Macaca mulatta (rhesus monkey): 714173
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Entry
714173 CDS
T01028
Symbol
PLCG2
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 isoform X1
KO
K05859
phosphatidylinositol phospholipase C, gamma-2 [EC:
3.1.4.11
]
Organism
mcc
Macaca mulatta (rhesus monkey)
Pathway
mcc00562
Inositol phosphate metabolism
mcc01100
Metabolic pathways
mcc01521
EGFR tyrosine kinase inhibitor resistance
mcc04012
ErbB signaling pathway
mcc04014
Ras signaling pathway
mcc04020
Calcium signaling pathway
mcc04062
Chemokine signaling pathway
mcc04064
NF-kappa B signaling pathway
mcc04066
HIF-1 signaling pathway
mcc04070
Phosphatidylinositol signaling system
mcc04072
Phospholipase D signaling pathway
mcc04360
Axon guidance
mcc04370
VEGF signaling pathway
mcc04380
Osteoclast differentiation
mcc04517
IgSF CAM signaling
mcc04611
Platelet activation
mcc04613
Neutrophil extracellular trap formation
mcc04625
C-type lectin receptor signaling pathway
mcc04650
Natural killer cell mediated cytotoxicity
mcc04662
B cell receptor signaling pathway
mcc04664
Fc epsilon RI signaling pathway
mcc04666
Fc gamma R-mediated phagocytosis
mcc04670
Leukocyte transendothelial migration
mcc04722
Neurotrophin signaling pathway
mcc04750
Inflammatory mediator regulation of TRP channels
mcc04919
Thyroid hormone signaling pathway
mcc04933
AGE-RAGE signaling pathway in diabetic complications
mcc04935
Growth hormone synthesis, secretion and action
mcc05167
Kaposi sarcoma-associated herpesvirus infection
mcc05169
Epstein-Barr virus infection
mcc05170
Human immunodeficiency virus 1 infection
mcc05171
Coronavirus disease - COVID-19
mcc05200
Pathways in cancer
mcc05205
Proteoglycans in cancer
mcc05206
MicroRNAs in cancer
mcc05214
Glioma
mcc05223
Non-small cell lung cancer
mcc05225
Hepatocellular carcinoma
Module
mcc_M00130
Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:
mcc00001
]
09100 Metabolism
09101 Carbohydrate metabolism
00562 Inositol phosphate metabolism
714173 (PLCG2)
09130 Environmental Information Processing
09132 Signal transduction
04012 ErbB signaling pathway
714173 (PLCG2)
04014 Ras signaling pathway
714173 (PLCG2)
04370 VEGF signaling pathway
714173 (PLCG2)
04064 NF-kappa B signaling pathway
714173 (PLCG2)
04066 HIF-1 signaling pathway
714173 (PLCG2)
04020 Calcium signaling pathway
714173 (PLCG2)
04070 Phosphatidylinositol signaling system
714173 (PLCG2)
04072 Phospholipase D signaling pathway
714173 (PLCG2)
09133 Signaling molecules and interaction
04517 IgSF CAM signaling
714173 (PLCG2)
09150 Organismal Systems
09151 Immune system
04611 Platelet activation
