KEGG   Moschus berezovskii (Chinese forest musk deer): 129547146
Entry
129547146         CDS       T09065                                 
Symbol
PIK3CB
Name
(RefSeq) phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform isoform X1
  KO
K00922  phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
Organism
mbez  Moschus berezovskii (Chinese forest musk deer)
Pathway
mbez00562  Inositol phosphate metabolism
mbez01100  Metabolic pathways
mbez01521  EGFR tyrosine kinase inhibitor resistance
mbez01522  Endocrine resistance
mbez01524  Platinum drug resistance
mbez04012  ErbB signaling pathway
mbez04014  Ras signaling pathway
mbez04015  Rap1 signaling pathway
mbez04024  cAMP signaling pathway
mbez04062  Chemokine signaling pathway
mbez04066  HIF-1 signaling pathway
mbez04068  FoxO signaling pathway
mbez04070  Phosphatidylinositol signaling system
mbez04071  Sphingolipid signaling pathway
mbez04072  Phospholipase D signaling pathway
mbez04081  Hormone signaling
mbez04140  Autophagy - animal
mbez04150  mTOR signaling pathway
mbez04151  PI3K-Akt signaling pathway
mbez04152  AMPK signaling pathway
mbez04210  Apoptosis
mbez04211  Longevity regulating pathway
mbez04213  Longevity regulating pathway - multiple species
mbez04218  Cellular senescence
mbez04360  Axon guidance
mbez04370  VEGF signaling pathway
mbez04380  Osteoclast differentiation
mbez04510  Focal adhesion
mbez04550  Signaling pathways regulating pluripotency of stem cells
mbez04611  Platelet activation
mbez04613  Neutrophil extracellular trap formation
mbez04620  Toll-like receptor signaling pathway
mbez04625  C-type lectin receptor signaling pathway
mbez04630  JAK-STAT signaling pathway
mbez04650  Natural killer cell mediated cytotoxicity
mbez04660  T cell receptor signaling pathway
mbez04662  B cell receptor signaling pathway
mbez04664  Fc epsilon RI signaling pathway
mbez04666  Fc gamma R-mediated phagocytosis
mbez04668  TNF signaling pathway
mbez04670  Leukocyte transendothelial migration
mbez04722  Neurotrophin signaling pathway
mbez04725  Cholinergic synapse
mbez04750  Inflammatory mediator regulation of TRP channels
mbez04810  Regulation of actin cytoskeleton
mbez04910  Insulin signaling pathway
mbez04914  Progesterone-mediated oocyte maturation
mbez04915  Estrogen signaling pathway
mbez04917  Prolactin signaling pathway
mbez04919  Thyroid hormone signaling pathway
mbez04923  Regulation of lipolysis in adipocytes
mbez04926  Relaxin signaling pathway
mbez04929  GnRH secretion
mbez04930  Type II diabetes mellitus
mbez04931  Insulin resistance
mbez04932  Non-alcoholic fatty liver disease
mbez04933  AGE-RAGE signaling pathway in diabetic complications
mbez04935  Growth hormone synthesis, secretion and action
mbez04960  Aldosterone-regulated sodium reabsorption
mbez04973  Carbohydrate digestion and absorption
mbez05010  Alzheimer disease
mbez05017  Spinocerebellar ataxia
mbez05020  Prion disease
mbez05100  Bacterial invasion of epithelial cells
mbez05132  Salmonella infection
mbez05135  Yersinia infection
mbez05142  Chagas disease
mbez05146  Amoebiasis
mbez05160  Hepatitis C
mbez05161  Hepatitis B
mbez05162  Measles
mbez05163  Human cytomegalovirus infection
mbez05164  Influenza A
mbez05165  Human papillomavirus infection
