KEGG   Moschus berezovskii (Chinese forest musk deer): 129564326
Entry
129564326         CDS       T09065                                 
Symbol
ARAF
Name
(RefSeq) serine/threonine-protein kinase A-Raf isoform X1
  KO
K08845  A-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
Organism
mbez  Moschus berezovskii (Chinese forest musk deer)
Pathway
mbez01521  EGFR tyrosine kinase inhibitor resistance
mbez01522  Endocrine resistance
mbez04010  MAPK signaling pathway
mbez04012  ErbB signaling pathway
mbez04068  FoxO signaling pathway
mbez04270  Vascular smooth muscle contraction
mbez04650  Natural killer cell mediated cytotoxicity
mbez04720  Long-term potentiation
mbez04726  Serotonergic synapse
mbez04730  Long-term depression
mbez04810  Regulation of actin cytoskeleton
mbez04910  Insulin signaling pathway
mbez04914  Progesterone-mediated oocyte maturation
mbez04928  Parathyroid hormone synthesis, secretion and action
mbez05010  Alzheimer disease
mbez05022  Pathways of neurodegeneration - multiple diseases
mbez05034  Alcoholism
mbez05160  Hepatitis C
mbez05161  Hepatitis B
mbez05200  Pathways in cancer
mbez05205  Proteoglycans in cancer
mbez05208  Chemical carcinogenesis - reactive oxygen species
mbez05210  Colorectal cancer
mbez05211  Renal cell carcinoma
mbez05212  Pancreatic cancer
mbez05213  Endometrial cancer
mbez05214  Glioma
mbez05215  Prostate cancer
mbez05218  Melanoma
mbez05219  Bladder cancer
mbez05220  Chronic myeloid leukemia
mbez05221  Acute myeloid leukemia
mbez05223  Non-small cell lung cancer
mbez05224  Breast cancer
mbez05225  Hepatocellular carcinoma
mbez05226  Gastric cancer
Brite
KEGG Orthology (KO) [BR:mbez00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    129564326 (ARAF)
   04012 ErbB signaling pathway
    129564326 (ARAF)
   04068 FoxO signaling pathway
    129564326 (ARAF)
 09140 Cellular Processes
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    129564326 (ARAF)
 09150 Organismal Systems
  09151 Immune system
   04650 Natural killer cell mediated cytotoxicity
    129564326 (ARAF)
  09152 Endocrine system
   04910 Insulin signaling pathway
    129564326 (ARAF)
   04914 Progesterone-mediated oocyte maturation
    129564326 (ARAF)
   04928 Parathyroid hormone synthesis, secretion and action
    129564326 (ARAF)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    129564326 (ARAF)
  09156 Nervous system
   04726 Serotonergic synapse
    129564326 (ARAF)
   04720 Long-term potentiation
    129564326 (ARAF)
   04730 Long-term depression
    129564326 (ARAF)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    129564326 (ARAF)
   05205 Proteoglycans in cancer
    129564326 (ARAF)
   05208 Chemical carcinogenesis - reactive oxygen species
    129564326 (ARAF)
  09162 Cancer: specific types
   05210 Colorectal cancer
    129564326 (ARAF)
   05212 Pancreatic cancer
    129564326 (ARAF)
   05225 Hepatocellular carcinoma
    129564326 (ARAF)
   05226 Gastric cancer
    129564326 (ARAF)
   05214 Glioma
    129564326 (ARAF)
   05221 Acute myeloid leukemia
    129564326 (ARAF)
   05220 Chronic myeloid leukemia
    129564326 (ARAF)
   05218 Melanoma
    129564326 (ARAF)
   05211 Renal cell carcinoma
    129564326 (ARAF)
   05219 Bladder cancer
    129564326 (ARAF)
   05215 Prostate cancer
    129564326 (ARAF)
   05213 Endometrial cancer
    129564326 (ARAF)
   05224 Breast cancer
    129564326 (ARAF)
   05223 Non-small cell lung cancer
    129564326 (ARAF)
  09172 Infectious disease: viral
   05161 Hepatitis B
    129564326 (ARAF)
