Mesocricetus auratus (golden hamster): 101831977 Help Entry 101831977         CDS       T08306                                  Symbol Jak2 Name (RefSeq) tyrosine-protein kinase JAK2   KO K04447   Janus kinase 2 [EC:2.7.10.2] Organism maua  Mesocricetus auratus (golden hamster) Pathway maua01521   EGFR tyrosine kinase inhibitor resistance maua04062   Chemokine signaling pathway maua04081   Hormone signaling maua04148   Efferocytosis maua04151   PI3K-Akt signaling pathway maua04217   Necroptosis maua04550   Signaling pathways regulating pluripotency of stem cells maua04630   JAK-STAT signaling pathway maua04658   Th1 and Th2 cell differentiation maua04659   Th17 cell differentiation maua04725   Cholinergic synapse maua04917   Prolactin signaling pathway maua04920   Adipocytokine signaling pathway maua04933   AGE-RAGE signaling pathway in diabetic complications maua04935   Growth hormone synthesis, secretion and action maua05140   Leishmaniasis maua05145   Toxoplasmosis maua05152   Tuberculosis maua05161   Hepatitis B maua05164   Influenza A maua05167   Kaposi sarcoma-associated herpesvirus infection maua05168   Herpes simplex virus 1 infection maua05200   Pathways in cancer maua05207   Chemical carcinogenesis - receptor activation maua05235   PD-L1 expression and PD-1 checkpoint pathway in cancer maua05417   Lipid and atherosclerosis Brite KEGG Orthology (KO) [BR:maua00001]  09130 Environmental Information Processing   09132 Signal transduction    04630 JAK-STAT signaling pathway     101831977 (Jak2)    04151 PI3K-Akt signaling pathway     101831977 (Jak2)   09133 Signaling molecules and interaction    04081 Hormone signaling     101831977 (Jak2)  09140 Cellular Processes   09141 Transport and catabolism    04148 Efferocytosis     101831977 (Jak2)   09143 Cell growth and death    04217 Necroptosis     101831977 (Jak2)   09144 Cellular community - eukaryotes    04550 Signaling pathways regulating pluripotency of stem cells     101831977 (Jak2)  09150 Organismal Systems   09151 Immune system    04658 Th1 and Th2 cell differentiation     101831977 (Jak2)    04659 Th17 cell differentiation     101831977 (Jak2)    04062 Chemokine signaling pathway     101831977 (Jak2)   09152 Endocrine system    04920 Adipocytokine signaling pathway     101831977 (Jak2)    04917 Prolactin signaling pathway     101831977 (Jak2)    04935 Growth hormone synthesis, secretion and action     101831977 (Jak2)   09156 Nervous system    04725 Cholinergic synapse     101831977 (Jak2)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     101831977 (Jak2)    05207 Chemical carcinogenesis - receptor activation     101831977 (Jak2)    05235 PD-L1 expression and PD-1 checkpoint pathway in cancer     101831977 (Jak2)   09172 Infectious disease: viral    05161 Hepatitis B     101831977 (Jak2)    05164 Influenza A     101831977 (Jak2)    05168 Herpes simplex virus 1 infection     101831977 (Jak2)    05167 Kaposi sarcoma-associated herpesvirus infection     101831977 (Jak2)   09171 Infectious