KEGG   Macaca fascicularis (crab-eating macaque): 101867305
Entry
101867305         CDS       T02918                                 
Symbol
MAPK12
Name
(RefSeq) mitogen-activated protein kinase 12 isoform X1
  KO
K04441  p38 MAP kinase [EC:2.7.11.24]
Organism
mcf  Macaca fascicularis (crab-eating macaque)
Pathway
mcf01522  Endocrine resistance
mcf04010  MAPK signaling pathway
mcf04015  Rap1 signaling pathway
mcf04068  FoxO signaling pathway
mcf04071  Sphingolipid signaling pathway
mcf04114  Oocyte meiosis
mcf04148  Efferocytosis
mcf04218  Cellular senescence
mcf04261  Adrenergic signaling in cardiomyocytes
mcf04370  VEGF signaling pathway
mcf04380  Osteoclast differentiation
mcf04517  IgSF CAM signaling
mcf04550  Signaling pathways regulating pluripotency of stem cells
mcf04611  Platelet activation
mcf04613  Neutrophil extracellular trap formation
mcf04620  Toll-like receptor signaling pathway
mcf04621  NOD-like receptor signaling pathway
mcf04622  RIG-I-like receptor signaling pathway
mcf04625  C-type lectin receptor signaling pathway
mcf04657  IL-17 signaling pathway
mcf04658  Th1 and Th2 cell differentiation
mcf04659  Th17 cell differentiation
mcf04660  T cell receptor signaling pathway
mcf04664  Fc epsilon RI signaling pathway
mcf04668  TNF signaling pathway
mcf04670  Leukocyte transendothelial migration
mcf04714  Thermogenesis
mcf04722  Neurotrophin signaling pathway
mcf04723  Retrograde endocannabinoid signaling
mcf04728  Dopaminergic synapse
mcf04750  Inflammatory mediator regulation of TRP channels
mcf04912  GnRH signaling pathway
mcf04914  Progesterone-mediated oocyte maturation
mcf04917  Prolactin signaling pathway
mcf04926  Relaxin signaling pathway
mcf04932  Non-alcoholic fatty liver disease
mcf04933  AGE-RAGE signaling pathway in diabetic complications
mcf04935  Growth hormone synthesis, secretion and action
mcf04936  Alcoholic liver disease
mcf05014  Amyotrophic lateral sclerosis
mcf05020  Prion disease
mcf05022  Pathways of neurodegeneration - multiple diseases
mcf05132  Salmonella infection
mcf05133  Pertussis
mcf05135  Yersinia infection
mcf05140  Leishmaniasis
mcf05142  Chagas disease
mcf05145  Toxoplasmosis
mcf05152  Tuberculosis
mcf05161  Hepatitis B
mcf05163  Human cytomegalovirus infection
mcf05167  Kaposi sarcoma-associated herpesvirus infection
mcf05169  Epstein-Barr virus infection
mcf05170  Human immunodeficiency virus 1 infection
mcf05171  Coronavirus disease - COVID-19
mcf05205  Proteoglycans in cancer
mcf05208  Chemical carcinogenesis - reactive oxygen species
mcf05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
mcf05415  Diabetic cardiomyopathy
mcf05417  Lipid and atherosclerosis
mcf05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:mcf00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    101867305 (MAPK12)
   04015 Rap1 signaling pathway
    101867305 (MAPK12)
   04370 VEGF signaling pathway
    101867305 (MAPK12)
   04668 TNF signaling pathway
    101867305 (MAPK12)
   04068 FoxO signaling pathway
    101867305 (MAPK12)
   04071 Sphingolipid signaling pathway
    101867305 (MAPK12)
  09133 Signaling molecules and interaction
   04517 IgSF CAM signaling
    101867305 (MAPK12)
 09140 Cellular Processes
  09141 Transport and catabolism
   04148 Efferocytosis
    101867305 (MAPK12)
  09143 Cell growth and death
   04114 Oocyte meiosis
    101867305 (MAPK12)
   04218 Cellular senescence
    101867305 (MAPK12)
  09144 Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    101867305 (MAPK12)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    101867305 (MAPK12)
   04613 Neutrophil extracellular trap formation
    101867305 (MAPK12)
   04620 Toll-like receptor signaling pathway
    101867305 (MAPK12)
   04621 NOD-like receptor signaling pathway
    101867305 (MAPK12)
   04622 RIG-I-like receptor signaling pathway
    101867305 (MAPK12)
   04625 C-type lectin receptor signaling pathway
    101867305 (MAPK12)
   04660 T cell receptor signaling pathway
    101867305 (MAPK12)
   04658 Th1 and Th2 cell differentiation
    101867305 (MAPK12)
   04659 Th17 cell differentiation
    101867305 (MAPK12)
   04657 IL-17 signaling pathway
    101867305 (MAPK12)
   04664 Fc epsilon RI signaling pathway
    101867305 (MAPK12)
   04670 Leukocyte transendothelial migration
    101867305 (MAPK12)
  09152 Endocrine system
   04912 GnRH signaling pathway
    101867305 (MAPK12)
   04914 Progesterone-mediated oocyte maturation
    101867305 (MAPK12)
   04917 Prolactin signaling pathway
    101867305 (MAPK12)
   04926 Relaxin signaling pathway
    101867305 (MAPK12)
   04935 Growth hormone synthesis, secretion and action
    101867305 (MAPK12)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    101867305 (MAPK12)
