Mesocricetus auratus (golden hamster): 101829120 Help Entry 101829120         CDS       T08306                                  Symbol Ryr3 Name (RefSeq) ryanodine receptor 3 isoform X1   KO K04963   ryanodine receptor 3 Organism maua  Mesocricetus auratus (golden hamster) Pathway maua04020   Calcium signaling pathway maua04371   Apelin signaling pathway maua04713   Circadian entrainment maua04921   Oxytocin signaling pathway maua04970   Salivary secretion maua05010   Alzheimer disease maua05012   Parkinson disease maua05020   Prion disease maua05022   Pathways of neurodegeneration - multiple diseases Brite KEGG Orthology (KO) [BR:maua00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     101829120 (Ryr3)    04020 Calcium signaling pathway     101829120 (Ryr3)  09150 Organismal Systems   09152 Endocrine system    04921 Oxytocin signaling pathway     101829120 (Ryr3)   09154 Digestive system    04970 Salivary secretion     101829120 (Ryr3)   09159 Environmental adaptation    04713 Circadian entrainment     101829120 (Ryr3)  09160 Human Diseases   09164 Neurodegenerative disease    05010 Alzheimer disease     101829120 (Ryr3)    05012 Parkinson disease     101829120 (Ryr3)    05020 Prion disease     101829120 (Ryr3)    05022 Pathways of neurodegeneration - multiple diseases     101829120 (Ryr3)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:maua04040]     101829120 (Ryr3) Ion channels [BR:maua04040]  Voltage-gated cation channels   Ryanodine receptor    101829120 (Ryr3) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 MIR SPRY Ins145_P3_rec RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_6 EF-hand_8 EF-hand_5 Motif Other DBs NCBI-GeneID:  101829120 NCBI-ProteinID:  XP_040601940 UniProt:  A0A3Q0D1N0 LinkDB All DBs Position Unknown AA seq 4870 aa AA seqDB search MAEAGEGGEDEIQFLRTEDEVVLQCIANIHKEQRKFCLAAEGLGNRLCFLEPTSEAKYIP PDLCVCNFVLEQSLSVRALQEMLANTIENGGEGAAQGGGHRTLLYGHAILLRHSFSGMYL TCLTTSRSQTDKLAFDVGLREHATGEACWWTIHPASKQRSEGEKVRIGDDLILVSVSSER YLHLSISNGSIQVDASFMQTLWNVHPTCSGSSIEEGYLLGGHVVRLFHGHDECLTIPSTD QNDSQHRRVFYEAGGAGTRARSLWRVEPLRISWSGSNIRWGQAFRLRHLTTGHYLALTED QGLLLQDRGKSDTKSTAFSFRASKEIKEKLDSSHKRDTEGMGVPEIKYGDSICFVQHLAS GLWVTYKAQDAKTSRLGPLKRKVILHQEGHMDDGLTLQRCQREESQAARIIRNTTALFSQ FVSGNNRTTAPVTLPIEEVLQTLQDLIAYFQPPEEEMQHEDKQNKLRSLKNRQNLFKEEG MLALVLNCIDRLNIYNSVAHFAGIAREESGTAWKEILNLLYKLLAALIRGNRNNCAQFSN NLDWLISKLDRLESSSGILEVLHCILTESPEALNLIAEGHIKSIISLLDKHGRNHKVLDV LCSLCLCNGVAVRANQNLICDNLLPRRNLLLQTRLINDVTSIRPNIFLGVAEGSPQYKKW YFELIIDQVEPFLTAEPTHLRVGWASSSGYAPYPGGGEGWGGNGVGDDLYSYGFDGLHLW SGRIPRAVASINQHLLKSDDVVSCCLDLGVPSISFRINGQPVQGMFENFNTDGLFFPVMS FSAGVKVRFLMGGRHGEFKFLPPSGYAPCYEALLPKEKMRLEPVKEYKRDADGVRDLLGT TQFLSQASFIPCPIDTSQVVLPLHLEKIRDRLAENIHELWGMNKIELGWTFGKIRDDNKR