KEGG   Macaca mulatta (rhesus monkey): 709959
Entry
709959            CDS       T01028                                 
Symbol
PIK3CA
Name
(RefSeq) phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
  KO
K00922  phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
Organism
mcc  Macaca mulatta (rhesus monkey)
Pathway
mcc00562  Inositol phosphate metabolism
mcc01100  Metabolic pathways
mcc01521  EGFR tyrosine kinase inhibitor resistance
mcc01522  Endocrine resistance
mcc01524  Platinum drug resistance
mcc04012  ErbB signaling pathway
mcc04014  Ras signaling pathway
mcc04015  Rap1 signaling pathway
mcc04024  cAMP signaling pathway
mcc04062  Chemokine signaling pathway
mcc04066  HIF-1 signaling pathway
mcc04068  FoxO signaling pathway
mcc04070  Phosphatidylinositol signaling system
mcc04071  Sphingolipid signaling pathway
mcc04072  Phospholipase D signaling pathway
mcc04081  Hormone signaling
mcc04140  Autophagy - animal
mcc04150  mTOR signaling pathway
mcc04151  PI3K-Akt signaling pathway
mcc04152  AMPK signaling pathway
mcc04210  Apoptosis
mcc04211  Longevity regulating pathway
mcc04213  Longevity regulating pathway - multiple species
mcc04218  Cellular senescence
mcc04360  Axon guidance
mcc04370  VEGF signaling pathway
mcc04380  Osteoclast differentiation
mcc04510  Focal adhesion
mcc04550  Signaling pathways regulating pluripotency of stem cells
mcc04611  Platelet activation
mcc04613  Neutrophil extracellular trap formation
mcc04620  Toll-like receptor signaling pathway
mcc04625  C-type lectin receptor signaling pathway
mcc04630  JAK-STAT signaling pathway
mcc04650  Natural killer cell mediated cytotoxicity
mcc04660  T cell receptor signaling pathway
mcc04662  B cell receptor signaling pathway
mcc04664  Fc epsilon RI signaling pathway
mcc04666  Fc gamma R-mediated phagocytosis
mcc04668  TNF signaling pathway
mcc04670  Leukocyte transendothelial migration
mcc04722  Neurotrophin signaling pathway
mcc04725  Cholinergic synapse
mcc04750  Inflammatory mediator regulation of TRP channels
mcc04810  Regulation of actin cytoskeleton
mcc04910  Insulin signaling pathway
mcc04914  Progesterone-mediated oocyte maturation
mcc04915  Estrogen signaling pathway
mcc04917  Prolactin signaling pathway
mcc04919  Thyroid hormone signaling pathway
mcc04923  Regulation of lipolysis in adipocytes
mcc04926  Relaxin signaling pathway
mcc04929  GnRH secretion
mcc04930  Type II diabetes mellitus
mcc04931  Insulin resistance
mcc04932  Non-alcoholic fatty liver disease
mcc04933  AGE-RAGE signaling pathway in diabetic complications
mcc04935  Growth hormone synthesis, secretion and action
mcc04960  Aldosterone-regulated sodium reabsorption
mcc04973  Carbohydrate digestion and absorption
mcc05010  Alzheimer disease
mcc05017  Spinocerebellar ataxia
mcc05020  Prion disease
mcc05100  Bacterial invasion of epithelial cells
mcc05132  Salmonella infection
mcc05135  Yersinia infection
mcc05142  Chagas disease
mcc05146  Amoebiasis
mcc05160  Hepatitis C
mcc05161  Hepatitis B
mcc05162  Measles
mcc05163  Human cytomegalovirus infection
mcc05164  Influenza A
mcc05165  Human papillomavirus infection
mcc05166  Human T-cell leukemia virus 1 infection
