KEGG   Macaca mulatta (rhesus monkey): 701951
Entry
701951            CDS       T01028                                 
Symbol
PLCB2
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2
  KO
K05858  phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
Organism
mcc  Macaca mulatta (rhesus monkey)
Pathway
mcc00562  Inositol phosphate metabolism
mcc01100  Metabolic pathways
mcc04015  Rap1 signaling pathway
mcc04020  Calcium signaling pathway
mcc04022  cGMP-PKG signaling pathway
mcc04062  Chemokine signaling pathway
mcc04070  Phosphatidylinositol signaling system
mcc04071  Sphingolipid signaling pathway
mcc04072  Phospholipase D signaling pathway
mcc04081  Hormone signaling
mcc04082  Neuroactive ligand signaling
mcc04261  Adrenergic signaling in cardiomyocytes
mcc04270  Vascular smooth muscle contraction
mcc04310  Wnt signaling pathway
mcc04371  Apelin signaling pathway
mcc04540  Gap junction
mcc04611  Platelet activation
mcc04613  Neutrophil extracellular trap formation
mcc04621  NOD-like receptor signaling pathway
mcc04713  Circadian entrainment
mcc04720  Long-term potentiation
mcc04723  Retrograde endocannabinoid signaling
mcc04724  Glutamatergic synapse
mcc04725  Cholinergic synapse
mcc04726  Serotonergic synapse
mcc04728  Dopaminergic synapse
mcc04730  Long-term depression
mcc04742  Taste transduction
mcc04750  Inflammatory mediator regulation of TRP channels
mcc04911  Insulin secretion
mcc04912  GnRH signaling pathway
mcc04915  Estrogen signaling pathway
mcc04916  Melanogenesis
mcc04918  Thyroid hormone synthesis
mcc04919  Thyroid hormone signaling pathway
mcc04921  Oxytocin signaling pathway
mcc04922  Glucagon signaling pathway
mcc04924  Renin secretion
mcc04925  Aldosterone synthesis and secretion
mcc04926  Relaxin signaling pathway
mcc04927  Cortisol synthesis and secretion
mcc04928  Parathyroid hormone synthesis, secretion and action
mcc04929  GnRH secretion
mcc04933  AGE-RAGE signaling pathway in diabetic complications
mcc04934  Cushing syndrome
mcc04935  Growth hormone synthesis, secretion and action
mcc04961  Endocrine and other factor-regulated calcium reabsorption
mcc04970  Salivary secretion
mcc04971  Gastric acid secretion
mcc04972  Pancreatic secretion
mcc04973  Carbohydrate digestion and absorption
mcc05010  Alzheimer disease
mcc05016  Huntington disease
mcc05017  Spinocerebellar ataxia
mcc05022  Pathways of neurodegeneration - multiple diseases
mcc05142  Chagas disease
mcc05143  African trypanosomiasis
mcc05146  Amoebiasis
mcc05163  Human cytomegalovirus infection
mcc05200  Pathways in cancer
mcc05415  Diabetic cardiomyopathy
mcc05417  Lipid and atherosclerosis
Module
mcc_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:mcc00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    701951 (PLCB2)
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    701951 (PLCB2)
   04310 Wnt signaling pathway
    701951 (PLCB2)
   04371 Apelin signaling pathway
    701951 (PLCB2)
   04020 Calcium signaling pathway
    701951 (PLCB2)
