Mugil cephalus (flathead mullet): 125022729 Help Entry 125022729         CDS       T08342                                  Symbol ryr2a Name (RefSeq) ryanodine receptor 2 isoform X1   KO K04962   ryanodine receptor 2 Organism mcep  Mugil cephalus (flathead mullet) Pathway mcep04020   Calcium signaling pathway mcep04260   Cardiac muscle contraction mcep04261   Adrenergic signaling in cardiomyocytes mcep04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:mcep00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     125022729 (ryr2a)    04020 Calcium signaling pathway     125022729 (ryr2a)  09150 Organismal Systems   09153 Circulatory system    04260 Cardiac muscle contraction     125022729 (ryr2a)    04261 Adrenergic signaling in cardiomyocytes     125022729 (ryr2a)  09180 Brite Hierarchies   09183 Protein families: signaling and cellular processes    04040 Ion channels [BR:mcep04040]     125022729 (ryr2a)    04990 Domain-containing proteins not elsewhere classified [BR:mcep04990]     125022729 (ryr2a) Ion channels [BR:mcep04040]  Voltage-gated cation channels   Ryanodine receptor    125022729 (ryr2a) Domain-containing proteins not elsewhere classified [BR:mcep04990]  EF-hand domain-containing proteins   Other EF-hand domain-containing proteins    125022729 (ryr2a) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY MIR Ins145_P3_rec RIH_assoc Ion_trans EF-hand_7 EF-hand_1 EF-hand_8 EF-hand_6 Motif Other DBs NCBI-GeneID:  125022729 NCBI-ProteinID:  XP_047465588 LinkDB All DBs Position 16:complement(23751053..23986097) Genome browser AA seq 4996 aa AA seqDB search MADGGEGEDEIQFLRTDDEVVLQCSATIHKEQQKLCLAAEGFGDRLCFLESISNSKNVPP DLSICTFVLEQSLSVRALQEMLASTEEKTEGTAQGGGHRTLLYGHAVLLRHSYSGMYLCC LSTSRSSTDKLAFDVGLQEDTTGEACWWTIHPASKQRSEGEKVRVGDDLILVSVSSERYL HLSYGNGSLHVDAAFQQTLWSVAPICSGSEVAQGFLIGGDVLRLLHGHMDECLTVPSGEH GDDQRRTVHYEGGPVSSHARSLWRLETLRVLWSGSHIRWGQPFRLRHVTTGKYLSLIEDK SLMLVDKEKADVKSTAFCFRSSKEKLDLGVRKEVDGMGTPDIKYGDSVCYIQHVDTCLWL TYQTVDAKCARMGGIQRKAIMHHEGHMDDGLTLSRSQHEESHTARVIRSTAFLFNLFIRG LDALRKKGKSSTLDLPIDSVSLSLQDLIGYFQPPDEHLEHEDKQNRLRALKKRQNLFQEE GVISLGLECIDRLHVYNSAAHFAETVGREAAEAWSSILNSLYQLLAALIRGNRKNCAQFS GSLDWLISRLEQLEASSGILEVLHCVLVESPEALNIIKEGHIKSIISLLDKHGRNHKVLD VLCSLCVCHGVAVRANQHLICDNLLPGRDLLLQTRLINHTTSIHPNIFLGVSDGSAQYRK WYYELIVDQALPFVTAEATHLRVGWANTNGYAPYPSGGEGWGGNGVGDDLYSYGFDGLHL WSGCVARTVSSPNHHLLGSEDVVSCCLDLSVPSISFRINGQPVQGMFENFNSDGLFFPVA SFSAGVRVRFLLGGRHGEFKFLPPPGYAPCYEAVLPREKLKLEASQNQTAARDLLGPNIT LSQAAFTPTPVDTSQIVLPPHLERIREKLAENIHELWVMNKIELGWTYGAVRDDNKRQHP CLVEFSKLPEQERSYNLQMSLETLKTLLALGCHVGLADEHAVGKVKSMKLSSTYELSSGY KPAPLDLSHIKLTTAQETMVDKLAENAHNVWARDRIRQGWTYGIQQDVKTRRNPRLVPYT LLDERTKKSNKDSLREAVRTLLGYGYNLETSDQDSAQSDFSNMSAERFRIFRAEKTYCVN TGKWYFELEVLTVGEMRVGWARPGCLPDQDLGSDDQAFVFDGFKVQRWHQGNEHFGRAWQ IGDVVGCMVDLKEHTMMFTLNGEVMLDDSGSELAFKDFDPGEGFIPVCSLGVSQVGRMNF GRDVSSLRYFTICGLQEGYEPFAVNMNRNITMWFSKRLPQFVPVAPNHQHIEVTRIDGTV ESCPCLKVTQKSFSSQNSYSDITFYRLSMPIECAESRSPFKGSLFSPNKELEDFETGSEF EVLMKSSHSHNGPNRPDRDEFNNHKDYTQEKTSKLKQRFTLKKNKQDNISPSSACLSEEV MAEDRDDYEFLMQVPTHNYYSVRIFPGQDPSSVWVGWVTSDFHQYDPGFELHKVQTVTVT LGDEKGKVHESIKRSNCYMVWAGESSSPGQGRNNNGLEIGCLVDTTNGLLTFTANGKELS TYYQVEPSTKLFPAVFAKATSPSIFQFELGCIKNVMPLSAGLFKSERNNPVPQCPPRLHV QFLTPVLWSRVPNHFLKVSISRVNDRHGWLVQCNEPLQFMSLHIPEENRSLDILELSEQK DLLKFHYHTLRLYSAICALGNNRVAHALCSHIDEAQLLQAIENKYMPGLLRAGYYDLLID IHLSSYATARLMMNNEYIVPMTDETKSITLFPDEKKKHGLPGIGLSTSLRPRMQFSCPNF VCGTRESYRNSGNNGSGSGERFQYSPEFPLDILKIKTIEMLTEAVREGSMHVRDPIGGST ESLFVPLIKLVYTMLIMGIFQNGDLKNILQLIEPSVFLELRNGQEEIHKELEMTKEVETE GGEKDGGRNILKEGLLQMKLPEPVKLQMCHVLQYLCDCQVRHRIEAVVAFSDDFVACLQE NQRFRYNEVMLALNMSAALTAKKTKEFRSPPQEQINMLLNFKDEKQECPCPEHVREQLTD FHEDLMRHCGIELDEERGGDGESDFTIRGRLMSLVEKVAYLKKKMANLPKDKKDRKPYCD FDAHWSSASLFPLNIQSQGVGLGMKPSVHGTLQQLISDTMVRWAQESVIEAPELVRAMFV LLHRQYDGIGGQVRALPKTYTINSVSIEDTINLLAALGQIRSLLSVRMGREEEKLMIRGL GDIMNNKVFYQHPNLMRALGMHETVMEVMVNVLSGGGSKEITFPKMVANCCRFLCYFCRI SRQNQKAMFDHLSYLLENSSVGLASPSMRGSTPLDVAAASVMDNNELALALREPDLEKVV QYLAGCGLQSCAMLVCKQYPDIGWNPVEGERYLDFLRFAVFCNGESVEENANVVVRLLIR RPECFGPALRGEGGDGLLAAMEEAIKISLDPSRDGPSPTSESSKTLSDMDEEDDTIHMGN AIMTFYAALIDLLGRCAPEMHLIHAGKGEAIRIRAILRSLIPIEDLVGVISISFSMPNLA KDGLVVEPDMSAGFCPDHKAAMVLFLDRVYGIENQNFLLHLLEVGFLPDLRAAASLDTVT LSATDMALALNRYLCTAVLPLLTKCAPLFAGTEPFASLIDSFLHTVYRLSKGCCLTKAQR DVIEECLLAVCGKLRPSMMQHLLRRLVFDVPLLNEHTKMPLKLLTNHYERCWKYYCLAGG WGNFGAASEEELHLSRKLFWGIFDALSCKQYDEELYKLALPCLSAVAGALPPDYMESNYM AMMEKHSSMDLEGNFIPQPADTTNVTVSEKLDYFIARYAEHNHEKWCIEKFSSGWSYGEQ ICEITKSHPLLKPYKGLSEKDKEVYCAPIRESLKTMLSWGWSIDRIREGDPSSRHDKSRR ISQASQLSFEGSPAFSPRPIDMSNVTLSRDMQSLAELLAENYHNIWAMKKKMELELKGGG NHPLLVPYDTLTAKEKSKDREKAQDILKFLQINGYSVSRSEKLQELDTPAIEKRFAYTFL QQLITYVDQAHQQMMELDLETRLKGEQTPHEQQIKFFGKVVLPLVDLYFKNHRLYFLSTA IHPVSSGGHASNKEKEMVTSLFCKLGVLVRHRISLFGNNATSIVNCLQILGQSLDARTVM KTGLESVKAALRSYFSNAAEDLEKTQENLKLGQFTHSREQPRGVTQIINYTTFALLPVLS SLFEHIGQSMFGEDLILADVQKSCYRILNSLYFLGTNKSIYVERHRPGIGKCLAAFSAAF PVAFLEPHMNKFNNFSIYNSKASLDRAGLPGQVGEVCPMIPSLERSLEDIMELAESGIRY TQMPHVMEVVLPMLCNYMSHWWEHGPESNLEKADSCSTSVTSEHMNSLLGNILKIIYNNL GIDEGAWMKRLAVFSQPIIGKAKAQLLKTHFLPLMEKLKKKAAVVLMDEENSKVEGRGEM SETELLIMDQFTILVRDLYAFYPILIRFVDYNRATWLKESSPEAEELFRMVAEVFIFWAK SHNFKREEQNFVVQNEINNMSFLITDTKCKMSKGIVSDQERKKMKRKGDRYSMQTSLIVA TLKRLLPIGLNMCAPGEQELIALAKNRFIQKDTEEEVREIIRNNLHLQGKVEDPAIRWQM ALYREFPSHHEDTSDPEKTVARVLDIAHVLFYLDQVEHPQRSKKAVWHKLLSKQRKRAVV ACFRMAPLYNLPRHRAVNLFLQGYEKSWIEAEEHYFEDKLIEDLAKPGEKELFEEEEGMK HIDPLHQLIQLFSRTALTEKYKLDEDNLYMAYADIMAKSCHDEEDEDGVVKSFEEKEMEK QKLLYQQARLHDRGAAEMVLQTISASKGEMGPMVASTLKLGIAILNGGNSTVQQKMLDYL RDKKDVGFFQSLAGLMQSCSVLDLNAFERQNKAEGLGMVTEEGSVITHERGEKVMQNDEF