mcc05167  Kaposi sarcoma-associated herpesvirus infection
mcc05168  Herpes simplex virus 1 infection
mcc05169  Epstein-Barr virus infection
mcc05170  Human immunodeficiency virus 1 infection
mcc05171  Coronavirus disease - COVID-19
mcc05200  Pathways in cancer
mcc05203  Viral carcinogenesis
mcc05205  Proteoglycans in cancer
mcc05206  MicroRNAs in cancer
mcc05207  Chemical carcinogenesis - receptor activation
mcc05208  Chemical carcinogenesis - reactive oxygen species
mcc05210  Colorectal cancer
mcc05211  Renal cell carcinoma
mcc05212  Pancreatic cancer
mcc05213  Endometrial cancer
mcc05214  Glioma
mcc05215  Prostate cancer
mcc05218  Melanoma
mcc05220  Chronic myeloid leukemia
mcc05221  Acute myeloid leukemia
mcc05222  Small cell lung cancer
mcc05223  Non-small cell lung cancer
mcc05224  Breast cancer
mcc05225  Hepatocellular carcinoma
mcc05226  Gastric cancer
mcc05230  Central carbon metabolism in cancer
mcc05231  Choline metabolism in cancer
mcc05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
mcc05415  Diabetic cardiomyopathy
mcc05417  Lipid and atherosclerosis
mcc05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:mcc00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    709959 (PIK3CA)
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    709959 (PIK3CA)
   04014 Ras signaling pathway
    709959 (PIK3CA)
   04015 Rap1 signaling pathway
    709959 (PIK3CA)
   04370 VEGF signaling pathway
    709959 (PIK3CA)
   04630 JAK-STAT signaling pathway
    709959 (PIK3CA)
   04668 TNF signaling pathway
    709959 (PIK3CA)
   04066 HIF-1 signaling pathway
    709959 (PIK3CA)
   04068 FoxO signaling pathway
    709959 (PIK3CA)
   04070 Phosphatidylinositol signaling system
    709959 (PIK3CA)
   04072 Phospholipase D signaling pathway
    709959 (PIK3CA)
   04071 Sphingolipid signaling pathway
    709959 (PIK3CA)
   04024 cAMP signaling pathway
    709959 (PIK3CA)
   04151 PI3K-Akt signaling pathway
    709959 (PIK3CA)
   04152 AMPK signaling pathway
    709959 (PIK3CA)
   04150 mTOR signaling pathway
    709959 (PIK3CA)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    709959 (PIK3CA)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    709959 (PIK3CA)
  09143 Cell growth and death
   04210 Apoptosis
    709959 (PIK3CA)
   04218 Cellular senescence
    709959 (PIK3CA)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    709959 (PIK3CA)
   04550 Signaling pathways regulating pluripotency of stem cells
    709959 (PIK3CA)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    709959 (PIK3CA)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    709959 (PIK3CA)
   04613 Neutrophil extracellular trap formation
    709959 (PIK3CA)
   04620 Toll-like receptor signaling pathway
    709959 (PIK3CA)
   04625 C-type lectin receptor signaling pathway
    709959 (PIK3CA)
   04650 Natural killer cell mediated cytotoxicity
    709959 (PIK3CA)
   04660 T cell receptor signaling pathway
    709959 (PIK3CA)
   04662 B cell receptor signaling pathway
    709959 (PIK3CA)
   04664 Fc epsilon RI signaling pathway
    709959 (PIK3CA)
   04666 Fc gamma R-mediated phagocytosis