disease: bacterial    05152 Tuberculosis     101831977 (Jak2)   09174 Infectious disease: parasitic    05145 Toxoplasmosis     101831977 (Jak2)    05140 Leishmaniasis     101831977 (Jak2)   09166 Cardiovascular disease    05417 Lipid and atherosclerosis     101831977 (Jak2)   09167 Endocrine and metabolic disease    04933 AGE-RAGE signaling pathway in diabetic complications     101831977 (Jak2)   09176 Drug resistance: antineoplastic    01521 EGFR tyrosine kinase inhibitor resistance     101831977 (Jak2)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:maua01001]     101831977 (Jak2) Enzymes [BR:maua01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.10  Protein-tyrosine kinases     2.7.10.2  non-specific protein-tyrosine kinase      101831977 (Jak2) Protein kinases [BR:maua01001]  Non-receptor tyrosine kinases   JAK family [OT]    101831977 (Jak2) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  PK_Tyr_Ser-Thr Pkinase FERM_F2 FERM_F1 SH2_1 Jak1_Phl SH2 ABC1 FERM_C_FAK1 RIO1 Kinase-like FERM_M Motif Other DBs NCBI-GeneID:  101831977 NCBI-ProteinID:  XP_005063770 UniProt:  A0A1U7QD80 LinkDB All DBs Position Unknown AA seq 1132 aa AA seqDB search MGMACLTMTEMEATSTSPVHQNGDIPGNPNSVKQIDPVLQVYLYHSLGKADGDYLKFPIG EYVAEEICVAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNILYRIRFYF PHWYCSGSNRTYRYGVSRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLG MAVLDMMRIAKEKDQTPLAVYNSVSYKTFLPKCVRAKIQDYHILTRKRIRYRFRRFIQQF SQCKATARNLKLKYLINLETLQSAFYTEQFEVKESARGPSGEEIFATIIITGNGGIQWSR GRHKESETLTEQGLQLYCDFPDIIDVSIKQANQECSNESRLVTIHKQDGKILEIELSSLR EALSFVSLIDGYYRLTADAHHYLCKEVAPPSVLENMHSNCHGPISMDFAISKLKKAGNQT GLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLIMKNDNREYNLSGTKRNFSNLKDLLNC YQMETVRSDSIIFQFTKCCPPKPKDKSNLLVFRTNGISDVQMSPTLQRHNNVNQMVFHKI RNEDLIFNESLGQGTFTKIFKGVRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASM MSQLSHKHLVLNYGVCVCGEENILVQEFVKFGSLDTYLKKNKNSINILWKLGVAKQLAWA MHFLEEKSLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVP PECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDKHQLPAPKWTEL ANLINNCMDYEPDFRPAFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRD PTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIE ILKSLQHDNIVKYKGVCYSAGRRNLRLIMEYLPYGSLRDYLQKHKERIDHKKLLQYTSQI CKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFW YAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPVEFMRMIGNDKQGQMIVFHLIE LLKSNGRLPRPEGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDSLAA NT seq 3399 nt NT seq  +upstreamnt  +downstreamnt atgggaatggcttgccttacaatgacagaaatggaggctacctccacatctcctgtacat cagaatggtgatattcctggaaatcctaattctgtgaagcagatagatccagtccttcag gtgtatttgtaccattctcttgggaaagctgacggagactatctgaagtttccaattgga gagtatgttgcagaagaaatttgtgtggctgcttctaaagcttgtggtattacacctgtg tatcataatatgtttgccttaatgagcgaaacagaaaggatctggtatccacccaaccat gtcttccacatagatgagtcaaccaggcataatatactctacagaataagattttacttt cctcactggtattgcagtggcagcaacagaacctatcgatacggagtatctcgtggggct gaagctcctcttcttgacgactttgtcatgtcttacctttttgctcagtggcggcatgat