TCDLFRFLQLLCEGHNSDFQNYLRTQTGNNTTVNIIISTVDYLLRVQESISDFYWYYSGK DVIDDQGQRNFSKAIRVAKQVFNTLTEYIQGPCTGNQQSLAHSRLWDAVVGFLHVFAHMQ MKLSQDSSQIELLKELMDLQKDMVVMLLSMLEGNVVNGTIGKQMVDMLVESSNNVEMILK FFDMFLKLKDLTSSDAFKEYDPDGKGVISKRDFHKAMESHKHYTQSETEFLLSCAETDEN ELLDYEEFVERFHEPAKDIGFNVAVLLTNLSEHMPHDARLQTFLELAESVLNYFQPYLGR IEIMGSAKRIERVYFEISESSRTQWEKPQVKESKRQFIFDVVNEGGEKEKMELFVNFCED TIFEMQLAAQMSDVGERSVVKEESEQEKPDEENPDTSFFSVTTVHMALISLQHNITLLIK VLSMKSLKKQVKKIKNMTVKDIVTTLVSFYWSVLLGLLHVAFSVTRGFCRILYCACMGGN LVDGAKAIKVSDLLANMVDPTQDEVRGEGENREKRLSDHSSPKEDLADLSVSTSETDLLS DIFGLDLRREGGQYKVTPHNPNASLTELLNTPVPSLTPPQEPQNELRRRHQSKNSSSGEN EATPETQCEPEKTSDGCEEKQEEQQKNEKIKPKVRRHHISKSDEPDLQGSAFLKKIIAYQ RKLLNYFARNFYNMRMLALFVAFAINFILLFYKVSTSSSVVEDRQVLDATTQPDGNGQWY PLDGETLEPRLERMDGAGEPLKPVTVRFVLEESSGYMEPMLRILAILHTVISFFCIIGYY CLKVPLVIFKHEKEVARKLEFDGLYITEQPSEDDIKGQWDRLVINTQSFPNNYWDKFVKR KVMDKYGEFYGHDRISELLGMDKAALDFSDAHKKRKPRRDSSLTAVLNSIDVKYQIWKLG VVFTDNSFLYLAWYMTMSILGHYNNFFFAAHLLDIAMGFKTLRTILSSVTHNGKQLVLTV GLLAVVVYLYTVVAFNFFRKFYNKSEDGELPDMKCDDMLTCYMFHMYVGVRAGGGIGDQI EDPAGDEYEIYRIIFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVKEDMETKCFIC GIGNDYFDTVPHGFETHTLQEHNLANYLFFVMYLINKDETEHTGQESYVWKMYQERCWEF FPAGDCFRKQYEDQLN NT seq 14991 nt NT seq  +upstreamnt  +downstreamnt atggctgacggaggtgaaggcgaggatgaaattcagttcctgcggactgatgatgaggtg gtcctgcagtgttcagctacaattcacaaggaacaacagaaactctgtttggctgctgaa ggcttcggagatagactttgctttcttgaatccatctccaactccaagaatgttcctcca gatctgtctatttgcacttttgtgttggagcagtcactgtcagtacgagcacttcaggag atgcttgccagcaccgaggagaagactgaggggacagcacagggtggtggtcatcgcacg ttactctacggacacgccgtcctactacgacactcttacagtggaatgtacctgtgctgt ctttcaacctcccgttcatccacggacaaactggcttttgatgtgggactgcaagaagat accacaggtgaggcgtgttggtggactatccatccagcatcaaaacagcgttcagagggc gagaaggtcagagtcggagatgatctcatcctggtcagcgtctcctctgaaagatatctg catctgtcgtatggtaatggcagtctccatgtagatgcagccttccagcagacactatgg agtgtggctcccatatgttctggtagtgaagtagcacaaggttttcttataggaggggac gtcctgcgtcttcttcatggtcacatggatgagtgcctaactgttccatctggggagcat ggggatgatcagaggaggacagtgcactatgagggaggaccagtgtccagtcatgccagg tccctgtggaggctggagacactgcgggttctttggagtggcagtcatatccgctggggt cagcctttcagactgagacatgtgaccactgggaagtatctgagtctcatagaagacaag tctctcatgctggtggacaaagagaaagctgatgtcaagtctacagcattctgcttccgg tcttccaaggaaaagttggaccttggtgtaaggaaggaggtggacgggatgggtactcct gacattaagtatggtgactcagtgtgttacatccaacatgttgacacctgtctgtggctt acataccagactgttgatgccaagtgtgctcgcatgggcggaatacagagaaaggctatc atgcaccatgagggtcacatggatgatgggctaactctgtctcgatcacaacatgaggag agccacactgcgagagtcatccggagtactgcctttcttttcaaccttttcatcaggggt ctagatgcattaagaaaaaaaggaaagagctctactttagacctgccaatagactcagtc agcctaagtctgcaggacctgattggatacttccaaccacctgatgaacacttggaacat gaagacaagcagaaccgactcagggcactgaagaaacggcaaaacctcttccaggaggag ggggtgatcagcctgggattggagtgtattgatcgccttcacgtctacaatagtgcagct