   05160 Hepatitis C
    129564326 (ARAF)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    129564326 (ARAF)
   05022 Pathways of neurodegeneration - multiple diseases
    129564326 (ARAF)
  09165 Substance dependence
   05034 Alcoholism
    129564326 (ARAF)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    129564326 (ARAF)
   01522 Endocrine resistance
    129564326 (ARAF)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:mbez01001]
    129564326 (ARAF)
Enzymes [BR:mbez01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     129564326 (ARAF)
Protein kinases [BR:mbez01001]
 Serine/threonine kinases: TKL group
  RAF family [OT]
   129564326 (ARAF)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Pkinase RBD C1_1 Kinase-like zf-RING-like ABC1 Pkinase_fungal TUG-UBL1 Kdo
Other DBs
NCBI-GeneID: 129564326
NCBI-ProteinID: XP_055294199
LinkDB
Position
Unknown
AA seq 611 aa
MEPPRGPPANGAEPSRSVGTVKVYLPNKQRTVVTVRDGMSVYDSLDKALKVRGLNQDCCV
VYRLIKGRKTVTAWDTAIAPLDGEELIVEVLEDVPLTMHNFVRKTFFSLAFCDFCLKFLF
HGFRCQTCGYKFHQHCSSKVPTVCVDMSTNRRQFYHSVQDLSGSSRQHEVPSNRSLNEPL
TPQSPSLSPASSCTQHRDPEHFSFPAQANTPLQRIRSTSTPNVHMVSTTAPMDSGLIQLT
GQNFNTDAAGNRGGGDGVPRGSPSPASVSSGRKSPHSKSPSEQRERKSLADDKKKVKNLG
YRDSGYYWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVAQPTAEQAQAFKNEM
QVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQ
GMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAA
EVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGSRDQIIFMVGRGYLSPDLSKIS
SNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELP
ACLLSAARLVP
NT seq 1836 nt   +upstreamnt  +downstreamnt
atggagccaccacggggcccccctgccaacggggccgagccctcccggtcagtgggcacc
gtcaaagtgtacctgcccaacaagcagcgcacggtggtgactgtccgggatggcatgagt
gtgtatgactctctagacaaggccctcaaggtgcggggtctcaatcaagattgctgtgtg
gtttaccggctcatcaaggggcgaaagacagtcactgcctgggacacagccattgccccc
ctggatggcgaggagctcattgtggaggtcctcgaagacgtccccctgaccatgcacaat
tttgtacggaagacattcttcagcctggccttttgtgacttctgccttaagtttctgttc
catggcttccgctgccaaacctgtggatacaagttccaccagcattgttcctccaaggtc
cccacagtctgtgtcgacatgagtaccaaccgccgacagttctaccacagtgtccaggat
ttgtccggaagctccagacaacacgaggttccctcaaaccgctccctgaatgagccgctc
acccctcagagtcccagcctttcccctgccagctcctgcacccagcaccgcgaccccgag
cacttctccttccctgcccaggccaacacccccctccagcgcatccgctccacatccacc
cccaatgtccacatggtcagcaccacagcccccatggactccggcctcatccagctcact
ggccagaatttcaacactgatgctgctgggaatagaggtggtggtgatggagtcccccgg
gggagccccagcccagccagcgtgtcctcgggaaggaagtccccacattccaagtcccca
tcagagcagcgggaacggaagtccttggctgatgacaagaagaaagtgaagaatttgggg
taccgggactcgggctattactgggaggtgccacccagtgaggtgcagttgctgaagagg
atcgggacgggctcgtttggcaccgtgtttcgcgggcggtggcatggcgatgtggccgtg
aaggtgctcaaggtggcccaacccacagctgagcaggcgcaggccttcaagaacgagatg
caggtgctcagaaagacacgtcatgtcaacatcttgctgttcatgggcttcatgacccgg
ccaggatttgccatcatcacacagtggtgtgagggctccagtctctaccaccacctgcat
gtggctgacacacgcttcgacatggtccagctcattgatgtggcccgccagactgctcag
ggcatggactacctccatgccaagaacatcatccaccgagatctcaagtctaacaacatc
ttcctgcatgaggggctcacggtgaagatcggggacttcggcctggccacagtaaagacg
cggtggagtggggcccagcccttggagcaaccctcgggctctgtgctatggatggcagct
gaggtgatccgtatgcaggacccgaacccctacagcttccagtcagatgtctacgcctat
ggggttgtgctctatgagctcatgaccggctcactgccttacagccacattggcagccga
gaccagattatctttatggtgggccgtggctatctgtccccggacctcagcaaaatctcc
agcaattgccccaaggccatgaggcgcctgctgtctgactgcctgaagttccagcgagag
gagcggcccctttttccccagatcctggccacgattgagctgctgcagcggtcactcccc
aagattgagcggagtgcctccgaaccctccttgcaccgtacccaggctgatgagttgcct
gcctgcctactcagcgcagcccgccttgtgccttag

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