Mycobacterium tuberculosis variant bovis AF2122/97: BQ2027_MB0570
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Entry
BQ2027_MB0570 CDS
T00132
Symbol
menD
Name
(GenBank) PROBABLE BIFUNCTIONAL MENAQUINONE BIOSYNTHESIS PROTEIN MEND : 2-SUCCINYL-6-HYDROXY-2,4-CYCLOHEXADIENE-1-CARBOXYLATE SYNTHASE (SHCHC SYNTHASE) + 2-OXOGLUTARATE DECARBOXYLASE (ALPHA-KETOGLUTARATE DECARBOXYLASE) (KDC)
KO
K02551
2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase [EC:
2.2.1.9
]
Organism
mbo
Mycobacterium tuberculosis variant bovis AF2122/97
Pathway
mbo00130
Ubiquinone and other terpenoid-quinone biosynthesis
mbo01100
Metabolic pathways
mbo01110
Biosynthesis of secondary metabolites
mbo01240
Biosynthesis of cofactors
Brite
KEGG Orthology (KO) [BR:
mbo00001
]
09100 Metabolism
09108 Metabolism of cofactors and vitamins
00130 Ubiquinone and other terpenoid-quinone biosynthesis
BQ2027_MB0570 (menD)
Enzymes [BR:
mbo01000
]
2. Transferases
2.2 Transferring aldehyde or ketonic groups
2.2.1 Transketolases and transaldolases
2.2.1.9 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase
BQ2027_MB0570 (menD)
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Gene cluster
GFIT
Motif
Pfam:
TPP_enzyme_N
Motif
Other DBs
NCBI-ProteinID:
CAB5248278
Pasteur:
Mb0570
UniProt:
A0A679LC32
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Position
647541..649205
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AA seq
554 aa
AA seq
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MNPSTTQARVVVDELIRGGVRDVVLCPGSRNAPLAFALQDADRSGRIRLHVRIDERTAGY
LAIGLAIGAGAPVCVAMTSGTAVANLGPAVVEANYARVPLIVLSANRPYELLGTGANQTM
EQLGYFGTQVRASISLGLAEDAPERTSALNATWRSATCRVLAAATGARTANAGPVHFDIP
LREPLVPDPEPLGAVTPPGRPAGKPWTYTPPVTFDQPLDIDLSVDTVVISGHGAGVHPNL
AALPTVAEPTAPRSGDNPLHPLALPLLRPQQVIMLGRPTLHRPVSVLLADAEVPVFALTT
GPRWPDVSGNSQATGTRAVTTGAPRPAWLDRCAAMNRHAIAAVREQLAAHPLTTGLHVAA
AVSHALRPGDQLVLGASNPVRDVALAGLDTRGIRVRSNRGVAGIDGTVSTAIGAALAYEG
AHERTGSPDSPPRTIALIGDLTFVHDSSGLLIGPTEPIPRSLTIVVSNDNGGGIFELLEQ
GDPRFSDVSSRIFGTPHDVDVGALCRAYHVESRQIEVDELGPTLDQPGAGMRVLEVKADR
SSLRQLHAAIKAAL
NT seq
1665 nt
NT seq
+upstream
nt +downstream
nt
gtgaacccctcgacgacacaggcgcgcgtcgtcgtcgacgaactgatccgcggcggcgtt
cgcgacgtggtgctgtgtccgggctcgcgcaatgcgccgctggccttcgcgctgcaggac
gccgaccggtccggccggatccggttgcacgttcgcatcgatgaacgcaccgccggctac
ctggccatcgggctggcaatcggggcgggcgcgccggtgtgtgtcgcgatgacatccggc
accgccgtggccaacctcggtccggcggtggtggaggcaaactacgctcgggtgccgctg
atcgtgctgtcagccaatcggccctacgagctgctgggcaccggcgccaaccagaccatg
gaacagctgggctatttcggcacccaggtgcgcgccagcatcagcctggggctggccgag
gacgcacccgagcggacctcggcgctcaacgcgacctggcgatcggctacgtgccgagtg
ttggcggccgccacgggtgctcgcaccgccaacgcgggccccgtgcacttcgacatcccg
ctgcgcgaaccgctggtgcccgatcccgagcccctcggcgcggtcaccccgccgggccgg
cctgctggcaagccgtggacctacacgccgccggtcaccttcgaccagccactggacatc
gacctgtcggtcgacaccgtggtcatctccgggcatggcgctggcgtgcaccccaacctc
gcggcgttgccgaccgtcgcagaaccgacggcgccgcggtccggggacaacccgttgcac
ccgctggcgctgccgctgctgcgccctcaacaggtgatcatgctgggccggccgacactg
catcgtccggtatcggtgctgctggccgacgcagaagtgccggtattcgcattgacaacc
ggtccacgctggccggatgtctcgggtaactcgcaggccaccggcacgcgggcggtcacc
accggcgcgccgcggcccgcgtggctggaccggtgtgcggcgatgaaccggcacgcgatc
gcggcggttcgggaacagctcgcggcgcacccgttgaccaccgggctgcatgtcgcggcg
gcggtgtcgcatgcgctgcggcccggtgaccagctggtgctcggggcatccaatccggtg
cgggatgtggcgttggccggtttggacacccgcggcatccgggtacggtccaaccgtggg
gtcgccggcatcgacggcaccgtgtccaccgcgatcggggcggccctagcttatgagggg
gctcacgagcgcaccggcagcccggactccccgccccgcaccatcgcactgatcggcgac
ctgacgttcgtgcacgacagctccgggctgttgatcgggccgaccgaaccgataccgcgg
tcattgaccatcgtggtgtctaatgacaacggcggcggcatcttcgaattgctcgagcag
ggtgatcccaggttctccgacgtgtcatcgcgaatcttcggcaccccacacgacgtcgat
gtgggcgcattgtgccgcgcctaccacgtggaatctcgccagatcgaggtcgacgaactc
ggaccgaccctcgatcaacccggtgccggcatgcgcgtgctcgaggtcaaggccgaccgg
tcgtcgttgcgacaattgcacgccgccatcaaggcggctctgtga
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