mbez05166  Human T-cell leukemia virus 1 infection
mbez05167  Kaposi sarcoma-associated herpesvirus infection
mbez05168  Herpes simplex virus 1 infection
mbez05169  Epstein-Barr virus infection
mbez05170  Human immunodeficiency virus 1 infection
mbez05171  Coronavirus disease - COVID-19
mbez05200  Pathways in cancer
mbez05203  Viral carcinogenesis
mbez05205  Proteoglycans in cancer
mbez05206  MicroRNAs in cancer
mbez05207  Chemical carcinogenesis - receptor activation
mbez05208  Chemical carcinogenesis - reactive oxygen species
mbez05210  Colorectal cancer
mbez05211  Renal cell carcinoma
mbez05212  Pancreatic cancer
mbez05213  Endometrial cancer
mbez05214  Glioma
mbez05215  Prostate cancer
mbez05218  Melanoma
mbez05220  Chronic myeloid leukemia
mbez05221  Acute myeloid leukemia
mbez05222  Small cell lung cancer
mbez05223  Non-small cell lung cancer
mbez05224  Breast cancer
mbez05225  Hepatocellular carcinoma
mbez05226  Gastric cancer
mbez05230  Central carbon metabolism in cancer
mbez05231  Choline metabolism in cancer
mbez05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
mbez05415  Diabetic cardiomyopathy
mbez05417  Lipid and atherosclerosis
mbez05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:mbez00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    129547146 (PIK3CB)
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    129547146 (PIK3CB)
   04014 Ras signaling pathway
    129547146 (PIK3CB)
   04015 Rap1 signaling pathway
    129547146 (PIK3CB)
   04370 VEGF signaling pathway
    129547146 (PIK3CB)
   04630 JAK-STAT signaling pathway
    129547146 (PIK3CB)
   04668 TNF signaling pathway
    129547146 (PIK3CB)
   04066 HIF-1 signaling pathway
    129547146 (PIK3CB)
   04068 FoxO signaling pathway
    129547146 (PIK3CB)
   04070 Phosphatidylinositol signaling system
    129547146 (PIK3CB)
   04072 Phospholipase D signaling pathway
    129547146 (PIK3CB)
   04071 Sphingolipid signaling pathway
    129547146 (PIK3CB)
   04024 cAMP signaling pathway
    129547146 (PIK3CB)
   04151 PI3K-Akt signaling pathway
    129547146 (PIK3CB)
   04152 AMPK signaling pathway
    129547146 (PIK3CB)
   04150 mTOR signaling pathway
    129547146 (PIK3CB)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    129547146 (PIK3CB)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    129547146 (PIK3CB)
  09143 Cell growth and death
   04210 Apoptosis
    129547146 (PIK3CB)
   04218 Cellular senescence
    129547146 (PIK3CB)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    129547146 (PIK3CB)
   04550 Signaling pathways regulating pluripotency of stem cells
    129547146 (PIK3CB)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    129547146 (PIK3CB)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    129547146 (PIK3CB)
   04613 Neutrophil extracellular trap formation
    129547146 (PIK3CB)
   04620 Toll-like receptor signaling pathway
    129547146 (PIK3CB)
   04625 C-type lectin receptor signaling pathway
    129547146 (PIK3CB)
   04650 Natural killer cell mediated cytotoxicity
    129547146 (PIK3CB)
   04660 T cell receptor signaling pathway
    129547146 (PIK3CB)
   04662 B cell receptor signaling pathway
    129547146 (PIK3CB)