    709959 (PIK3CA)
   04670 Leukocyte transendothelial migration
    709959 (PIK3CA)
   04062 Chemokine signaling pathway
    709959 (PIK3CA)
  09152 Endocrine system
   04910 Insulin signaling pathway
    709959 (PIK3CA)
   04923 Regulation of lipolysis in adipocytes
    709959 (PIK3CA)
   04929 GnRH secretion
    709959 (PIK3CA)
   04915 Estrogen signaling pathway
    709959 (PIK3CA)
   04914 Progesterone-mediated oocyte maturation
    709959 (PIK3CA)
   04917 Prolactin signaling pathway
    709959 (PIK3CA)
   04926 Relaxin signaling pathway
    709959 (PIK3CA)
   04935 Growth hormone synthesis, secretion and action
    709959 (PIK3CA)
   04919 Thyroid hormone signaling pathway
    709959 (PIK3CA)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    709959 (PIK3CA)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    709959 (PIK3CA)
  09156 Nervous system
   04725 Cholinergic synapse
    709959 (PIK3CA)
   04722 Neurotrophin signaling pathway
    709959 (PIK3CA)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    709959 (PIK3CA)
  09158 Development and regeneration
   04360 Axon guidance
    709959 (PIK3CA)
   04380 Osteoclast differentiation
    709959 (PIK3CA)
  09149 Aging
   04211 Longevity regulating pathway
    709959 (PIK3CA)
   04213 Longevity regulating pathway - multiple species
    709959 (PIK3CA)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    709959 (PIK3CA)
   05206 MicroRNAs in cancer
    709959 (PIK3CA)
   05205 Proteoglycans in cancer
    709959 (PIK3CA)
   05207 Chemical carcinogenesis - receptor activation
    709959 (PIK3CA)
   05208 Chemical carcinogenesis - reactive oxygen species
    709959 (PIK3CA)
   05203 Viral carcinogenesis
    709959 (PIK3CA)
   05230 Central carbon metabolism in cancer
    709959 (PIK3CA)
   05231 Choline metabolism in cancer
    709959 (PIK3CA)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    709959 (PIK3CA)
  09162 Cancer: specific types
   05210 Colorectal cancer
    709959 (PIK3CA)
   05212 Pancreatic cancer
    709959 (PIK3CA)
   05225 Hepatocellular carcinoma
    709959 (PIK3CA)
   05226 Gastric cancer
    709959 (PIK3CA)
   05214 Glioma
    709959 (PIK3CA)
   05221 Acute myeloid leukemia
    709959 (PIK3CA)
   05220 Chronic myeloid leukemia
    709959 (PIK3CA)
   05218 Melanoma
    709959 (PIK3CA)
   05211 Renal cell carcinoma
    709959 (PIK3CA)
   05215 Prostate cancer
    709959 (PIK3CA)
   05213 Endometrial cancer
    709959 (PIK3CA)
   05224 Breast cancer
    709959 (PIK3CA)
   05222 Small cell lung cancer
    709959 (PIK3CA)
   05223 Non-small cell lung cancer
    709959 (PIK3CA)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    709959 (PIK3CA)
   05170 Human immunodeficiency virus 1 infection
    709959 (PIK3CA)
   05161 Hepatitis B
    709959 (PIK3CA)
   05160 Hepatitis C
    709959 (PIK3CA)
   05171 Coronavirus disease - COVID-19
    709959 (PIK3CA)
   05164 Influenza A
    709959 (PIK3CA)
   05162 Measles
    709959 (PIK3CA)
   05168 Herpes simplex virus 1 infection
    709959 (PIK3CA)
   05163 Human cytomegalovirus infection
    709959 (PIK3CA)
   05167 Kaposi sarcoma-associated herpesvirus infection
