KEGG   Macaca fascicularis (crab-eating macaque): 102130142
Entry
102130142         CDS       T02918                                 
Symbol
IGF1R
Name
(RefSeq) insulin-like growth factor 1 receptor isoform X1
  KO
K05087  insulin-like growth factor 1 receptor [EC:2.7.10.1]
Organism
mcf  Macaca fascicularis (crab-eating macaque)
Pathway
mcf01521  EGFR tyrosine kinase inhibitor resistance
mcf01522  Endocrine resistance
mcf04010  MAPK signaling pathway
mcf04014  Ras signaling pathway
mcf04015  Rap1 signaling pathway
mcf04066  HIF-1 signaling pathway
mcf04068  FoxO signaling pathway
mcf04081  Hormone signaling
mcf04114  Oocyte meiosis
mcf04140  Autophagy - animal
mcf04144  Endocytosis
mcf04150  mTOR signaling pathway
mcf04151  PI3K-Akt signaling pathway
mcf04152  AMPK signaling pathway
mcf04211  Longevity regulating pathway
mcf04213  Longevity regulating pathway - multiple species
mcf04510  Focal adhesion
mcf04520  Adherens junction
mcf04550  Signaling pathways regulating pluripotency of stem cells
mcf04730  Long-term depression
mcf04913  Ovarian steroidogenesis
mcf04914  Progesterone-mediated oocyte maturation
mcf05200  Pathways in cancer
mcf05202  Transcriptional misregulation in cancer
mcf05205  Proteoglycans in cancer
mcf05214  Glioma
mcf05215  Prostate cancer
mcf05218  Melanoma
mcf05224  Breast cancer
mcf05225  Hepatocellular carcinoma
Brite
KEGG Orthology (KO) [BR:mcf00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    102130142 (IGF1R)
   04014 Ras signaling pathway
    102130142 (IGF1R)
   04015 Rap1 signaling pathway
    102130142 (IGF1R)
   04066 HIF-1 signaling pathway
    102130142 (IGF1R)
   04068 FoxO signaling pathway
    102130142 (IGF1R)
   04151 PI3K-Akt signaling pathway
    102130142 (IGF1R)
   04152 AMPK signaling pathway
    102130142 (IGF1R)
   04150 mTOR signaling pathway
    102130142 (IGF1R)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    102130142 (IGF1R)
 09140 Cellular Processes
  09141 Transport and catabolism
   04144 Endocytosis
    102130142 (IGF1R)
   04140 Autophagy - animal
    102130142 (IGF1R)
  09143 Cell growth and death
   04114 Oocyte meiosis
    102130142 (IGF1R)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    102130142 (IGF1R)
   04520 Adherens junction
    102130142 (IGF1R)
   04550 Signaling pathways regulating pluripotency of stem cells
    102130142 (IGF1R)
 09150 Organismal Systems
  09152 Endocrine system
   04913 Ovarian steroidogenesis
    102130142 (IGF1R)
   04914 Progesterone-mediated oocyte maturation
    102130142 (IGF1R)
  09156 Nervous system
   04730 Long-term depression
    102130142 (IGF1R)
  09149 Aging
   04211 Longevity regulating pathway
    102130142 (IGF1R)
   04213 Longevity regulating pathway - multiple species
    102130142 (IGF1R)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    102130142 (IGF1R)
   05202 Transcriptional misregulation in cancer
    102130142 (IGF1R)
   05205 Proteoglycans in cancer
    102130142 (IGF1R)
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    102130142 (IGF1R)
   05214 Glioma
    102130142 (IGF1R)
   05218 Melanoma
    102130142 (IGF1R)
   05215 Prostate cancer
    102130142 (IGF1R)
   05224 Breast cancer
    102130142 (IGF1R)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    102130142 (IGF1R)
   01522 Endocrine resistance
    102130142 (IGF1R)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:mcf01001]
