Macaca mulatta (rhesus monkey): 697930
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Entry
697930 CDS
T01028
Symbol
LRRK2
Name
(RefSeq) leucine-rich repeat serine/threonine-protein kinase 2 isoform X1
KO
K08844
leucine-rich repeat kinase 2 [EC:
2.7.11.1
]
Organism
mcc
Macaca mulatta (rhesus monkey)
Pathway
mcc05012
Parkinson disease
mcc05022
Pathways of neurodegeneration - multiple diseases
Brite
KEGG Orthology (KO) [BR:
mcc00001
]
09160 Human Diseases
09164 Neurodegenerative disease
05012 Parkinson disease
697930 (LRRK2)
05022 Pathways of neurodegeneration - multiple diseases
697930 (LRRK2)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
mcc01001
]
697930 (LRRK2)
09182 Protein families: genetic information processing
04131 Membrane trafficking [BR:
mcc04131
]
697930 (LRRK2)
09183 Protein families: signaling and cellular processes
04147 Exosome [BR:
mcc04147
]
697930 (LRRK2)
Enzymes [BR:
mcc01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.11 Protein-serine/threonine kinases
2.7.11.1 non-specific serine/threonine protein kinase
697930 (LRRK2)
Protein kinases [BR:
mcc01001
]
Serine/threonine kinases: TKL group
LRRK family
697930 (LRRK2)
Membrane trafficking [BR:
mcc04131
]
Exocytosis
Calcium ion-dependent exocytosis
Kinases and associated proteins
697930 (LRRK2)
Exosome [BR:
mcc04147
]
Exosomal proteins
Exosomal proteins of other body fluids (saliva and urine)
697930 (LRRK2)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
ARM_LRRK2
Beta-prop_LRRK2
ANK_LRRK2
Pkinase
PK_Tyr_Ser-Thr
LRR_8
Roc
COR
LRR_4
Ras
LRR_14
LRR_9
LRR_13
Arf
Beta-prop_EML_2
Beta-prop_RSE1_2nd
WD40_CDC20-Fz
Ank_2
T2SSE
LRR_6
Beta-prop_BBS7
LRR_NXF1-5
AAA_22
nSTAND3
WD40_like
AAA_7
PduV-EutP
AAA_16
Kdo
Septin
NACHT
ABC_tran
cobW
WDR55
GTP_EFTU
MMR_HSR1
MobB
TrwB_AAD_bind
WD40_Prp19
FtsK_SpoIIIE
G-alpha
TsaE
TniB
AAA_29
ARM_LIN_2nd
Motif
Other DBs
NCBI-GeneID:
697930
NCBI-ProteinID:
XP_015006935
Ensembl:
ENSMMUG00000015857
LinkDB
All DBs
Position
11:39533177..39678644
Genome browser
AA seq
2547 aa
AA seq
DB search
MASGSCQGCEEDEETLKKLIVRLNNVQEGKQIETLVQILEDLLVFTYSEHASKLFQGKNI
HVPLLIVLDSYMRVASVQQVGWSLLCKLIEICPGTMQSLMGPQDVGNDWEVLGVHQLILK
MLTVHNASVNLSMIGLKTLDLLLTSGKITLLILDEESDIFMLIFDAMHSFPANDEIQKLG
CKALHVLFERVSEEQLTEFVENKDYMILLSALTNFKDEEEIVLHVLHCLHSLAIPCNNVE
VLMSGNVRCYNIVVEAMKAFPISEKIQEVSCCLLHRLTLGNFFNILVLNEVHEFVVKAVQ
RYPENAALQISALSCLALLTETIFLNQDLEEKNENQENDDEGEEVKLFWLEACYKALTWH
RKNKHVQEAACWALNNLLMYQNSLHEKIGDEDGHFPAHREVMLSMLMHSSSKEVFQASAN
ALSTLLEQNVNFRKILLSKGIYLNVLELMQKHIHSPEVAESGCKMLNHLFEGSNTSLDTM