cactttgctgagacagtaggaagggaagctgcagaggcctggagctccatcctcaactcc ctctaccagctgctggctgccctcatcagaggaaacaggaagaactgtgctcagttttct ggttcattggactggctgattagcagactggagcaactggaggcctcttctggtatattg gaggttcttcactgtgtcctggtggagagtccagaggcgctaaatattataaaagaggga cacatcaaatccattatatcccttttggacaagcacggacgcaaccataaggttctagac gtgttgtgttcattatgtgtatgtcacggtgtagcggtacgtgccaaccagcacttgatc tgtgacaacctgctaccaggtagagatctgctattgcagactcgcctgataaaccacaca accagcattcatcccaacatctttctgggtgtcagtgatggctctgcccagtacaggaaa tggtactacgagctgattgtggatcaggcattgccatttgtcacagcagaagccactcac cttagggtaggctgggccaacaccaatggctatgcgccctaccctagtgggggagagggc tggggaggcaatggtgtaggggatgacctctactcatatggctttgatggactccatctt tggtcaggatgtgttgcacggactgttagttcacccaatcatcaccttttgggatcagag gatgtggtaagctgctgcttggatctcagcgtacccagtatctccttcaggatcaacggc caaccagttcagggcatgtttgagaacttcaactctgatggcctcttcttccctgtggcc agcttttctgctggtgtcagggtccgtttcctacttgggggtcgtcatggagagttcaag ttccttcctccaccaggttatgccccttgctatgaggctgtgttgcccagggagaagcta aaacttgaggccagtcagaaccagactgcagctagagatcttctaggaccaaacatcacc ttgagtcaggcagcattcacccccacacctgtggacaccagccagattgttctaccaccc cacttggagaggatcagggaaaaacttgcagaaaacatccatgaactgtgggtaatgaac aagatagaactgggctggacctatggtgcagtacgagatgacaacaaacgtcaacaccca tgtctggtggagttttccaagcttccagaacaggaacgaagctacaacttacagatgtct cttgagactctgaaaactctcctggctttgggttgccatgttggtcttgcagatgaacat gctgtaggaaaagtcaagagcatgaaattgtcatccacctatgagctttccagtggttac aaacctgctcccctggacttgagtcatatcaaactgacgaccgcccaggaaactatggtg gacaaactggctgagaatgcacacaacgtgtgggcaagagaccgtatccgacagggctgg acatatggcatccagcaggatgtgaaaacccgtcgaaatcctcggctggtcccgtacact ctactggatgagagaaccaagaagtccaacaaagatagtctgagagaggctgtcaggact ctgctgggatatggatataacctggaaacatctgaccaggacagtgctcaatctgacttc agcaatatgtctgctgagaggttccgcattttcagagcagagaaaacctactgtgttaat actgggaagtggtactttgagcttgaggtattaacagttggagaaatgagggtgggctgg gccaggccaggatgcctgccagaccaggatctaggatctgatgaccaggcctttgtcttt gatggcttcaaggtccagcgctggcaccaaggcaatgagcacttcgggcgtgcctggcag ataggggatgtggtgggatgcatggtggatctgaaggagcacaccatgatgttcacactg aatggagaagttatgctggatgattctggatctgagctggccttcaaggattttgaccct ggcgaaggttttatcccagtgtgtagtctaggtgtgagccaggtgggaagaatgaacttt ggtagagacgtcagcagtctaaggtacttcaccatctgtggcctgcaggaaggctacgaa ccctttgctgtcaacatgaaccggaacatcacaatgtggttcagcaagaggttgcctcag tttgtgcctgtggcccccaaccaccaacacattgaggtgacgaggatagatggaacagta gagtcgtgtccttgcctaaaggttacccagaagtcattcagctcacagaacagttacagt gacattaccttctacagactgagcatgcccatagagtgcgctgaatccagatccccattt aaaggcagccttttctcaccaaacaaggaactggaggactttgaaactggttcagaattt gaggtcctgatgaagtcatcacacagtcacaatggtcccaacagacctgacagagatgaa ttcaacaaccacaaagactatacgcaggagaaaacatccaagctcaaacaacggtttaca ttgaagaaaaacaagcaagacaacatctctccctcatctgcttgcctgtcagaggaggtg atggccgaagacagagatgattatgaattcctcatgcaagttcctactcataactactac