QHPCLVEFSKLPETEKNYNLQMSTETLKTLLALGCHIAHVNPAAEEDLKRVKLPKNYMMS NGYKPAPLDLSDVKLLPPQELLVDKLAENAHNVWAKDRIKQGWTYGIQQDLKNKRNPRLV PYVLLDERTKKSNRDSLREAVRTFVGYGYNIEPSDQELVADPTVEKVSIDKIRFFRVERS YAVKSGKWYFEFEVVTGGDMRVGWARPGCRPDIELGADDQAFVFEGSRGQRWHQGSGYFG RTWQPGDVVGCMINLDDASMIFTLNGELLITNKGSELAFADYEIENGFVPICSLGLSQIG RMNLGTDASTFKFYTMCGLQEGFEPFAVNMNRDVAVWFSKRLPTFVNVPKDHPHIEVVRI DGTMDSPPCLKVTHKTFGTQNSNASMIYCRLSMPVECHSSFSHSPCLDSEAFQKRKQMQE ILSHTTTQCYYAIRIFAGQDPSCVWVGWVTPDYHLYSEKFDLNKNCTVTVTLGDERGRVH ESVKRSNCYMVWGGDIVASSQRSSRSNVDLEIGCLVDLSMGMLSFSANGKELGTCYQVEP NTKVFPAVFLQPTSTSLFQFELGKLKNAMPLSAAIFKSEEKNPIPQCPPRLDVQTIQPVL WSRMPSSFLKVETERVSERHGWVVQCLEPLQMMALHIPEENRCVDILELCEQEDLMQFHY HTLRLYSAVCALGNSRVAYALCSHVDLSQLFYAIDNKYLPGLLRSGFYDLLISIHLANAK ERKLMMKNEYIIPITSTTRNIRLYPDESKRHGLPGVGLRTCLKPGFRFSTPCFVVTHEEH QKQSPEIPLEILKTKALSMLTEAVHCSGAHIRDPVGGSVEFQFVPVLKLIGTLLVMGVFD DDDVRQILLLIDPSVFGEHSGETEEGAEKEVTQVEEKAVEAGEKASKEAPVKGLLQTRLP ESVKLQMCELLSYLCDCELQHRVEAIVAFGDIYVSKLQANQKFRYNELMQALNMSAALTA RKTREFRSPPQEQINMLLNFHLGENCPCPEEIREELYDFHEDLLVHCGVPLEEEEEEEED TSWTGKLRALVYKIKGPPKPEKEQPTEEEERYPTTLKELVSQTMIRWAQENQIQDAELVR IMFNLLRRQYDSIGELLQALRKTYTISQASVSDTINLLAALGQIRSLLSVRMGKEEELLM INGLGDIMNNKVFYQHPNLMRVLGMHETVMEVMVNVLGTEKSQIAFPKMVASCCRFLCYF CRISRQNQKAMFEHLSYLLENSSVGLASPSMRGSTPLDVAASSVMDNNELALGLEEPDLE KVVTYLAGCGLQSCPMLLAKGYPDVGWNPIEGERYLSFLRFAVFVNSESVEENASVVVKL LIRRPECFGPALRGEGGNGLLAAMQGAIKISENPALDLPSQGYKTEVSEDDEEEEETVHM GNAIMSFYSALIDLLGRCAPEMHLIQTGKGEAIRIRSILRSLVPTEDLVGIISIPLKLPS LNKDGSVSEPDMAANFCPDHKAPMVLFLDRVYGIKDQTFLLHLLEVGFLPDLRASASLDT VSLSTTEAALALNRYICSAVLPLLTRCSPLFSGTEHCTSLIDSTLQTIYRLSKGRSLTKA QRDTIEECLLAICNHLRPSMLQQLLRRLVFDVPQLSEYSKMPLKLLTNHYEQCWKYYCLP SGWGSYGLAVEEELHLTEKLFWGIFDSLSHKKYDLDLFRMALPCLSAIAGALPPDYLDTR ITATLEKQVSIDADGNFDPKPINTMNFSLPEKLEYIVTKYAEHSHDKWACDKSHSGWKYG ISLDENVKTHPLIRPFKTLTEKEKEIYRWPARESLKTMLAVGWTVERTKEGEALVQQREN EKLRCMPQTNQGNSYSPAPLDLSNVVLSRELQGMVEVVAENYHNIWAKKKKLELESKGGG SHPLLVPYDTLTAKEKFRDREKAQDLFKFLQVNGIIVSRGMKDMELDASSMEKRFAYKFL KKILKYVDSAQEFIAHLEAIVSSGKTEKSPHDQEIKFFAKVLLPLVDQYFTNHRLYFLSS PLKPLSSSGYASHKEKEMVASLFCKLAALVRHRISLFGSDSTTMVSCLHILAQTLDTRTV MKSGSELVKAGLRSFFENAAEDLEKTSENLKLGKFTHSRTQIKGVSQNINYTTVALLPIL TSIFEHIAQHQFGVDLLLSDVQISCYHILCSLYSLGTGKNIYVERQRPALGECLASLAAA IPVAFLEPSLNRYNPLSVFNTKTPRERSILGMPDKVEEMCPDMPQLEGLMKEINRLAESG ARYTEMPHVIEVILPMLCNYLSYWWERGPENLTPSTGPCCTKVTSEHLSLILGNILKIIN NNLGIDEASWMKRIAVYAQPIISKARPDLLKSHFIPTLEKLKKKAVKTVQEEEQLKTDVK GDTQEAELLILDEFAILCRDLYAFYPMLIRYVDNNRSNWLKSPDSDSDQLFRMVAEVFIL WCKSHNFKREEQNFVIQNEINNLAFLTGDSKSKMSKAMQVKSGGQDQERKKTKRRGDLYS IQTSLIVAALKKMLPIGLNMCTPGDQELISLAKSRYSCRDTDEEVKEHLRNNLHLQEKSD DPAVKWQLNLYKDVLRNEEPSNPEKTVERVQRISAALFHLEQVEQPLRSKKAVWHKLLSK QRKRAVVACFRMAPLYNLPRHRSINLFLHGYQRFWIETEAYSFEEKLVQDLAKSPKVEEE EEEETEKQPDPLHQIILHFSRNALTERSKLEDDPLYTSYSSMMAKSCQSGEDEEDEEDKE