tttgtgcacggatggataaaagtacccgtgactcatgaaactcaagaagagtgtcttggg atggcagtattagatatgatgagaatagctaaagagaaggaccaaactccactggctgtt tataactctgtcagctacaagacattcttaccaaagtgcgttcgagcaaaaatccaagac tatcatattttaaccaggaagcgaataaggtatagatttcgcagattcattcagcagttc agtcaatgcaaagccactgccagaaacctgaaacttaagtatcttataaacttggaaact ctgcagtctgccttctacacagagcaatttgaagtaaaagaatctgcaagaggtccttca ggtgaggagatttttgcaaccattataataactggaaacggtggaattcagtggtcaaga gggagacataaggaaagtgagaccctgacagaacagggtttacagttatattgtgatttt cctgatattattgatgtcagcattaagcaagcaaatcaggaatgctcaaatgaaagtaga cttgtcactatccataagcaagatggtaaaattttggaaatagaacttagctcgttaaga gaagctttgtcatttgtgtccttaattgacggctattacagactcactgcggatgcacat cattacctctgtaaggaagtagcccctccctctgtgctggagaacatgcacagcaactgc catggccccatttcaatggattttgccattagtaaactgaagaaggcaggtaaccagacg ggactgtatgtactccgatgtagccctaaggactttaacaaatactttctgacctttgct gttgagcgagaaaatgttattgaatataaacattgtctgattatgaagaatgacaataga gagtacaacctcagtggaactaagaggaacttcagtaatcttaaggaccttttgaattgc taccagatggaaactgtgcgctccgacagtatcatcttccagtttactaaatgctgtccc ccaaagccaaaagataaatccaatcttcttgtcttcagaacaaatggtatttctgatgtt cagatgtcaccaacattacagaggcataataatgtgaaccaaatggtttttcacaaaatc agaaatgaagatttgatatttaatgaaagtcttggccaaggtacttttacaaaaattttt aaaggtgtaagaagagaagttggagactatggccaactgcatgaaacagaagttcttttg aaagttctggataaagcacatagaaattattcggagtctttctttgaggcggcaagcatg atgagccagctttctcacaagcacttggttttgaattatggagtatgtgtctgtggcgag gagaacattctggttcaagagtttgtaaaatttggatcactggatacatacctgaaaaaa aacaaaaattccataaatatattatggaaacttggagtggctaaacagttggcatgggcc atgcattttctagaagaaaaatcccttatccatgggaatgtgtgtgccaaaaatatcctg cttatccgagaagaagacaggaaaacagggaatccacctttcatcaaactcagtgaccct ggcattagcatcaccgttctaccaaaggacattcttcaggagagaataccatgggtacca cctgaatgcattgaaaatcctaaaaacctaaatctggcaacagacaagtggagttttggc accactctgtgggaaatctgcagtggaggagacaaaccactgagtgctctggactctcaa agaaagctgcagttttatgaagataaacatcagcttcctgcacctaagtggacagaatta gcaaaccttataaacaattgcatggattatgaaccagatttcaggcctgcctttagagcc atcatccgtgatcttaacagcctatttactccagattatgaactactaacagagaatgac atgctgccaaacatgagaataggtgccctaggattttctggtgcttttgaagatagagac cctacacagtttgaagagagacacttgaagtttctacagcaacttggcaagggtaatttt gggagtgtggagatgtgccgatatgacccactacaggacaacactggggaggtggtggct gttaaaaaactgcagcacagcactgaagagcatctcagagactttgaaagggaaattgaa atcctgaagtccttgcagcatgacaacattgtgaagtacaagggagtgtgctacagtgct ggtcggcgaaacctaagattaattatggaatatttgccatatggaagtttacgagattat ctccaaaaacacaaagaacggatagatcacaaaaaacttctgcagtacacatctcagata tgcaagggtatggaatatcttggtacaaaaaggtatatccacagagatctagcaacaaga aatatactggtggaaaatgagaacagagttaaaataggagattttggattaaccaaagtc ttgccacaggacaaagaatactacaaagtaaaagaaccaggtgaaagtcccatattctgg tatgctccagaatccctgacagagagcaagttttctgtggcctcagatgtgtggagcttt ggcgtggttctgtatgaacttttcacatacattgagaagagtaaaagtccaccagtggaa tttatgcgaatgattggcaatgataaacaaggacagatgattgtgttccatttgatagag cttctgaagagtaatggaagattaccaagaccagaaggatgcccagatgagatttatatg atcatgacagaatgctggaacaacaatgtcaatcagcgtccctctttcagggacctagca cttagggtggatcaaatccgggacagtttggctgcgtga

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