KEGG   Macaca fascicularis (crab-eating macaque): 102136227
Entry
102136227         CDS       T02918                                 
Symbol
KDR
Name
(RefSeq) vascular endothelial growth factor receptor 2
  KO
K05098  kinase insert domain protein receptor [EC:2.7.10.1]
Organism
mcf  Macaca fascicularis (crab-eating macaque)
Pathway
mcf01521  EGFR tyrosine kinase inhibitor resistance
mcf04010  MAPK signaling pathway
mcf04014  Ras signaling pathway
mcf04015  Rap1 signaling pathway
mcf04020  Calcium signaling pathway
mcf04151  PI3K-Akt signaling pathway
mcf04370  VEGF signaling pathway
mcf04510  Focal adhesion
mcf04517  IgSF CAM signaling
mcf04518  Integrin signaling
mcf05205  Proteoglycans in cancer
mcf05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:mcf00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    102136227 (KDR)
   04014 Ras signaling pathway
    102136227 (KDR)
   04015 Rap1 signaling pathway
    102136227 (KDR)
   04370 VEGF signaling pathway
    102136227 (KDR)
   04020 Calcium signaling pathway
    102136227 (KDR)
   04151 PI3K-Akt signaling pathway
    102136227 (KDR)
  09133 Signaling molecules and interaction
   04517 IgSF CAM signaling
    102136227 (KDR)
   04518 Integrin signaling
    102136227 (KDR)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    102136227 (KDR)
 09160 Human Diseases
  09161 Cancer: overview
   05205 Proteoglycans in cancer
    102136227 (KDR)
  09166 Cardiovascular disease
   05418 Fluid shear stress and atherosclerosis
    102136227 (KDR)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    102136227 (KDR)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:mcf01001]
    102136227 (KDR)
  09183 Protein families: signaling and cellular processes
   04090 CD molecules [BR:mcf04090]
    102136227 (KDR)
Enzymes [BR:mcf01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     102136227 (KDR)
Protein kinases [BR:mcf01001]
 Receptor tyrosine kinases (RTK)
  VEGFR family [OT]
   102136227 (KDR)
CD molecules [BR:mcf04090]
 Proteins
  102136227 (KDR)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr VEGFR1-3_N_Ig-like Ig_3 I-set Pkinase Ig_2 ig VEGFR-1-like_Ig-like V-set VEGFR-2_TMD Ig_VEGFR-1-like_5th C2-set_2 Ig_PDGFR_d4 Haspin_kinase BppU_N ABC1
Other DBs
NCBI-GeneID: 102136227
NCBI-ProteinID: XP_005555327
Ensembl: ENSMFAG00000043201
UniProt: A0A2K5VE63
LinkDB
Position
5:join(78773391..78773457,78777534..78777627,78779940..78780136,78783323..78783453,78783692..78783860,78784478..78784617,78785272..78785449,78787977..78788091,78788179..78788342,78790852..78791008,78791935..78792058,78792798..78792906,78793751..78794092,78796257..78796403,78796737..78796868,78799922..78800028,78800452..78800587,78800958..78801062,78802380..78802493,78803078..78803166,78803784..78803937,78805990..78806087,78808619..78808741,78808895..78809006,78809223..78809322,78809728..78809833,78810949..78811100,78816059..78816158,78816652..78816737,78818482..78818704)
