Mesocricetus auratus (golden hamster): 101843291
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Entry
101843291 CDS
T08306
Symbol
Lrrk2
Name
(RefSeq) leucine-rich repeat serine/threonine-protein kinase 2 isoform X1
KO
K08844
leucine-rich repeat kinase 2 [EC:
2.7.11.1
]
Organism
maua
Mesocricetus auratus (golden hamster)
Pathway
maua05012
Parkinson disease
maua05022
Pathways of neurodegeneration - multiple diseases
Brite
KEGG Orthology (KO) [BR:
maua00001
]
09160 Human Diseases
09164 Neurodegenerative disease
05012 Parkinson disease
101843291 (Lrrk2)
05022 Pathways of neurodegeneration - multiple diseases
101843291 (Lrrk2)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
maua01001
]
101843291 (Lrrk2)
09182 Protein families: genetic information processing
04131 Membrane trafficking [BR:
maua04131
]
101843291 (Lrrk2)
09183 Protein families: signaling and cellular processes
04147 Exosome [BR:
maua04147
]
101843291 (Lrrk2)
Enzymes [BR:
maua01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.11 Protein-serine/threonine kinases
2.7.11.1 non-specific serine/threonine protein kinase
101843291 (Lrrk2)
Protein kinases [BR:
maua01001
]
Serine/threonine kinases: TKL group
LRRK family
101843291 (Lrrk2)
Membrane trafficking [BR:
maua04131
]
Exocytosis
Calcium ion-dependent exocytosis
Kinases and associated proteins
101843291 (Lrrk2)
Exosome [BR:
maua04147
]
Exosomal proteins
Exosomal proteins of other body fluids (saliva and urine)
101843291 (Lrrk2)
BRITE hierarchy
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
ARM_LRRK2
Beta-prop_LRRK2
ANK_LRRK2
Pkinase
PK_Tyr_Ser-Thr
LRR_8
LRR_4
Roc
COR-B
Ras
COR-A
LRR_1
WD40_CDC20-Fz
Beta-prop_RSE1_2nd
Beta-prop_WDR36-Utp21_1st
Beta-prop_EML_2
LRR_9
Ank_2
Arf
Beta-prop_EML
LRR_NXF1-5
PduV-EutP
T2SSE
ARM_CUL7_CUL9
Beta-prop_THOC3
LRR_13
nSTAND3
Beta-prop_RIG_2nd
ABC_tran
LRR_6
Arm
GTP_EFTU
AAA_22
MobB
Kdo
G-alpha
AAA_16
AAA_7
NACHT
AAA_29
TrwB_AAD_bind
FtsK_SpoIIIE
NB-ARC
Ank_5
MMR_HSR1
TsaE
nSTAND_NTPase5
cobW
TniB
SRP54
Beta-prop_HPS5
Motif
Other DBs
NCBI-GeneID:
101843291
NCBI-ProteinID:
XP_005067184
UniProt:
A0A1U7Q7Z2
LinkDB
All DBs
Position
Unknown
AA seq
2527 aa
AA seq
DB search
MASGGSQGCEEEEEEEALKKLIVRLNNVQEGKQIETLLQLLEDILVFTYSDRASKLFEGK
NLHVPLLIVLDSYLKVSSVQQVGWSLLCKLIEVCPGTLPSLIGPQDIGKDWEFLGIHQLI
LKMLTVHHANVNLSTVGLKALDLLLDSGKITLLILDEECDIFLLIFDAMNTYSANDEVQK
LGCKTLHVLFERVSEEQLMEFVENKDYMILLSTLRNFKGDKEIVFHVLCCLHSLAVPCNN
VEVLMSGNVRCYNIVVEAMKAFPDNEKIQEVSCSLLHRLTLGNFFNILVLNEVHIFVVKA
VRQYPENAALQISALSCLALLTETIFLNQDLEERNEPQENNDEEDTEKLFWLEPCCKALM