    102130142 (IGF1R)
  09183 Protein families: signaling and cellular processes
   04090 CD molecules [BR:mcf04090]
    102130142 (IGF1R)
Enzymes [BR:mcf01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     102130142 (IGF1R)
Protein kinases [BR:mcf01001]
 Receptor tyrosine kinases (RTK)
  INSR family [OT]
   102130142 (IGF1R)
CD molecules [BR:mcf04090]
 Proteins
  102130142 (IGF1R)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Recep_L_domain Furin-like Pkinase fn3 Ig_DSCAM-DSCAML_C Kinase-like
Other DBs
NCBI-GeneID: 102130142
NCBI-ProteinID: XP_005560632
Ensembl: ENSMFAG00000002967
UniProt: A0A2K5W796
LinkDB
Position
7:join(83520740..83520833,83579109..83579654,83764650..83764962,83770698..83770846,83773375..83773519,83782557..83782771,83785174..83785300,83786891..83787129,83789818..83789985,83790524..83790728,83796284..83796567,83797967..83798103,83798620..83798779,83803661..83803763,83804341..83804411,83808882..83809111,83809375..83809485,83813426..83813585,83817161..83817290,83822794..83822928,83831287..83831668)
AA seq 1367 aa
MKSGSGEGSPTSLWGLLFLSAALSLWPTSGEICGPGIDIRNDYQQLKRLENCTVIEGYLH
ILLISKAEDYRSYRFPKLTVITEYLLLFRVAGLESLGDLFPNLTVIRGWKLFYNYALVIF
EMTNLKDIGLYNLRNITRGAIRIEKNADLCYLSTVDWSLILDAVSNNYIVGNKPPKECGD
LCPGTMEEKPMCEKTTINNEYNYRCWTTNRCQKMCPSACGKRACTENNECCHPECLGSCS
APDNDTACVACRHYYYAGVCVPACPPNTYRFEGWRCVDRDFCANILSAESSDSEGFVIHD
GECMQECPSGFIRNGSQSMYCIPCEGPCPKVCEEEKKTKTIDSVTSAQMLQGCTIFKGNL
LINIRRGNNIASELENFMGLIEVVTGYVKIRHSHALVSLSFLKNLRLILGEEQLEGNYSF
YVLDNQNLQQLWDWDHRNLTIKAGKMYFAFNPKLCVSEIYRMEEVTGTKGRQSKGDINTR
NNGERASCESDVLHFTSTTTWKNRIIITWHRYRPPDYRDLISFTVYYKEAPFKNVTEYDG
QDACGSNSWNMVDVDLPPNKDVEPGILLHGLKPWTQYAVYVKAVTLTMVENDHIRGAKSE
ILYIRTNASVPSIPLDVLSASNSSSQLIVKWNPPSLPNGNLSYYIVRWQRQPQDGYLYRH
NYCSKDKIPIRKYADGTIDIEEVTENPKTEVCGGEKGPCCACPKTEAEKQAEKEEAEYRK
VFENFLHNSIFVPRPERKRRDVMQVANTTMSSRSRNTTVADTYNITDLEELETEYPFFES
RVDNKERTVISNLRPFTLYRIDIHSCNHEAEKLGCSASNFVFARTMPAEGADDIPGPVTW
EPRPENSIFLKWPEPENPNGLILMYEIKYGSQVEDQRECVSRQEYRKYGGAKLNRLNPGN
YTARIQATSLSGNGSWTDPVFFYVQAKTGYENFIHLIIALPVAVLLIVGGLVIMLYVFHR
KRNNSRLGNGVLYASVNPEYFSAADVYVPDEWEVAREKITMSRELGQGSFGMVYEGVAKG
VVKDEPETRVAIKTVNEAASMRERIEFLNEASVMKEFNCHHVVRLLGVVSQGQPTLVIME
LMTRGDLKSYLRSLRPEMENNPVLAPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARN
CMVAEDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKDGVFTTYSDVWSFGV
VLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFL
EIISSIKDEMEPGFREVSFYYSEENKLPEPEELDLEPENMESVPLDPSASSSSLPLPDRH
SGHKAENGPGPGVLVLRASFDERQPYAHMNGGRKNERALPLPQSSTC
NT seq 4104 nt   +upstreamnt  +downstreamnt
atgaagtctggctctggagaagggtccccgacctcgctgtgggggctcctgtttctctcc
gccgcgctctcgctctggccgacgagtggagaaatctgtgggccgggcatcgacatccgc
aacgactatcagcagctgaagcgcctggagaactgcacggtgatcgagggctacctccac
atcctgctcatctccaaggccgaggactaccgcagctaccgcttccccaagctcacggtc
atcaccgagtacttgctgttgttccgagtggctggcctagagagcctcggagacctgttc
cccaacctcacggtaatccgcggctggaaactcttctacaactacgccctggtcatcttt
gagatgaccaatctcaaggatattgggctttacaacctgaggaacattactcggggggcc
atcaggattgagaaaaatgctgacctctgttacctctccactgtggactggtccctgatc
ctggatgcagtgtccaataactacattgtggggaataagcccccaaaggaatgcggggac
ctgtgtccggggaccatggaggagaagccgatgtgcgagaagaccaccatcaacaatgag
tacaactaccgctgctggaccacaaaccgctgccagaaaatgtgcccgagtgcctgtggg
aagagggcatgcaccgagaacaacgagtgctgccaccccgagtgcctgggcagctgcagc
gcgcctgacaacgacacggcctgtgtagcttgccgccactactactacgccggtgtctgc
gtgcctgcctgcccgcccaacacctacaggtttgagggctggcgctgtgtggaccgtgac
