KEGG   Macaca fascicularis (crab-eating macaque): 102125312
Entry
102125312         CDS       T02918                                 
Symbol
RAF1
Name
(RefSeq) RAF proto-oncogene serine/threonine-protein kinase isoform X1
  KO
K04366  RAF proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
Organism
mcf  Macaca fascicularis (crab-eating macaque)
Pathway
mcf01521  EGFR tyrosine kinase inhibitor resistance
mcf01522  Endocrine resistance
mcf04010  MAPK signaling pathway
mcf04012  ErbB signaling pathway
mcf04014  Ras signaling pathway
mcf04015  Rap1 signaling pathway
mcf04022  cGMP-PKG signaling pathway
mcf04024  cAMP signaling pathway
mcf04062  Chemokine signaling pathway
mcf04068  FoxO signaling pathway
mcf04071  Sphingolipid signaling pathway
mcf04072  Phospholipase D signaling pathway
mcf04140  Autophagy - animal
mcf04150  mTOR signaling pathway
mcf04151  PI3K-Akt signaling pathway
mcf04210  Apoptosis
mcf04218  Cellular senescence
mcf04270  Vascular smooth muscle contraction
mcf04360  Axon guidance
mcf04370  VEGF signaling pathway
mcf04371  Apelin signaling pathway
mcf04510  Focal adhesion
mcf04540  Gap junction
mcf04550  Signaling pathways regulating pluripotency of stem cells
mcf04613  Neutrophil extracellular trap formation
mcf04625  C-type lectin receptor signaling pathway
mcf04630  JAK-STAT signaling pathway
mcf04650  Natural killer cell mediated cytotoxicity
mcf04660  T cell receptor signaling pathway
mcf04662  B cell receptor signaling pathway
mcf04664  Fc epsilon RI signaling pathway
mcf04666  Fc gamma R-mediated phagocytosis
mcf04720  Long-term potentiation
mcf04722  Neurotrophin signaling pathway
mcf04726  Serotonergic synapse
mcf04730  Long-term depression
mcf04810  Regulation of actin cytoskeleton
mcf04910  Insulin signaling pathway
mcf04912  GnRH signaling pathway
mcf04914  Progesterone-mediated oocyte maturation
mcf04915  Estrogen signaling pathway
mcf04916  Melanogenesis
mcf04917  Prolactin signaling pathway
mcf04919  Thyroid hormone signaling pathway
mcf04921  Oxytocin signaling pathway
mcf04926  Relaxin signaling pathway
mcf04928  Parathyroid hormone synthesis, secretion and action
mcf04929  GnRH secretion
mcf04935  Growth hormone synthesis, secretion and action
mcf05010  Alzheimer disease
mcf05022  Pathways of neurodegeneration - multiple diseases
mcf05034  Alcoholism
mcf05132  Salmonella infection
mcf05152  Tuberculosis
mcf05160  Hepatitis C
mcf05161  Hepatitis B
mcf05163  Human cytomegalovirus infection
mcf05164  Influenza A
mcf05165  Human papillomavirus infection
mcf05167  Kaposi sarcoma-associated herpesvirus infection
mcf05170  Human immunodeficiency virus 1 infection
mcf05200  Pathways in cancer
mcf05205  Proteoglycans in cancer
mcf05206  MicroRNAs in cancer
mcf05207  Chemical carcinogenesis - receptor activation
mcf05208  Chemical carcinogenesis - reactive oxygen species
mcf05210  Colorectal cancer
mcf05211  Renal cell carcinoma
mcf05212  Pancreatic cancer
mcf05213  Endometrial cancer
mcf05214  Glioma
mcf05215  Prostate cancer
mcf05218  Melanoma
mcf05219  Bladder cancer
mcf05220  Chronic myeloid leukemia
mcf05221  Acute myeloid leukemia
mcf05223  Non-small cell lung cancer
mcf05224  Breast cancer
mcf05225  Hepatocellular carcinoma
mcf05226  Gastric cancer
mcf05230  Central carbon metabolism in cancer
mcf05231  Choline metabolism in cancer
mcf05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:mcf00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    102125312 (RAF1)
   04012 ErbB signaling pathway
    102125312 (RAF1)
   04014 Ras signaling pathway
    102125312 (RAF1)
   04015 Rap1 signaling pathway
    102125312 (RAF1)
   04370 VEGF signaling pathway
    102125312 (RAF1)
   04371 Apelin signaling pathway
    102125312 (RAF1)
   04630 JAK-STAT signaling pathway
    102125312 (RAF1)
   04068 FoxO signaling pathway
    102125312 (RAF1)
   04072 Phospholipase D signaling pathway
    102125312 (RAF1)
   04071 Sphingolipid signaling pathway
    102125312 (RAF1)
   04024 cAMP signaling pathway
    102125312 (RAF1)
   04022 cGMP-PKG signaling pathway
