| Entry |
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| Symbol |
CYP17A1
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| Name |
(RefSeq) steroid 17-alpha-hydroxylase/17,20 lyase
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| KO |
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| Organism |
mcf Macaca fascicularis (crab-eating macaque)
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| Pathway |
| mcf04927 | Cortisol synthesis and secretion |
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| Module |
| mcf_M00109 | C21-Steroid hormone biosynthesis, progesterone => cortisol/cortisone |
| mcf_M00110 | C19/C18-Steroid hormone biosynthesis, pregnenolone => androstenedione => estrone |
| mcf_M00976 | C19-Steroid hormone biosynthesis, pregnenolone => testosterone => dihydrotestosterone |
| mcf_M00977 | C19-Steroid hormone biosynthesis (androgen backdoor pathway), pregnenolone => androsterone => dihydrotestosterone |
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| Brite |
KEGG Orthology (KO) [BR:mcf00001]
09100 Metabolism
09103 Lipid metabolism
00140 Steroid hormone biosynthesis
102133235 (CYP17A1)
09150 Organismal Systems
09152 Endocrine system
04913 Ovarian steroidogenesis
102133235 (CYP17A1)
04917 Prolactin signaling pathway
102133235 (CYP17A1)
04927 Cortisol synthesis and secretion
102133235 (CYP17A1)
09160 Human Diseases
09167 Endocrine and metabolic disease
04934 Cushing syndrome
102133235 (CYP17A1)
09180 Brite Hierarchies
09181 Protein families: metabolism
00199 Cytochrome P450 [BR:mcf00199]
102133235 (CYP17A1)
Enzymes [BR:mcf01000]
1. Oxidoreductases
1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
1.14.14 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
1.14.14.19 steroid 17alpha-monooxygenase
102133235 (CYP17A1)
1.14.14.32 17alpha-hydroxyprogesterone deacetylase
102133235 (CYP17A1)
Cytochrome P450 [BR:mcf00199]
Cytochrome P450, animal type
CYP17 family
102133235 (CYP17A1)
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| SSDB |
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| Motif |
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| Other DBs |
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| LinkDB |
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| Position |
9:complement(join(111860854..111861137,111861659..111861762,111862657..111862826,111863139..111863354,111864361..111864447,111865089..111865318,111865559..111865697,111867467..111867763))
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| AA seq |
508 aa
MWELVALLLLTLAYLFWPKRRCPGAKYPKSLLSLPLVGSLPFLPRHGHMHNNFFKLQKKY
GPIYSVRMGTKTTVIVGHHQLAKEVLIKKGKDFSGRPQVTTLDILSNNRKGIAFADYGAH
WQLHRRLAMATFALFKDGDQKLEKIICQEISTLCDMLATHNGQTIDISFPVFVAITNVIS
LICFNISYKNGDPELKIVHNYNEGIIDSLGKESLVDLFPWLKVFPNKTLEKLKRHVKTRN
DLLTKIFENYKEKFHSDSITNMLDVLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIF
GAGVETTTSVVKWIVAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREV
LRIRPVAPMLIPHKANVDSSIGEFAVDKGTHVIINLWALHHNEKEWHQPDQFMPERFLNP
AGTQLISPSLSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLEVPDDGQLPSLEGNP
KVVFLIDSFKVKIKVRQAWREAQAEGST |
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| NT seq |
1527 nt +upstreamnt +downstreamnt
atgtgggagcttgtggctctcttgctgctcaccctagcctatttattttggcccaagaga
aggtgccctggtgccaagtatcctaagagcctcctgtccctgcccctggtgggcagcctg
ccattcctccccagacatggccatatgcataacaactttttcaagctgcagaaaaaatat
ggccccatctattccgttcgtatgggcaccaagactacagtgattgttggccaccaccag
ctggccaaggaggtgcttattaagaagggcaaggacttctctgggcggcctcaagtgaca
actctagacatcctgtccaacaatcgtaagggtattgcctttgctgactacggcgcacat
tggcagctgcatcgaaggctggcgatggccacctttgccctgttcaaggatggcgatcag
aagctggagaagatcatttgtcaggaaatcagtacattgtgtgatatgctggccacccac
aacggacagaccatagacatctcctttcctgtcttcgtggcgataaccaatgtcatctcc
ttgatctgcttcaacatctcctacaagaatggggaccctgagttgaagatcgtacataat
tacaatgaaggcatcatagacagcctgggcaaggagagcctggtggacctattcccctgg
ttgaaggttttccccaacaaaactctggaaaaattaaagaggcatgttaaaacacgaaat
gatctgctgactaaaatatttgaaaattacaaggagaaattccacagcgactctatcacc
aacatgctggacgtactgatgcaagccaagatgaattcagataatggcaacgctggccca
gatcaagactcagagctgctttcagataaccacattctcaccaccataggggacatcttt
ggggctggcgtggagaccaccacctctgtggtgaaatggatcgtggccttcctgctgcac
aatcctcaggtgaagaagaagctctacgaggagattgaccagaatgtgggtttcagccgc
acaccaaccatcagtgaccgtaaccgtctcctcctgctggaggccaccatccgagaggtg
cttcgcatcaggcccgtggcccctatgctcatcccccacaaggccaacgttgactccagc
atcggtgagtttgctgtggacaagggcacacacgttatcatcaatctgtgggcgctgcat
cacaatgagaaggagtggcaccagccggaccagttcatgcctgagcgtttcttgaatcca
gcggggacccagcttatctcaccatcattaagctacttgcccttcggagcaggacctcgc
tcctgtataggtgagatcctggcccgccaggagctcttcctcatcatggcctggctgctg
cagaggttcgacctggaggtgccagatgatgggcagctgccctccctggaaggcaaccca
aaggtggtctttctgatcgactctttcaaagtgaagatcaaggtgcgccaggcctggagg
gaagcccaggctgagggtagcacctaa |
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