ttctgcgccaacatcctcagcgccgagagcagcgactccgagggtttcgtgatccacgac
ggcgagtgcatgcaggagtgcccctcaggcttcatccgcaacggcagccagagcatgtac
tgcatcccttgtgaaggtccttgccccaaggtctgtgaggaagaaaagaaaacaaagacc
attgattctgttacttctgctcagatgctccaaggatgcaccatcttcaagggcaatttg
ctcattaacatccgacgggggaataacattgcttcagaactggagaacttcatggggctc
atcgaggtggtgacgggctacgtgaagatccgccattcccatgccttggtctccttgtcc
ttcctaaaaaaccttcgcctcatcttaggagaggagcagctagaagggaattactccttc
tacgtcctcgacaaccagaacttgcagcaactatgggactgggaccaccgcaacctgacc
atcaaagcagggaaaatgtactttgctttcaatcccaaattgtgtgtttcggaaatttac
cgcatggaggaagtgacggggactaaagggcgccaaagcaaaggggacataaacaccagg
aacaacggggagagagcctcctgtgaaagtgacgtcctgcatttcacctccaccaccacg
tggaagaatcgcatcatcataacctggcaccggtaccggccccctgactacagggatctc
atcagcttcaccgtttactacaaggaagcaccttttaagaatgtcacggagtatgatggg
caggatgcctgcggctccaacagctggaacatggtggacgtggacctcccgcccaacaag
gacgtggagcccggcatcttactgcatgggctgaagccctggactcagtacgccgtttac
gtcaaggctgtgaccctcaccatggtggagaacgaccatatccgtggggccaagagtgag
atcttgtacattcgcaccaatgcttcagttccttccattccgttggacgttctttcagca
tcgaactcctcttctcagttaatcgtgaagtggaaccctccctctctgcccaacggcaac
ctgagttactacattgtgcgctggcagcggcagcctcaggacggctacctttaccggcac
aattactgctccaaagacaaaatccccatcaggaagtatgccgacggcaccattgacatt
gaggaggtcacagagaacccgaagactgaggtgtgtggtggagagaaagggccttgctgc
gcctgccccaaaactgaagctgagaagcaggccgagaaggaggaggctgagtaccgcaaa
gtctttgagaatttcctgcacaactccatctttgtgcccagacctgaaaggaagcggaga
gatgtcatgcaagtggccaacaccaccatgtccagccgaagcaggaacaccacggtggca
gacacctacaacatcacagatctggaagagctagagacagagtaccctttctttgagagc
agagtggataataaggagagaactgtcatttctaaccttcggcctttcacattgtaccgc
attgatatccacagctgcaaccacgaggctgagaaactgggctgcagcgcctccaacttt
gtctttgcaaggactatgcctgcagaaggagcagatgacattcctgggccagtgacctgg
gagccaaggcctgaaaactccatctttttaaagtggccagaacctgagaatcccaatgga
ttgattctaatgtatgaaataaaatacggatcacaagttgaggatcagcgagaatgtgtg
tccagacaggaatacaggaagtatggaggggccaagctaaaccggctaaacccggggaac
tacacagcccggattcaggctacatctctctctgggaatgggtcgtggacagatcctgtg
ttcttctatgtccaggccaaaacaggatatgaaaacttcatccatctgatcatcgctctg
cccgtcgctgtcctgttgatcgtgggagggttggtgatcatgctgtacgtcttccataga
aagagaaataacagcaggctggggaatggagtgctgtacgcgtctgtgaacccggagtac
ttcagcgctgcggatgtgtacgttcctgatgagtgggaggtggctcgggagaagatcacc
atgagccgggaacttgggcaggggtcgtttgggatggtctatgaaggagttgccaagggt
gtggtgaaagacgaacctgaaaccagagtggccattaaaacagtgaacgaggccgcgagc
atgcgtgaaaggatcgagtttctcaacgaggcttctgtgatgaaggagttcaattgtcac
catgtggtgcggttgctgggtgtggtgtcccagggccagccaacgctggtcatcatggaa
ctgatgacgcggggcgatctcaaaagttatctccggtctctgaggccagaaatggagaat
aatccagtcctagcacctccaagcctaagcaagatgattcagatggctggagagattgca
gacggcatggcatacctcaacgccaacaagttcgtccacagagaccttgctgcccggaat
tgcatggtagccgaggatttcacagtcaaaattggagattttgggatgacgcgagatatc
tatgagacagactattaccggaaaggagggaaagggctgttgcccgtgcgctggatgtct
cccgagtccctcaaggatggagtcttcaccacttactcggacgtctggtccttcggggtt
gtcctctgggagatcgccacactggccgagcagccctaccagggcttgtccaacgagcaa
gtccttcgcttcgtcatggagggcggccttctggacaagccagacaactgccccgacatg
ctgtttgaattgatgcgcatgtgctggcagtacaaccccaagatgaggccttccttcctg
gagatcatcagcagcatcaaagacgagatggagcctggcttccgggaggtctccttctac
tacagtgaggagaacaagctgcccgagccggaggagctggacctggagccagagaacatg
gagagcgtccccctggacccctcggcctcctcgtcctccctgccactgcccgacagacac
tcaggacacaaggccgagaacggccccggccctggagtgctggtgctccgcgccagcttc
gatgagagacagccttacgcacacatgaacggtggccgcaagaacgagcgggccttgccg
ctgccccagtcttcgacctgctga

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