KEGG   Macaca fascicularis (crab-eating macaque): 101925220
Entry
101925220         CDS       T02918                                 
Symbol
PLCB4
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 isoform X2
  KO
K05858  phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
Organism
mcf  Macaca fascicularis (crab-eating macaque)
Pathway
mcf00562  Inositol phosphate metabolism
mcf01100  Metabolic pathways
mcf04015  Rap1 signaling pathway
mcf04020  Calcium signaling pathway
mcf04022  cGMP-PKG signaling pathway
mcf04062  Chemokine signaling pathway
mcf04070  Phosphatidylinositol signaling system
mcf04071  Sphingolipid signaling pathway
mcf04072  Phospholipase D signaling pathway
mcf04081  Hormone signaling
mcf04082  Neuroactive ligand signaling
mcf04261  Adrenergic signaling in cardiomyocytes
mcf04270  Vascular smooth muscle contraction
mcf04310  Wnt signaling pathway
mcf04371  Apelin signaling pathway
mcf04540  Gap junction
mcf04611  Platelet activation
mcf04613  Neutrophil extracellular trap formation
mcf04621  NOD-like receptor signaling pathway
mcf04713  Circadian entrainment
mcf04720  Long-term potentiation
mcf04723  Retrograde endocannabinoid signaling
mcf04724  Glutamatergic synapse
mcf04725  Cholinergic synapse
mcf04726  Serotonergic synapse
mcf04728  Dopaminergic synapse
mcf04730  Long-term depression
mcf04742  Taste transduction
mcf04750  Inflammatory mediator regulation of TRP channels
mcf04911  Insulin secretion
mcf04912  GnRH signaling pathway
mcf04915  Estrogen signaling pathway
mcf04916  Melanogenesis
mcf04918  Thyroid hormone synthesis
mcf04919  Thyroid hormone signaling pathway
mcf04921  Oxytocin signaling pathway
mcf04922  Glucagon signaling pathway
mcf04924  Renin secretion
mcf04925  Aldosterone synthesis and secretion
mcf04926  Relaxin signaling pathway
mcf04927  Cortisol synthesis and secretion
mcf04928  Parathyroid hormone synthesis, secretion and action
mcf04929  GnRH secretion
mcf04933  AGE-RAGE signaling pathway in diabetic complications
mcf04934  Cushing syndrome
mcf04935  Growth hormone synthesis, secretion and action
mcf04961  Endocrine and other factor-regulated calcium reabsorption
mcf04970  Salivary secretion
mcf04971  Gastric acid secretion
mcf04972  Pancreatic secretion
mcf04973  Carbohydrate digestion and absorption
mcf05010  Alzheimer disease
mcf05016  Huntington disease
mcf05017  Spinocerebellar ataxia
mcf05022  Pathways of neurodegeneration - multiple diseases
mcf05142  Chagas disease
mcf05143  African trypanosomiasis
mcf05146  Amoebiasis
mcf05163  Human cytomegalovirus infection
mcf05200  Pathways in cancer
mcf05415  Diabetic cardiomyopathy
mcf05417  Lipid and atherosclerosis
Module
mcf_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:mcf00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    101925220 (PLCB4)
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    101925220 (PLCB4)
   04310 Wnt signaling pathway
    101925220 (PLCB4)
   04371 Apelin signaling pathway
    101925220 (PLCB4)
   04020 Calcium signaling pathway
    101925220 (PLCB4)
   04070 Phosphatidylinositol signaling system
    101925220 (PLCB4)
   04072 Phospholipase D signaling pathway
    101925220 (PLCB4)
   04071 Sphingolipid signaling pathway
    101925220 (PLCB4)