    709959 (PIK3CA)
   05169 Epstein-Barr virus infection
    709959 (PIK3CA)
   05165 Human papillomavirus infection
    709959 (PIK3CA)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    709959 (PIK3CA)
   05135 Yersinia infection
    709959 (PIK3CA)
   05100 Bacterial invasion of epithelial cells
    709959 (PIK3CA)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    709959 (PIK3CA)
   05142 Chagas disease
    709959 (PIK3CA)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    709959 (PIK3CA)
   05017 Spinocerebellar ataxia
    709959 (PIK3CA)
   05020 Prion disease
    709959 (PIK3CA)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    709959 (PIK3CA)
   05418 Fluid shear stress and atherosclerosis
    709959 (PIK3CA)
   05415 Diabetic cardiomyopathy
    709959 (PIK3CA)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    709959 (PIK3CA)
   04932 Non-alcoholic fatty liver disease
    709959 (PIK3CA)
   04931 Insulin resistance
    709959 (PIK3CA)
   04933 AGE-RAGE signaling pathway in diabetic complications
    709959 (PIK3CA)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    709959 (PIK3CA)
   01524 Platinum drug resistance
    709959 (PIK3CA)
   01522 Endocrine resistance
    709959 (PIK3CA)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:mcc04131]
    709959 (PIK3CA)
Enzymes [BR:mcc01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.153  phosphatidylinositol-4,5-bisphosphate 3-kinase
     709959 (PIK3CA)
Membrane trafficking [BR:mcc04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    709959 (PIK3CA)
SSDB
Motif
Pfam: PI3Ka PI3_PI4_kinase PI3K_C2 PI3K_rbd PI3K_p85B DUF2321 ABC1 Ribosomal_S15
Other DBs
NCBI-GeneID: 709959
NCBI-ProteinID: NP_001247597
Ensembl: ENSMMUG00000005188
UniProt: H9FVU5
LinkDB
Position
2:84324191..84360336
AA seq 1068 aa
MPPRPSSGELWGIHLMPPRILVECLLPNGMIVTLECLREATLITIKHELFKEARKYPLHQ
LLQDESSYIFVSVTQEAEREEFFDETRRLCDLRLFQPFLKVIEPVGNREEKILNREIGFA
IGMPVCEFDMVKDPEVQDFRRNILNVCKEAVDLRDLNSPHSRAMYVYPPNVESSPELPKH
IYNKLDKGQIIVVIWVIVSPNNDKQKYTLKINHDCVPEQVIAEAIRKKTRSMLLSSEQLK
LCVLEYQGKYILKVCGCDEYFLEKYPLSQYKYIRSCIMLGRMPNLMLMAKESLYSQLPMD
CFTMPSYSRRISTATPYMNGETSTKSLWVINSALRIKILCATYVNVNIRDIDKIYVRTGI
YHGGEPLCDNVNTQRVPCSNPRWNEWLNYDIYIPDLPRAARLCLSICSVKGRKGAKEEHC
PLAWGNINLFDYTDTLVSGKMALNLWPVPHGLEDLLNPIGVTGSNPNKETPCLELEFDWF
SSVVKFPDMSVIEEHANWSVSREAGFSYSHAGLSNRLARDNELRENDKEQLKAISTRDPL
SEITEQEKDFLWSHRHYCVTIPEILPKLLLSVKWNSRDEVAQMYCLVKDWPPIKPEQAME
LLDCNYPDPMVRGFAVRCLEKYLTDDKLSQYLIQLVQVLKYEQYLDNLLVRFLLKKALTN
QRIGHFFFWHLKSEMHNKTVSQRFGLLLESYCRACGMYLKHLNRQVEAMEKLINLTDILK
QEKKDETQKVQMKFLVEQMRRPDFMDALQGFLSPLNPAHQLGNLRLEECRIMSSAKRPLW
LNWENPDIMSELLFQNNEIIFKNGDDLRQDMLTLQIIRIMENIWQNQGLDLRMLPYGCLS
IGDCVGLIEVVRNSHTIMQIQCKGGLKGALQFNSHTLHQWLKDKNKGEIYDAAIDLFTRS
CAGYCVATFILGIGDRHNSNIMVKDDGQLFHIDFGHFLDHKKKKFGYKRERVPFVLTQDF
LIVISKGAQECTKTREFERFQEMCYKAYLAIRQHANLFINLFSMMLGSGMPELQSFDDIA
YIRKTLALDKTEQEALEYFMKQMNDAHHGGWTTKMDWIFHTIKQHALN
NT seq 3207 nt   +upstreamnt  +downstreamnt
atgcctccacgaccatcatcaggtgaactgtggggcatccacttgatgcccccaagaatc
ctagtagaatgtttactaccaaatggaatgatagtgactttagaatgcctccgtgaggct
acattaataaccataaagcatgaactatttaaagaagcaagaaaataccccctccatcaa