AAVLPKIITVMKSHETSLPVQLEALRAILHFIVPGMPEESREDAESHRKLNMVKKQCFKN
DIHKLVLAALNRFIGNPGIQKCGLKVISFIAHFTDALGVLSLEGAVDSVLHTLQMYPDDQ
EIQCLGLSLIGCLITKKNLCIGTGHLLAKILASSLYRFKDVAEVQTEGFQTILAILKLSA
SFSKLLVHHSFDLVIFHQMSSSIMEQKDQQFLNLCCKCFAKVAMDDDLKNMMLERACDQN
NSIMVECLLLLGADANQAKEGTSLICQVCEKESSPKLVELLLNSGSREQDVRKALTISIG
KGDSQIISLLLRRLALDMANNSICLGGFCIGKVEPSWLGPLFPDKTSNLRKQTNIASTLA
RMVIRYQMKSAMEEGAASGSDGNFSEDVLSKFDEWTFIPDSSMDSVFAQSDDLDSEGSEG
SFLVKKKSNSISVGEFYRDAVLQRCSPNLQRHSSSLGPIFDHEDLLRRKRKILSSDDSLR
SSKLQSHMRHSDSISSLASEREYITSLDLSANELRDIDALSQKSCISGHLEHLEKLELHQ
NALTSFPQQLCETLKSLTHLDLHSNKFTSFPSYLLKMSCVANLDVSRNDIGPSVVLDPAV
KCPTLKQFNLSYNQLSSVPENLADGIEKLEQLILEGNKISGICSPLRLKELKILNLSKNH
ISSLSENFLEACPKVESFSARMNFLAAMPFLPPSMTSLKLSQNKFTCIPEAILNLPHLRS
LDMSSNDIQYLPGPAHWKSLNLRELLFSHNQISILDLSEKAYLWSRVEKLHLSHNKLKEI
PPEIGCLENLTSLDVSYNLELRSFPNEMGKLSKIWDLPLDELRLNFDFKHIGCKAKDIIR
FLQQRLKKAVPYNRMKLMVVGNTGSGKTTLLQQLMKTKKSDLGMQSATVGIDVKDWPIQI
RGKRKRDLVLNVWDFAGREEFYSTHPHFMTQRALYLAVYDLSKGQAEVDAMKPWLFNIKA
RASSSPVILVGTHLDVSDERQRKACIGKITKELLNKRGFPAIRDYHFVNATEESDALAKL
RKTIINESLNFKIRDQPVVGQLIPDCYVELEKIILSERKNVPIEFPVIDQKRLLQLVREN
QLQLDENELPHAVHFLNESGVLLHFQDPALQLSDLYFVEPKWLCKIMAQILTVKVEGCPK
HPKGIISRRDVEKFLSKKRRFPKNYMSQYFKLLEKFQIALPIGEEYLLVPSSLSDHRPVI
ELPHCENSEIIIRLYEMPYFPMGFWSRLINRLLEISPYMLSGRERALRPNRMYWRQGIYL
NWSPEAYCLVGSEVLDNHPESFLKITVPSCRKGCILLGQVVDHIDSLMEEWFPGLLEIDI
CGEGETLLKKWALYSFNDGEEHQKILLDDLMKKAEEGDLLVNPDQPRLTIPISQIAPDLI
LADLPRNIMLNNDELEFEQAPEFLLGDGSFGSVYRAAYEGEEVAVKIFNKHTSLRLLRQE
LVVLCHLHHPSLISLLAAGIRPRMLVMELASKGSLDRLLQQDKASLTRTLQHRIALHVAD
GLRYLHSAMIIYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMGIKTSEGTPGFRA
PEVARGNVIYNQQADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELAIQGKLPDPVKEYG
CAPWPMVEKLITKCLKENPQERPTSAQVFDILNSAELVCLTRHILLPKNVIVDCMVATHH
NSRNASIWLGCGHTNRGQLSFLDLNTEGYTSEEVADSRILCLALVHLPVQKESWIVSGTQ
SGTLLVINTEDGKKRHTLEKMTDSITCLYCNSFSKQSKQKNFLLVGTADGNLAIFEDKTV
KLEGAAPLKILNIGNVSTPLMCLSESTNSTERNVMWGGCGTKIFSFSNDFTIQKLIETRT
SQLFSSDSKVYSRLRYTADCNVLFSYAAFSDSNIVTVVVDTVLYIAKKNSPVVEVWDKKT
EKLCELIDCVHFLREVMVKVNKESKHKMSYSGRVKALCLQKNTALWIGTGGGHILLLDLS
TRRVIRIIYNFCDSVRVMMTAQLGSLKNVMLVLGYNRKSTEGTQQQKEIQSCLTVWDINL
PHEVQNLEKHIEVRKELAEKMRGTSIE
NT seq
7644 nt
NT seq
+upstream
nt +downstream
nt
atggctagtggcagctgtcaggggtgcgaggaggacgaggaaactctgaagaagttgata
gtcaggctgaacaatgtccaggaaggtaaacagatagaaacgctggtccaaatcctggag
gatctgctggtgttcacgtactccgagcacgcctccaagttatttcaaggcaaaaatatc
catgtgcctctgttgatcgtcttggactcgtatatgagagtcgcgagtgtgcagcaggtg
ggttggtcacttctgtgcaaattaatagaaatctgcccgggtacaatgcaaagcttaatg