   04664 Fc epsilon RI signaling pathway
    129547146 (PIK3CB)
   04666 Fc gamma R-mediated phagocytosis
    129547146 (PIK3CB)
   04670 Leukocyte transendothelial migration
    129547146 (PIK3CB)
   04062 Chemokine signaling pathway
    129547146 (PIK3CB)
  09152 Endocrine system
   04910 Insulin signaling pathway
    129547146 (PIK3CB)
   04923 Regulation of lipolysis in adipocytes
    129547146 (PIK3CB)
   04929 GnRH secretion
    129547146 (PIK3CB)
   04915 Estrogen signaling pathway
    129547146 (PIK3CB)
   04914 Progesterone-mediated oocyte maturation
    129547146 (PIK3CB)
   04917 Prolactin signaling pathway
    129547146 (PIK3CB)
   04926 Relaxin signaling pathway
    129547146 (PIK3CB)
   04935 Growth hormone synthesis, secretion and action
    129547146 (PIK3CB)
   04919 Thyroid hormone signaling pathway
    129547146 (PIK3CB)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    129547146 (PIK3CB)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    129547146 (PIK3CB)
  09156 Nervous system
   04725 Cholinergic synapse
    129547146 (PIK3CB)
   04722 Neurotrophin signaling pathway
    129547146 (PIK3CB)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    129547146 (PIK3CB)
  09158 Development and regeneration
   04360 Axon guidance
    129547146 (PIK3CB)
   04380 Osteoclast differentiation
    129547146 (PIK3CB)
  09149 Aging
   04211 Longevity regulating pathway
    129547146 (PIK3CB)
   04213 Longevity regulating pathway - multiple species
    129547146 (PIK3CB)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    129547146 (PIK3CB)
   05206 MicroRNAs in cancer
    129547146 (PIK3CB)
   05205 Proteoglycans in cancer
    129547146 (PIK3CB)
   05207 Chemical carcinogenesis - receptor activation
    129547146 (PIK3CB)
   05208 Chemical carcinogenesis - reactive oxygen species
    129547146 (PIK3CB)
   05203 Viral carcinogenesis
    129547146 (PIK3CB)
   05230 Central carbon metabolism in cancer
    129547146 (PIK3CB)
   05231 Choline metabolism in cancer
    129547146 (PIK3CB)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    129547146 (PIK3CB)
  09162 Cancer: specific types
   05210 Colorectal cancer
    129547146 (PIK3CB)
   05212 Pancreatic cancer
    129547146 (PIK3CB)
   05225 Hepatocellular carcinoma
    129547146 (PIK3CB)
   05226 Gastric cancer
    129547146 (PIK3CB)
   05214 Glioma
    129547146 (PIK3CB)
   05221 Acute myeloid leukemia
    129547146 (PIK3CB)
   05220 Chronic myeloid leukemia
    129547146 (PIK3CB)
   05218 Melanoma
    129547146 (PIK3CB)
   05211 Renal cell carcinoma
    129547146 (PIK3CB)
   05215 Prostate cancer
    129547146 (PIK3CB)
   05213 Endometrial cancer
    129547146 (PIK3CB)
   05224 Breast cancer
    129547146 (PIK3CB)
   05222 Small cell lung cancer
    129547146 (PIK3CB)
   05223 Non-small cell lung cancer
    129547146 (PIK3CB)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    129547146 (PIK3CB)
   05170 Human immunodeficiency virus 1 infection
    129547146 (PIK3CB)
   05161 Hepatitis B
    129547146 (PIK3CB)
   05160 Hepatitis C
    129547146 (PIK3CB)
   05171 Coronavirus disease - COVID-19
    129547146 (PIK3CB)
   05164 Influenza A
    129547146 (PIK3CB)
   05162 Measles
    129547146 (PIK3CB)
