KEGG   Mesocricetus auratus (golden hamster): 101831758
Entry
101831758         CDS       T08306                                 
Symbol
Plcg2
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2
  KO
K05859  phosphatidylinositol phospholipase C, gamma-2 [EC:3.1.4.11]
Organism
maua  Mesocricetus auratus (golden hamster)
Pathway
maua00562  Inositol phosphate metabolism
maua01100  Metabolic pathways
maua01521  EGFR tyrosine kinase inhibitor resistance
maua04012  ErbB signaling pathway
maua04014  Ras signaling pathway
maua04020  Calcium signaling pathway
maua04062  Chemokine signaling pathway
maua04064  NF-kappa B signaling pathway
maua04066  HIF-1 signaling pathway
maua04070  Phosphatidylinositol signaling system
maua04072  Phospholipase D signaling pathway
maua04360  Axon guidance
maua04370  VEGF signaling pathway
maua04380  Osteoclast differentiation
maua04517  IgSF CAM signaling
maua04611  Platelet activation
maua04613  Neutrophil extracellular trap formation
maua04625  C-type lectin receptor signaling pathway
maua04650  Natural killer cell mediated cytotoxicity
maua04662  B cell receptor signaling pathway
maua04664  Fc epsilon RI signaling pathway
maua04666  Fc gamma R-mediated phagocytosis
maua04670  Leukocyte transendothelial migration
maua04722  Neurotrophin signaling pathway
maua04750  Inflammatory mediator regulation of TRP channels
maua04919  Thyroid hormone signaling pathway
maua04933  AGE-RAGE signaling pathway in diabetic complications
maua04935  Growth hormone synthesis, secretion and action
maua05167  Kaposi sarcoma-associated herpesvirus infection
maua05169  Epstein-Barr virus infection
maua05170  Human immunodeficiency virus 1 infection
maua05171  Coronavirus disease - COVID-19
maua05200  Pathways in cancer
maua05205  Proteoglycans in cancer
maua05206  MicroRNAs in cancer
maua05214  Glioma
maua05223  Non-small cell lung cancer
maua05225  Hepatocellular carcinoma
Module
maua_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:maua00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    101831758 (Plcg2)
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    101831758 (Plcg2)
   04014 Ras signaling pathway
    101831758 (Plcg2)
   04370 VEGF signaling pathway
    101831758 (Plcg2)
   04064 NF-kappa B signaling pathway
    101831758 (Plcg2)
   04066 HIF-1 signaling pathway
    101831758 (Plcg2)
   04020 Calcium signaling pathway
    101831758 (Plcg2)
   04070 Phosphatidylinositol signaling system
    101831758 (Plcg2)
   04072 Phospholipase D signaling pathway
    101831758 (Plcg2)
  09133 Signaling molecules and interaction
   04517 IgSF CAM signaling
    101831758 (Plcg2)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    101831758 (Plcg2)
   04613 Neutrophil extracellular trap formation
    101831758 (Plcg2)
   04625 C-type lectin receptor signaling pathway
    101831758 (Plcg2)
   04650 Natural killer cell mediated cytotoxicity
    101831758 (Plcg2)
   04662 B cell receptor signaling pathway
    101831758 (Plcg2)
   04664 Fc epsilon RI signaling pathway
    101831758 (Plcg2)
   04666 Fc gamma R-mediated phagocytosis
    101831758 (Plcg2)
   04670 Leukocyte transendothelial migration
    101831758 (Plcg2)
   04062 Chemokine signaling pathway
    101831758 (Plcg2)
  09152 Endocrine system
   04935 Growth hormone synthesis, secretion and action
    101831758 (Plcg2)
   04919 Thyroid hormone signaling pathway
    101831758 (Plcg2)