ggaccccaggatgttggaaatgattgggaagtccttggtgttcaccaattgattcttaaa
atgctaacagttcataatgccagtgtaaacttgtcaatgattggactgaagaccttagat
ctcctcctaacttcaggtaaaatcaccttactgatattggatgaagaaagtgatattttc
atgttaatttttgatgccatgcactcatttccagccaatgatgaaatccagaaacttgga
tgcaaagctttacatgtgctgtttgaaagagtctcagaggagcaactaactgaatttgtt
gagaacaaagattatatgatattgttaagtgcgttaacaaattttaaagatgaagaggaa
attgtgcttcatgtactgcattgtttacattccctagcaattccttgcaataatgtggaa
gtcctcatgagtggcaatgtcaggtgttataatattgtggtggaagctatgaaagcattc
cctatcagtgaaaaaattcaagaagtgagttgctgtttgctccataggcttacattaggt
aatttttttaatatcctggtattaaacgaagtccatgaatttgtggtgaaagctgtgcag
cggtacccagagaacgcagcattacagatctcagcgctcagctgtttggccctcctcact
gagaccattttcttaaatcaagatttagaggaaaagaatgagaatcaagagaatgatgat
gagggggaagaagttaaattgttttggctggaagcctgttacaaagcgttaacgtggcat
agaaagaacaagcacgtgcaggaggctgcatgctgggcactaaataatctccttatgtac
caaaacagtttacatgagaagattggagatgaagatggccatttcccagctcatagggaa
gtgatgctgtccatgctgatgcattcatcatcaaaggaagttttccaggcatctgctaat
gcattgtcaactcttttagaacaaaatgttaatttcagaaaaatcctgttatcaaaagga
atatacctgaatgttttggagttaatgcagaagcatatacattctcctgaagtggctgaa
agtggctgtaaaatgctaaatcatctttttgaaggaagcaacacatccctggatacaatg
gcagcagtgctccccaaaataataacagttatgaaaagtcatgagacatcattaccagtg
cagctggaggcgcttcgagctattttacattttatagtgccaggcatgccagaagaatcc
agagaggatgcagaatctcatcgtaagctaaatatggttaaaaaacagtgtttcaagaat
gatattcacaaactggtcctagcagctttgaacaggttcattggaaatcctgggattcag
aaatgtggattaaaagtaatttcttttattgcacattttactgatgcattaggggtgtta
tccctggaaggtgctgtggattcagtgcttcacacactgcagatgtatccagatgaccaa
gaaattcagtgtctgggtttaagtcttataggatgcttgattacaaagaagaatttatgc
ataggaactggacatctgctggcaaaaattctggcttccagcttataccgatttaaggat
gttgctgaagtacagactgaaggatttcagacaatcttagcaatcctcaaattgtcagca
tctttttctaagctgctggtgcatcattcgtttgacttagtaatattccatcaaatgtct
tccagtatcatggaacaaaaggatcaacagtttctaaacctctgttgcaagtgttttgca
aaagtagctatggatgatgacttaaaaaatatgatgctagagagagcgtgtgatcagaat
aacagcatcatggttgaatgcttgcttctattaggagcagatgccaatcaagcaaaggag
ggaacttctttaatttgtcaggtatgtgagaaagagagcagtcccaaattggtggaactc
ttattgaatagtggatctcgtgaacaagatgtacgaaaagcgctgacaataagcattggg
aaaggcgacagccagatcatcagcttgctcttaaggaggctggccctggacatggccaac
aatagcatttgccttggagggttttgtataggaaaagttgaaccttcttggcttggtcct
ttatttccagataagacttctaatttaaggaaacaaacaaatatagcatctacactagca
agaatggtgatcagatatcagatgaaaagtgccatggaagaaggagcagcctcaggcagt
gatggaaatttttctgaagatgtgctgtctaaatttgatgaatggacctttattcctgac
tcttctatggacagtgtctttgctcaaagtgatgatctagatagtgaaggaagtgaaggc
tcatttcttgtgaaaaagaaatcaaattcaattagtgtaggagaattttaccgagatgcc
