KEGG   Macaca mulatta (rhesus monkey): 715745
Entry
715745            CDS       T01028                                 
Symbol
MAPK12
Name
(RefSeq) mitogen-activated protein kinase 12 isoform X1
  KO
K04441  p38 MAP kinase [EC:2.7.11.24]
Organism
mcc  Macaca mulatta (rhesus monkey)
Pathway
mcc01522  Endocrine resistance
mcc04010  MAPK signaling pathway
mcc04015  Rap1 signaling pathway
mcc04068  FoxO signaling pathway
mcc04071  Sphingolipid signaling pathway
mcc04114  Oocyte meiosis
mcc04148  Efferocytosis
mcc04218  Cellular senescence
mcc04261  Adrenergic signaling in cardiomyocytes
mcc04370  VEGF signaling pathway
mcc04380  Osteoclast differentiation
mcc04550  Signaling pathways regulating pluripotency of stem cells
mcc04611  Platelet activation
mcc04613  Neutrophil extracellular trap formation
mcc04620  Toll-like receptor signaling pathway
mcc04621  NOD-like receptor signaling pathway
mcc04622  RIG-I-like receptor signaling pathway
mcc04625  C-type lectin receptor signaling pathway
mcc04657  IL-17 signaling pathway
mcc04658  Th1 and Th2 cell differentiation
mcc04659  Th17 cell differentiation
mcc04660  T cell receptor signaling pathway
mcc04664  Fc epsilon RI signaling pathway
mcc04668  TNF signaling pathway
mcc04670  Leukocyte transendothelial migration
mcc04714  Thermogenesis
mcc04722  Neurotrophin signaling pathway
mcc04723  Retrograde endocannabinoid signaling
mcc04728  Dopaminergic synapse
mcc04750  Inflammatory mediator regulation of TRP channels
mcc04912  GnRH signaling pathway
mcc04914  Progesterone-mediated oocyte maturation
mcc04917  Prolactin signaling pathway
mcc04926  Relaxin signaling pathway
mcc04932  Non-alcoholic fatty liver disease
mcc04933  AGE-RAGE signaling pathway in diabetic complications
mcc04935  Growth hormone synthesis, secretion and action
mcc04936  Alcoholic liver disease
mcc05014  Amyotrophic lateral sclerosis
mcc05020  Prion disease
mcc05022  Pathways of neurodegeneration - multiple diseases
mcc05132  Salmonella infection
mcc05133  Pertussis
mcc05135  Yersinia infection
mcc05140  Leishmaniasis
mcc05142  Chagas disease
mcc05145  Toxoplasmosis
mcc05152  Tuberculosis
mcc05161  Hepatitis B
mcc05163  Human cytomegalovirus infection
mcc05167  Kaposi sarcoma-associated herpesvirus infection
mcc05169  Epstein-Barr virus infection
mcc05170  Human immunodeficiency virus 1 infection
mcc05171  Coronavirus disease - COVID-19
mcc05205  Proteoglycans in cancer
mcc05208  Chemical carcinogenesis - reactive oxygen species
mcc05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
mcc05415  Diabetic cardiomyopathy
mcc05417  Lipid and atherosclerosis
mcc05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:mcc00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    715745 (MAPK12)
   04015 Rap1 signaling pathway
    715745 (MAPK12)
   04370 VEGF signaling pathway
    715745 (MAPK12)
   04668 TNF signaling pathway
    715745 (MAPK12)
   04068 FoxO signaling pathway
    715745 (MAPK12)
   04071 Sphingolipid signaling pathway
    715745 (MAPK12)
 09140 Cellular Processes
  09141 Transport and catabolism
   04148 Efferocytosis
    715745 (MAPK12)
  09143 Cell growth and death
   04114 Oocyte meiosis
    715745 (MAPK12)
   04218 Cellular senescence
    715745 (MAPK12)
  09144 Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    715745 (MAPK12)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    715745 (MAPK12)
   04613 Neutrophil extracellular trap formation
    715745 (MAPK12)
   04620 Toll-like receptor signaling pathway
    715745 (MAPK12)
   04621 NOD-like receptor signaling pathway
    715745 (MAPK12)
   04622 RIG-I-like receptor signaling pathway
    715745 (MAPK12)
   04625 C-type lectin receptor signaling pathway
    715745 (MAPK12)
   04660 T cell receptor signaling pathway
    715745 (MAPK12)
   04658 Th1 and Th2 cell differentiation
    715745 (MAPK12)
   04659 Th17 cell differentiation
    715745 (MAPK12)
   04657 IL-17 signaling pathway
    715745 (MAPK12)
   04664 Fc epsilon RI signaling pathway
    715745 (MAPK12)
   04670 Leukocyte transendothelial migration
    715745 (MAPK12)
  09152 Endocrine system
   04912 GnRH signaling pathway
    715745 (MAPK12)
   04914 Progesterone-mediated oocyte maturation
    715745 (MAPK12)
   04917 Prolactin signaling pathway
    715745 (MAPK12)
   04926 Relaxin signaling pathway
    715745 (MAPK12)
   04935 Growth hormone synthesis, secretion and action