   05168 Herpes simplex virus 1 infection
    129547146 (PIK3CB)
   05163 Human cytomegalovirus infection
    129547146 (PIK3CB)
   05167 Kaposi sarcoma-associated herpesvirus infection
    129547146 (PIK3CB)
   05169 Epstein-Barr virus infection
    129547146 (PIK3CB)
   05165 Human papillomavirus infection
    129547146 (PIK3CB)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    129547146 (PIK3CB)
   05135 Yersinia infection
    129547146 (PIK3CB)
   05100 Bacterial invasion of epithelial cells
    129547146 (PIK3CB)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    129547146 (PIK3CB)
   05142 Chagas disease
    129547146 (PIK3CB)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    129547146 (PIK3CB)
   05017 Spinocerebellar ataxia
    129547146 (PIK3CB)
   05020 Prion disease
    129547146 (PIK3CB)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    129547146 (PIK3CB)
   05418 Fluid shear stress and atherosclerosis
    129547146 (PIK3CB)
   05415 Diabetic cardiomyopathy
    129547146 (PIK3CB)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    129547146 (PIK3CB)
   04932 Non-alcoholic fatty liver disease
    129547146 (PIK3CB)
   04931 Insulin resistance
    129547146 (PIK3CB)
   04933 AGE-RAGE signaling pathway in diabetic complications
    129547146 (PIK3CB)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    129547146 (PIK3CB)
   01524 Platinum drug resistance
    129547146 (PIK3CB)
   01522 Endocrine resistance
    129547146 (PIK3CB)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:mbez04131]
    129547146 (PIK3CB)
Enzymes [BR:mbez01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.153  phosphatidylinositol-4,5-bisphosphate 3-kinase
     129547146 (PIK3CB)
Membrane trafficking [BR:mbez04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    129547146 (PIK3CB)
SSDB
Motif
Pfam: PI3_PI4_kinase PI3Ka PI3K_rbd PI3K_p85B PI3K_C2 Tom37_C DUF4381
Other DBs
NCBI-GeneID: 129547146
NCBI-ProteinID: XP_055268859
LinkDB
Position
Unknown
AA seq 1070 aa
MCFYFMMPPAMADVLDIWAVDSQIASDGSIPVDFLLPTGIYIQLEVPREATISCIKQMLW
KQVTNYPMFNLLMEIDSYMFACVNQTAVYEELEDETRRLCDVRPFLPVLKLVTRSCDPGE
KLDSKIGVLIGRGLHEFDALKDPEVNEFRIKMRRFSEEKIQSLVGLSWMDWLKHTYPPEL
EPSVPENLEDKLYGGKLIVAVHFENCQDVFSFQVFPNMNPIKINELAIQKRLTIHGKEDE
VSPYDYVLQVSGRVEYVFGDHSLIQFQYIRNCVMNRTLPHFILVECCKIKKLYEQEMVAI
EAAINRNSSNLPLPLPPKKTRIISHVWENNNPFQIVLVKGNKLNTEEAVKVHVRAGLFHG
TELLCKTVVSSEISGKNDHIWNEPLEFDINTCDLPRMTRLCFAVYAVLDKVKTKKSTKTM
NPSKYQTIRKSGKVHYPVAWVNTMVFDFKGQLRSGDIILHSWSSFPDELEEMLNPMGTVQ
TNPYTENATALHIKFPENKKQPYYYPPFDKIIEKAAEIASSDSANVSSRGGKKFLAVLKE
ILDRDPLSQLCENEMDLIWTLRQDCRENFPHALPKLLLSIKWNKLEDVAQLQALLQIWPK
LPPREALELLDFNYPDQYVREYAVGCLQQMSDEELSQYLLQLVQVLKYEPFLDCALSRFL
LERALANRRIGQFLFWHLRSEVHIPAVSVQFGVILEAYCRGSVGHMKALSKQVEALNKLK
TLNSLIKLNAMKLNRAKGKEAMHTCLKQNAYREALSDLQSPLNPCVILSELYVEKCKYMD
SKMKPLWLVYNNKVFGEDSVGVIFKNGDDLRQDMLTLQMLRLMDLLWKEAGLDLRMLPYG
CLATGDRSGLIEVVSTSETIADIQLNSSNVAAAAAFNKDALLNWLKEYNSGDDLDRAIEE
FTLSCAGYCVASYVLGIGDRHSDNIMVKKTGQLFHIDFGHILGNFKSKFGIKRERVPFIL
TYDFIHVIQQGKTGNTEKFGRFRQCCEDAYLILRRHGNLFITLFALMLTAGLPELTSVKD
IQYLKDSLALGKSEEEALKQFKQKFDEALRESWTTKVNWMAHTVRKDYRS
NT seq 3213 nt   +upstreamnt  +downstreamnt
atgtgcttctacttcatgatgcctcctgctatggcagacgtccttgacatctgggcagtg