KTFEEKEMEKQKTLYQQARLHERGAAEMVLQMISASKGEMSPMVVETLKLGIAILNGGNA GVQQKMLDYLKEKKDAGFFQSLSGLMQSCSVLDLNAFERQNKAEGLGMVTEEGTLIVRER GEKVLQNDEFTQDLFRFLQLLCEGHNSDFQNFLRTQMGNTTTVNIIISTVDYLLRLQESI SDFYWYYSGKDIIDESGQHNFSKALAVTKQIFNSLTEYIQGPCIGNQQSLAHSRLWDAVV GFLHVFANMQMKLSQDSSQIELLKELLDLLQDMVVMLLSLLEGNVVNGTIGKQMVDTLVE SSTNVEMILKFFDMFLKLKDLTSSDTFKEYDPDGKGIISRKEFQKAMEGLKQYTQSEIDF LLSCTEADENDMFNYVDFVERFHEPAKDIGFNVAVLLTNLSEHMPNDSRLKCLLDPAESV LNYFEPYLGRIEIMGGAKKIERVYFEISESSRTQWEKPQVKESKRQFIFDVVNEGGEQEK MELFVNFCEDTIFEMQLASQISESDSADRLEEEEEEGEDSAYAIEMEGEEEEEKTFESAS AFAVACASVKRNITTFLRRATLKNLRKQYRNVKKMSAKELVKVFFSFFWTLFVGLLHLLF SVLGGIFQILWNTVFGGGLVEGAKNIRVTKILGDMPDPTQFGIHDDAVEADRAEVIEPGV TAELVHFVKGEPGDTDIMSDLFGIHSKKESGLKQGPEVGLGDLSEIIGKDEPPTLESTVR KKRKAQAAEMKAVREVEGKAEWEKADMEDREKEDKFKEEGQAEYLWAEMTAKKTRRRGQK ADKPEAFMANFFKGLEIYQTKLLHYLARNFYNLRFLALFVAFAINFILLFYKVTEEPLEE ETEDVANLWNSFNDDDEEEAMVFFVLQESTGYMAPTLRALAIVHTIISLVCVVGYYCLKV PLVVFKREKEIARKLEFDGLYITEQPSEDDIKGQWDRLVINTPSFPSNYWDKFVKRKVIN KYGDLYGAERIAELLGLDKNALDFSPVEETKAEAASLVSWLSSIDMKYHIWKLGVVFTDN SFLYLAWYTTMSILGHYNNFFFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTVGLLAVV VYLYTVVAFNFFRKFYNKSEDDDEPDMKCDDMMTCYLFHMYVGVRAGGGIGDEIEDPAGD PYEMYRIVFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVREDMETKCFICGIGNDY FDTTPHGFETHTLQEHNLANYLFFLMYLINKDETEHTGQESYVWKMYQERCWDFFPAGDC FRKQYEDQLG NT seq 14613 nt NT seq  +upstreamnt  +downstreamnt atggccgaagcgggagaaggaggcgaggatgagatccagtttctgcggactgaggatgaa gtggtactccagtgcatagcaaacattcataaggaacagcggaagttctgcctggcagct gagggacttgggaaccgcctgtgcttcttggaacccacctcagaagccaagtacattcct ccagatctctgtgtctgcaatttcgtgctggaacagtccttatctgtcagagcactacag gaaatgcttgcgaacaccattgaaaatggcggagaaggggcagcacaagggggtggccac aggaccctgctctatggccatgcaattctcctgcggcactctttcagtggaatgtatcta acatgcttgaccacatcaagatcccagactgataaacttgcctttgatgtaggtctgcgg gaacatgccacaggagaagcctgttggtggaccatacatcctgcttccaaacagagatct gaaggagagaaagtacggattggagatgaccttatcctcgtcagtgtgtcctctgaaaga taccttcatctctcgatatcaaatggtagcatccaagtggatgcctcctttatgcaaaca ctctggaatgtacatcctacgtgttcgggaagtagcatcgaagaaggatacctacttggt gggcatgtagtccgccttttccatggtcatgatgagtgtttgacaataccatctacagac cagaatgattctcaacacaggagggtgttctacgaagctggaggagctgggaccagagcc aggtctctatggagagtggaaccccttcggataagctggagtggcagtaacatcaggtgg ggccaggccttccgcctccggcatctcaccacaggccactacctggccttgacagaggac caaggccttcttctacaagatcggggaaaatcggacaccaagtccacagccttctccttc cgcgcatcaaaggaaatcaaggagaagttggattccagtcacaagagagacacagaaggc atgggagtcccagagattaagtatggagactctatctgctttgtccaacatttggccagt ggcctttgggtcacctacaaagcacaagatgccaaaacgtcccgcctgggacccctgaaa agaaaggtcatactccatcaggaaggccacatggatgacggattaacattgcagaggtgc cagcgggaggagtcccaggctgctcgcatcatccggaacacaacagccttattcagccag