  09156 Nervous system
   04728 Dopaminergic synapse
    101867305 (MAPK12)
   04723 Retrograde endocannabinoid signaling
    101867305 (MAPK12)
   04722 Neurotrophin signaling pathway
    101867305 (MAPK12)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    101867305 (MAPK12)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    101867305 (MAPK12)
  09159 Environmental adaptation
   04714 Thermogenesis
    101867305 (MAPK12)
 09160 Human Diseases
  09161 Cancer: overview
   05205 Proteoglycans in cancer
    101867305 (MAPK12)
   05208 Chemical carcinogenesis - reactive oxygen species
    101867305 (MAPK12)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    101867305 (MAPK12)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    101867305 (MAPK12)
   05161 Hepatitis B
    101867305 (MAPK12)
   05171 Coronavirus disease - COVID-19
    101867305 (MAPK12)
   05163 Human cytomegalovirus infection
    101867305 (MAPK12)
   05167 Kaposi sarcoma-associated herpesvirus infection
    101867305 (MAPK12)
   05169 Epstein-Barr virus infection
    101867305 (MAPK12)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    101867305 (MAPK12)
   05135 Yersinia infection
    101867305 (MAPK12)
   05133 Pertussis
    101867305 (MAPK12)
   05152 Tuberculosis
    101867305 (MAPK12)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    101867305 (MAPK12)
   05140 Leishmaniasis
    101867305 (MAPK12)
   05142 Chagas disease
    101867305 (MAPK12)
  09164 Neurodegenerative disease
   05014 Amyotrophic lateral sclerosis
    101867305 (MAPK12)
   05020 Prion disease
    101867305 (MAPK12)
   05022 Pathways of neurodegeneration - multiple diseases
    101867305 (MAPK12)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    101867305 (MAPK12)
   05418 Fluid shear stress and atherosclerosis
    101867305 (MAPK12)
   05415 Diabetic cardiomyopathy
    101867305 (MAPK12)
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    101867305 (MAPK12)
   04932 Non-alcoholic fatty liver disease
    101867305 (MAPK12)
   04933 AGE-RAGE signaling pathway in diabetic complications
    101867305 (MAPK12)
  09176 Drug resistance: antineoplastic
   01522 Endocrine resistance
    101867305 (MAPK12)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:mcf01001]
    101867305 (MAPK12)
Enzymes [BR:mcf01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.24  mitogen-activated protein kinase
     101867305 (MAPK12)
Protein kinases [BR:mcf01001]
 Serine/threonine kinases: CMGC group
  MAPK family [OT]
   101867305 (MAPK12)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr ABC1
Other DBs
NCBI-GeneID: 101867305
NCBI-ProteinID: XP_045219314
Ensembl: ENSMFAG00000034798
LinkDB
Position
10:join(1296390..1296514,1296594..1296723,1299796..1299854,1301192..1301303,1301422..1301520,1301760..1301807,1302287..1302401,1302606..1302677,1303091..1303170,1303254..1303332,1303415..1303588,1305323..1305402)
AA seq 390 aa
MSSPPPARSGFYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDSRTGAKVAIKKLYR
PFQSELFAKRAYRELRLLKHMRHENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLM
KHEKLGEDRIQFLVYQMLKGLRYIHAAGIIHRVSPGGGATHQPSPSAIPRLHVLPDLKPG
NLAVNEDCELKILDFGLARQADSEMTGYVVTRWYRAPEVILNWMRYTQTVDIWSVGCIMA
EMITGKTLFKGSDHLDQLKEIMKVTGTPPAEFVQRLQSDEAKNYMKGLPELEKKDFASIL
TNASPLAVNLLEKMLVLDAEQRVTAAEALAHPYFESLHDTEDEPQVQKYDDSFDDVDRTL
DEWKRVTYKEVLSFKPPRQLGARVSKETAL
NT seq 1173 nt   +upstreamnt  +downstreamnt
atgagctctccgccgcctgcccgcagtggcttttaccgccaggaggtgactaagacggcc
tgggaggtgcgcgccgtgtaccgggacctgcagcccgtgggctcgggcgcctatggcgcg
gtgtgctcggccgtggacagccgcaccggcgctaaggtggccatcaagaagctgtaccgg
cccttccagtcggagctgttcgccaagcgcgcctaccgcgagctgcgcctgctcaagcac
atgcgccacgagaacgtgattgggctgctggatgtgttcactcctgatgagaccctggat
gacttcacagacttttacctggtgatgccattcatgggcaccgacctgggcaagctcatg
aaacatgagaagctgggcgaggaccggatccagttcctcgtgtaccagatgctgaagggg
ctgaggtatatccatgctgccggcatcatccacagagtgagtcctggtggaggagccacc
catcagccatcccccagcgcaatcccccgcctccacgtcctacctgacctgaagcctggc
aacctggctgtgaacgaagactgtgagctgaagatcctggactttggcctggccaggcag
gcagacagcgagatgactggctatgtggtgacccggtggtaccgggcacccgaggtcatc
ttgaattggatgcgctacacgcagacggtggacatctggtctgtggggtgcatcatggcg
gagatgatcacaggcaagacgctgttcaaaggcagtgaccacctggaccagctgaaggag
atcatgaaagtgacagggacgcctccagctgagtttgtgcagcggctgcagagtgatgag
gccaagaactacatgaagggcctccctgagttggagaagaaggattttgcctccatcctg
accaatgcaagccctctggctgtgaacctcctggagaagatgctggtgctggatgcggag
cagcgggtgacggcagccgaggcactggcccatccctacttcgagtccctgcacgacacg
gaagatgagccccaggtccagaagtatgacgactcctttgatgacgtggaccgcacgctg
gatgaatggaagcgtgttacttacaaagaggtgctcagcttcaagcctccccggcagctg
ggagccagggtctccaaggagacggctctgtga

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