RHRKNKHVQEAACWALNNLLMYQNSLHEKIGEDDGQFPAHREVMLSMLMHSSSKDVFQAA
AHALSTLLEQNVNFRKILLAKGVYLNVLELMQRHAHVPEVAESGCKMLSHLFEGSNASLD
TMAAVVPRIITVMKTHETSLSVQLEALRAVLHFVESGIPEESSDDSQCKLNMLKKQYFRT
DIHKLILAALNRFIGNPGIQKCGLKVLSSLTRLPDALEMLALHGAVDAALHTLQMYPDDQ
EIQCLGLHLTGCLITKKNFCVRTGHLLAKVLVSSLQRFIDVAEVQTTGLQTILAILELSV
SFSKLLVHHSFDLVIFHQMSSSVIEQKDEQFLNLCCKCFAKLAVDDESKSTMLERACEQD
NSIMVECLLLLGADANQSKGATSLIYQVCERENSPKLVELLLNAGCREQDVRKALTVSIQ
KGDSQVISLLLRRLALDLANNSICLGGFCIRKIDPSWLGPLFPDKSSNLKKQTNRGSVLA
RKVLRYQMKNSLQEGVTSGSDGNISEDALAKFGEWTFIPDSSMDSVFGHSDDLDSEGSEN
SFLMKRKSNSISVGEFYRDPVLQRSSPNSQRHSNSLGPIFDHEDLLRRKRKILPSDESVR
SSKLQSHMRHSESSSSLASEREYITSLDLSANELKDIDALSQRCCLSGHLEHLTKLELHQ
NALTGFPQQLCETLKCLTHLDLHSNKFTSFPSFLLKMACITNLDASRNDIGPAIVFDPLV
KCPSLKHLNLSYNQLSSIPENLTQVAEKLEQLLLEGNKISGICSPLSLKELKILNLSKNH
ILSLPEDFLEACPKVETFSARMNSLASMPVLPFSITSLKLSQNCFTCIPEAIFILPHLRS
LDMSHNNIECLPGPAHWKSLNLRELFFSHNQISTLDLSEKPQVWSRVEKLHLSHNKLKEI
PPAIGCLENLTSLDVSYNLDLRSFPNEMGKLSKIWDLPLDGLHLNLDFKHIGCKAKDIIR
FLQQRLKKAVPYNRMKLMIVGNTGSGKTTLLQQLMKVRKSDLGLQSATVGIDVRDWPIQI
RGKRKKDLVLNVWDFAGREEFYSTHPHFMTQRALYLAVYDLSKGQAEVDAMKPWLFNIKA
RASSSPVILVGTHLDVSDEKQRKTCISKITKELLNKRGFPTIRDYHFVNATEESDALAKL
RKTIINESLNFKIRDQPVVGQLIPDCYVELEKIILSERKAVPVEFPVINRKQLLQLVTDH
QLQLDENELPHAIHFLNESGVLLHFQDPALQLSDLYFVEPKWLCKVMAQILTVKVEGGLK
HPKGIISRRDVEKFLSKKKRFPKNYMAQYFKLLEKFQIALPIGEEYLLVPSSLSDHRPVI
ELPHCENSEIIIRLYEMPYFPMGFWSRLINRLLEISPFMLSGRERALRPNRMYWRQGIYL
NWSPEAYCLVGSEVLDNRPESFLKITVPSGRKGCILLGQVVDHIDSLMEEWFPGLLEIDI
CGEGETLLKKWALYSFNDGEEHQKILLDDLMKKAEEGDLLINPDQPRLTIPISQIAPDLI
LADLPRNIMLNNDELEFEEAPEFLLGDGSFGSVYRAAYEGEEVAVKIFNKHTSLRLLRQE
LVVLCHLHHPSLISLLAAGIRPRMLVMELASKGSLDRLLQQDKASLTRTLQHRIALHVAD
GLRYLHSAMIIYRDLKPHNVLLFTLYPNTAIIAKIADYGIAQYCCRMGIKTSEGTPGFRA
PEVARGNVIYNQQADVYSFGLLLHDIWTTGNRIIEGLRFPNEFDELAIQGKLPDPVKEYG
CAPWPMVEKLIKKCLKENPQERPTSAQVFDVLNSAELICLMRHILIPKNIIVECMVASNP
NSKSATLWLGCGNTEKGQLSFFDLNTERYSYEEVTDSRILCLALVHLPAEKESWIVCGTQ
SGDLLVINAEDETKRHSLEKMTDSITCLYCNSFAKQSKQSNFLLVGTADGNLVIFEDKNV
KCKGAAPLKTLHIGDISTPLMCLSVSMNSSERHITWGGCGTKIFSFSSDFTIQKLIETRT
NQLFSYAAFSDSNIIAVAVDTTLFIAKKNSPVVEVWDKKTEKLCELIDCVHFLKEVMVKT
NKESKHKLSYSGRVKALCLQKNTALWIGTGGGHILLLDLSTRRVIRTIHNFCDSVRAMAM
AQLGSLKSVMLVLGYKRKSTDGTQEQKEIQSCLSIWDINLPHEVQNLEKHIEVRTELADK
MKRTSVD
NT seq
7584 nt
NT seq
+upstream
nt +downstream
nt
atggccagtggtggctcgcagggctgcgaggaggaagaggaggaggaggcgctgaagaag
ttgatagtcagactgaataatgtgcaggaaggcaagcagatcgagacgttgctccagctc
ctggaggacatactggtgttcacctactccgacagagcctccaagttatttgaaggcaaa
aatttacacgtgccgctgttgattgtcctggactcctacttgaaagtctccagtgtgcag
