Mycobacterium tuberculosis variant bovis AF2122/97: BQ2027_MB2474C
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Entry
BQ2027_MB2474C CDS
T00132
Symbol
folC
Name
(GenBank) PROBABLE FOLYLPOLYGLUTAMATE SYNTHASE PROTEIN FOLC (FOLYLPOLY-GAMMA-GLUTAMATE SYNTHETASE) (FPGS)
KO
K11754
dihydrofolate synthase / folylpolyglutamate synthase [EC:
6.3.2.12
6.3.2.17
]
Organism
mbo
Mycobacterium tuberculosis variant bovis AF2122/97
Pathway
mbo00790
Folate biosynthesis
mbo01100
Metabolic pathways
mbo01240
Biosynthesis of cofactors
Brite
KEGG Orthology (KO) [BR:
mbo00001
]
09100 Metabolism
09108 Metabolism of cofactors and vitamins
00790 Folate biosynthesis
BQ2027_MB2474C (folC)
Enzymes [BR:
mbo01000
]
6. Ligases
6.3 Forming carbon-nitrogen bonds
6.3.2 Acid-D-amino-acid ligases (peptide synthases)
6.3.2.12 dihydrofolate synthase
BQ2027_MB2474C (folC)
6.3.2.17 tetrahydrofolate synthase
BQ2027_MB2474C (folC)
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Gene cluster
GFIT
Motif
Pfam:
Mur_ligase_C
Mur_ligase_M
Motif
Other DBs
NCBI-ProteinID:
SIU01089
Pasteur:
Mb2474c
UniProt:
A0A1R3Y188
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All DBs
Position
complement(2718709..2720172)
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AA seq
487 aa
AA seq
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MNSTNSGPPDSGSATGVVPTPDEIASLLQVEHLLDQRWPETRIDPSLTRISALMDLLGSP
QRSYPSIHIAGTNGKTSVARMVDALVTALHRRTGRTTSPHLQSPVERISIDGKPISPAQY
VATYREIEPLVALIDQQSQASAGKGGPAMSKFEVLTAMAFAAFADAPVDVAVVEVGMGGR
WDATNVINAPVAVITPISIDHVDYLGADIAGIAGEKAGIITRAPDGSPDTVAVIGRQVPK
VMEVLLAESVRADASVAREDSEFAVLRRQIAVGGQVLQLQGLGGVYSDIYLPLHGEHQAH
NAVLALASVEAFFGAGAQRQLDGDAVRAGFAAVTSPGRLERMRSAPTVFIDAAHNPAGAS
ALAQTLAHEFDFRFLVGVLSVLGDKDVDGILAALEPVFDSVVVTHNGSPRALDVEALALA
AGERFGPDRVRTAENLRDAIDVATSLVDDAAADPDVAGDAFSRTGIVITGSVVTAGAART
LFGRDPQ
NT seq
1464 nt
NT seq
+upstream
nt +downstream
nt
atgaattcgacgaattccggcccgcctgactcgggatcggccaccggcgtcgtgcccact
ccggacgagatcgcgtccctgctgcaggttgagcatctactcgaccaacgctggccggag
acccgcatcgatccgagcctgacccggatcagcgcgttgatggacctgctgggctcgccc
caacgcagctatccgtcgatccatatcgcgggcaccaacggcaagacctcggtggcgcgc
atggtcgacgcgctggtcaccgcgctgcaccggcgcaccggccgaaccaccagcccacac
ctgcagtcaccggtggaacgcatttcgatcgacggcaagccgatcagcccggcgcagtat
gtggcgacctaccgggagatcgagccgttggtggcgctgatcgaccagcagtcgcaggct
tctgcgggtaagggtggcccggcgatgagcaagttcgaggtgctcaccgcgatggcgttc
gcggcctttgcggacgcgcccgtcgacgtggcagtggtcgaggtgggcatgggcggacgt
tgggacgccaccaacgtgatcaacgcaccggtcgccgtcatcaccccgatcagcattgat
cacgtcgactatctcggtgccgatatcgccgggatcgccggggagaaggcgggcatcatc
actcgggcccccgacggttcgccggacaccgtcgcggtcatcgggcgtcaggtcccgaag
gtcatggaggtgctgctggccgaatcggtgcgcgccgacgcgtcggtggcccgggaggat
tccgaattcgcggtgctacggcgacagatcgcggtcggcggtcaggtactgcaactgcag
ggcctcggcggggtttactccgacatctacttgccgctgcacggtgaacaccaggcgcac
aacgcggtgctcgccctcgcttccgtcgaggcctttttcggtgccggtgcgcagcgtcag
ctcgacggcgacgccgtccgggccggctttgccgccgtcaccagtcccggccggttggag
cgcatgcgcagcgcacccacggtgttcatcgacgccgcgcacaatccggccggggcgagt
gctctggcacaaacgctggcgcatgagttcgacttccgatttctggtcggggtgctcagc
gtgctgggcgacaaggacgtggacggcatcctggccgcactggagccggtgttcgattcc
gtcgtcgtgacccacaacgggtcgccgcgggcgctggatgtcgaggccctggcgctggcg
gccggcgagcggttcggacccgaccgggtgcgcaccgccgagaacctgcgcgatgctatc
gacgttgccacctcactggtcgacgacgccgccgccgacccggatgtggccggggacgca
ttctcgagaaccgggatcgtcatcaccggctcggttgtcaccgcaggggcggctcggacc
ttgttcggtcgtgatccgcaatga
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