gtattacaacgttgctcaccaaatttgcaaaggcattccagttccttggggcccattttt
gatcatgaagatttactgagaagaaaaagaaaaatattatcttcagatgattcactcagg
tcatcaaaacttcaatcccatatgaggcattcagacagcatttcttctctggcttctgag
agagaatatattacatcactagacctttcagcaaatgaactaagagatattgatgcccta
agccagaaatcctgtataagtggtcatttggagcatcttgaaaagctggagcttcaccag
aatgcactcacgagctttccacaacagctatgtgaaactctgaagagtttgacacatttg
gacttgcacagtaataaatttacatcatttccttcttacttgttgaaaatgagttgtgtt
gctaaccttgatgtctctcgaaatgacattggaccctcagtggttttagatcctgcagtg
aaatgtccaactctgaaacagtttaacctgtcatataaccagctgtcttctgttcctgag
aaccttgctgatgggatagagaaactggagcagctcattttagaaggaaataaaatatca
gggatatgctcccccttgagactgaaggaactgaagattttaaaccttagtaaaaaccac
atttcatccctatcagagaactttcttgaggcttgtcctaaagtggagagtttcagtgcc
agaatgaattttcttgctgctatgcctttcttgcctccttccatgacaagcctaaaatta
tctcaaaacaaatttacatgtattccagaagcaattttaaatcttccacacttgcggtct
ttagatatgagcagcaatgatattcaatatctaccaggtcctgcacactggaaatctttg
aacttaagggaactcttatttagccataatcagatcagcatcttggacttgagtgaaaaa
gcgtatttatggtctagagtagagaaactgcatctttctcacaataaactgaaagagatt
cctcctgagattggctgtcttgaaaatctgacatctctggatgtcagttacaacttggaa
ctaagatcctttcccaatgaaatggggaaattaagcaaaatatgggatcttcctttggat
gaactgcgtcttaactttgattttaaacatataggatgtaaagccaaagacatcataagg
tttcttcagcagcggttaaaaaaggctgtgccctataaccgaatgaaacttatggttgtt
ggaaatactgggagtggtaaaaccaccttgttgcagcaattaatgaaaaccaagaaatca
gatcttggaatgcaaagtgccacagttggcatagatgtgaaagactggcctatccaaata
agaggcaaaagaaagagagatctcgttctgaatgtgtgggattttgcaggtcgtgaggaa
ttctatagcactcatcctcattttatgacgcagcgagcattgtaccttgctgtctatgac
cttagcaaaggacaggctgaagttgatgccatgaagccttggctcttcaatataaaggct
cgcgcttcttcttcccctgtgattctcgttggcacacatttggatgtttctgatgagagg
cagcgcaaagcctgcataggtaaaatcaccaaggaactcctgaataagcgagggttccct
gctatacgagattaccactttgtgaatgccaccgaggaatctgatgctttggcaaaactt
cggaaaaccatcataaacgagagccttaatttcaagatccgagatcagcctgttgttgga
cagctgattccagactgctatgtagaacttgagaaaatcattttatcggagcgtaaaaat
gtgccaattgaatttcctgtaattgaccagaaacgattattacaactagtgagagaaaat
cagttgcagttagatgaaaatgagcttcctcacgcagttcactttctaaatgaatcagga
gtccttcttcattttcaagacccagcactgcagttaagtgacttgtattttgtggaaccc
aagtggctttgtaaaatcatggcacagattttgacagtgaaagtggaaggttgtccaaaa
caccctaagggaattatttcacgtagagatgtggaaaaatttctttcgaagaaaaggaga
tttccaaagaactacatgtcacagtattttaagctcctagaaaaattccagattgctttg
ccaataggagaagaatatttgctggttccaagcagtttgtctgaccacaggcctgtgata
gagcttccccattgtgagaactctgaaattatcatccgactatatgaaatgccttatttt
ccaatgggattttggtcgaggttaatcaatcgattacttgagatttcaccttacatgctt
tcagggagagaacgagcacttcgcccaaacagaatgtattggcgacaaggcatctactta