   04070 Phosphatidylinositol signaling system
    701951 (PLCB2)
   04072 Phospholipase D signaling pathway
    701951 (PLCB2)
   04071 Sphingolipid signaling pathway
    701951 (PLCB2)
   04022 cGMP-PKG signaling pathway
    701951 (PLCB2)
  09133 Signaling molecules and interaction
   04082 Neuroactive ligand signaling
    701951 (PLCB2)
   04081 Hormone signaling
    701951 (PLCB2)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04540 Gap junction
    701951 (PLCB2)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    701951 (PLCB2)
   04613 Neutrophil extracellular trap formation
    701951 (PLCB2)
   04621 NOD-like receptor signaling pathway
    701951 (PLCB2)
   04062 Chemokine signaling pathway
    701951 (PLCB2)
  09152 Endocrine system
   04911 Insulin secretion
    701951 (PLCB2)
   04922 Glucagon signaling pathway
    701951 (PLCB2)
   04929 GnRH secretion
    701951 (PLCB2)
   04912 GnRH signaling pathway
    701951 (PLCB2)
   04915 Estrogen signaling pathway
    701951 (PLCB2)
   04921 Oxytocin signaling pathway
    701951 (PLCB2)
   04926 Relaxin signaling pathway
    701951 (PLCB2)
   04935 Growth hormone synthesis, secretion and action
    701951 (PLCB2)
   04918 Thyroid hormone synthesis
    701951 (PLCB2)
   04919 Thyroid hormone signaling pathway
    701951 (PLCB2)
   04928 Parathyroid hormone synthesis, secretion and action
    701951 (PLCB2)
   04916 Melanogenesis
    701951 (PLCB2)
   04924 Renin secretion
    701951 (PLCB2)
   04925 Aldosterone synthesis and secretion
    701951 (PLCB2)
   04927 Cortisol synthesis and secretion
    701951 (PLCB2)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    701951 (PLCB2)
   04270 Vascular smooth muscle contraction
    701951 (PLCB2)
  09154 Digestive system
   04970 Salivary secretion
    701951 (PLCB2)
   04971 Gastric acid secretion
    701951 (PLCB2)
   04972 Pancreatic secretion
    701951 (PLCB2)
   04973 Carbohydrate digestion and absorption
    701951 (PLCB2)
  09155 Excretory system
   04961 Endocrine and other factor-regulated calcium reabsorption
    701951 (PLCB2)
  09156 Nervous system
   04724 Glutamatergic synapse
    701951 (PLCB2)
   04725 Cholinergic synapse
    701951 (PLCB2)
   04728 Dopaminergic synapse
    701951 (PLCB2)
   04726 Serotonergic synapse
    701951 (PLCB2)
   04720 Long-term potentiation
    701951 (PLCB2)
   04730 Long-term depression
    701951 (PLCB2)
   04723 Retrograde endocannabinoid signaling
    701951 (PLCB2)
  09157 Sensory system
   04742 Taste transduction
    701951 (PLCB2)
   04750 Inflammatory mediator regulation of TRP channels
    701951 (PLCB2)
  09159 Environmental adaptation
   04713 Circadian entrainment
    701951 (PLCB2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    701951 (PLCB2)
  09172 Infectious disease: viral
   05163 Human cytomegalovirus infection
    701951 (PLCB2)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    701951 (PLCB2)
   05142 Chagas disease
    701951 (PLCB2)
   05143 African trypanosomiasis