   04022 cGMP-PKG signaling pathway
    101925220 (PLCB4)
  09133 Signaling molecules and interaction
   04082 Neuroactive ligand signaling
    101925220 (PLCB4)
   04081 Hormone signaling
    101925220 (PLCB4)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04540 Gap junction
    101925220 (PLCB4)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    101925220 (PLCB4)
   04613 Neutrophil extracellular trap formation
    101925220 (PLCB4)
   04621 NOD-like receptor signaling pathway
    101925220 (PLCB4)
   04062 Chemokine signaling pathway
    101925220 (PLCB4)
  09152 Endocrine system
   04911 Insulin secretion
    101925220 (PLCB4)
   04922 Glucagon signaling pathway
    101925220 (PLCB4)
   04929 GnRH secretion
    101925220 (PLCB4)
   04912 GnRH signaling pathway
    101925220 (PLCB4)
   04915 Estrogen signaling pathway
    101925220 (PLCB4)
   04921 Oxytocin signaling pathway
    101925220 (PLCB4)
   04926 Relaxin signaling pathway
    101925220 (PLCB4)
   04935 Growth hormone synthesis, secretion and action
    101925220 (PLCB4)
   04918 Thyroid hormone synthesis
    101925220 (PLCB4)
   04919 Thyroid hormone signaling pathway
    101925220 (PLCB4)
   04928 Parathyroid hormone synthesis, secretion and action
    101925220 (PLCB4)
   04916 Melanogenesis
    101925220 (PLCB4)
   04924 Renin secretion
    101925220 (PLCB4)
   04925 Aldosterone synthesis and secretion
    101925220 (PLCB4)
   04927 Cortisol synthesis and secretion
    101925220 (PLCB4)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    101925220 (PLCB4)
   04270 Vascular smooth muscle contraction
    101925220 (PLCB4)
  09154 Digestive system
   04970 Salivary secretion
    101925220 (PLCB4)
   04971 Gastric acid secretion
    101925220 (PLCB4)
   04972 Pancreatic secretion
    101925220 (PLCB4)
   04973 Carbohydrate digestion and absorption
    101925220 (PLCB4)
  09155 Excretory system
   04961 Endocrine and other factor-regulated calcium reabsorption
    101925220 (PLCB4)
  09156 Nervous system
   04724 Glutamatergic synapse
    101925220 (PLCB4)
   04725 Cholinergic synapse
    101925220 (PLCB4)
   04728 Dopaminergic synapse
    101925220 (PLCB4)
   04726 Serotonergic synapse
    101925220 (PLCB4)
   04720 Long-term potentiation
    101925220 (PLCB4)
   04730 Long-term depression
    101925220 (PLCB4)
   04723 Retrograde endocannabinoid signaling
    101925220 (PLCB4)
  09157 Sensory system
   04742 Taste transduction
    101925220 (PLCB4)
   04750 Inflammatory mediator regulation of TRP channels
    101925220 (PLCB4)
  09159 Environmental adaptation
   04713 Circadian entrainment
    101925220 (PLCB4)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    101925220 (PLCB4)
  09172 Infectious disease: viral
   05163 Human cytomegalovirus infection
    101925220 (PLCB4)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    101925220 (PLCB4)
   05142 Chagas disease
    101925220 (PLCB4)
   05143 African trypanosomiasis
    101925220 (PLCB4)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    101925220 (PLCB4)
   05016 Huntington disease
    101925220 (PLCB4)
   05017 Spinocerebellar ataxia
    101925220 (PLCB4)
   05022 Pathways of neurodegeneration - multiple diseases