AA seq 1356 aa
MASKVLLAVALWLCVETRAASVGLPSVSLDLPRLSIQKDILTIKANTTLQITCRGQRDLD
WLWPNNQSGSEQRVEVTECSDGLFCKTLTIPKVIGNDTGAYKCFYRETDLASVIYVYVQD
YRSPFIASVSDQHGVVYITENKNKTVVIPCLGSISNLNVSLCARYPEKRFVPDGNRISWD
SKKGFTIPSYMISYAGMVFCEAKINDESYQSIMYIVVVVGYRIYDVVLSPSHGVELSVGE
KLVLNCTARTELNVGIDFNWEYPSSKHQHKKLVNRDLKTQSGSEMKKFLSTLTIDGVTRS
DQGLYTCAASSGLMTKKNSTFVRVHEKPFVAFGSGMESLVEATVGERVRIPVKYLGYPPP
EIKWYKNGIPLESNHTVKVGHVLTIMEVSERDTGNYTVILTNPISKEKQSHVVSLVVYVP
PQIGEKSLISPVDSYQYGTTQTLTCTVYAIPPPHHIHWYWQLEEECPNEPSQAVSVTNPY
PCEEWRSVEDFQGGNKIEVNKNQFALIEGKNKTVSTLVIQAANVSALYKCEAVNKVGRGE
RVISFHVTRGPEITLQPDLQPTEQESVSLWCTADKSTFENLTWYKLGPQPLPVHVGELPT
PVCKNLDTLWKLNATIFSNSTNDILIMELKNASLQDQGDYVCVAQDRKTKKRHCVVRQLT
VLERVAPMITGNLENQTTSIGETIEVSCTASGNPPPQIMWFKDNETLVEDSGIVLKDGNR
NLTIRRVRKEDEGLYTCQACSVLGCAKVEAFFIIEGAQEKTNLEIIILVGTAVIAMFFWL
LLVIILRTVKRANGGELKTGYLSIVMDPDELPLDEHCERLPYDASKWEFPRDRLKLGKPL
GRGAFGQVIEADAFGIDKTATCRTVAVKMLKEGATHSEHRALMSELKILIHIGHHLNVVN
LLGACTKPGGPLMVIVEFCKFGNLSTYLRSKRNEFVPYKTKGARFRQGKDYVGAIPVDLK
RRLDSITSSQSSASSGFVEEKSLSDVEEEEAPEDLYKDFLTLEHLICYSFQVAKGMEFLA
SRKCIHRDLAARNILLSEKNVVKICDFGLARDIYKDPDYVRKGDARLPLKWMAPETIFDR
VYTIQSDVWSFGVLLWEIFSLGASPYPGVKIDEEFCRRLKEGTRMRAPDYTTPEMYQTML
DCWHGEPSQRPTFSELVEHLGNLLQANAQQDGKDYIVLPISETLSMEEDSGLSLPTSPVS
CMEEEEVCDPKFHYDNTAGISQYLQNSKRKSRPVSVKTFEDIPLEEPEVKVIPDDNQTDS
GMVLASEELKTLEDRTKLAPSFSGMVSSKSRESVASEGSNQTSGYQSGYHSDDTDTTVYS
SEEAELLKLIEIGVQTGSTAQILQPDSGTTLSSPPV
NT seq 4071 nt   +upstreamnt  +downstreamnt
atggcgagcaaggtgctgctggccgtcgccctgtggctctgcgtggagacccgggccgcc
tctgtgggtttgcctagtgtttctcttgatctgcccaggctcagcatacaaaaagacata
cttacaattaaggctaatacaactcttcaaattacttgcaggggacagagggacttggac
tggctttggcccaataatcagagtggcagtgagcaaagggtggaggtgactgagtgcagc
gatggcctcttctgtaagacgctcacaattccaaaagtgatcggaaatgacactggagcc
tacaagtgcttctaccgggaaactgacttggcctcggtcatttatgtctatgttcaagat
tacagatctccatttattgcttctgttagtgaccaacatggagtcgtgtacattactgag
aacaaaaacaaaactgtggtgattccatgtctcgggtccatttcaaatctcaacgtgtca
ctttgtgcaaggtacccagaaaagagatttgttcctgatggtaacagaatttcctgggac
agcaagaagggctttactattcccagctatatgatcagctatgctggcatggtcttctgt
gaagcaaaaattaatgatgaaagttaccagtctattatgtacatagttgtggttgtaggg
tataggatttatgatgtggttctgagtccgtctcatggagttgaactatctgttggagag
aagcttgtcttaaattgtacagcaagaactgaactaaatgtggggattgacttcaactgg
gaatacccttcttcgaagcatcagcataagaaacttgtaaaccgagatctaaaaacccag
tctgggagtgagatgaagaaatttttgagcaccttaactatagatggtgtaacccggagt
gaccaaggattgtacacctgtgcagcgtccagtgggctgatgaccaagaagaacagcaca
tttgtcagggtccatgaaaaaccttttgttgcttttggaagtggcatggaatctctggtg
gaagccacggtgggggagcgtgtcagaatccctgtgaagtaccttggttacccgccccca
gaaataaaatggtataaaaatggaataccccttgagtccaatcacacagttaaagtgggg
catgtactgacgatcatggaagtgagtgaaagagacacaggaaattacactgtcatcctt
accaatcccatttcaaaggagaagcagagtcacgtggtctctctggttgtgtatgtccca
ccccagattggtgagaaatctctgatctctcctgtggattcctaccagtacggcaccact