    715745 (MAPK12)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    715745 (MAPK12)
  09156 Nervous system
   04728 Dopaminergic synapse
    715745 (MAPK12)
   04723 Retrograde endocannabinoid signaling
    715745 (MAPK12)
   04722 Neurotrophin signaling pathway
    715745 (MAPK12)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    715745 (MAPK12)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    715745 (MAPK12)
  09159 Environmental adaptation
   04714 Thermogenesis
    715745 (MAPK12)
 09160 Human Diseases
  09161 Cancer: overview
   05205 Proteoglycans in cancer
    715745 (MAPK12)
   05208 Chemical carcinogenesis - reactive oxygen species
    715745 (MAPK12)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    715745 (MAPK12)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    715745 (MAPK12)
   05161 Hepatitis B
    715745 (MAPK12)
   05171 Coronavirus disease - COVID-19
    715745 (MAPK12)
   05163 Human cytomegalovirus infection
    715745 (MAPK12)
   05167 Kaposi sarcoma-associated herpesvirus infection
    715745 (MAPK12)
   05169 Epstein-Barr virus infection
    715745 (MAPK12)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    715745 (MAPK12)
   05135 Yersinia infection
    715745 (MAPK12)
   05133 Pertussis
    715745 (MAPK12)
   05152 Tuberculosis
    715745 (MAPK12)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    715745 (MAPK12)
   05140 Leishmaniasis
    715745 (MAPK12)
   05142 Chagas disease
    715745 (MAPK12)
  09164 Neurodegenerative disease
   05014 Amyotrophic lateral sclerosis
    715745 (MAPK12)
   05020 Prion disease
    715745 (MAPK12)
   05022 Pathways of neurodegeneration - multiple diseases
    715745 (MAPK12)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    715745 (MAPK12)
   05418 Fluid shear stress and atherosclerosis
    715745 (MAPK12)
   05415 Diabetic cardiomyopathy
    715745 (MAPK12)
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    715745 (MAPK12)
   04932 Non-alcoholic fatty liver disease
    715745 (MAPK12)
   04933 AGE-RAGE signaling pathway in diabetic complications
    715745 (MAPK12)
  09176 Drug resistance: antineoplastic
   01522 Endocrine resistance
    715745 (MAPK12)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:mcc01001]
    715745 (MAPK12)
Enzymes [BR:mcc01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.24  mitogen-activated protein kinase
     715745 (MAPK12)
Protein kinases [BR:mcc01001]
 Serine/threonine kinases: CMGC group
  MAPK family [OT]
   715745 (MAPK12)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr ABC1
Other DBs
NCBI-GeneID: 715745
NCBI-ProteinID: XP_001112396
Ensembl: ENSMMUG00000014106
LinkDB
Position
10:1219854..1229702
AA seq 390 aa
MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDSHTGAKVAIKKLYR
PFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLM
KHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRVSPGGGATHQPSPSAIPRLHVLPDLKPG
NLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMA
EMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASIL
TNASPLAVNLLEKMLVLDAEQRVTAAEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTL
DEWKRVTYKEVLSFKPPRQLGARVSKETAL
NT seq 1173 nt   +upstreamnt  +downstreamnt
atgagctctccgccgcctgcccgcagtggcttttaccgccaggaggtgactaagacggcc
tgggaggtgcgcgccgtgtaccgggacctgcagcccgtgggctcgggcgcctatggcgcg
gtgtgctcggccgtggacagccacaccggcgctaaggtggccatcaagaagctgtaccgg
cccttccagtcggagctgttcgccaagcgcgcctaccgcgagctgcgcctgctcaagcac
atgcgccacgagaacgtgattgggctgctggatgtgttcactcctgatgagaccctggat
gacttcacagacttttacctggtgatgccattcatgggcaccgacctgggcaagctcatg
aaacatgagaagctgggcgaggaccggatccagttcctcgtgtaccagatgctgaagggg
ctgaggtatatccatgctgccggcatcatccacagagtgagtcctggtggaggagccacc
catcagccctcccccagcgcaatcccccgcctccacgtcctacctgacctgaagcctggc
aacctggctgtgaacgaagactgtgagctgaagatcctggactttggcctggccaggcag
gcagacagcgagatgactggctatgtggtgacccggtggtaccgggcacccgaggtcatc
ttgaattggatgcgctacacgcagacggtggacatctggtctgtggggtgcatcatggcg
gagatgatcacaggcaagacgctgttcaaaggcagcgaccacctggaccagctgaaggag
atcatgaaagtgacagggacgcctccagctgagtttgtgcagcggctgcagagtgatgag
gccaagaactacatgaagggcctccctgagttggagaagaaggattttgcctccatcctg
accaatgcaagccctctagctgtgaacctcctggagaagatgctggtgctggatgcggag
cagcgggtgacggcagccgaggcactggcccatccctacttcgagtccctgcacgacacg
gaagatgagccccaggtccagaagtatgacgactcctttgatgacgtggaccgcacgctg
gatgaatggaagcgtgttacttacaaagaggtgctcagcttcaagcctccccggcagctg
ggagccagggtctccaaggagacggctctgtga

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