    101925220 (PLCB4)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    101925220 (PLCB4)
   05415 Diabetic cardiomyopathy
    101925220 (PLCB4)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    101925220 (PLCB4)
   04934 Cushing syndrome
    101925220 (PLCB4)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:mcf04131]
    101925220 (PLCB4)
Enzymes [BR:mcf01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     101925220 (PLCB4)
Membrane trafficking [BR:mcf04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    101925220 (PLCB4)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    101925220 (PLCB4)
SSDB
Motif
Pfam: PI-PLC-X PH_14 PI-PLC-Y PLCB1-4-like_EFh EF-hand_like C2 PLC-beta_C EF-hand_7 EF-hand_6
Other DBs
NCBI-GeneID: 101925220
NCBI-ProteinID: XP_015313288
Ensembl: ENSMFAG00000034037
LinkDB
Position
10:complement(join(77848368..77848456,77850655..77850691,77854373..77854459,77854902..77854959,77859046..77859147,77867917..77868092,77870236..77870311,77874268..77874383,77883508..77883573,77883731..77883780,77890261..77890411,77891778..77891866,77903300..77903504,77905808..77905972,77907381..77907483,77916534..77916585,77918507..77918631,77918973..77919057,77919699..77919840,77925960..77926060,77931893..77931988,77933834..77933924,77936926..77937010,77937588..77937667,77939998..77940091,77941544..77941754,77945805..77945913,77952823..77952880,77953536..77953636,77954644..77954725,77962686..77962739,77965261..77965340,77989978..77990121,77990949..77991008,77991791..77991871,78020902..78020985))
AA seq 1194 aa
MAKPYEFNWQKEVPSFLQEGAVFDRYEEESFVFEPNCLFKVDEFGFFLTWKSEGKEGQVL
ECSLINSIRSGAIPKDPKILAALEAVGKSENDLEGRIVCVCSGTDLVNISFTYMVAENPE
VTKQWVEGLRSIIHNFRANNVSPMTCLKKHWMKLAFMTNTNGKIPVRSITRTFASGKTEK
VIFQALKELGLPSGKNDEIEPTAFTYEKFYELTQKICPRTDIEDLFKKINGDKTDYLTVD
QLVSFLNEHQRDPRLNEILFPFYDAKRAMQIIEMYEPDEDLKKKGLISSDGFCRYLMSDE
NAPVFLDRLELYQEMDHPLAHYFISSSHNTYLTGRQFGGKSSVEMYRQVLLAGCRCVELD
CWDGKGEDQEPIITHGKAMCTDILFKDVIQAIKETAFVTSEYPVILSFENHCSKYQQYKM
SKYCEDLFGDLLLKQALESHPLEPGRPLPSPNDLKRKILIKNKRLKPEVEKKQLEALRSM
MEAGESASPANILEDDNEEEIESADQDEEAHPEFKFGNELSADDLGHKEAVANSVKKGLV
TVEDEQAWMASYKYVGATTNIHPYLSTMINYAQPVKFQGFHVAEERNIHYNMSSFNESVG
LGYLKTHAIEFVNYNKRQMSRIYPKGGRVDSSNYMPQIFWNAGCQMVSLNYQTPDLAMQL
NQGKFEYNGSCGYLLKPDFMRRPDRTFDPFSETPVDGVIAATCSVQVISGQFLSDKKIGT
YVEVDMYGLPTDTIRKEFRTRMVMNNGLNPVYNEESFVFRKVILPDLAVLRIAVYDDNNK
LIGQRILPLDGLQAGYRHISLRNEGNKPLSLPTIFCNIVLKTYVPDGFGDIVDALSDPKK
FLSITEKRADQMRAMGIETSDIADVPSDTSKNDKKGKANTTKANVTPQSSSELRPTTTAA
LASGVEAKKGIELIPQVRIEDLKQMKAYLKHLKKQQKELNSLKKKHAKEHSTMQKLHCTQ
VDKIVAQYDKEKSTHEKILEKAMKKKGGSNCLEMKKETEIKIQTLTSDHKSKVKEIVAQH
TKEWSEMINTHSAEEQEIRDLHLSQQCELLKKLLISAHEQQTQQLKLSHDRESKEMRAHQ
AKISMENSKAISQDKSIKNKAERERRVRELNSSNTKKFLEERKRLAMKQSKEMDQLKKVQ
LEHLEFLEKQNEQLLKSCHAVSQSQGEGDAADGEIGSRDGPQTSNSSMKLQNAN
NT seq 3585 nt   +upstreamnt  +downstreamnt
atggccaaaccttatgaatttaactggcagaaggaagttccttcctttttgcaagaagga
gcagtttttgacagatacgaagaggaatcctttgtgtttgaacccaactgcctcttcaaa
gtggatgagtttggcttctttctgacatggaaaagtgaaggcaaggaaggacaggtgcta
gaatgctccctcatcaacagtattcggtcgggagccataccaaaggatcccaaaatcttg
gctgctcttgaagctgttggaaaatcagaaaatgatctggaaggtcggatagtttgtgtc
tgcagtggcacagatctagtgaacattagttttacctacatggtggctgaaaatccagaa
gtaactaagcaatgggtagaaggcctgagatcaatcatacacaacttcagggccaacaat