caggtgggttggtcacttctgtgcaaattaatagaagtttgcccagggacattgccaagc
ttaataggaccacaggatattggaaaagattgggagttcctcggtattcatcaattgatt
ctcaaaatgttaactgttcaccatgccaatgtaaacctgtcaacagtcggactaaaagcc
ttagatctcctcctagattcaggaaaaatcactttgctgatactggatgaagaatgtgat
attttcttgttaatctttgatgctatgaacacatactcggccaatgatgaagtccagaaa
cttggatgcaagactttgcatgtgttgtttgagagagtttccgaggaacagctgatggag
tttgttgagaacaaagattacatgatactgctgagtacactcaggaatttcaaaggggat
aaggaaattgtatttcatgtgctctgctgcctgcattccctggcggttccctgcaacaat
gttgaagtcctcatgagtgggaatgtcaggtgttacaatattgtggtggaagccatgaaa
gcgttccctgacaatgaaaaaattcaagaagtgagctgctccttgctccacaggcttaca
ttaggtaatttcttcaacatcctggtgctgaatgaagtgcatatctttgtggttaaagct
gtccggcagtatccagagaatgcagccttgcagatctctgcactcagctgtttagcactt
ctcactgagaccattttcttaaaccaagacttggaggaaagaaatgagcctcaggagaac
aatgatgaggaggacactgagaagctattctggttggaaccctgttgtaaagccctgatg
cgccatcggaagaacaaacatgtgcaggaagccgcatgctgggcactaaataatctcctt
atgtaccagaacagtttacatgagaagattggagaggacgatggccagttccctgcacac
agagaagtgatgctgtccatgctgatgcattcttcttccaaagatgtcttccaggcagct
gctcatgcactctccactctcttggaacaaaatgttaatttcagaaaaatcctgctggca
aaaggagtatacctgaatgtcttggagttgatgcagaggcatgcccatgttcctgaggtg
gcagagagtggctgcaagatgttgagtcatctgtttgaaggaagtaatgcttcactggat
acaatggcagcagtggtccccaggataataacagtgatgaaaacccacgagacatctctg
tcagtgcagctggaggcattgcgagctgttttgcattttgtagagtcaggaataccagaa
gaatccagcgatgactctcaatgcaaactaaacatgctaaaaaagcagtatttcaggact
gacatccacaagctgattctagcagctctgaacaggttcattgggaatcccgggattcag
aaatgtggactgaaagtattgtcttccctaacacgtcttcccgatgccttagagatgctg
gccctgcatggtgcagttgatgcagcgcttcacactttacagatgtatccagatgaccaa
gaaattcagtgcctgggcttacaccttacaggatgcttgattacaaagaagaatttctgc
gtacggacagggcacctcctggcaaaagttctggtttccagtttacagcgctttatagat
gttgctgaagtacagaccacaggattgcagacaatcctggcaatacttgaattgtcagta
tctttctccaagctgctagtgcaccactcatttgatttggtaatattccatcagatgtct
tccagcgtcatagaacaaaaggatgagcagttcctcaatctatgttgcaaatgctttgcc
aaactggctgtggatgacgagtcgaaaagcacaatgctagagagagcatgtgagcaggat
aacagcatcatggttgagtgtttgcttctgttgggagctgatgccaatcaatcgaaaggg
gcaacttctttaatttatcaggtatgcgagagagagaacagtccaaaactggtggagctg
ttactgaatgctggatgccgtgagcaagatgtacggaaagcactgactgtcagcatccaa
aagggcgacagccaggtcatcagtttgctcctgaggaggctggccctggacctggccaac
aacagcatttgccttggaggattttgcataagaaaaattgatccttcttggcttggtcct
ttattcccagataagtcatctaatttaaagaaacaaacaaacagaggatctgtcctagca
agaaaagtgctccgatatcagatgaaaaacagtttgcaagaaggagtgacttcaggcagc
gacggcaacatttctgaagatgccctggcgaaatttggtgaatggacgttcattcccgac
tcttctatggacagtgtatttgggcacagtgatgacttggatagtgaaggcagtgagaac