caaacgctgacgtgtacggtctacgctattcctcccccgcatcacatccactggtattgg
cagttggaggaagagtgccccaacgagcccagccaagctgtctcagtgacaaacccatac
ccttgtgaagaatggagaagtgtggaggacttccagggaggaaataaaattgaagtcaat
aaaaatcaatttgctctaattgaaggaaaaaacaaaactgtaagtacccttgttatccaa
gcggcaaatgtgtcagctttgtacaaatgtgaagcggtcaacaaagtcgggagaggagag
agggtgatctccttccatgttaccaggggtcctgaaattactttgcaacctgacttgcag
cccactgaacaggagagcgtgtctttgtggtgcactgcagacaaatctacatttgagaac
ctcacatggtacaagcttggcccacagcctctgccagtccacgtgggagagttgcccaca
cctgtttgcaagaacttggatactctttggaaattgaatgccactatattctctaatagc
acaaatgacattttgatcatggagcttaagaatgcatccttgcaggaccaaggagactat
gtctgcgttgctcaagacaggaagaccaagaaaagacattgcgtggtcaggcagctcaca
gtcctcgagcgcgtggcacccatgatcacaggaaacctggagaatcagacgacgagtatt
ggggaaaccattgaagtctcatgcacggcatctgggaatccccctccacagatcatgtgg
tttaaagataatgagacccttgtagaagactcaggcattgtattgaaggatgggaaccgg
aacctcactatccgcagagtgaggaaggaggacgaaggcctctacacctgccaggcatgc
agtgttcttggctgtgcaaaagtggaggcatttttcataatagaaggtgcccaggaaaag
acgaacttggaaatcattattctagtaggcacagcagtgattgccatgttcttctggcta
cttcttgtcatcattctacggaccgttaagcgggccaatggaggggaactgaagacaggc
tacttgtccatcgtcatggatcctgatgaactcccattggacgaacactgtgaacgactg
ccttatgatgccagcaaatgggaattccccagagaccggctgaagctaggtaagccgctt
ggccgtggtgcctttggccaagtgattgaagcagatgcctttggaattgacaagacagca
acttgcaggacagtagcagtcaaaatgttgaaagaaggagcaacacacagtgagcatcga
gccctcatgtctgaactcaagatcctcattcatattggtcaccatctcaatgtggtcaac
cttctaggtgcctgtaccaagccaggagggccactcatggtgattgtggaattctgcaag
tttggaaacctatccacttacctgaggagcaagagaaatgaatttgtcccctacaagacc
aaaggggcacgattccgtcaagggaaagactatgttggagcaatccctgtggatctgaaa
cggcgcttggacagcatcaccagtagccagagctcagccagctctggatttgtggaggag
aagtccctcagtgatgtagaagaagaggaagctcctgaagacctgtataaggacttcctg
accttggagcatctcatctgttacagcttccaagtggctaagggcatggagttcttggca
tcacgaaagtgtatccacagggacctggcggcacgaaatatcctcttatcggagaagaac
gtggttaaaatctgtgactttggcttggcccgggatatttataaagatccagattatgtc
agaaaaggagatgctcgcctccctttgaaatggatggccccagaaacaatttttgacaga
gtgtacacaatccagagtgacgtctggtcttttggcgtgttgctgtgggaaatattttcc
ttgggtgcttctccatatcctggggtaaagattgatgaagaattttgtaggcgattgaaa
gaaggaactagaatgagggcccccgattatactacaccagaaatgtaccagaccatgctg
gactgctggcacggggagcccagtcagagacccacgttttcagagttggtggaacatttg
ggaaatctcttgcaagctaatgctcagcaggacggcaaagactatattgttcttccgata
tcagagactttgagcatggaagaggattctggactctctctgcctacctcacctgtttcc
tgtatggaggaggaggaagtatgtgaccccaaattccattatgacaacacagcaggaatc
agtcagtatctgcagaacagtaagcgaaagagccggcctgtgagtgtaaaaacatttgaa
gacatcccattagaagaaccagaagtaaaagtaatcccagatgacaaccagacggacagt
ggtatggttcttgcctcagaagagctgaaaactttggaagacagaaccaaattagctcca
tcttttagtggaatggtgtccagcaaaagcagggagtctgtggcatctgagggctcaaac
cagacaagtggctaccagtccggatatcactccgacgacacagacaccactgtgtactcc
agtgaggaagcagaacttttaaagctgatagagatcggagtgcaaaccggcagcacagcc
cagattctccagcctgactcggggaccacattgagctcccctcctgtttaa

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