Macaca mulatta (rhesus monkey): 694184 Help Entry 694184            CDS       T01028                                  Symbol JAK2 Name (RefSeq) tyrosine-protein kinase JAK2   KO K04447   Janus kinase 2 [EC:2.7.10.2] Organism mcc  Macaca mulatta (rhesus monkey) Pathway mcc01521   EGFR tyrosine kinase inhibitor resistance mcc04062   Chemokine signaling pathway mcc04081   Hormone signaling mcc04148   Efferocytosis mcc04151   PI3K-Akt signaling pathway mcc04217   Necroptosis mcc04550   Signaling pathways regulating pluripotency of stem cells mcc04630   JAK-STAT signaling pathway mcc04658   Th1 and Th2 cell differentiation mcc04659   Th17 cell differentiation mcc04725   Cholinergic synapse mcc04917   Prolactin signaling pathway mcc04920   Adipocytokine signaling pathway mcc04933   AGE-RAGE signaling pathway in diabetic complications mcc04935   Growth hormone synthesis, secretion and action mcc05140   Leishmaniasis mcc05145   Toxoplasmosis mcc05152   Tuberculosis mcc05161   Hepatitis B mcc05164   Influenza A mcc05167   Kaposi sarcoma-associated herpesvirus infection mcc05168   Herpes simplex virus 1 infection mcc05200   Pathways in cancer mcc05207   Chemical carcinogenesis - receptor activation mcc05235   PD-L1 expression and PD-1 checkpoint pathway in cancer mcc05417   Lipid and atherosclerosis Brite KEGG Orthology (KO) [BR:mcc00001]  09130 Environmental Information Processing   09132 Signal transduction    04630 JAK-STAT signaling pathway     694184 (JAK2)    04151 PI3K-Akt signaling pathway     694184 (JAK2)   09133 Signaling molecules and interaction    04081 Hormone signaling     694184 (JAK2)  09140 Cellular Processes   09141 Transport and catabolism    04148 Efferocytosis     694184 (JAK2)   09143 Cell growth and death    04217 Necroptosis     694184 (JAK2)   09144 Cellular community - eukaryotes    04550 Signaling pathways regulating pluripotency of stem cells     694184 (JAK2)  09150 Organismal Systems   09151 Immune system    04658 Th1 and Th2 cell differentiation     694184 (JAK2)    04659 Th17 cell differentiation     694184 (JAK2)    04062 Chemokine signaling pathway     694184 (JAK2)   09152 Endocrine system    04920 Adipocytokine signaling pathway     694184 (JAK2)    04917 Prolactin signaling pathway     694184 (JAK2)    04935 Growth hormone synthesis, secretion and action     694184 (JAK2)   09156 Nervous system    04725 Cholinergic synapse     694184 (JAK2)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     694184 (JAK2)    05207 Chemical carcinogenesis - receptor activation     694184 (JAK2)    05235 PD-L1 expression and PD-1 checkpoint pathway in cancer     694184 (JAK2)   09172 Infectious disease: viral    05161 Hepatitis B     694184 (JAK2)    05164 Influenza A     694184 (JAK2)    05168 Herpes simplex virus 1 infection     694184 (JAK2)    05167 Kaposi sarcoma-associated herpesvirus infection     694184 (JAK2)   09171 Infectious disease: bacterial    05152 Tuberculosis     694184 (JAK2)   09174 Infectious disease: parasitic    05145 Toxoplasmosis     694184 (JAK2)    05140 Leishmaniasis     694184 (JAK2)   09166 Cardiovascular disease    05417 Lipid and atherosclerosis     694184 (JAK2)   09167 Endocrine and metabolic disease    04933 AGE-RAGE signaling pathway in diabetic complications     694184 (JAK2)   09176 Drug resistance: antineoplastic    01521 EGFR tyrosine kinase inhibitor resistance     694184 (JAK2)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:mcc01001]     694184 (JAK2) Enzymes [BR:mcc01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.10  Protein-tyrosine kinases     2.7.10.2  non-specific protein-tyrosine kinase      694184 (JAK2) Protein kinases [BR:mcc01001]  Non-receptor tyrosine kinases   JAK family [OT]    694184 (JAK2) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  PK_Tyr_Ser-Thr Pkinase FERM_F2 FERM_F1 SH2_1 Jak1_Phl SH2 ABC1 FERM_C_FAK1 RIO1 Kinase-like FERM_M Motif Other DBs NCBI-GeneID:  694184 NCBI-ProteinID:  NP_001252830 Ensembl:  ENSMMUG00000014558 UniProt:  A0A5F8ATC5 LinkDB All DBs Position 15:complement(78701446..78857474) Genome browser AA seq 1132 aa AA seqDB search MGMACLTMTEMEGTSTSSIYQNGDISGNANSMKQIDPVLQVYLYHSLGKSEADYLTFPSG EYVAEEICIAASKACGITPVYHNMFALMSETERIWYPPNHVFHIDESTRHNVLYRIRFYF PRWYCSGSNRAYRHGISRGAEAPLLDDFVMSYLFAQWRHDFVHGWIKVPVTHETQEECLG MAVLDMMRIAKENDQTPLAIYNSISYKTFLPECIRAKIQDYHILTRKRIRYRFRRFIQQF SQCKATARNLKLKYLINLETLQSAFYTEKFEVKEPGSGPSGEEIFATIIITGNGGIQWSR GKHKESETLTEQDLQLYCDFPNIIDVSIKQANQEGSDESRVVTIHKQDGKNLEIELSSLR EALSFVSLIDGYYRLTADAHHYLCKEVAPPTVLENIQSNCHGPISMDFAISKLKKAGNQT GLYVLRCSPKDFNKYFLTFAVERENVIEYKHCLITKNENEEYNLSGTKKNFSSLKDLLNC YQMETVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRPTHMNQMVFHKI RNEDLIFNESLGQGTFTKIFKGIRREVGDYGQLHETEVLLKVLDKAHRNYSESFFEAASM MSKLSHKHLVLNYGVCVCGEENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWA MHFLEENTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVP PECIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQLPAPKWAEL ANLINNCMDYEPDFRPSFRAVIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRD PTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIE ILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHKKLLQYTSQI CKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFW YAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIE LLKNNGRLPRPDGCPDEIYMIMTECWNNNVNLRPSFRDLALRVDQIRDNMAG NT seq 3399 nt NT seq  +upstreamnt  +downstreamnt atgggaatggcctgccttactatgacagaaatggagggaacatccacatcttctatatat cagaatggtgatatttctggaaatgccaattctatgaagcaaatagatccagtccttcag gtgtatctttaccattcccttgggaaatctgaggcagattatctgacctttccatctggg gagtatgttgcagaagaaatctgtattgctgcttctaaagcttgtggtatcacacctgtg tatcataatatgtttgctttaatgagtgaaacagaaaggatctggtatccacccaaccat gtcttccatatagatgagtcaaccaggcataatgtactctacagaataagattttacttt cctcgttggtattgcagcggcagcaacagagcctatcggcatggaatatctcgaggtgct gaagctcctcttcttgatgactttgtcatgtcttacctctttgctcagtggcggcatgat tttgtgcatggatggataaaagtacctgtgactcatgaaacacaggaagaatgtcttggg