tcatttctcatgaaaaggaagtcaaattcgattagtgtgggggaattttatagagatccg
gttttgcagcgttcctcaccaaattcacagaggcactccaattccttgggtcccattttt
gatcatgaagatttactgagaagaaaaagaaaaatactgccttcagatgagtcagtcagg
tcatcgaagcttcagtcccacatgaggcattcagaaagctcttcttccctggcttcggag
agagaatacatcacatcattagacctttctgccaatgaactgaaagatattgatgccctg
agccagaggtgctgcctcagtggccacctggaacatctcaccaagctggaacttcaccag
aatgcactcacgggcttccctcagcagctgtgcgagactctgaagtgtttgacacatttg
gatttgcacagcaacaaattcacctcatttccctccttcttgttgaaaatggcatgtatc
accaacctagatgcctctcgaaatgacattgggccagcaattgtattcgaccccctggtg
aaatgtcccagtctcaaacaccttaacctgtcttacaaccagctctcttccatcccagag
aacctcacccaagtggcagagaaactggagcagctcctattggaaggaaataaaatatct
gggatttgttctcccttgagcctgaaggaactgaagattttaaatcttagtaaaaaccac
attctatccctacctgaagacttccttgaggcttgtccaaaagtggagactttcagtgct
cggatgaattctcttgcttcgatgcctgtcttacccttttccataacaagcctaaaatta
tctcaaaactgtttcacatgcattccagaagcgattttcattctcccacacttgcggtcc
ttggacatgagccacaacaacattgagtgcctgccagggcctgcgcactggaagtctctg
aacttaagggagctcttcttcagccataaccaaatcagcaccttggacttgagtgaaaag
ccacaggtgtggtcaagagtagagaaactgcatctctctcataataaactgaaagagatt
cctcctgcaattggctgtcttgaaaatctgacatctcttgatgtcagttacaacttggac
ctgaggtcctttccgaacgaaatggggaagttaagcaaaatatgggatcttcctctggat
ggactgcatctgaatttagactttaagcacataggatgcaaagccaaagacatcataagg
ttcctccaacaacggcttaaaaaggcagtgccctacaaccggatgaagcttatgattgtg
ggaaatactgggagtggtaagaccacgctactgcagcaactcatgaaagtgaggaaatca
gatcttggcttgcagagcgccacggtgggcatcgatgtcagagactggcctatccaaata
cgaggcaaaaggaagaaggaccttgttctcaatgtctgggattttgcaggccgtgaggaa
ttctacagcactcacccccacttcatgacccagagagctctgtatctcgctgtctacgac
ctcagcaaggggcaggcagaggtggatgccatgaagccctggctcttcaacatcaaggct
cgtgcctcttcttccccggtgattctggtgggcacacatttggatgtatcagacgagaag
cagcgcaaaacctgcataagcaaaatcaccaaggaactcctaaacaagcgaggattcccc
accatccgggactaccacttcgtgaatgccaccgaggagtctgatgcgctggcaaagctt
cggaaaaccatcatcaatgagagtcttaatttcaagatccgagatcagcctgtggttggg
cagctgattccagattgctacgtagaactggagaaaatcattctgtcagagcgcaaagct
gtgccagttgagtttcctgtaattaaccggaaacagttattacaactcgtgacagaccat
cagctgcagctggatgagaacgagctcccacacgccatccatttcctaaatgagtcagga
gtccttctgcattttcaagatcctgcactgcagctaagcgacctgtattttgtggaaccc
aagtggctttgtaaagtcatggcacagattttgacagtgaaagtggagggcggtctgaaa
catcctaagggcatcatttcacggagagatgtagaaaaattcctttcaaagaaaaagcga
ttcccaaagaactacatggcacagtactttaaactcttagaaaaattccagattgccttg
ccaataggagaagaatatttgctggttccaagcagcttgtctgaccacaggcctgtgata
gagctcccccactgtgagaactctgagatcatcattcgcttatacgaaatgccatacttt
ccaatgggattttggtctagactgatcaatcgattacttgaaatatcacctttcatgctt