tttgtcagtggaaacaatcgcacaactgcccctgtcaccttgcctatagaagaggtcctg cagaccctacaggacttgattgcctacttccagccaccagaggaggagatgcaacatgaa gacaaacagaataagctccgttctctcaaaaacagacagaatcttttcaaggaggaggga atgttggccctggtactgaactgcatcgatcgcttaaatatctacaatagcgtagcacac tttgcagggatcgcaagggaagagagtggcacggcttggaaagaaatcctgaacctgctc tacaaattgctagctgctctcattcgtggaaatagaaacaactgtgctcaattctccaat aaccttgactggttaattagtaaattggacagactagaatcttcctcaggtatcttggag gtcttgcactgcatcttgactgaaagcccagaagccttaaacctgatagcagagggtcac atcaagtccatcatctccctcctggataagcatggccggaatcacaaggttctcgatgtc ctgtgttccctctgtctctgcaatggggtcgcggtaagagccaaccagaatctgatctgt gacaacctactaccccggaggaacctgctgctgcagacacggctaattaatgatgtcacc agtatccggccaaacatcttcctgggagttgctgaaggctcaccacagtacaagaagtgg tactttgagttaattatcgaccaggtggaacctttcctaacagcagagcccacacatctc cgagtgggctgggcctcctcctcaggctatgccccataccctggaggtggagaaggatgg ggaggcaatggcgtcggtgatgacctctactcctatggctttgatggacttcatctttgg tcaggccggatacccagagctgtggcctccatcaaccagcatttgctgaagtcagatgat gtggtgagttgctgccttgaccttggagtgcctagcatttctttccgaatcaatggacaa cctgtgcaggggatgtttgagaatttcaacacagacggactcttcttccctgtgatgagc ttttcagctggtgtcaaagtacgcttcctgatgggtggtcggcatggagaatttaagttc ctgcctccctctggctatgccccttgctatgaagccttacttccaaaggagaagatgaga ttggagcctgtcaaagaatataaacgtgatgctgatggtgttagggatctgttgggtacc actcagttcctctcccaggcctctttcatcccttgccccatagacaccagtcaggttgtt ttgccacttcacctagagaagatccgagacagactggctgaaaacatccacgagctttgg ggaatgaataaaatagaactcggctggacgtttggtaagatacgggatgacaacaaaaga caacacccctgccttgtagagttttcaaagctccctgaaactgagaagaattacaacctg caaatgtcaaccgaaaccttgaaaaccctgctggccctgggatgtcacattgctcatgtt aacccagctgctgaagaggatctaaaaagagtcaaactgcccaaaaactatatgatgtcc aatgggtataagccagcccctttggatttatctgatgttaagctgttaccacctcaagaa cttttagtggataaacttgcagaaaatgcacacaatgtttgggcaaaggacagaataaaa caaggatggacctatggcattcaacaggatttgaagaacaaaagaaatccccgtctggtg ccttatgtattactggatgagcgtaccaagaaatcgaatagggacagcctgcgtgaagct gtaaggacatttgttggttatggatataacattgagccatcagaccaagaactagtagct gaccctacagttgagaaggtcagcatagacaagattcgatttttccgggtagagcggtca tatgcagtaaagtctggaaagtggtactttgaatttgaagtggtaactggaggagacatg cgtgttggctgggccaggccaggttgtcgtcctgacattgaactgggtgctgatgaccaa gccttcgtgtttgaaggcagcaggggtcagcgttggcatcaaggtagtgggtactttgga cgaacttggcagccaggagatgtggtcgggtgtatgattaacctggatgatgcttccatg atcttcacactgaatggggaactgctgattaccaacaaaggctctgaacttgcctttgct gactatgaaattgagaatggttttgtacccatttgctctctggggctgtcacagattggc cgtatgaatcttgggacagatgccagtaccttcaagttttatactatgtgtggccttcag gagggctttgagccttttgcggtgaatatgaaccgagacgttgccgtgtggttcagcaag cgcctcccaacatttgtgaacgtgccgaaggatcatccccacatagaggttgtaaggatt gatggcaccatggacagccccccatgcctcaaggtgacccacaagacatttggcacacag aacagcaatgccagcatgatctactgccgcctgagcatgcctgtcgaatgccactcctct ttcagccacagcccctgtctagacagtgaagccttccagaaaaggaaacagatgcaagaa