    102125312 (RAF1)
   04151 PI3K-Akt signaling pathway
    102125312 (RAF1)
   04150 mTOR signaling pathway
    102125312 (RAF1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    102125312 (RAF1)
  09143 Cell growth and death
   04210 Apoptosis
    102125312 (RAF1)
   04218 Cellular senescence
    102125312 (RAF1)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    102125312 (RAF1)
   04540 Gap junction
    102125312 (RAF1)
   04550 Signaling pathways regulating pluripotency of stem cells
    102125312 (RAF1)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    102125312 (RAF1)
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    102125312 (RAF1)
   04625 C-type lectin receptor signaling pathway
    102125312 (RAF1)
   04650 Natural killer cell mediated cytotoxicity
    102125312 (RAF1)
   04660 T cell receptor signaling pathway
    102125312 (RAF1)
   04662 B cell receptor signaling pathway
    102125312 (RAF1)
   04664 Fc epsilon RI signaling pathway
    102125312 (RAF1)
   04666 Fc gamma R-mediated phagocytosis
    102125312 (RAF1)
   04062 Chemokine signaling pathway
    102125312 (RAF1)
  09152 Endocrine system
   04910 Insulin signaling pathway
    102125312 (RAF1)
   04929 GnRH secretion
    102125312 (RAF1)
   04912 GnRH signaling pathway
    102125312 (RAF1)
   04915 Estrogen signaling pathway
    102125312 (RAF1)
   04914 Progesterone-mediated oocyte maturation
    102125312 (RAF1)
   04917 Prolactin signaling pathway
    102125312 (RAF1)
   04921 Oxytocin signaling pathway
    102125312 (RAF1)
   04926 Relaxin signaling pathway
    102125312 (RAF1)
   04935 Growth hormone synthesis, secretion and action
    102125312 (RAF1)
   04919 Thyroid hormone signaling pathway
    102125312 (RAF1)
   04928 Parathyroid hormone synthesis, secretion and action
    102125312 (RAF1)
   04916 Melanogenesis
    102125312 (RAF1)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    102125312 (RAF1)
  09156 Nervous system
   04726 Serotonergic synapse
    102125312 (RAF1)
   04720 Long-term potentiation
    102125312 (RAF1)
   04730 Long-term depression
    102125312 (RAF1)
   04722 Neurotrophin signaling pathway
    102125312 (RAF1)
  09158 Development and regeneration
   04360 Axon guidance
    102125312 (RAF1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    102125312 (RAF1)
   05206 MicroRNAs in cancer
    102125312 (RAF1)
   05205 Proteoglycans in cancer
    102125312 (RAF1)
   05207 Chemical carcinogenesis - receptor activation
    102125312 (RAF1)
   05208 Chemical carcinogenesis - reactive oxygen species
    102125312 (RAF1)
   05230 Central carbon metabolism in cancer
    102125312 (RAF1)
   05231 Choline metabolism in cancer
    102125312 (RAF1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    102125312 (RAF1)
  09162 Cancer: specific types
   05210 Colorectal cancer
    102125312 (RAF1)
   05212 Pancreatic cancer
    102125312 (RAF1)
   05225 Hepatocellular carcinoma
    102125312 (RAF1)
   05226 Gastric cancer
    102125312 (RAF1)
   05214 Glioma
    102125312 (RAF1)
   05221 Acute myeloid leukemia
    102125312 (RAF1)
   05220 Chronic myeloid leukemia
    102125312 (RAF1)
   05218 Melanoma
    102125312 (RAF1)
   05211 Renal cell carcinoma
    102125312 (RAF1)
   05219 Bladder cancer
    102125312 (RAF1)
   05215 Prostate cancer
    102125312 (RAF1)
   05213 Endometrial cancer
    102125312 (RAF1)
   05224 Breast cancer
    102125312 (RAF1)
   05223 Non-small cell lung cancer
    102125312 (RAF1)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    102125312 (RAF1)
   05161 Hepatitis B
    102125312 (RAF1)
   05160 Hepatitis C
    102125312 (RAF1)
   05164 Influenza A
    102125312 (RAF1)
   05163 Human cytomegalovirus infection
    102125312 (RAF1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    102125312 (RAF1)
   05165 Human papillomavirus infection
    102125312 (RAF1)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    102125312 (RAF1)
   05152 Tuberculosis
    102125312 (RAF1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    102125312 (RAF1)