714173 (PLCG2)
04613 Neutrophil extracellular trap formation
714173 (PLCG2)
04625 C-type lectin receptor signaling pathway
714173 (PLCG2)
04650 Natural killer cell mediated cytotoxicity
714173 (PLCG2)
04662 B cell receptor signaling pathway
714173 (PLCG2)
04664 Fc epsilon RI signaling pathway
714173 (PLCG2)
04666 Fc gamma R-mediated phagocytosis
714173 (PLCG2)
04670 Leukocyte transendothelial migration
714173 (PLCG2)
04062 Chemokine signaling pathway
714173 (PLCG2)
09152 Endocrine system
04935 Growth hormone synthesis, secretion and action
714173 (PLCG2)
04919 Thyroid hormone signaling pathway
714173 (PLCG2)
09156 Nervous system
04722 Neurotrophin signaling pathway
714173 (PLCG2)
09157 Sensory system
04750 Inflammatory mediator regulation of TRP channels
714173 (PLCG2)
09158 Development and regeneration
04360 Axon guidance
714173 (PLCG2)
04380 Osteoclast differentiation
714173 (PLCG2)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
714173 (PLCG2)
05206 MicroRNAs in cancer
714173 (PLCG2)
05205 Proteoglycans in cancer
714173 (PLCG2)
09162 Cancer: specific types
05225 Hepatocellular carcinoma
714173 (PLCG2)
05214 Glioma
714173 (PLCG2)
05223 Non-small cell lung cancer
714173 (PLCG2)
09172 Infectious disease: viral
05170 Human immunodeficiency virus 1 infection
714173 (PLCG2)
05171 Coronavirus disease - COVID-19
714173 (PLCG2)
05167 Kaposi sarcoma-associated herpesvirus infection
714173 (PLCG2)
05169 Epstein-Barr virus infection
714173 (PLCG2)
09167 Endocrine and metabolic disease
04933 AGE-RAGE signaling pathway in diabetic complications
714173 (PLCG2)
09176 Drug resistance: antineoplastic
01521 EGFR tyrosine kinase inhibitor resistance
714173 (PLCG2)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
04131 Membrane trafficking [BR:
mcc04131
]
714173 (PLCG2)
Enzymes [BR:
mcc01000
]
3. Hydrolases
3.1 Acting on ester bonds
3.1.4 Phosphoric-diester hydrolases
3.1.4.11 phosphoinositide phospholipase C
714173 (PLCG2)
Membrane trafficking [BR:
mcc04131
]
Exocytosis
Calcium ion-dependent exocytosis
Phospholipases
714173 (PLCG2)
Endocytosis
Macropinocytosis
Phospholipase C
714173 (PLCG2)
BRITE hierarchy
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
PI-PLC-X
SH2
PI-PLC-Y
EF_HAND_2_PLCG
C2
SH3_1
SH3_9
PH
PH_12
EF_HAND_1_PLCG
SH2_1
SH3_2
PH_14
EF-hand_like
Motif
Other DBs
NCBI-GeneID:
714173
NCBI-ProteinID:
XP_001111717
Ensembl:
ENSMMUG00000005334
UniProt:
F7GH26
LinkDB
All DBs
Position
20:68792174..68987061
Genome browser
AA seq
1265 aa
AA seq
DB search
MSTMVNVDSLAEYEKSQIKRALELGTVMTVFSFRKSTPERRTVQVIMETRQVAWSKTADK