atactctctcacacaacaacacaatgctactatgctatccgcatttttgctgggcaggac ccatcatgtgtctgggttggatgggtgactcctgactaccatttatacagtgaaaagttt gacctgaataaaaactgcactgtgactgtcactctgggagatgaaagaggtcgggtccat gaaagtgtgaaacgcagcaactgctacatggtctggggtggggacattgtagctagttcc caaagatcaagtcgaagcaatgtagacctggagattggctgccttgtagatctgtcaatg ggcatgttgtccttctcagctaacgggaaggaacttggcacctgctatcaggtggagcct aacaccaaagtattcccagcagtcttcctccagcctacaagcacttctttgtttcagttt gaacttggaaaactgaagaatgcaatgcccttgtcagcagccatatttaagagtgaagag aagaaccccatcccacagtgtccacctcggctggatgtccaaaccatccagcctgtgcta tggagtcgcatgcccagcagcttcctcaaggtggagacagagagggtgagcgagcgccat ggctgggtggtgcagtgcctagaacccctgcaaatgatggcactccacatcccagaggag aacaggtgtgtggacatccttgagctctgtgagcaggaggacctgatgcagttccattac cacacactgagactttacagtgccgtgtgtgccctgggaaatagccgagttgcctatgcc ctgtgcagccatgtggacctctcacagctcttctatgccattgacaacaagtacttgcct ggcctccttcgatctggtttctatgacctgctcattagtatccacctggccaacgctaag gagaggaagctgatgatgaagaatgagtacatcatccccatcaccagcaccaccaggaat atccgcctatacccagatgagtccaagaggcatgggctgcccggggtgggcctgaggaca tgccttaagccaggcttcaggttctctactccttgcttcgtggtgactcatgaggagcat cagaagcagagccctgagatcccattggagattctcaagacaaaggctctgagcatgctg acagaggctgtgcattgcagtggggcccatatccgagaccccgtgggcggttctgtggag ttccagtttgtacctgtgctgaaactcattggaaccctgctcgtcatgggcgtttttgat gatgatgatgttcgccagattctcctcttgattgatccctctgtgtttggggagcacagt ggggagacagaggagggagcagaaaaagaagtgacccaagtagaggaaaaggcagtggag gctggagaaaaggccagcaaggaggctccagtcaaaggcttgttgcagacccgactacct gagtctgtcaagctgcagatgtgtgaactcctcagctacctctgtgactgtgaattgcaa catcgagtagaggctattgtggcatttggtgacatttatgtgtctaagcttcaggcaaat cagaagttccgctacaatgagctcatgcaggctctgaacatgtctgcagcccttactgcc cggaagacaagggagttccgttcacctccccaggagcagatcaacatgctcctcaacttt cacctgggagagaattgcccctgcccagaggagattcgcgaggagctgtatgacttccat gaggaccttctggttcactgtggggttcccttggaggaagaagaggaggaggaggaggac acttcctggacaggaaaactgcgtgctttggtgtataaaatcaagggcccacctaagcca gaaaaggagcaaccaacagaagaagaggaacggtatcctacaacactgaaggaactagtc tcacagacaatgatccgctgggcccaggagaaccaaatccaggatgcagagttggtgaga attatgttcaacctcctcagaagacaatatgacagcattggggagctgctacaggccctg cggaagacctacaccatcagccaggcctctgtgagcgacaccatcaacctgctggctgcc ctgggccagattcgatcccttctgagtgtcaggatgggcaaggaagaggagcttctcatg atcaacgggctaggggacataatgaacaacaaggtgttttaccagcaccccaaccttatg cgagtccttggcatgcatgagacagtgatggaggtgatggtgaacgtattgggtacagag aaatcacagattgccttcccaaaaatggttgctagctgctgtcgcttcctctgctatttc tgtcgaattagcaggcaaaatcagaaggccatgttcgagcatctaagttacctgctggag aacagcagtgtgggcctagcttccccatcgatgagggggtccaccccactggatgtggca gcctcctctgtgatggacaacaacgagttagccctgggtttagaagaaccggatcttgag aaggtggtaacctacttggcaggttgtggccttcagagctgtcccatgcttctggccaaa ggataccctgatgttggctggaaccccattgagggggaacgctacctgtccttcctgagg tttgccgtcttcgtgaacagtgaaagtgtggaggaaaatgccagtgttgtggtcaagctg