gtcagtccaatgacgtgcctcaagaaacactggatgaaattggcatttatgaccaacaca
aatggtaaaattccagttaggagtattactagaacctttgcatcggggaaaacagaaaag
gtgatctttcaagcactcaaggagttaggtcttcccagtggaaagaatgatgaaattgag
cccacggcatttacttatgaaaagttctatgaactgacacaaaagatttgtcctcggaca
gatatagaagatcttttcaaaaaaatcaatggagacaaaactgattatttaacggtagac
caattagtgagctttctaaatgaacatcaacgagatcctcgattgaatgaaattttattt
ccattttatgatgccaaaagggcaatgcagatcattgagatgtatgaacctgatgaagat
ttgaagaaaaaaggccttatatcaagtgatgggttttgcagatatctgatgtcagatgaa
aacgccccagtcttcctagatcgtttagaactttaccaagaaatggaccatcctctggct
cactacttcatcagttcttcccataacacttacctgactggcagacagttcggcgggaag
tcttcggtagagatgtacagacaggttctcctggctggttgcagatgtgttgaacttgac
tgctgggatggaaaaggtgaagaccaagaaccaataataactcatggaaaagcaatgtgt
acagatatcctttttaaggatgtaattcaagccatcaaggaaactgcgtttgtcacatca
gaatatcctgtaattctctcctttgaaaatcactgcagcaaatatcaacagtacaagatg
tccaaatattgcgaagatctatttggagatctcctgttgaaacaagcgcttgaatcacat
ccacttgaaccaggcagacctttgccatcccccaatgacctcaaaagaaaaatactcata
aaaaacaagaggctgaaacctgaagttgaaaaaaaacagctggaagctttgagaagcatg
atggaagctggagaatctgcctccccagcaaacatcttagaggatgataatgaagaggag
atcgaaagtgctgaccaagatgaggaagctcaccccgaattcaaatttggaaatgaactt
tctgctgatgacttgggtcacaaggaagctgttgcaaatagcgtcaagaagggcctggta
actgtagaagatgagcaggcgtggatggcatcttataaatatgtaggtgctaccactaat
atccatccatatttgtccacaatgatcaactacgcccagcctgtaaagtttcaaggtttc
catgtggcagaagaacgcaatattcattataacatgtcttcttttaatgaatcagtcggt
cttggctacttgaagacacatgcaattgaatttgtcaattataacaaacggcaaatgagt
cgcatttaccccaagggaggccgagtcgattccagtaattacatgcctcagattttctgg
aacgctggctgccagatggtttccctgaactatcaaaccccagatttggcgatgcaattg
aatcagggaaaatttgagtataatggatcgtgcgggtaccttctcaaaccagatttcatg
aggcggcctgatcgaacatttgaccccttctctgaaactcctgttgatggcgttattgca
gccacttgctcagtgcaggttatatcaggtcaattcttatcagataagaaaattggcacc
tatgtagaagtggatatgtatgggttgcccactgacactatacgtaaggaattccgaact
cgtatggttatgaataatggactaaatccagtttacaatgaagagtctttcgtatttcgg
aaggtgatcctgccagacctggctgtcttgagaatagcagtgtatgatgataacaacaag
ctgattggccagaggatcctcccgcttgatggcctccaagcaggataccgacacatttcc
cttcgaaatgagggaaataagccattatcactgccaacaattttctgcaatattgttctt
aaaacatacgtgcctgatggatttggagatattgtggatgctttatcagatccaaagaaa
tttctctcaattacagaaaagagagcagaccaaatgagagctatgggcattgaaactagt
gacatagctgatgtgcccagtgacacttccaaaaatgacaagaaaggaaaggccaatacc
accaaagcaaacgtgacccctcagagtagctctgagctcagaccaaccaccacagctgcc
ctggcctctggtgtggaagccaaaaaaggtattgaacttatccctcaagtaaggatagaa
gatttaaagcagatgaaggcttacttgaagcatttaaagaaacagcagaaagagctaaat
tctttaaagaagaaacatgcaaaggagcacagtaccatgcagaagttacactgcacgcaa
gttgacaaaattgtggcacagtatgacaaagagaagtcgactcatgagaaaatcctagag
aaggcaatgaagaagaaggggggaagtaattgtctcgaaatgaaaaaagaaacagaaatt
aaaattcagacgctgacatcagatcacaaatctaaggtcaaagagattgtagcacagcac
acaaaggaatggtcagaaatgatcaatacccacagtgctgaggagcaagaaatccgagac
ctgcacctcagccagcagtgtgagctgctgaaaaagctactcatcagtgcccacgagcag
caaacccagcagctgaaactgtcccatgacagggaaagcaaggaaatgcgagcacaccag
gctaagatttctatggaaaatagcaaagccatcagccaagataaatctatcaagaataag
gcagaacgggaaaggcgagtcagggagttaaacagcagcaacactaaaaagtttctggaa
gaaagaaagagactcgcaatgaagcagtccaaagaaatggatcagttgaaaaaagtccag
cttgaacatctagaattcctagagaaacagaatgagcagcttttgaaatcctgtcatgca
gtgtcccaatcgcaaggcgaaggagatgcagcagatggtgaaattggaagccgagatgga
ccgcagaccagcaacagtagtatgaaactccaaaatgcaaactga

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