KEGG   Macaca fascicularis (crab-eating macaque): 102141214
Entry
102141214         CDS       T02918                                 
Symbol
MAP2K1
Name
(RefSeq) dual specificity mitogen-activated protein kinase kinase 1 isoform X1
  KO
K04368  mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
Organism
mcf  Macaca fascicularis (crab-eating macaque)
Pathway
mcf01521  EGFR tyrosine kinase inhibitor resistance
mcf01522  Endocrine resistance
mcf04010  MAPK signaling pathway
mcf04012  ErbB signaling pathway
mcf04014  Ras signaling pathway
mcf04015  Rap1 signaling pathway
mcf04022  cGMP-PKG signaling pathway
mcf04024  cAMP signaling pathway
mcf04062  Chemokine signaling pathway
mcf04066  HIF-1 signaling pathway
mcf04068  FoxO signaling pathway
mcf04071  Sphingolipid signaling pathway
mcf04072  Phospholipase D signaling pathway
mcf04114  Oocyte meiosis
mcf04140  Autophagy - animal
mcf04148  Efferocytosis
mcf04150  mTOR signaling pathway
mcf04151  PI3K-Akt signaling pathway
mcf04210  Apoptosis
mcf04218  Cellular senescence
mcf04270  Vascular smooth muscle contraction
mcf04370  VEGF signaling pathway
mcf04371  Apelin signaling pathway
mcf04380  Osteoclast differentiation
mcf04510  Focal adhesion
mcf04540  Gap junction
mcf04550  Signaling pathways regulating pluripotency of stem cells
mcf04613  Neutrophil extracellular trap formation
mcf04620  Toll-like receptor signaling pathway
mcf04650  Natural killer cell mediated cytotoxicity
mcf04660  T cell receptor signaling pathway
mcf04662  B cell receptor signaling pathway
mcf04664  Fc epsilon RI signaling pathway
mcf04666  Fc gamma R-mediated phagocytosis
mcf04668  TNF signaling pathway
mcf04720  Long-term potentiation
mcf04722  Neurotrophin signaling pathway
mcf04725  Cholinergic synapse
mcf04726  Serotonergic synapse
mcf04730  Long-term depression
mcf04810  Regulation of actin cytoskeleton
mcf04910  Insulin signaling pathway
mcf04912  GnRH signaling pathway
mcf04914  Progesterone-mediated oocyte maturation
mcf04915  Estrogen signaling pathway
mcf04916  Melanogenesis
mcf04917  Prolactin signaling pathway
mcf04919  Thyroid hormone signaling pathway
mcf04921  Oxytocin signaling pathway
mcf04926  Relaxin signaling pathway
mcf04928  Parathyroid hormone synthesis, secretion and action
mcf04929  GnRH secretion
mcf04934  Cushing syndrome
mcf04935  Growth hormone synthesis, secretion and action
mcf05010  Alzheimer disease
mcf05022  Pathways of neurodegeneration - multiple diseases
mcf05034  Alcoholism
mcf05132  Salmonella infection
mcf05135  Yersinia infection
mcf05160  Hepatitis C
mcf05161  Hepatitis B
mcf05163  Human cytomegalovirus infection
mcf05164  Influenza A
mcf05165  Human papillomavirus infection
mcf05166  Human T-cell leukemia virus 1 infection
mcf05167  Kaposi sarcoma-associated herpesvirus infection
mcf05170  Human immunodeficiency virus 1 infection
mcf05200  Pathways in cancer
mcf05205  Proteoglycans in cancer
mcf05206  MicroRNAs in cancer
mcf05207  Chemical carcinogenesis - receptor activation
mcf05208  Chemical carcinogenesis - reactive oxygen species
mcf05210  Colorectal cancer
mcf05211  Renal cell carcinoma
mcf05212  Pancreatic cancer
mcf05213  Endometrial cancer
mcf05214  Glioma
mcf05215  Prostate cancer
mcf05216  Thyroid cancer
mcf05218  Melanoma
mcf05219  Bladder cancer
mcf05220  Chronic myeloid leukemia
mcf05221  Acute myeloid leukemia
mcf05223  Non-small cell lung cancer
mcf05224  Breast cancer
mcf05225  Hepatocellular carcinoma
mcf05226  Gastric cancer
mcf05230  Central carbon metabolism in cancer
mcf05231  Choline metabolism in cancer
mcf05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:mcf00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    102141214 (MAP2K1)
   04012 ErbB signaling pathway
    102141214 (MAP2K1)
   04014 Ras signaling pathway
    102141214 (MAP2K1)
   04015 Rap1 signaling pathway
    102141214 (MAP2K1)
   04370 VEGF signaling pathway
    102141214 (MAP2K1)