cttcttcaagatgaatcttcttacattttcgtaagtgttacccaagaagcagaaagggaa
gaattttttgatgaaacaagacgactttgtgaccttcggctttttcaaccctttttaaaa
gtaattgaaccagtaggcaaccgtgaagaaaagatcctcaatcgagaaattggttttgct
attggcatgccagtgtgtgaatttgatatggttaaagatccagaagtacaggacttccga
agaaatattctgaatgtttgtaaagaagctgtggatcttagggatctcaattcacctcat
agtagagcaatgtatgtctatcctccaaatgtagaatcttcgccagaattgccaaagcac
atatataataaattagataaagggcaaataatagtggtgatttgggtaatagtttctcca
aataatgacaagcagaagtatactctgaaaatcaaccatgactgtgtaccagaacaagta
attgctgaagcaatcaggaaaaaaactcgaagtatgttgctatcctctgaacagctaaaa
ctctgtgttttagaatatcagggcaagtatattttaaaagtgtgtggatgtgatgaatac
ttcctagaaaaatatcctctgagtcagtataagtatataagaagctgtataatgcttggg
aggatgcccaatttgatgttgatggctaaagaaagcctttattctcaactgccaatggac
tgttttacaatgccatcttattccagacgcatttccacagctacaccatatatgaatgga
gaaacatctacaaaatccctttgggttataaatagtgcactcagaataaaaattctttgt
gcaacctacgtgaatgtaaatattcgagacattgataagatctatgttcgaacaggtatc
taccatggaggagaacccttatgtgacaatgtgaacactcaaagagtaccttgttccaat
cccaggtggaatgaatggctgaattatgatatatacattcctgaccttcctcgtgctgct
cgactttgcctttccatttgctctgttaaaggccgaaagggtgctaaagaggaacactgt
ccattggcatggggaaatataaacttgtttgattacacagacactctagtatctggaaaa
atggctttgaatctttggccagtacctcatggattagaagatttgctgaaccctattggt
gttactggatcaaatccaaataaagaaactccatgcttagagttggagtttgactggttc
agcagtgtggtaaagttcccagatatgtcagtgattgaagagcatgccaattggtctgtg
tcccgagaagcaggatttagctattcccacgcaggactgagtaacaggctagctagagac
aatgaattaagggaaaatgacaaagaacagctcaaagcaatttctacacgagatcctctc
tctgaaatcactgagcaggagaaagattttctgtggagccacagacactattgtgtaact
atccccgaaattctacccaaattgcttctgtctgttaaatggaattctagagatgaagta
gcccagatgtattgcttggtaaaagactggcctccaatcaaacctgaacaggctatggaa
cttctggactgtaattacccagatcctatggttcgaggttttgctgttcggtgcttggaa
aaatatttaacagatgacaaactttctcagtatttaattcagctagtacaggtcctaaaa
tatgaacaatatttggataacttgcttgtgagatttttactgaagaaagcattgactaat
caaaggattgggcactttttcttttggcatttaaaatctgagatgcacaataaaacagtt
agccagaggtttggcctgcttttggagtcctattgtcgtgcatgtgggatgtatttgaag
cacctgaataggcaagtcgaggcaatggaaaagctcattaacttaactgacattctcaaa
caggagaaaaaggatgaaacacaaaaggtacagatgaagtttttagttgagcaaatgagg
cgaccagatttcatggatgctctgcagggctttctatctcctctaaaccctgctcatcaa
ctaggaaatctcaggcttgaagagtgtcgaattatgtcctctgcaaaaaggccactgtgg
ttgaattgggagaacccagacatcatgtcagagttactgtttcagaacaatgagatcatc
tttaaaaatggggatgatttacggcaagatatgctaacacttcaaattattcgtattatg
gaaaatatctggcaaaatcaaggtcttgatcttcgaatgttaccttatggttgtctgtca
atcggtgactgtgtgggacttattgaggtggtgcgaaattctcacactattatgcaaatt
cagtgcaaaggcggcttgaaaggtgcactgcagttcaacagccacactctacatcagtgg
ctcaaagacaagaacaaaggagaaatatatgatgcagccattgacctgtttacacgttca
tgtgctggatattgtgtcgctaccttcattctgggaattggagatcgtcacaatagtaac
atcatggtgaaagacgatggacaactgtttcatatagattttggacactttttggatcac
aagaagaaaaaatttggctataaacgagaacgtgtgccatttgttttgacacaggatttc
ttaatagtgattagtaaaggagcccaagaatgcacaaagacaagagaatttgagaggttt
caggagatgtgttacaaggcttatctagctattcgacagcatgccaatctcttcataaat
cttttctcaatgatgcttggctctggaatgccagaactacaatcttttgatgacattgca
tacattcgaaagaccctagccttagataaaactgagcaagaggctttggaatatttcatg
aaacaaatgaatgatgcacatcatggtggctggacaacaaaaatggattggatcttccac
acaattaaacagcatgcattgaactga

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