gactcacagatagcgtctgatggctccatacccgtggattttcttttgcccactgggatt
tatatccagttggaggtgcctcgtgaagctaccatttcctgtattaagcagatgttatgg
aaacaagttaccaattacccaatgtttaacctccttatggaaatcgactcctatatgttt
gcatgtgtgaatcaaactgctgtatatgaggagctcgaagatgaaacaagaagactctgt
gatgtcagaccttttcttccagttctcaaattagtgacaagaagttgtgacccaggggaa
aaattagactcaaaaattggagtccttataggaagaggtctgcatgaatttgatgccttg
aaggatcctgaagtgaatgaattccgaataaaaatgcgcagattcagtgaggaaaagatt
caatcgcttgtgggattatcttggatggattggctaaagcatacctatccacctgagctt
gaaccatccgtccctgaaaatttagaagataaactttatggaggaaagctcattgtggct
gttcattttgaaaattgtcaggatgtgtttagttttcaggtatttccgaatatgaatcct
atcaaaataaatgaattggcaatccaaaaacgtctgactattcatgggaaagaagatgaa
gttagcccttatgactatgtgttgcaagtcagtgggagagtagaatatgtgtttggtgat
cattcactaattcagttccagtatatccggaactgtgtaatgaacagaacattgccccat
tttatacttgtggagtgttgcaagatcaagaagctgtatgaacaggaaatggttgccata
gaggctgccataaatcgaaattcatctaaccttcctcttcctttaccaccaaagaaaact
cgaattatttctcatgtttgggaaaataacaaccctttccaaattgtcttggttaaggga
aataaacttaacaccgaagaagctgtaaaagttcatgtcagggccggcctttttcatggt
actgaactcctgtgtaaaactgtcgtaagctcagagatatcagggaaaaatgatcatatt
tggaatgaaccactggaatttgatatcaacacttgtgacctgccacgaatgactcgatta
tgttttgctgtttatgcagttttggataaagtgaaaactaagaaatcaactaaaaccatg
aatccctctaaatatcagaccatcaggaaatctggaaaagtgcattatcctgtagcctgg
gtaaatacgatggtttttgactttaaaggacagttgagatctggagatataatattacac
agctggtcttcatttcctgatgaacttgaagaaatgttgaatccaatgggaactgttcaa
acaaatccatatacagaaaatgcaacagctttgcacataaaattcccagagaataaaaaa
caaccttattactatcctcccttcgataagattattgaaaaagcagctgagattgcaagc
agtgatagtgctaatgtatcaagtcgaggtggaaagaagtttcttgctgtattgaaagaa
atcttggacagggatccattgtctcaactgtgtgagaatgaaatggatcttatttggact
ttgcgacaagactgcagagagaatttcccacacgcattgccgaaattgttgctgtcgatc
aagtggaataaacttgaggatgttgctcagcttcaagcactgcttcagatttggcctaaa
cttcctccccgggaggcccttgagcttctagatttcaactatccagatcagtatgtgcga
gaatatgctgtgggctgcctgcaacagatgagtgatgaagaactctctcagtatctttta
cagttggtgcaagttttaaaatatgagccttttcttgattgtgccttgtctagattccta
ctagaaagagcacttgctaatcggaggatagggcagtttttattttggcacctcagatct
gaagtacacattcctgctgtttcagtacaatttggtgttatccttgaagcatactgccgg
ggaagcgtaggtcacatgaaagcgctttctaagcaggttgaagcactgaataaactaaaa
actttaaatagtttaatcaaactgaatgcaatgaagctaaatagagccaaagggaaagaa
gcaatgcacacttgtttaaaacagaatgcttaccgtgaagccctctctgacctgcagtca
cctctgaacccctgtgttatcctctcagaactctatgttgagaagtgtaaatacatggat
tccaaaatgaagcctttgtggcttgtgtacaacaacaaggtgtttggtgaggattcagtt
ggagtgatttttaaaaatggtgatgatttacggcaggatatgttgacactccagatgctg
cgcttgatggatttactctggaaagaagctggtctggaccttcggatgctaccttatggc
tgcttagcaacaggagaccgctctggcctcattgaagttgtgagcacctctgaaacaatt
gctgacattcagctgaacagtagcaatgttgctgcagcagcagcattcaacaaagacgcc
cttctgaactggcttaaagaatacaattctggggatgacctggaccgagccattgaggaa
tttaccctatcctgtgccggctactgtgtagcttcttatgtccttgggattggtgacaga
catagtgataacatcatggtcaaaaaaactggtcagctcttccacattgactttggacat
attcttggaaatttcaagtctaaatttggcattaaaagggagcgagtgccttttattctt
acttatgatttcattcatgtgattcaacaaggaaaaacaggaaacacagaaaaatttggc
cggttccgccagtgttgtgaggatgcatatctgattttacgccggcatgggaatctcttc
atcacactctttgcactgatgttgactgcagggcttcctgagctcacctcagtcaaggat
atacagtatcttaaggactctcttgccttagggaagagtgaagaagaagcactcaagcaa
ttcaagcaaaaatttgatgaggcactcagggaaagttggactactaaagtcaattggatg
gcccacacagttcggaaagactacagatcttaa

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