   05022 Pathways of neurodegeneration - multiple diseases
    102125312 (RAF1)
  09165 Substance dependence
   05034 Alcoholism
    102125312 (RAF1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    102125312 (RAF1)
   01522 Endocrine resistance
    102125312 (RAF1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:mcf01001]
    102125312 (RAF1)
Enzymes [BR:mcf01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     102125312 (RAF1)
Protein kinases [BR:mcf01001]
 Serine/threonine kinases: TKL group
  RAF family [OT]
   102125312 (RAF1)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr RBD C1_1 Kinase-like ABC1 zf-RING-like Pkinase_fungal C1_2
Other DBs
NCBI-GeneID: 102125312
NCBI-ProteinID: XP_045241657
Ensembl: ENSMFAG00000038061
LinkDB
Position
2:complement(join(150867745..150867888,150868079..150868213,150868354..150868485,150868915..150869033,150870827..150870873,150874349..150874525,150875252..150875336,150883686..150883803,150884151..150884278,150884387..150884414,150887526..150887585,150888186..150888339,150890076..150890174,150892454..150892611,150892917..150893019,150895385..150895497,150902198..150902404))
AA seq 668 aa
MEHIQGAWKTISNGFGFKDAVFDGSSCISPTIVQQFGYQRRASDDGKLTDPSKTSNTIRV
FLPNKQRTVVNVRNGMSLHDCLMKALKVRGLQPECCAVFRLLHEHKGKKARLDWNTDAAS
LIGEELQVDFLDHVPLTTHNFARKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKV
PTMCVDWSNIRQLLLFPNSTIGDSGVPALPSLTMRRMRESVSRMPVSSQHRYSTPHAFTF
NTSSPSSEGSLSQRQRSTSTPNVHMVSTTLPVDSRMIENNSLNASPRAWSRRFCLRGRDA
IRSHSESASPSALSSSPNNLSPTGWSQPKTPVPAQRERAPVSGTQEKNKIRPRGQRDSSY
YWEIEASEVMLSTRIGSGSFGTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKT
RHVNILLFMGYMTKDNLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLH
AKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQ
DNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKA
MKRLVADCVKKVKEERPLFPQILSSIELLQHSLPKINRSASEPSLHRAAHTEDINACTLT
TSPRLPVF
NT seq 2007 nt   +upstreamnt  +downstreamnt
atggagcacatacagggagcttggaagacgatcagcaatggttttggattcaaagatgcc
gtgtttgatggctccagctgcatctctcctacaatagttcagcagtttggctatcagcgc
cgggcatcagatgatggcaaactcacagatccttctaagacaagcaatactatccgtgtt
ttcttgccaaacaagcaaagaacagtggtcaatgtacgaaatggaatgagcttgcatgac
tgccttatgaaagcactcaaggtgaggggccttcaaccagagtgctgtgcagtgttcaga
cttctccatgaacacaaaggtaaaaaagcacgcttagattggaatactgatgctgcctct
ttgattggggaagaacttcaagtagatttcctggatcatgttccgctcacaacacacaac
tttgctcggaagacgttcctgaagcttgccttctgtgacatctgtcagaaattcctgctc
aatggatttcgatgtcagacttgtggctacaaatttcatgagcactgtagcaccaaagta
cctactatgtgtgtggactggagtaatatcagacaactcttattgtttccaaattccact
attggtgatagtggagtcccagcactaccttctttgactatgcgtcgtatgcgagagtct
gtttccaggatgcctgttagttctcagcacaggtattctacacctcacgccttcaccttt
aacacctccagtccctcatctgaaggttccctttcccagaggcagaggtcgacgtccaca
cctaatgtccacatggtcagcaccaccctgcctgtggacagcaggatgattgagaataac
agcctgaatgcttctcccagggcgtggtccagacgattttgtttgaggggaagagatgca
attcgaagtcacagcgaatcagcctcaccttcagccctgtccagtagccccaacaatctg
agcccaacaggctggtcacagccgaaaacacccgtgccagcacaaagagagcgggcacca
gtatctgggacccaggagaaaaacaaaattaggcctcgtggacagagagattcaagctat
tactgggaaatagaagccagtgaagtgatgctgtccactcggattgggtcaggctctttt
ggaactgtttataagggcaaatggcacggagacgttgcagtaaagatcctaaaggttgtc
gacccaaccccagagcaattccaggccttcaggaatgaggtggctgttctgcgcaaaaca
cggcatgtgaacattctgcttttcatggggtacatgacaaaggacaacctggcaattgtg
acccagtggtgcgagggcagcagcctctacaaacacctgcatgtccaggagaccaagttt
cagatgttccagctaattgacattgcccggcagacggctcagggaatggactatttgcat
gcaaagaacatcatccacagagacatgaaatccaacaatatatttctccatgaaggccta
acagtgaaaattggagattttggtttggcaacagtaaagtcacgctggagtggttctcag
caggttgaacaacctactggctctgtcctgtggatggccccagaggtgatccgaatgcag
gataacaacccattcagtttccagtcagatgtctactcctatggcatcgtattgtatgag
ctgatgacgggggaacttccttactctcacatcaacaaccgagatcagatcatcttcatg
gtgggccgagggtatgcctccccagatcttagtaagctatataagaactgccccaaagca
atgaagaggctggtagctgactgtgtgaagaaagtaaaggaagagaggcctctttttccc
cagatcctgtcttccattgagctgctccaacactctctaccgaagatcaaccggagcgct
tccgagccatccttgcatcgggcagcccacactgaggatatcaatgcttgcacgctgacc
acatccccgaggctgcctgtcttctag

DBGET integrated database retrieval system