aattggtctcctgaagcttattgtctggtaggatctgaagtcttagacaatcacccagag
agtttcttaaaaattacagttccttcttgtagaaaaggctgtattcttttgggccaagtt
gtggaccacattgattctctcatggaggaatggtttcctgggttgctggagattgatatt
tgtggtgaaggagaaactctgttgaagaaatgggcattatatagttttaatgatggtgaa
gagcatcaaaaaatcttacttgatgacttgatgaagaaagcagaggaaggagatctctta
gtaaatccagatcaaccaaggctcaccattccaatatctcagattgcccctgacttgatt
ttggctgacctgcctagaaatattatgttgaataatgatgagctggaatttgaacaagct
ccagagtttctcctaggtgatggcagttttggatcagtttatcgagcagcctatgaagga
gaagaagtggctgtgaagatttttaataaacacacatcacttaggctgttaagacaagag
ctggtggtgctttgccacctccaccaccccagtttgatatctttgctggcagctggtatt
cgtccccggatgttggtgatggagttagcctccaagggttccttggatcgcctgcttcag
caggacaaagccagcctcactagaaccctacagcacaggattgcactccatgtggctgat
ggtttgagatacctccattcagccatgattatataccgagacttgaagccccacaatgtg
ctgcttttcacactgtatcccaatgctgccatcattgcaaagattgctgactacggcatt
gctcagtactgctgtagaatggggataaaaacgtcagagggcacaccagggtttcgtgca
cctgaagttgccagaggaaatgtcatttataatcaacaagctgatgtttattcatttggt
ttgctactctatgacattttgacaactggaggtagaatagtagagggtttgaagtttcca
aatgagtttgatgaattagcaatacaaggaaaattacctgatccagttaaagaatatggt
tgtgccccatggcctatggttgagaaattaattacaaagtgtttgaaagaaaatcctcaa
gaaaggcctacttctgcccaggtctttgacattttgaattcagctgaattagtctgtctg
acgagacacattttattacctaaaaacgtaattgttgactgcatggttgctacacatcac
aacagcaggaatgcaagcatttggctgggctgtgggcacaccaacagaggacagctctca
tttcttgacttaaatactgaaggatacacttctgaggaggttgctgatagtagaatattg
tgcttagccttggtgcatcttcctgttcaaaaagaaagctggattgtgtccgggacacag
tctggtactctcctggtcatcaataccgaagatgggaaaaagagacataccctagaaaag
atgactgattccatcacttgtttgtattgcaattccttttccaagcaaagcaaacaaaaa
aattttcttttggttggaaccgctgatggcaatttagcaatttttgaagataaaactgtt
aagcttgaaggagctgctcctttgaagatactaaatataggaaatgtcagtactccattg
atgtgtttgagtgaatccacaaattcaacagaaagaaatgtaatgtggggaggatgtggc
acaaagattttctccttttctaatgatttcaccattcagaaactcattgagacaagaaca
agccaactgttctcaagtgattctaaagtatattcgaggttaagatatactgcagactgc
aatgtattgttttcttacgcagctttcagtgattccaacatcgtaacagtggtggtagac
actgttctctatattgctaagaaaaatagccctgttgtggaagtgtgggataagaaaact
gaaaaactctgcgaactaatagactgtgtgcattttttaagggaggtaatggtaaaagta
aacaaggaatcaaaacacaaaatgtcttattctgggagagtgaaagctctctgccttcag
aagaacactgctctttggataggaactggaggaggccatattttactcctggatctttca
actcgtcgagttatacgtataatttacaacttttgtgattcggtcagagtcatgatgaca
gcacagctagggagccttaaaaatgtcatgctggtattgggctataaccggaaaagtact
gaaggtacacaacagcagaaagagatacaatcttgcttgactgtttgggacatcaatctt
ccacatgaagtgcaaaatttagaaaaacacattgaagtgagaaaagaattagctgaaaaa
atgagaggaacatctattgaataa
DBGET
integrated database retrieval system