    701951 (PLCB2)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    701951 (PLCB2)
   05016 Huntington disease
    701951 (PLCB2)
   05017 Spinocerebellar ataxia
    701951 (PLCB2)
   05022 Pathways of neurodegeneration - multiple diseases
    701951 (PLCB2)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    701951 (PLCB2)
   05415 Diabetic cardiomyopathy
    701951 (PLCB2)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    701951 (PLCB2)
   04934 Cushing syndrome
    701951 (PLCB2)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:mcc04131]
    701951 (PLCB2)
Enzymes [BR:mcc01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     701951 (PLCB2)
Membrane trafficking [BR:mcc04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    701951 (PLCB2)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    701951 (PLCB2)
SSDB
Motif
Pfam: PLC-beta_C PI-PLC-X PH_14 PI-PLC-Y PLCB1-4-like_EFh EF-hand_like C2 IATP
Other DBs
NCBI-GeneID: 701951
NCBI-ProteinID: NP_001253955
Ensembl: ENSMMUG00000020535
UniProt: H9YV70
LinkDB
Position
7:complement(16697480..16717629)
AA seq 1185 aa
MSLLNPVLLPPRVKAYLSQGERFIKWDDETTIASPVILRVDPKGYYLYWTYQSKEMEFLD
ITSIRDTRFGKFAKMPKSQKLRDVFNMDFPDNSFLLKTLTVVSGPDMVDLTFHNFVSYKE
NVGKVWAEDILALVKHPLTANASRSTFLDKILVKLKMQLNSEGKIPVKNFFQMFPADRKR
VEAALSACHLPKGKNDAINPEDFPEPVYKSFLMSLCPRPEINEIFTSYHAKAKPYMTKEH
LTKFINQKQRDSRLNSLLFPPARPDQVQGLIDKYEPSGINVQRGQLSPEGMVWFLCGPEN
SVLAQDKLLLHHDMTQPLNHYFINSSHNTYLTAGQFSGLSSAEMYRQVLLSGCRCVELDC
WKGKPPDEEPIITHGFTMTTDIFFKEAIEAIAESAFKTSPYPIILSFENHVDSPRQQAKM
AEYCRTIFGDMLLTEPLEKFPLKPGVPLPSPEDLRGKILIKNKKNQFSSPTSSSKDPGGE
AEGSSPRSAPAGEGTVWAGEEGTELEDEEVEEEEEEESGNLDEEEIKKMQSDEGTAGLEV
TAYEEMSSLVNYIQPTKFISFEFSAQKNRSYVISSFTELKAYDLLSKASVQFVDYNKRQM
SRIYPKGTRMDSSNYMPQMFWNAGCQMVALNFQTMDLPMQQNMAVFEFNGQSGYLLKHEF
MRRPDKQFNPFSVDRIDVVVATTLSITVISGQFLSERSVRTYVEVELFGLPGDPKRRYRT
KLSPSTNSINPVWKEEPFVFEKILVPELASLRVAVMEEGNKFLGHRIIPINALNSGYHHL
CLHSESNMPLTMPALFVFLEMKDYVPGAWADLTVALANPIKFFSAHDKRSVKLKDIMGGL
PEKPFPLASPVASQVNGALAPRSNGSPAARAWAREEAMKEVAEPRTASLEELRELKGVVK
LQRRHEKELRELERRGARRWEELLQRGAAQLAELGPRGAGGGGAGKLGPGKGSRKKRSLP
CEESAGAAPGESPEGMDARVRELKDRLELELLRQGEEQYECVLKRKEQHAAEQISKMMEL
AREKQAAELKALKETAEIDTKEMKKKLETKRLERIQGMTKVTADKMAQERLKREINSSHI
QEVVQVIKQMTENLEKHQEKLEEKQAACLEQIREMEKQFQKEALAEYEARMKGLEAEVKE
SVRACFRTCFPSETKDKPERDCECPPELCEQDPVVAKTDVQESRL
NT seq 3558 nt   +upstreamnt  +downstreamnt
atgtctctgctcaaccctgtgctgctgccccccagggtgaaggcctatctgagccaaggg
gagcgcttcatcaaatgggatgatgaaactacaattgcctctccagttatcctccgtgtg
gatcctaagggctactacttatactggacatatcaaagcaaggagatggagtttctggat
atcaccagcatccgggacactcgctttgggaagtttgccaagatgcccaagagccagaag
ctccgggacgtcttcaacatggactttcctgacaacagcttcctgctgaagacgctcacc
gtggtgtctggcccggacatggtggacctcaccttccacaacttcgtctcctacaaggag
aacgtgggcaaggtctgggctgaggacatactggccctagtcaagcatccgctgacggcc
aacgcctcccgcagcaccttcctggacaagatcctcgtgaagctcaagatgcagctcaac
tctgaagggaagattccagtgaagaactttttccagatgtttcctgctgaccgcaagcgg
gtggaagctgctctcagtgcctgccacctccctaaaggcaagaatgacgccatcaatcct
gaggacttcccagaacctgtctacaagagtttcctcatgagcctctgtcctcggccagaa