   04371 Apelin signaling pathway
    102141214 (MAP2K1)
   04668 TNF signaling pathway
    102141214 (MAP2K1)
   04066 HIF-1 signaling pathway
    102141214 (MAP2K1)
   04068 FoxO signaling pathway
    102141214 (MAP2K1)
   04072 Phospholipase D signaling pathway
    102141214 (MAP2K1)
   04071 Sphingolipid signaling pathway
    102141214 (MAP2K1)
   04024 cAMP signaling pathway
    102141214 (MAP2K1)
   04022 cGMP-PKG signaling pathway
    102141214 (MAP2K1)
   04151 PI3K-Akt signaling pathway
    102141214 (MAP2K1)
   04150 mTOR signaling pathway
    102141214 (MAP2K1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    102141214 (MAP2K1)
   04148 Efferocytosis
    102141214 (MAP2K1)
  09143 Cell growth and death
   04114 Oocyte meiosis
    102141214 (MAP2K1)
   04210 Apoptosis
    102141214 (MAP2K1)
   04218 Cellular senescence
    102141214 (MAP2K1)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    102141214 (MAP2K1)
   04540 Gap junction
    102141214 (MAP2K1)
   04550 Signaling pathways regulating pluripotency of stem cells
    102141214 (MAP2K1)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    102141214 (MAP2K1)
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    102141214 (MAP2K1)
   04620 Toll-like receptor signaling pathway
    102141214 (MAP2K1)
   04650 Natural killer cell mediated cytotoxicity
    102141214 (MAP2K1)
   04660 T cell receptor signaling pathway
    102141214 (MAP2K1)
   04662 B cell receptor signaling pathway
    102141214 (MAP2K1)
   04664 Fc epsilon RI signaling pathway
    102141214 (MAP2K1)
   04666 Fc gamma R-mediated phagocytosis
    102141214 (MAP2K1)
   04062 Chemokine signaling pathway
    102141214 (MAP2K1)
  09152 Endocrine system
   04910 Insulin signaling pathway
    102141214 (MAP2K1)
   04929 GnRH secretion
    102141214 (MAP2K1)
   04912 GnRH signaling pathway
    102141214 (MAP2K1)
   04915 Estrogen signaling pathway
    102141214 (MAP2K1)
   04914 Progesterone-mediated oocyte maturation
    102141214 (MAP2K1)
   04917 Prolactin signaling pathway
    102141214 (MAP2K1)
   04921 Oxytocin signaling pathway
    102141214 (MAP2K1)
   04926 Relaxin signaling pathway
    102141214 (MAP2K1)
   04935 Growth hormone synthesis, secretion and action
    102141214 (MAP2K1)
   04919 Thyroid hormone signaling pathway
    102141214 (MAP2K1)
   04928 Parathyroid hormone synthesis, secretion and action
    102141214 (MAP2K1)
   04916 Melanogenesis
    102141214 (MAP2K1)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    102141214 (MAP2K1)
  09156 Nervous system
   04725 Cholinergic synapse
    102141214 (MAP2K1)
   04726 Serotonergic synapse
    102141214 (MAP2K1)
   04720 Long-term potentiation
    102141214 (MAP2K1)
   04730 Long-term depression
    102141214 (MAP2K1)
   04722 Neurotrophin signaling pathway
    102141214 (MAP2K1)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    102141214 (MAP2K1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    102141214 (MAP2K1)
   05206 MicroRNAs in cancer
    102141214 (MAP2K1)
   05205 Proteoglycans in cancer
    102141214 (MAP2K1)
   05207 Chemical carcinogenesis - receptor activation
    102141214 (MAP2K1)
   05208 Chemical carcinogenesis - reactive oxygen species
    102141214 (MAP2K1)
   05230 Central carbon metabolism in cancer
    102141214 (MAP2K1)
   05231 Choline metabolism in cancer
    102141214 (MAP2K1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    102141214 (MAP2K1)
  09162 Cancer: specific types
   05210 Colorectal cancer
    102141214 (MAP2K1)
   05212 Pancreatic cancer
    102141214 (MAP2K1)
   05225 Hepatocellular carcinoma
    102141214 (MAP2K1)
   05226 Gastric cancer
    102141214 (MAP2K1)
   05214 Glioma
    102141214 (MAP2K1)
   05216 Thyroid cancer
    102141214 (MAP2K1)
   05221 Acute myeloid leukemia
    102141214 (MAP2K1)
   05220 Chronic myeloid leukemia
    102141214 (MAP2K1)