tcagtgcggatcttccctggtcaggaccccagcagtgtttgggtaggctgggtaacctca gacttccatcaatatgacccagggtttgagctgcacaaggtccaaactgtcactgttacg ctgggagatgagaagggcaaagttcatgaaagtattaaacgcagcaactgttacatggtg tgggctggggagagcagcagtcctggtcaaggaaggaacaacaacggcttagagattggc tgtttggttgacacaacaaatggtttgttgaccttcacagccaatggcaaagaactcagc acatactaccaggtggaacccagtaccaagctgtttccagcagtctttgccaaggccacc agtcccagtatcttccagtttgaactggggtgtattaagaatgtgatgcctctatcagct ggtctgtttaagagtgagaggaacaacccagttccccagtgtcctcctcggcttcatgtc cagtttctcactcctgtgctgtggagtcgtgttcccaaccacttcctcaaggtatcaata tccagagtgaatgaccgacatggctggctggtccagtgtaatgaacctctgcaattcatg tctctacacataccagaggagaacaggtcattggatatcctggagctgtcagagcagaag gacctattaaagtttcactaccataccctcagactgtactctgcaatctgtgcgctgggt aacaaccgggtagctcatgccctctgctcccacattgatgaggcacagcttctgcaagct atagagaataagtatatgccaggtctgcttcgagcgggttactacgatctcctcatcgac atccacttaagcagctatgctacagctcgccttatgatgaacaatgagtacattgttccc atgacagatgaaacaaagagtatcaccctttttccagatgagaagaaaaaacatggcttg cctggaattggactcagcacttctctccgacccagaatgcaattctcatgcccaaatttt gtatgcgggaccagagagtcttatcgtaacagtggcaacaatggatcaggttctggagaa cgtttccagtacagtcctgaatttcccttagatatactgaaaattaaaaccatcgagatg ctgacagaagcagtgcgtgaaggaagcatgcacgtacgggatccaataggaggcagcaca gagagtctttttgtccccctcatcaagctcgtttacaccatgcttatcatggggattttc cagaatggagatctaaaaaacattctccaactgatagaaccgtctgttttcttggaactg cgaaacgggcaagaggaaattcacaaagaactggagatgacaaaggaggtggagactgag ggtggagaaaaggatggaggaagaaacatacttaaagaagggctcttacagatgaaactg ccagagcctgtaaaactgcagatgtgccatgtcctgcaatacttgtgtgactgccaggtg cgccatcgaattgaagcagtggtggccttctctgatgactttgtggcttgtcttcaagaa aaccaacggttccgctacaatgaggtgatgctggcacttaacatgtcagcagccctcact gccaagaagaccaaagaattcagatctcccccacaggaacagatcaacatgttgctgaac tttaaggatgagaagcaggagtgtccctgtccagaacacgtccgagagcagctgacagat ttccatgaagatcttatgagacactgtggtatagagttggacgaggagagaggtggtgac ggagaaagcgacttcaccatacgaggccgactcatgtcactagtggagaaagtggcttat ttgaagaagaagatggccaaccttccaaaagacaaaaaagacaggaagccatactgtgac tttgatgctcactggtcgtctgcctccctctttccacttaacatacagtctcagggtgtc ggacttgggatgaaaccctctgtgcatggtacattacagcagttgatttcagatactatg gtccgctgggctcaggagtcagttattgaggctccggaactagtcagagctatgtttgtc ttgctgcaccgccagtatgatggcattggaggacaggtgcgggcacttcctaaaacctac actataaactctgtgtcgattgaggacactatcaacttattggctgctctgggtcaaatc agatccctcctaagtgtacgaatgggtagagaagaggagaaactgatgatcagaggactg ggtgatattatgaacaacaaggtattctaccagcatcctaacctgatgagagctttgggg atgcatgagactgtcatggaggtcatggtcaacgtactcagtggaggaggctccaaagaa atcacttttcccaaaatggtggccaactgttgtcgttttctgtgctacttctgtcgaatt agccgtcagaaccagaaagctatgtttgaccatctaagctacctactggagaacagcagt gttggccttgcatctccctctatgcgaggatccactcccctggatgtggctgcagcctct gtcatggataataatgagctggccctggctttaagagagccagatctagagaaggtggtg cagtaccttgctggctgtgggctgcagagctgtgcgatgctggtgtgtaaacaataccct