tctggaagagagcgagcactacgcccaaacagaatgtactggcgacagggaatctacttg
aattggtccccagaagcatattgtctggtaggatccgaagtcttagacaatcgcccagag
agtttcttgaaaattacagttccatctggtaggaaaggttgtattcttttgggccaagtc
gtggatcacattgactccctcatggaggaatggtttcctgggttgctggagatcgacatt
tgtggggaaggagaaactcttttgaagaaatgggcattgtacagttttaatgatggggag
gaacatcagaagatcctactcgacgacttgatgaagaaagcagaagagggagacctgcta
ataaatccagatcaaccaaggctcactattccaatatctcagattgctcctgacttgatt
ttggctgacctgcctagaaatattatgttgaacaatgatgaactggaatttgaggaagca
cctgagtttctcttaggtgatggaagttttggatcagtctatcgagctgcctatgaagga
gaggaagtggctgtgaagatttttaacaaacacacatcacttaggctgttaagacaagag
ttggtggttctttgccatctccaccacccaagcttgatatctttgctggcagctgggatt
cgtcctcggatgttggtaatggaattggcctccaagggttccttggatcgtctgctgcaa
caggacaaggccagcctcaccagaaccctccaacacaggattgcattacatgtggctgat
ggcctgagatatctccactcagccatgattatttaccgtgatctgaaaccccacaacgtg
ttgctttttaccctctatcccaacactgccatcattgcgaagattgcagactacgggatt
gcacagtactgctgcagaatgggaataaagacctcagagggtaccccagggttccgggca
cctgaagttgccagaggaaacgtcatttataaccaacaggctgatgtttattcgttcggc
ttactgcttcacgacatttggacaactgggaatagaatcatagagggcttgaggtttcca
aatgagtttgatgaattagcaatacaagggaaattgccagatccagttaaagaatatggc
tgtgccccatggcctatggttgagaagttaattaaaaaatgtttgaaagaaaatcctcaa
gaaaggcccacttctgcccaggtctttgacgttttgaattcagctgaattgatttgtctc
atgcgacacattttaatacctaagaacattattgtggaatgtatggtggcttcaaatccc
aacagcaagagtgcaactctctggttgggctgtgggaacaccgaaaaagggcagctctcc
ttctttgacttaaacacagaaagatacagttatgaggaagtgactgatagtcggatcctg
tgcttggctttggtgcatcttcctgctgagaaggagagctggattgtgtgtggcacacag
tctggggatctcctggtcatcaatgctgaggatgagacaaagagacacagcctggaaaag
atgactgactccattacttgtttgtattgcaattcctttgccaagcagagcaagcaaagt
aattttcttttggtgggaaccgctgatgggaatttagtgatatttgaagataagaatgtt
aagtgtaaaggagctgcccccttgaagacactacacataggcgatatcagtacacccctg
atgtgcttgagtgtgtccatgaattcatccgaaagacacatcacatggggagggtgtggc
acaaagatcttctccttctccagtgatttcaccattcagaaactcattgagacaagaacc
aaccaactgttttcttatgcagccttcagcgattctaacatcatagctgtggcagtagac
acgactctctttattgccaagaaaaacagccccgtggtagaggtgtgggacaaaaaaacg
gaaaagctctgtgaattaatagactgtgtgcacttcttaaaggaggtgatggtaaaaact
aacaaggaatcaaaacacaagctgtcctactctgggcgggtgaaagcgctctgcctgcag
aagaacacagctctctggataggaaccggaggaggccacattttactcctggatctttcc
actcgacgcgttatacgcaccatccacaacttctgtgattctgtgagagccatggccatg
gcacaattaggaagccttaaaagtgtcatgctggttttggggtacaagcggaagagtaca
gatggtacccaggaacaaaaagaaatacagtcttgcttgtctatttgggacatcaatctt
ccacatgaagtgcaaaatttagaaaaacacattgaagtaagaacagagttagctgataaa
atgaaaagaacatctgttgactag
DBGET
integrated database retrieval system