IEGFLDIMEIKEIRPGKNSKDFERAKAVRQKEDCCFTILYGTQFVLSTLSLAADSKEDAL
NWLSGLKILHQEAMNASTPTIIESWLRKQIYSVDQTRRNSISLRELKTILPLINFKVSSA
KFLKDKFVEIGAHRDELSFEQFHLFYKKLMFEQQKSILDEFKKDSSVFILGNTDRPDASA
VYLHDFQRFLIHEQQEHWAQDLSKVRERMTKFIDDTMRETAEPFLFVDEFLTYLFSRENS
IWDEKYDVVDMQDMNNPLSHYWISSSHNTYLTGDQLRSESSPEAYIRCLRMGCRCIELDC
WDGPDGKPIIYHGWTRTTKIKFDDVVQAIKEHAFVTSSFPVILSIEEHCSVEQQRHMAKT
FKEVFGDLLLMKPTEASADQLPSPSQLREKIIIKHKKLGPRGDVDVNVEDKKDEHKQQGE
LYMWDSIDQKWTRHYCAIADAKLSFSDDIEQTTEEEVPQDIPPTELHFGEKWFHKKVEKR
TSAEKLLQEYCMETGGKDGTFLVRESETFPNDYTLSFWRSGRVQHCRIRSTMEGGTLKYY
LTDNLTFSSIYALIQHYRETHLRCAEFELRLTDPVPNPNPHESKPWYYESLSRGEAEDML
MRIPRDGAFLIRKREGSDSYAITFRARGKVKHCRINRDGRHFVLGTSAYFESLVELVSYY
EKHSLYRKMRLRYPVTPELLERYNMERDINSLYDVSRMYVDPSEINPSMPQRTVKALYDY
KAKRSDELSFCRGALIHNVSKEPGGWWKGDYGTRIQQYFPSNYVEDISTADVEELEKQII
EDNPLGCLCRGILDLNTYNVVKAPQGKNQKPFVFILEPKKQGDPPVEFATDRVEELFEWF
QSIREITWKIDTKENNMKYWEKNQSIAIELSDLVVYCKPTSKTKDNLENPDFREIRSFVE
TKADSITRQKPVDLLRYNQKGLTRIYPKGQRVDSSNYDPFRLWLCGSQMVALNFQTADKF
MQMNHALFSLNGRTGYVLQPESMRAEKYDPMPPESQRKILMTLTVKVLGARHLPKLGRSI
ACPFVEVEICGADYDNNKFKTTVVNDNGLSPIWAPTQEKVTFEIYDPNLAFLRFVVYEED
MFSDPNFLAHATYPIKAIKSGFRSVPLKNGYSEDIELASLLVFCEMRPVLESEEELYSSC
RQLRRRQEELNNQLFLYDTHQNLRNANRDALVKEFNVNENQLQLYQEKCNKRLREKRVSN
SKFYS
NT seq
3798 nt
NT seq
+upstream
nt +downstream
nt
atgtccaccatggtcaatgtggattcccttgcggaatatgagaagagccagatcaagaga
gccctggagctggggacggtgatgactgtgttcagcttccgcaagtccacccctgagcgg
aggaccgtccaggtgatcatggagacgcggcaggtggcctggagcaagaccgctgacaag
atcgagggcttcttggatatcatggaaataaaagaaatccgcccagggaagaactccaaa
gatttcgaacgtgcaaaagcggttcgccagaaagaagattgctgcttcaccatcctgtat
ggcactcagttcgtcctcagcacactcagcttggcagctgactctaaagaagatgcactt
aattggctctctggcttgaaaatcttacaccaagaagcgatgaatgcgtccacacccacc
attatcgagagttggctgagaaagcagatatattctgtggatcaaaccagaagaaacagc
atcagtctccgagagttgaagaccatcttgcccctgatcaactttaaagtgagcagtgcc
aagttccttaaagataagtttgtggaaataggagcacacagagatgagctcagctttgaa
cagttccatctcttctataaaaaacttatgttcgagcagcaaaaatcgattctcgatgaa
ttcaaaaaggattcgtccgtgttcatcctggggaacacagacaggccggatgcctccgct
gtttacctgcatgacttccagaggtttctcatacatgaacagcaggagcattgggctcag
gatctgagcaaagtccgtgagcggatgacaaagttcatcgatgacaccatgcgcgaaact
gctgagcctttcttgtttgtggatgagttcctcacgtacctgttttcacgagaaaacagc
atctgggatgagaagtatgacgtggtggacatgcaggacatgaacaaccccctgtctcat
tactggatctcctcgtcccataacacgtacctcacaggtgaccagctgcggagcgagtca
tccccagaagcttacatccgctgcctgcgcatgggctgtcgctgcattgaactggactgc
tgggacgggcccgatgggaagccgatcatctaccacggctggacgcggaccaccaagatc
aagtttgacgatgtcgtacaggccatcaaagagcacgcctttgttacctcaagcttccca
gtgatcctgtccatcgaggagcactgcagcgtggagcagcagcgtcacatggccaagacc
ttcaaggaagtgtttggtgacctgctgctgatgaagcccacggaggccagcgctgaccag