gacatcggctggaaccctgtggagggggagcgatatctagacttcctgcgatttgctgtt ttctgcaatggtgaaagtgtggaagagaatgccaatgttgtggtaaggcttcttattcgg cgaccagaatgttttggtcctgcccttcgaggtgaaggtggcgacgggttgctggcagca atggaggaagccattaagatctctctagatccctctagagatggtccatcccctacgtct gaaagcagcaagacactcagtgacatggatgaggaagatgataccatccacatgggaaat gctatcatgactttctatgctgctcttattgacctccttggccgctgtgctccagagatg catttgatccatgctggtaaaggtgaagcaatccgtatcagagccattttgaggtctctc attcctattgaagacctggtgggagtcatcagcatttcattctccatgcctaacctagct aaagatgggttggttgtggaaccggacatgtcagcaggattctgtcctgaccataaagct gccatggtcctgtttcttgaccgggtctatggcatagaaaaccagaattttctccttcac ctcctggaagtcggattcttaccagatctgagggctgctgcctctctggacactgttact ctcagtgccacagatatggcacttgccctcaacaggtatttgtgtacagcagtgttacct cttctgactaaatgtgctccactgtttgcggggaccgagccctttgcatcactgatcgac tccttccttcacacggtgtaccgcctgtccaaaggttgctgcctcaccaaggcacagagg gatgtcatagaggagtgtctgctagctgtttgtggcaagctgaggccttcaatgatgcaa catctcctgaggaggctggtgtttgatgttccactgcttaatgaacacaccaagatgcct ctgaagctactgaccaatcactatgagcgttgctggaaatattattgcctggctggaggt tggggcaattttggagcagcgtcggaagaagagcttcacctctcaaggaaattgttctgg ggaatctttgatgctctgtcttgcaagcagtatgatgaggagctttataagcttgcgcta ccatgtctcagtgctgtggctggagcccttcctccagactacatggagtccaactacatg gccatgatggagaagcactcatctatggacttagagggaaatttcattccccagcctgca gacactaccaacgtgactgtctcagagaaactggactatttcattgcccgatacgcagag cacaaccatgagaagtggtgtattgaaaagttttccagtggctggtcatatggagaacag atctgtgaaattaccaagagccaccctctactgaaaccatacaaaggcctctctgagaag gataaagaggtgtactgtgcgcctatcagagagtctctaaaaaccatgctctcatggggt tggagcattgacaggataagggagggagacccttccagtcgccatgacaaatccagaagg atatcgcaggccagccagctgtcatttgaaggctctccagctttcagcccaagacccatt gatatgagcaatgttacactgtccagagatatgcagtctctggcagagttgcttgcagag aattatcataatatctgggccatgaaaaagaaaatggagctggaactcaaaggtggagga aaccatccactattagttccttatgatacactcactgccaaagaaaaatccaaagacaga gaaaaagcacaagacatcctgaagttccttcagatcaatggttactctgtgtccagaagt gagaagttgcaggaactagacacaccagcaatagagaaacgatttgcctacacgttcctc cagcagctcatcacatatgtagaccaagcccaccaacaaatgatggagttagatctggaa acaaggctgaagggagagcagactccacatgaacagcagattaagttctttgggaaggtc gtgttgccattggtggatctgtactttaaaaaccacaggctgtacttcctatctacagcc atacatccagtgagcagtggtggccacgcctctaataaagaaaaggagatggtaaccagt cttttctgcaaactcggagttcttgtcagacataggatatcactttttggtaacaatgca acatcaatagtcaactgtttgcagatactaggacaaagcttggacgccaggacagtgatg aagactggactggagtcagtgaaggcagctttacggtcatacttcagtaatgctgctgag gatttggagaagactcaagagaacctgaaacttggccagttcactcacagcagagagcag ccgcgcggtgtcacacagatcatcaattacaccacatttgctctgctgcctgtcctgtcg tccctgtttgagcatatcggacagagcatgtttggagaagacctcatattggctgatgtt cagaaatcttgctacagaatcctcaacagcctctactttctgggaaccaacaaaagcatc tatgtggaaagacatcgcccaggaataggaaagtgtttagctgccttctcagcagccttt cctgttgcctttctcgagccacacatgaacaagtttaacaacttttccatctacaacagc