatgttttatctgtgggatt ggaaatgattatttcgacacggttcctcacggctttgagacgcacacgctacaggaacac aacctggccaactatctatttttctttatgtatctcatcaataaagatgaaacggagcac acggggcaggagtcatacgtttggaaaatgtaccaggaacgctgctgggaattctttcct gctggtgactgtttccgcaaacaatatgaggaccagctcaattaa

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