ctcatcagacgtcctgagtgctttgggccagcgctgaggggtgaaggaggaaatggactg ctagccgccatgcagggcgccattaagatctcagagaaccctgcactcgacctcccctcc caaggttacaagacggaagtctcagaggacgatgaggaggaggaagagactgtgcacatg ggcaatgcaattatgtcattttactcagctctcatcgatctactgggccgctgtgctcct gagatgcacctcattcaaacaggaaaaggggaagccatccggattcggtccatcctgcgc tctctggtccccacagaagacctggttgggatcatcagcattcccctgaaactgccctcc ctgaacaaagatggatcagtcagtgagccagacatggcagccaacttctgtcctgaccac aaggcacccatggtgctcttcttggaccgtgtttatggaattaaagaccaaaccttcctg ctccacttgctggaagttgggtttttacctgacttgcgagcatctgcatctctagataca gtgtccctcagcaccaccgaggctgcgttggcactgaacaggtacatatgttcggctgtg ctcccactgcttaccaggtgctcccctctcttttctgggacagagcactgcacctctctg attgattctacactgcagacaatatacaggctttccaaaggacgctccctcaccaaggca cagagggacacaatagaagaatgtttacttgccatttgcaatcacttgagaccttccatg ttacagcaactcctacgacgtctggtttttgatgtgccacagctcagcgagtacagcaaa atgcctcttaagcttctgaccaatcactatgagcagtgctggaagtattactgcctgcct tcaggatgggggagctatgggctggccgtggaggaggagctgcacctcactgagaagctc ttctggggaatttttgactccctttcccacaagaagtatgacctggatcttttccgaatg gccctgccttgtctcagtgctattgctggggccttgccaccagactatttagatacaaga atcactgccacattggaaaaacaggtctccatagatgcggatgggaactttgaccccaaa cctattaacaccatgaatttttccttgcctgaaaaattggaatacattgtcaccaagtat gctgagcattctcatgataaatgggcctgtgacaagagccacagtggatggaaatatggg atttccctggatgaaaacgtgaagacccacccactgatacggcccttcaagacattaaca gagaaggagaaggaaatttatcgctggcctgccagagaatccctgaaaaccatgcttgct gtgggctggactgtggaaaggactaaagaaggagaagctttggttcaacaaagagagaat gagaaacttcgatgtatgccccagaccaatcagggcaacagctacagccctgccccgctg gatctctcaaatgttgtgctgtccagggagctccagggaatggtggaggtggtggccgag aactaccataacatctgggccaagaagaagaagttggagctagagagcaaaggtggtggc agtcaccctcttttggtaccatatgacaccttgactgccaaggaaaagttcagggatcga gaaaaggcacaggacctgttcaaattcctccaggtgaatggcattatagtttccagaggg atgaaggacatggagctggatgcttcctccatggaaaagagatttgcctacaagtttttg aagaagatcctgaaatatgttgactctgctcaagagtttattgctcacttggaagctatt gtcagcagtgggaaaacagaaaagtctccccatgaccaggagatcaaattctttgccaaa gttctcctcccactggttgaccagtacttcaccaaccaccgtctttacttcctgtcatct cctctgaagccacttagcagcagcgggtatgcctcccacaaggagaaagaaatggtagcc agcctgttctgcaagctggctgctctcgtgagacacaggatctccctctttgggagtgat tcaactacaatggtgagctgtcttcacatcttagctcagacccttgacacaaggaccgtc atgaagtcaggctcagagctggtgaaagctgggttgcgctctttctttgaaaatgcagcg gaagacttggaaaagacttcagaaaacctgaagctggggaagtttacccattccagaacg cagatcaaaggtgtttctcagaatattaactacaccacagtggctctgcttcccatcctg acatccatctttgagcacatcgctcagcatcagtttggggtggatctactcttgagtgac gtgcagatttcatgctaccacattctgtgcagcctctattcccttgggactgggaaaaac atctatgttgaaaggcaacgtcccgctcttggagaatgtctggcttccctggcagctgcc atcccagtggcattcctggagcccagccttaatcgctataatcccctctcagtcttcaac accaagactcccagggaacggtctattctggggatgccagacaaggtggaagagatgtgt