aaagcaagtttagacagagcaggacttccaggtcaggttggagaagtttgtccaatgatc ccaagcttagagaggtctctagaggatattatggaactggcagaatctggcataagatac actcagatgccgcacgtcatggaggtggtgttgccaatgttgtgcaactacatgtctcac tggtgggaacatggaccagaaagcaacctggaaaaagctgacagctgcagcacatctgtc acctctgaacacatgaacagcctgctgggaaatatacttaagataatctataacaacctt ggaatagatgagggagcctggatgaaaagactggcagtcttctctcagccaattatcggc aaagccaaagcacagcttttaaagacacacttcctgcctctgatggagaaactcaagaag aaagcagcagttgtgctgatggatgaagaaaacagtaaggtggagggcaggggggagatg tcagagacggagcttctcatcatggaccagttcaccatactggtcagagacctatatgcc ttctaccctatcctcatacgatttgtcgactacaacagggccacctggctgaaagagtct agtccagaggcggaggaactgttccgaatggtggcagaggttttcatcttctgggccaag tctcataacttcaagagggaagagcagaactttgtagtccagaatgaaatcaacaacatg tccttcctcatcactgacaccaagtgtaagatgtcaaagggaatagtttcagaccaggag aggaagaagatgaagagaaaaggggatcgatactctatgcagacaagcctaattgttgcc actctgaagcgtctgttgcctataggactcaacatgtgtgctccaggggaacaggagctc atagcactggccaaaaaccgcttcattcagaaagatacagaggaagaagtaagagagatc atcaggaacaatctgcacttacaagggaaggttgaggacccggctattcgttggcaaatg gctctctacagagaattcccgagccatcatgaggatacctctgacccagagaagactgta gcaagagtactggacattgctcatgtcctcttctacctggaccaggtggaacatcctcag cgcagtaaaaaggctgtgtggcataaactgctgtcgaaacagaggaagagagctgtggtc gcttgcttcaggatggcaccactctataacctgccaaggcaccgggcagtgaacttgttt ctgcaagggtatgagaagtcctggattgaagcagaggaacactactttgaagataaactc atagaagaccttgctaagcctggtgaaaaggagttgtttgaggaagaggagggcatgaaa cacattgatccactgcatcagctcattcagctcttcagtagaacagccctcacagagaaa tataaactggatgaggacaatctttacatggcctatgcagacatcatggctaagagctgc cacgatgaagaggatgaagacggagtagtgaagagttttgaagagaaggagatggagaag cagaaattgttatatcaacaggctaggctccatgaccgtggggctgctgagatggtgctt caaaccatcagtgctagtaaaggtgagatgggtcccatggtggcatctactctgaagctt gggatagcaattctcaatggaggaaactctactgtgcagcagaaaatgttggattatctg agagacaagaaagatgtgggattctttcagagtctggctggtcttatgcagtcatgcagt gttctggatctaaatgcatttgagaggcagaacaaagctgagggactaggcatggtgaca gaggagggatcagtcatcactcatgagcgtggtgagaaggtcatgcagaatgatgagttc acctgtgacctattccgcttcctgcagctgctatgtgaagggcataattcagacttccag aactacttgaggacacaaacgggaaacaataccactgttaacatcatcatatctactgtt gactaccttctcagagttcaggagtctatcagtgatttctactggtattattctgggaaa gatgttattgatgatcaggggcagaggaatttctcaaaggcaattcgtgtggccaagcag gttttcaatactctcacagagtacatccagggtccatgtactggcaaccagcagagtttg gcccacagtcgactgtgggatgctgtggttggctttctacatgtctttgctcatatgcag atgaaattatctcaggactcaagtcagattgagttactgaaggaactgatggatctgcag aaagacatggtggtcatgctgctgtctatgttggagggcaacgttgtgaatgggactatt gggaaacaaatggtggacatgttggtggagtcctccaacaacgttgaaatgatcctcaag ttctttgacatgttcctaaaactaaaagacctgacatcctcagatgccttcaaggagtat gaccctgatggaaaaggtgtcatttccaagagggacttccataaggccatggagagccat aaacactacacacagtctgagactgagtttttgctgtcctgtgctgagactgatgagaat gaactcctggactatgaggaatttgtggaacgctttcatgagccagccaaggacataggc tttaacgtggcagttttgctgaccaacttgtcagagcacatgcctcacgatgcccggcta