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    101831758 (Plcg2)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    101831758 (Plcg2)
  09158 Development and regeneration
   04360 Axon guidance
    101831758 (Plcg2)
   04380 Osteoclast differentiation
    101831758 (Plcg2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    101831758 (Plcg2)
   05206 MicroRNAs in cancer
    101831758 (Plcg2)
   05205 Proteoglycans in cancer
    101831758 (Plcg2)
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    101831758 (Plcg2)
   05214 Glioma
    101831758 (Plcg2)
   05223 Non-small cell lung cancer
    101831758 (Plcg2)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    101831758 (Plcg2)
   05171 Coronavirus disease - COVID-19
    101831758 (Plcg2)
   05167 Kaposi sarcoma-associated herpesvirus infection
    101831758 (Plcg2)
   05169 Epstein-Barr virus infection
    101831758 (Plcg2)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    101831758 (Plcg2)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    101831758 (Plcg2)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:maua04131]
    101831758 (Plcg2)
Enzymes [BR:maua01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     101831758 (Plcg2)
Membrane trafficking [BR:maua04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    101831758 (Plcg2)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    101831758 (Plcg2)
SSDB
Motif
Pfam: PI-PLC-X SH2 PI-PLC-Y EF_HAND_2_PLCG C2 SH3_1 SH3_9 PH EF_HAND_1_PLCG PH_12 SH2_1 SH3_2 PH_14 GDPD
Other DBs
NCBI-GeneID: 101831758
NCBI-ProteinID: XP_005073128
UniProt: A0A1U7QIS1
LinkDB
Position
Unknown
AA seq 1267 aa
MTTMVNVDNLPEYEKSQLKRALELGTVMTVFSARKGTSERRTVQVIMETRQVAWSKTADK
IEGFLDIMEIKEIRPGKNSKDFERAKATVSRHKADCCFTIFYGTQFVLSTLSLATDSKED
AIKWLSGLKILLQEAMNASTPTMIESWLRKQIYSVDQTRRNSISLRELKAILPLVNFKVS
SVKFLKDKLVEIGAQKDELSFEQFHLFYKKLMFDQQKSILDEFKKDSSVFILGNTDRPDA
SAVYLQDFQRFLLHEQQELWAQDLNRVRERMTKFIDDTMRETAEPFLFVDEFLTYLFSRE
NSIWDEKYDVVDMQDMNNPLSHYWISSSHNTYLTGDQLRSESSTEAYIRCLRAGCRCIEL
DCWDGPDGKPIIYHGWTRTTKIKFDDVVQAIRDHAFVTSSFPVILSIEEHCGVEQQRHMA
KVFKEVLGDLLLTKPTEASADQLPSPSQLREKIIIKHKKLGPRGDVDVNVEDKKDEHKTQ
GELYMWDSIDQKWTRHYCAIADAKLSFSDDIEQAVEEELVQDTPPTELHFGEKWFHKKVE
RRTSAEKLLQEYCAETGAKDGTFLVRESETFPNDYTLSFWRSGRVQHCRIRSTMEGGVMK
YYLTDNLTFNSIYALIQHYRETHLRCAEFELRLTDPVPNPNPHESKPWYYDRLSRGEAED
MLMRIPRDGAFLIRKREGTDSYAITFRARGKVKHCRINRDGRHFVLGTSAYFESLVELVS
YYEKHALYRKMRLRYPVTPELLERYNMERDINSLYDVSRMYVDPSEINPSMPQRTVKALY
DYKAKRSDELTFCRGALIHNVSKEPGGWWKGDYGTRIQQYFPSNYVEDISAGDAEEMEKQ
IIEDNPLGSLCRGILDLNTYNVVKAPQGKNQKAFVFILEPKKPGDPPVEFATDRVEELFE
WFQSIREITWKIDTKENSMKYWERNQSIAIELSDLVVYCKPTSKTKDHLENPDFREIRSF
VETKADSIVRQKPIDLLRYNQKGLTRVYPKGQRVDSSNYDPFRLWLCGSQMVALNFQTAD
KYMQMNHALFSLNGRTGYVLQPESMRSEKYDPMPPESQRKILMTLTVKVLGARHLPKLGR
SIACPFVEVEICGAEYDSNKFKTTVVNDNGLSPVWAPTQEKVTFEIYDPNLAFLRFVVYE
EDMFSDPNFLAHATYPIKGIKSGFRSVPLKNGYSEDIELASLLVFCEMRPVLECEEELYS
SCRQLRRRQEELNNQLFLYDTHQNLRGANRDALVKEFNVNENQLQLYQEKCNRRLREKRV
SNSRFYS
NT seq 3804 nt   +upstreamnt  +downstreamnt
atgaccaccatggtcaatgtggacaatcttccagaatatgagaagagtcagctcaagaga
gccctggagctagggacagtgatgactgtgttcagtgcccgcaagggcacctcagagcgg
aggacggtgcaggtgatcatggagactcggcaggtggcatggagcaagactgcagacaag
atcgagggcttcctggacatcatggaaataaaggaaatccgtccagggaagaactccaag
gacttcgagagagccaaggccacggtctcccgccacaaggcagactgctgcttcaccatc
ttctacggcacccaattcgtcctcagcactctcagtttggcaaccgactcaaaggaggat
gcaatcaagtggctctctggcttgaagatcctactccaggaagcaatgaatgcatccacc
cccaccatgattgagagttggctgagaaagcagatttattcagtagatcaaaccagaaga
