Mycobacterium tuberculosis variant bovis BCG ATCC 35743: BCGT_0291
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Entry
BCGT_0291 CDS
T03796
Name
(GenBank) Uroporphyrinogen-III methyltransferase / Uroporphyrinogen-III synthase
KO
K13542
uroporphyrinogen III methyltransferase / synthase [EC:
2.1.1.107
4.2.1.75
]
Organism
mbx
Mycobacterium tuberculosis variant bovis BCG ATCC 35743
Pathway
mbx00860
Porphyrin metabolism
mbx01100
Metabolic pathways
mbx01110
Biosynthesis of secondary metabolites
mbx01120
Microbial metabolism in diverse environments
mbx01240
Biosynthesis of cofactors
Module
mbx_M00846
Siroheme biosynthesis, glutamyl-tRNA => siroheme
mbx_M00926
Heme biosynthesis, bacteria, glutamyl-tRNA => coproporphyrin III => heme
Brite
KEGG Orthology (KO) [BR:
mbx00001
]
09100 Metabolism
09108 Metabolism of cofactors and vitamins
00860 Porphyrin metabolism
BCGT_0291
Enzymes [BR:
mbx01000
]
2. Transferases
2.1 Transferring one-carbon groups
2.1.1 Methyltransferases
2.1.1.107 uroporphyrinogen-III C-methyltransferase
BCGT_0291
4. Lyases
4.2 Carbon-oxygen lyases
4.2.1 Hydro-lyases
4.2.1.75 uroporphyrinogen-III synthase
BCGT_0291
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Paralog
Gene cluster
GFIT
Motif
Pfam:
HEM4
TP_methylase
Motif
Other DBs
NCBI-ProteinID:
AHM06212
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Position
319669..321375
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AA seq
568 aa
AA seq
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MTIMTRGRKPRPGRIVFVGSGPGDPGLLTTRAAAVLANAALVFTDPDVPEPVVALIGTDL
PPVSGPAPAEPVAGNGDAAGGGSAQEHGRAASAVVSGGPDIRPALGDPADVAKTLTAEAR
SGVDVVRLVAGDPLTVDAVISEVNAVARTHLHIEIVPGLAASSAVPTYAGLPLGSSHTVA
DVRIDPENTDWDALAAAPGPLILQATASHLAESARSLIDHQLAESTPCVVTAHGTTCQQR
SVETTLQGLTDPAVLGATDPACSANGRDSQAGPLIVTIGKTVTSRAKLNWWESRALYGWT
VLVPRTKDQAGEMSERLTSYGALPVEVPTIAVEPPRSPAQMERAVKGLVDGRFQWIVFTS
TNAVRAVWEKFGEFGLDARAFSGVKIACVGESTADRVRAFGISPELVPSGEQSSLGLLDD
FPPYDSVFDPVNRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPATTREMIK
TGGFDAVCFTSSSTVRNLVGIAGKPHARTIIACIGPKTAETAAEFGLRVDVQPDTAAIGP
LVDALAEHAARLRAEGALPPPRKKSRRR
NT seq
1707 nt
NT seq
+upstream
nt +downstream
nt
gtgacaatcatgacgcgagggcgtaagccgagaccgggccgcatcgttttcgtgggctcc
ggtccgggcgaccccggcttgcttacgacacgggctgccgcggtgctggccaacgccgcg
ctggtgttcaccgatcccgacgtaccggagccggtggtggcgctgatcggcacggatctg
ccccccgtgtccggcccggcgcccgccgagccggttgccgggaacggcgatgcggccggc
ggaggaagtgcgcaggaacacggccgggccgcgtccgcggtagtctccggtggtcctgac
atccgcccggcgctgggcgatcccgccgatgtggccaagacgctgaccgccgaggcccgt
tcgggtgtcgacgtggtgcggctggtggcgggcgatccgctcacggtggatgcggtaatc
agcgaggtgaacgccgtcgcacgcacccacctgcacatcgaaatcgtgcccggcctggcc
gccagcagcgcggtcccgacctatgccgggttgccgctgggttcgtcgcacaccgtcgcc
gacgtgcgtatcgaccccgaaaacaccgactgggacgcgctggctgccgcacccgggccg
ctgatcctgcaggccaccgcatcgcatctagccgaatcggcccgcagcctgatcgatcac
cagctggccgagtccactccgtgcgtggtgaccgcacacggcaccacctgtcagcagcgt
tcggtcgagaccacacttcagggattgaccgacccggccgtcctgggcgctaccgacccc
gcgtgctccgcaaacgggagggactcccaggccggaccgctgatagtgaccatcggcaag
acggtgaccagtcgggcaaagctgaactggtgggagagccgcgccctctacggctggacg
gtgttggtgccgcgcaccaaggaccaggccggcgagatgagcgagcggctcacgtcgtac
ggcgcgctgccggtggaggtgccgaccatcgccgtcgagccgccgcgcagccccgcgcag
atggagcgcgccgtcaagggcctggtcgatggccgattccagtggatcgtgttcacctcc
accaacgcggtgcgtgcggtgtgggagaagttcggcgagttcggtctggatgcccgcgcg
ttctccggggtgaagatcgcctgtgtcggcgagtcgacggccgaccgggtgcgcgccttc
ggaatcagtcccgagctggtgccctccggggagcagtcctcgcttggcttgctagacgac
ttcccgccctacgacagcgttttcgacccggtgaaccgggttttgctgccgcgcgccgac
atcgccaccgaaacgctggccgagggactgcgagagcgtggctgggagatcgaggacgtc
accgcctaccggaccgtgcgggccgcgccgccgccggccactacccgggaaatgatcaag
acgggcgggtttgacgcggtatgtttcacctccagctcgacggtgcgaaacctggtcggc
atcgccggcaagccgcacgcgcggacgatcatcgcctgcatagggccaaagaccgccgag
accgcagccgagttcggcttgcgggtcgatgtccagccggacaccgccgccatcggcccg
ctggtcgatgcgctggccgagcatgccgcccggttgcgcgctgagggtgcgctgcccccg
ccgcgcaagaagagccgcaggcgctag
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