cagaccttcctggaactggcagagagtgtccttaactactttcaaccatacctaggccgg atcgagatcatgggcagtgctaagcgcattgaaagagtttactttgagattagcgaatct agtcggacacagtgggaaaaacctcaggttaaggaatccaagcgtcagttcatctttgat gtggtgaatgaagggggggagaaggagaagatggaactgtttgtgaatttctgcgaagac actatatttgaaatgcaactagcagctcagatgtctgatgttggtgaacgctcagtagtt aaagaggagagtgagcaggagaaaccagacgaggagaaccctgacacaagcttcttctct gttaccactgttcacatggcactgatatctctccaacacaacatcacactgctaataaag gtgctgtctatgaaaagcttgaagaaacaggtgaagaaaataaagaacatgacagtgaaa gatattgtgacaaccttggtctccttctactggtcagtgctgctaggactcctccatgtg gcgttcagtgtgactcgaggattttgcagaattctttactgcgcctgcatgggaggaaat ctggtggatggggccaaggccataaaggtgtcagatttgctggccaacatggtagacccc acccaggatgaggtgcggggtgagggtgagaacagagaaaagaggctatctgatcacagc tccccaaaggaggatctagctgacctgtcagttagcacaagtgaaactgacctgttgtct gacatttttggtctggacttacgaagggaggggggacagtacaaggtcaccccccataac ccaaatgccagccttactgaactcctcaacacccctgttccctccctgaccccacctcaa gaaccacagaatgaacttagaagaaggcatcagtcgaaaaactcttcttcaggggaaaat gaggcaacaccagagactcagtgtgaacctgaaaaaacatccgatggttgtgaagagaaa caagaggaacaacaaaagaatgagaaaattaaaccaaaagtgagaaggcatcacatctca aagtctgatgaacctgatctgcaggggtctgcctttttgaagaagatcatagcctaccag aggaaactactgaactactttgccaggaacttctataacatgaggatgctggccttgttt gttgcctttgcaatcaactttatcctcctgttctataaggtttctacttcctcatctgtg gttgaagaccggcaagtgttggatgccactacccaaccagatggcaatggtcagtggtat cccctagatggagaaacattggagccaaggctggagaggatggatggagctggggagccc ctgaagcctgtcacagtccgtttcgtcctggaggagagtagtggatacatggagcccatg ctacgtatcctggccattttacacacagtcatctccttcttctgcatcattggatactac tgtctcaaggtgccactggtgatatttaagcatgaaaaagaggtggccaggaagctggaa tttgatggcctttacattacagaacaaccatctgaggatgacatcaaaggacagtgggac agactggttatcaacacccaatctttccccaacaactactgggataagtttgtgaaaagg aaggtgatggataaatatggtgagttttatggccatgaccgcatcagtgaactgctggga atggacaaggctgctctggacttcagcgatgctcacaaaaagagaaagccccggagagac agctcactcactgctgtgctgaactctattgatgtaaagtaccagatctggaagctggga gttgtattcactgacaattccttcctgtatcttgcctggtatatgaccatgtccatcctc ggtcactataacaacttcttctttgccgcgcatctgctggacatcgccatgggttttaag acactgcgtaccatactctcctctgtcacacacaatggcaaacagctggtgttaacggtt ggcctgttagcagtggtggtgtacctctacacagtagtggcctttaacttcttcaggaag ttctacaacaagagtgaagatggagaacttccagacatgaagtgtgatgacatgttgaca tgttacatgttccacatgtatgtgggtgtgcgagcaggaggaggaatcggtgatcagatt gaagaccctgcgggtgacgagtatgaaatctaccgcatcatctttgatatcacttttttc ttctttgtcatcgttatacttctggccatcatccaggggttgatcattgatgcatttgga gagctgagggaccagcaagaacaagtgaaagaagacatggagaccaaatgttttatctgt ggaattggaaatgactactttgatacagtcccacatggctttgaaacacacaccttacag gagcacaacttggccaactacttattctttgtgatgtatctcatcaacaaagatgaaaca gagcacacaggccaggagtcttatgtctggaagatgtaccaagaacgttgctgggagttt ttccctgctggtgactgtttccgaaaacagtatgaagatcaactcaactga

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