atggcagtgttagatatgatgagaatagccaaagaaaatgatcaaaccccactggccatc tataattctatcagctacaagacattcttaccagaatgtattcgagcaaagatccaagac tatcatattttgacaaggaagcgaataaggtacagatttcgcagatttattcagcagttc agccaatgcaaagccactgccagaaacttgaaacttaagtatcttataaatctggaaacc ctgcagtctgccttctacacagagaaatttgaagtaaaagaacctggaagtggtccttca ggtgaggagatttttgcaaccattataataactggaaacggtggaattcagtggtcaaga gggaaacataaagaaagtgagacactgacagaacaggatttacagttatattgcgatttt cctaatattattgatgtcagtattaagcaagcaaaccaagagggttcagatgaaagccga gttgtaactatccataagcaagatggtaaaaatctggaaattgaacttagctcattaagg gaagctttgtctttcgtgtcattaattgatggatattatagattaactgcagatgcacat cattacctctgtaaagaagtagcacctccaacagtgcttgaaaatatacaaagcaactgt catggcccaatttcgatggattttgccattagtaaactgaagaaagcaggtaatcagact ggactgtatgtacttcgatgcagtcctaaggactttaataaatattttctgacttttgct gtcgagcgagaaaatgtcattgaatataaacactgtttgattacaaaaaatgagaatgaa gagtacaacctcagtgggacaaagaagaacttcagcagtcttaaagatcttttgaattgt taccagatggaaaccgttcgctcagacaatataattttccagtttactaagtgctgtccc ccaaagccaaaagataaatcaaaccttctagtcttcagaacgaatggtgtttctgatgta ccaacctcaccaacattacagaggcctactcatatgaaccaaatggtgtttcacaaaatc agaaatgaagatttgatatttaatgaaagccttggccaaggcactttcacaaagattttt aaaggcatacgaagagaagtaggagactatggtcaacttcatgaaacagaagttctttta aaagttctggataaagcacatagaaactattcagagtctttctttgaagcagcaagcatg atgagcaagctttctcacaagcatttggttttaaattatggagtatgtgtctgtggagag gagaatattctggttcaggagtttgtaaaatttggatcactagatacatacctgaaaaag aataaaaattgtataaatatattatggaaacttgaagttgcgaaacagttggcatgggcc atgcattttctagaagaaaacacccttattcatgggaatgtgtgcgccaaaaatattcta cttatcagagaagaagacaggaagacaggaaatcctcctttcatcaaacttagtgatcct ggcattagtattacagttttgccaaaggacattcttcaggagagaataccatgggtacca cctgaatgcattgaaaatcctaaaaatttaaatttggcaacagacaaatggagttttggt accactttgtgggaaatctgcagtggaggagataaacctctaagtgccctggattctcaa agaaagctgcaattttatgaagataggcaccagcttcctgcaccaaagtgggcagaatta gcaaaccttataaataattgtatggattatgaacccgatttcaggccttctttcagagcc gtcatacgagatcttaacagtttgtttactccagattatgaactattaacagaaaatgac atgttaccaaatatgaggataggtgccctagggttttctggtgcctttgaagacagggat cctacacagtttgaagagagacatttgaaatttctacagcaacttggcaagggtaacttt gggagtgtggagatgtgccggtatgaccctctacaggacaacactggggaggtggtggct gtaaaaaagcttcagcatagtactgaagagcacctgagagactttgaaagggaaattgaa atcctgaaatccctacagcatgacaacattgtaaagtacaagggagtgtgctacagtgct ggtcggcgtaatctaaaattaattatggaatatttaccatatggaagtttacgagactat cttcaaaaacataaagaacggatagatcacaaaaaacttctgcagtacacatctcagata tgcaagggtatggagtatcttggtacaaaaaggtatatccacagggatctggcaacaaga aatatattggtggagaatgagaacagagttaaaattggagattttgggttaaccaaagtc ttgccacaagacaaagaatactataaagtaaaagaacctggtgaaagtcccatattctgg tatgctccagaatcactgacagagagcaagttttctgtggcctcagatgtttggagcttt ggagtggttctgtatgaacttttcacatacattgagaagagtaaaagtccaccagcggaa tttatgcgcatgattggcaatgataaacaaggacagatgatcgtgttccatttgatagaa cttttgaagaataatggaagattaccaagaccagatggatgcccagatgagatttatatg atcatgacagaatgctggaacaataatgtaaatctacgcccctcctttagagatctagct cttcgagtggatcaaataagggataacatggctggatga

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