cctgacatgccccagctggaaggcctgatgaaggaaatcaataggttggccgagtcaggt gcccgctatacggagatgccccatgtcattgaagtgatcttgcccatgctctgcaactac ctgtcttactggtgggagcggggacctgagaacctgacccccagcacagggccctgctgc accaaggtcacctccgaacacctcagcctcatcctgggcaacatcctgaaaatcatcaac aacaacctaggcattgatgaggcctcctggatgaagcgtatcgcagtgtatgcgcagccc atcatcagcaaagccaggcctgatctgctgaaaagccacttcatccccaccctggagaag ctcaagaagaaggccgtcaagacggtgcaggaggaggagcagctgaagactgatgtcaag ggggacacccaggaggctgagctcctcatcctagacgagtttgcgatcctctgccgggac ctctatgccttctaccccatgctcatccgctatgtggacaacaacagatctaactggctt aaaagcccggactctgattctgaccagctcttccgcatggtggccgaggtcttcattctg tggtgtaaatctcataacttcaagagggaagagcaaaattttgtgattcaaaatgaaatt aataacttggcatttttaactggagacagcaaaagcaagatgtcaaaagccatgcaagta aagtctggaggacaggaccaggaacggaagaagacaaagaggcgaggagacttgtactcc atccagacctccctcatcgtggctgcgctcaagaaaatgctgcccattggtctgaacatg tgtacaccaggcgaccaggaactcatctctcttgcaaaatctcgatacagctgtagggac actgatgaagaggtcaaggaacatctgcggaataacctacatctgcaggaaaagtcagat gatccagctgtgaaatggcaactgaacctctacaaagatgttctgaggaatgaagaacct tccaatccagaaaagacagtggagcgtgtgcagaggatctcagcagctctcttccaccta gagcaggtggaacagcctttgaggtccaaaaaggctgtatggcacaaattgttgtcaaag caacggaaacgggcagtggtggcctgtttcaggatggctcctctctacaatttgcccagg caccgctctattaacctcttcctccatggctatcagagattttggatagaaacagaggcg tattcctttgaagagaaactagtacaggatttggctaaatctcccaaggttgaagaggag gaagaggaagagacagaaaagcagcctgatccacttcatcaaatcattctacactttagc cgcaatgcactgacggagaggagcaaattggaagatgaccctttgtatacctcctattcc agcatgatggccaagagttgtcagagtggtgaggatgaagaggatgaggaagacaaggaa aaaacatttgaagagaaggagatggagaagcagaaaacactgtatcagcaagcgcgcttg cacgagcgtggtgccgcagagatggtccttcagatgataagtgccagtaaaggtgagatg agccccatggtggttgagacgctgaagctggggattgccattctgaatggaggcaatgct ggtgtgcagcagaaaatgctagattacttaaaagagaaaaaagatgctggattctttcaa agcctttctggtctcatgcaatcttgcagcgtccttgatttgaatgcatttgagaggcag aataaagctgaaggcctgggaatggttacagaagagggaacactcattgttcgtgagcgt ggtgaaaaggtactccagaatgatgagttcacacaggatctctttagattccttcagttg ctttgtgaaggacataacagtgactttcagaacttcctgaggactcagatgggcaacacc accactgtgaacatcataatcagcactgtggactaccttctgcgtctgcaggaatcaatc agcgatttctattggtactattcaggaaaggacatcattgatgaatctggacagcacaat ttctctaaagctctggcagtcaccaagcagatttttaattctcttacagagtacatccag ggcccttgcatcgggaaccagcagagcctggctcacagtaggctgtgggatgcagtagtt ggattcctccatgtatttgctaacatgcagatgaagctctctcaggattccagtcagatc gagctgctgaaggaactcttggatctccttcaggacatggtggtgatgcttctgtcccta ctggaaggaaatgtggtaaacggaactattggaaagcagatggttgacacactggtagaa tcttctactaatgtagagatgatcttgaaattctttgacatgttcttgaaacttaaagac ttaaccagctcagacaccttcaaagaatatgacccggatggtaaagggatcatctccaga aaagaattccagaaggccatggaaggtctaaagcaatatacacagtcagagattgacttt ctcctttcatgtacagaagctgatgagaatgacatgtttaattatgttgattttgtggag aggttccatgagccagccaaggacataggcttcaatgtggcagtgttactgacaaatctc