aacagcatcagcctccgagaactgaaggccatcttgcccctggtcaacttcaaagtgagc
agtgtcaagttcctcaaggacaagctggtggaaattggtgcgcagaaagatgagctcagt
tttgaacagtttcatctcttctataaaaaactcatgtttgaccagcaaaaatcgatactt
gatgaattcaaaaaggactcctccgtgttcattctagggaacacagaccggcctgacgcc
tccgctgtctacctacaggatttccagaggtttcttttacatgaacaacaggagctgtgg
gctcaggatctgaacagagtccgggaacggatgaccaaatttattgatgacaccatgagg
gaaaccgcagagcccttcttgtttgtggacgagtttcttacgtatctgttttcacgggag
aacagcatctgggatgagaagtacgacgtagtggacatgcaggacatgaacaaccccttg
tcacattactggatctcctcttcccacaacacgtacctcactggggaccagctgcgtagc
gagtcctccacggaagcatatatccgctgtctgcgggctggctgccgttgcatagagttg
gactgctgggacgggcctgacggcaaacccatcatctaccacggctggacacggaccacc
aagatcaagtttgatgacgttgtgcaggccatccgggaccatgcctttgtcacctccagc
ttccctgtgatcttgtccatcgaggagcactgcggcgtggagcagcagcgtcacatggcc
aaggtgttcaaggaagtgttaggagatctgttgctgacgaagcccacggaggccagtgct
gaccagttgccctcgcccagccagctccgagagaagatcattatcaagcataagaagctg
ggcccccgaggtgacgtcgatgtcaacgtggaggacaagaaagatgagcacaagacccag
ggagagctatacatgtgggactccatcgaccagaaatggactcgccactactgtgccatc
gctgacgccaagctgtccttcagtgatgacatcgaacaggctgtggaggaggagctggtc
caggacactccccccacggagctgcacttcggggagaaatggttccataagaaagtggag
aggaggaccagtgcagagaagctgctgcaagagtactgtgctgagacgggggccaaggat
ggcaccttcctggtgcgggagagcgagaccttccccaatgactacacactctccttctgg
cggtccggtcgggtgcaacactgtcgaatccgctccaccatggagggtggagtcatgaag
tactacctaacagacaacctcacgttcaacagcatctatgccctcatccagcactaccgt
gagacacacctacgctgcgcagagttcgagctgcgactcaccgacccagtgcccaacccc
aacccacacgagtccaagccgtggtactatgacaggctgagcaggggggaagcagaggac
atgttgatgcggattccccgagacggggccttcctcatccggaagcgggaggggaccgac
tcctatgccatcaccttcagggccaggggcaaggtgaaacactgtcgcatcaaccgggat
ggccggcactttgtgctggggacctctgcctactttgagagcctggtggagcttgtcagc
tactatgagaagcacgcgctctatcgcaagatgcggctgcgctatcctgtgacccctgag
ctcctggagcgatataatatggaaagagacatcaactctctctatgacgtcagcaggatg
tatgtggacccgagtgaaatcaacccttccatgcctcagaggactgtgaaagcactctat
gactacaaagccaagcgcagcgatgaattaaccttctgccgtggcgcccttatccacaac
gtgtccaaggagccagggggatggtggaaaggggactatgggacccggatccagcagtac
ttcccgtccaactacgttgaggatatctccgcaggtgatgctgaggagatggagaagcag
attattgaagacaatccccttgggtctctctgcagaggcatattggaccttaatacctat
aatgttgtgaaggccccccaggggaaaaaccagaaagcgttcgtcttcatcctggagcct
aagaagcccggggaccctcccgtggagtttgcgaccgaccgtgtggaggagctgtttgag
tggtttcagagcatccgggagatcacttggaagattgacaccaaggagaacagcatgaag
tactgggagaggaaccagtccatcgccatcgagctctctgacttggttgtctactgcaag
ccaaccagcaaaaccaaggaccatttggaaaaccctgacttccgagaaatccgctccttc
gtggagacaaaggcggacagcattgtgcggcagaagcccattgatctattgcggtacaat
cagaagggcctcactcgtgtctaccctaagggccagagagttgactcttcaaactatgat
cccttccgcctgtggctgtgtggctcccagatggtggcgctcaatttccagactgcagac
aagtacatgcagatgaaccacgcactgttttcactcaatgggcggacagggtatgtccta
cagcctgagagcatgaggtctgagaagtacgacccgatgccaccagagtcccagaggaag
atcctgatgacactcactgtcaaggttcttggggcacgccacctccccaaactagggcgg
agtattgcctgtccttttgtagaggtggaaatctgcggggctgagtatgacagcaacaag
ttcaagacaacggttgtgaatgacaatggcctcagccctgtctgggctccaacgcaggag
aaggtgacatttgaaatttatgatccaaaccttgcgttcctccgctttgtggtctatgag
gaggacatgttcagtgaccccaacttcctggctcatgccacataccccattaaagggatc
aagtcagggtttagatcagtccctctgaagaatggatacagtgaagacatcgagttggct
tccctcctggttttctgtgagatgcggccggtcctggagtgtgaagaggaactctactcc
tcctgtcgccaactgaggaggcgacaagaagagctcaacaatcagctcttcctatacgac
acacaccagaacctgcgtggagccaaccgcgatgccctggtgaaggagttcaatgtcaac
gagaaccagctgcagctgtaccaggagaagtgcaaccggaggttgagagagaagagagtc
agcaacagcaggttctactcctag

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