ctgccctcgcccagccagctgcgggagaagatcatcatcaagcataagaagctgggtccc
cgaggcgacgtggatgtcaacgtggaggacaagaaggatgagcacaagcaacagggagag
ctgtacatgtgggattccatcgaccagaaatggactcggcactactgcgccattgctgac
gccaagctgtccttcagtgatgacattgaacagactacggaggaggaagtgccccaggat
ataccccctacagagctacattttggggagaaatggttccacaagaaggtggagaagagg
acgagtgccgagaagttgctgcaggaatactgcatggagacggggggcaaggacggcacc
ttcctggttcgggagagcgagaccttccccaatgactacaccctgtccttctggcggtca
ggccgggtgcagcactgccggatccgttccaccatggaaggtggaaccctaaagtactac
ctgactgacaacctcaccttcagcagcatctacgccctcatccagcactaccgcgagacg
cacctgcgctgcgccgagttcgagctgcggctcacggaccctgtgcccaaccccaacccc
cacgagtccaagccgtggtactatgagagcctgagccgcggagaggcagaggacatgctg
atgaggatcccccgggacggagccttcctgatccggaagcgagagggaagcgactcctac
gccatcaccttcagggctaggggcaaggtgaagcattgtcgaatcaaccgggatggccgg
cactttgtgctggggacctccgcctattttgagagcctggtggagctcgtcagttactac
gagaagcattcactctaccgaaagatgagactgcgctaccccgtgacccccgagctcctg
gagcgctacaacatggaaagagatataaactccctctacgacgtcagcagaatgtatgtg
gatcccagtgaaatcaatccgtccatgcctcagagaaccgtgaaagctctgtatgactac
aaagccaagcgaagcgatgagctgagcttctgccgtggtgccctcatccacaatgtctcc
aaggagcccgggggctggtggaaaggagactatggaaccaggatccagcagtacttccca
tccaactacgtcgaggacatctcaacggcagatgtcgaggagctggaaaagcagattatt
gaagacaatcccttagggtgtctttgcagaggaatattggacctcaatacctataacgtc
gtgaaagccccacagggaaaaaaccagaagccctttgtctttatcctggagcccaagaag
cagggcgatcctccggtggagtttgccacagacagggtggaggagctcttcgagtggttt
cagagcatccgagagatcacctggaagattgacaccaaggagaacaacatgaagtactgg
gagaagaaccagtccatcgccatcgagctctctgacctggttgtctactgcaaaccgacc
agcaaaaccaaggacaacttagaaaatcctgacttccgagaaatccgctcctttgtggag
acgaaggctgacagcatcaccagacagaagcccgtcgacctcctgaggtacaatcaaaag
ggcctgacccgcatctacccaaagggacaaagagttgactcttcaaactacgaccccttc
cgcctctggctgtgcggttctcagatggtggcactcaatttccagacagcagataagttc
atgcagatgaatcacgcgttgttttctctcaatgggcgcacgggctacgttctgcagcct
gagagcatgagggcagagaaatatgacccaatgccacccgagtcccagaggaagatcctg
atgacgctgacggtcaaggttctcggtgctcgccatctccccaaacttggacgaagtatt
gcctgtccttttgtagaggtggagatctgtggagccgactatgacaacaacaagttcaag
acgacggttgtgaatgataatggcctcagccctatctgggctccaacacaggagaaggtg
acatttgaaatttatgacccaaacctggcatttctgcgcttcgtggtttacgaagaagat
atgttcagtgatcccaactttcttgctcatgccacttaccccattaaagcaatcaaatca
ggattcaggtctgttcctctgaagaacgggtacagcgaggacatagagctggcttccctc
ctggtcttctgtgagatgcggccagtcctggagagcgaagaggaactttactcctcctgt
cgccagctaaggaggcggcaagaagaactgaacaaccaactctttctgtatgacacacac
cagaacttgcgcaatgccaaccgggatgccctggttaaagagttcaatgttaatgagaac
cagctccagctgtaccaggagaaatgcaacaagaggttaagagagaagagagtcagcaac
agcaagttttactcatag
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integrated database retrieval system