tctgaacacatgccaaacgattctcgcctgaagtgtctactggacccagcagaaagtgtg ctaaactactttgaaccatacctgggtcgaatcgagatcatgggtggggccaagaaaatt gagcgtgtttattttgagatcagtgaatccagtcgaactcagtgggagaagcctcaagtg aaggaatccaagcggcagttcatctttgatgtcgtcaatgaaggcggggagcaagagaag atggagctgtttgtgaacttctgtgaggacaccatctttgagatgcagttagcatcgcag atctcagaatctgactcagctgacagactggaagaggaagaggaagagggtgaagattct gcttatgcgatagaaatggagggggaggaggaggaagagaagacttttgagtcagcctct gcctttgcggtggcctgtgcctcagtaaagagaaacatcaccacctttctgaggagggca accctgaagaacctcaggaagcagtacaggaatgtgaagaagatgagtgcgaaggagctg gtgaaggtgttcttctctttcttctggacactgtttgtgggcctccttcacttgctcttc tctgtcttgggagggatcttccagatcctctggaacacagtgtttggaggggggcttgtg gaaggggcaaagaacatcagagtgaccaagatcctaggcgacatgcctgatcctacccag tttggcatccatgatgatgcagtggaggctgacagggcagaagtgattgagccgggtgtc accgctgagctggtccactttgtaaagggtgagccaggagatacagatattatgtcagac ctctttggaatccactcaaagaaagaaagtggcttaaaacaagggcctgaagtgggattg ggtgacctctctgaaatcatcggcaaggatgaaccccctacattagagagtactgtgcgg aagaaaaggaaagcacaggcagcagagatgaaagcagtgcgtgaagtagaaggaaaggct gaatgggagaaggctgacatggaagacagagaaaaggaggacaaattcaaggaggaggga caagctgagtacctgtgggcagaaatgaccgcgaagaagacacgacggcgtggccagaag gctgacaagccggaagccttcatggccaatttcttcaaaggcttggaaatctatcagact aagttactgcactacctggccaggaatttctacaacctgaggttccttgctctgtttgta gccttcgctatcaacttcatcctgcttttttataaggtcactgaagaacctttagaggag gagacggaggatgttgcaaacctgtggaactcctttaatgatgatgatgaggaagaagcg atggtgttctttgttcttcaggagagcacggggtatatggcaccaacactgcgtgccctg gccattgtccacaccatcatctctctggtctgtgtggtgggctattactgcctgaaggtg cctctggtggtattcaaaagggagaaagaaattgccaggaagctagagtttgatggtcta tatatcaccgaacagccatctgaagatgacatcaagggacagtgggaccgtttggtgatc aacacaccatcttttcctagtaactactgggacaagtttgtgaagagaaaggtgatcaac aagtatggagatctctatggagcagagcgcattgctgaactcctgggtttggacaaaaat gcccttgactttagcccagtagaagagaccaaagcagaggcggcatctctagtgtcatgg ctaagttccatcgacatgaagtaccatatttggaagctgggggtggttttcactgacaac tcctttctctaccttgcctggtacacaaccatgtccatcctgggccactacaacaacttc ttctttgctgctcatctgttggatattgcaatgggctttaagaccttgaggacgatcctg tcatctgtaactcacaatggcaaacagctggttctgactgttggcctcctggctgttgtt gtttacctctatactgtggtggctttcaacttcttccgcaagttctataacaaaagtgaa gatgacgatgagccggatatgaagtgtgatgacatgatgacatgctacctcttccacatg tacgtgggagtgagagcgggtggcggcatcggtgatgaaattgaagaccctgctggtgac ccttatgaaatgtatcgaatcgtttttgacattaccttcttcttctttgtaattgtcatc ttgctggccatcattcaaggtctgattattgatgcttttggagagctgagagaccagcag gaacaagtacgtgaagacatggagactaaatgcttcatctgtggcattggcaatgactac tttgacacaacccctcatggttttgaaacacatacgctgcaagagcacaacctagccaat tatctattctttctgatgtatctgattaacaaggatgaaacagaacacacgggtcaggaa tcttacgtgtggaagatgtaccaggaaaggtgttgggacttcttcccagctggcgactgc tttcgtaagcaatacgaagatcaactcgggtaa

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