   05218 Melanoma
    102141214 (MAP2K1)
   05211 Renal cell carcinoma
    102141214 (MAP2K1)
   05219 Bladder cancer
    102141214 (MAP2K1)
   05215 Prostate cancer
    102141214 (MAP2K1)
   05213 Endometrial cancer
    102141214 (MAP2K1)
   05224 Breast cancer
    102141214 (MAP2K1)
   05223 Non-small cell lung cancer
    102141214 (MAP2K1)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    102141214 (MAP2K1)
   05170 Human immunodeficiency virus 1 infection
    102141214 (MAP2K1)
   05161 Hepatitis B
    102141214 (MAP2K1)
   05160 Hepatitis C
    102141214 (MAP2K1)
   05164 Influenza A
    102141214 (MAP2K1)
   05163 Human cytomegalovirus infection
    102141214 (MAP2K1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    102141214 (MAP2K1)
   05165 Human papillomavirus infection
    102141214 (MAP2K1)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    102141214 (MAP2K1)
   05135 Yersinia infection
    102141214 (MAP2K1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    102141214 (MAP2K1)
   05022 Pathways of neurodegeneration - multiple diseases
    102141214 (MAP2K1)
  09165 Substance dependence
   05034 Alcoholism
    102141214 (MAP2K1)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    102141214 (MAP2K1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    102141214 (MAP2K1)
   01522 Endocrine resistance
    102141214 (MAP2K1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:mcf01001]
    102141214 (MAP2K1)
Enzymes [BR:mcf01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.12  Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
    2.7.12.2  mitogen-activated protein kinase kinase
     102141214 (MAP2K1)
Protein kinases [BR:mcf01001]
 Serine/threonine kinases: STE group
  STE7 family
   102141214 (MAP2K1)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr ABC1 Pkinase_fungal Kinase-like Haspin_kinase Seadorna_VP7
Other DBs
NCBI-GeneID: 102141214
NCBI-ProteinID: XP_005559922
Ensembl: ENSMFAG00000036522
LinkDB
Position
7:join(43045388..43045467,43095834..43096044,43097845..43097991,43106855..43106932,43107933..43107984,43146719..43146843,43149639..43149840,43152242..43152306,43154205..43154266,43154695..43154740,43155467..43155580)
AA seq 393 aa
MPKKKPTPIQLNPAPDGSAVNGTSSAETNLEALQKKLEELELDEQQRKRLEAFLTQKQKV
GELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHE
CNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYL
REKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHY
SVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSY
GMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAF
IKRSDAEEVDFAGWLCSTIGLHQPSTPTHAAGV
NT seq 1182 nt   +upstreamnt  +downstreamnt
atgcccaagaagaagccgacgcccatccagctgaacccggcccccgacggctccgcggtt
aacgggaccagctctgcggagaccaacttggaggccttgcagaagaagctggaggagcta
gagcttgatgagcagcagcgaaagcgccttgaggcctttctcacccagaagcagaaggtg
ggagaactgaaggatgacgactttgagaagatcagtgagctgggggccggcaatggcggt
gtggtgttcaaggtctcccacaagccttctggcctggtcatggccagaaagctaattcat
ctggagatcaaacccgcaatccggaaccagatcataagggaactgcaggtgctgcatgag
tgcaactctccatacatcgtgggcttctatggtgcattctacagtgatggcgagatcagt
atctgcatggagcacatggatggaggttctctggatcaagtcctgaagaaagctggaaga
attcctgaacaaattttaggaaaagttagcattgctgtaataaaaggcctgacatatctg
agggagaagcacaagatcatgcacagagatgtcaagccctccaacatcctagtcaactcc
cgtggggagatcaagctctgtgactttggggtcagcgggcagctcatcgactccatggcc
aactccttcgtgggcacaaggtcctacatgtcgccagaaagactccaggggactcattac
tctgtgcagtcagacatctggagcatgggactctctctggtagagatggcggttgggagg
tatcccatccctcctccagatgccaaggagctagaactgatgtttgggtgccaggtggag
ggagatgcggctgagaccccacctaggccaaggacccccgggaggccccttagctcatat
ggaatggacagccgacctcccatggcaatttttgagttgttggattacatagtcaacgag
cctcctccgaaattgcccagtggagttttcagtctggaatttcaagattttgtgaataaa
tgcttaataaaaaaccccgcagagagagcagatttgaagcaactcatggttcatgctttt
atcaagagatctgatgctgaggaagtggattttgcaggttggctctgctccactatcggc
cttcaccagcccagcacaccaacccatgctgctggcgtctaa

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