ataaatgagatcttcacttcttaccatgctaaggccaaaccctacatgacgaaggagcac
ttgaccaaattcatcaaccagaaacagcgggactcccggcttaactccctgctgttcccg
ccagcacggcctgaccaggtgcagggcctcatcgacaagtatgagcccagtggcatcaat
gtgcagaggggccagttgtcacctgagggcatggtctggtttctctgtgggccagagaac
agtgtgctggcccaggacaagctgctgctccaccacgacatgacacagccactcaatcat
tacttcatcaactcgtcccacaacacctacctgacagccggccagttctcaggcctctcc
tcggctgagatgtaccgccaggtgctgctgtccggctgccgttgcgtggagctagattgc
tggaaggggaaaccccctgacgaagagcccattatcacccacggcttcaccatgaccaca
gacatcttcttcaaagaagcaattgaggctattgcagaaagcgcctttaagacctccccg
tatcctatcatcctgtcgtttgagaaccatgtggactcaccccgccagcaggctaagatg
gctgagtattgccggacgatctttggggatatgctgctcacagagcccctggaaaagttc
ccactgaaaccaggtgtccccctgcccagccctgaggatctcaggggcaagatcctcatc
aagaacaagaagaaccagttttccagccccacctcctccagtaaggatcctggtggggag
gctgagggcagcagcccacgcagtgcccctgcaggtgagggcacagtgtgggctggcgag
gaagggactgagctggaggacgaggaggtggaagaggaagaggaggaggagtcaggaaac
ctggacgaagaagagattaagaagatgcagtcggatgagggcacagcgggcctggaagtg
acggcttatgaggagatgtccagcctagtcaattacattcagcccaccaagttcatctcc
tttgagttctctgctcaaaagaaccgaagttatgtcatctcgtccttcacagaactcaag
gcatatgacctgctctccaaggcctcggtgcagtttgtggactacaacaagcgccagatg
agccgcatttaccccaagggaacccgcatggactcctccaactacatgccccagatgttc
tggaatgctggatgccagatggttgccctcaacttccagacgatggacttgcccatgcag
cagaacatggcagtgtttgagttcaatgggcagagcggctacctcctcaagcacgagttc
atgcgccggccggacaagcagttcaaccccttctcagtggaccgcatcgacgtggtggtg
gccaccaccctttctatcacggtgatctctgggcagttcctgtcagaacgcagtgtgcgc
acctatgtggaagtggagctgtttggccttcctggggaccccaagaggcgctaccgaact
aagctgtcacccagtaccaattccatcaatcctgtctggaaggaggagccctttgtcttt
gagaagatcttggtgcctgagctggcctctctcagggtggctgtgatggaggaaggcaac
aagtttcttggacaccgcatcatccccatcaatgccctaaattctgggtaccaccacctg
tgcctacacagtgagagcaacatgcccctcaccatgcctgcgctcttcgtcttcctggag
atgaaggactacgtacctggtgcctgggcagatctcactgtggccctcgccaaccccatc
aagttcttcagtgcccatgacaagaggtctgtgaagctcaaggacatcatgggagggctg
cctgagaagcccttcccactggcgagtccagttgccagccaggtcaatggtgcgttggcc
ccaaggagcaatgggtcaccagcagccagggcctgggccagggaagaggctatgaaagaa
gttgcggagccacggaccgccagcctggaggagctccgggagctaaagggcgtcgtgaag
ctgcagcggcggcacgagaaggagctgcgggagttggagcggcgcggagcgcggcgctgg
gaggagctgctgcagcggggcgcggcgcagctggccgagctcgggccacggggcgcgggg
ggtggcggggccggcaagctcggcccgggcaaaggctctcgcaagaagaggagcctgcct
tgcgaggagagcgccggagccgcgccgggcgagagccctgagggcatggacgcgcgcgtg
cgggagctgaaggacaggctggagctggagctgctgcggcagggcgaggagcagtacgag
tgcgttctgaagcgcaaggagcagcacgcggccgagcaaatctccaaaatgatggagctg
gccagagagaaacaggcggcagagctgaaggccctgaaggagacggcggagatcgacacc
aaagagatgaagaaaaagctggagaccaagagactggagcggatccagggcatgaccaaa
gtcaccgcagataagatggcccaggagaggttgaagagagagattaacagctcccacatc
caggaagtagtgcaggtgatcaagcagatgacagagaacttggagaagcaccaggagaag
ctggaagagaagcaggctgcttgcctggaacagatacgggagatggaaaagcagttccag
aaggaggcgctggcagagtacgaggccaggatgaagggtctggaggcagaggtgaaggag
tcggtgagggcctgcttcaggacctgctttccctctgagaccaaggacaagcctgagagg
gactgcgagtgccccccagagctgtgtgagcaggacccagtcgtagcaaagacagatgtc
caggagagccgcctttga

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