KEGG   Macaca fascicularis (crab-eating macaque): 102142941
Entry
102142941         CDS       T02918                                 
Symbol
PLCE1
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X1
  KO
K05860  phosphatidylinositol phospholipase C, epsilon [EC:3.1.4.11]
Organism
mcf  Macaca fascicularis (crab-eating macaque)
Pathway
mcf00562  Inositol phosphate metabolism
mcf01100  Metabolic pathways
mcf04014  Ras signaling pathway
mcf04015  Rap1 signaling pathway
mcf04020  Calcium signaling pathway
mcf04024  cAMP signaling pathway
mcf04070  Phosphatidylinositol signaling system
mcf04919  Thyroid hormone signaling pathway
mcf04933  AGE-RAGE signaling pathway in diabetic complications
mcf05205  Proteoglycans in cancer
Module
mcf_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:mcf00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    102142941 (PLCE1)
 09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    102142941 (PLCE1)
   04015 Rap1 signaling pathway
    102142941 (PLCE1)
   04020 Calcium signaling pathway
    102142941 (PLCE1)
   04070 Phosphatidylinositol signaling system
    102142941 (PLCE1)
   04024 cAMP signaling pathway
    102142941 (PLCE1)
 09150 Organismal Systems
  09152 Endocrine system
   04919 Thyroid hormone signaling pathway
    102142941 (PLCE1)
 09160 Human Diseases
  09161 Cancer: overview
   05205 Proteoglycans in cancer
    102142941 (PLCE1)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    102142941 (PLCE1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:mcf04131]
    102142941 (PLCE1)
Enzymes [BR:mcf01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     102142941 (PLCE1)
Membrane trafficking [BR:mcf04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    102142941 (PLCE1)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    102142941 (PLCE1)
SSDB
Motif
Pfam: PI-PLC-X PI-PLC-Y RasGEF RA C2 EF-hand_like GDPD
Other DBs
NCBI-GeneID: 102142941
NCBI-ProteinID: XP_005566043
Ensembl: ENSMFAG00000020572
LinkDB
Position
9:join(102785316..102786521,102899262..102899550,102943178..102943494,102997817..102997962,103004818..103005076,103006682..103006887,103016663..103017338,103023051..103023233,103024927..103025044,103025934..103026090,103029224..103029346,103029436..103029572,103032889..103033127,103036010..103036071,103036157..103036322,103039293..103039400,103040425..103040541,103042205..103042363,103048485..103048614,103051511..103051552,103052501..103052622,103053538..103053655,103061910..103062041,103066431..103066721,103072524..103072687,103074500..103074761,103076654..103076772,103081328..103081456,103084993..103085202,103090200..103090358,103092571..103092789,103093112..103093300)
AA seq 2317 aa
MTSEEITASVLIPVTQRKVVSAQSAADESSEKVSDINISKAHTVRQSGETSHTISRLNKL
KEEPSGSNLPKILSITREKIVSDENSNEKCWEKSMPDSVKNLNINCNNILRNHQHGLPQR
QFYEMYNSVVEEDLCLETGILSPLERKVFPGIQLELDRPSMGINPLGNQSAIIETGRADP
DSSTAVFHFHYEVDRRMSDTFCTLSENLILDDCGNCVPLPGGEEKQKENYMAYTCKLMEL
AKNCDNKNEQLQCDHCDTLNDKYFCFEGSCQKVDMVYSSHSFCKEDFTDSQTAKTFLSHF
EDFPDNCEDVEEDAFKSKKERSTLLVRRFCKNDREVKKSVYTGTRAIVRTLPSGHIGLIA
WSYIDQKRNGPLLPCGRVMEPLSTVEIKQGGSRRLSEAQWYPIYNAVRRGEETENTVGSL
LHFFTKLPASETAHGRISVGPCLKQCVRDTVYEYRATLQRTSISQYITGSLLEATTSLGA
RSGLLSTFGGSTGRMMLKERQPGPSVANSNTLPSSSAGISKELIDLQPLIQFPEEVASIL
MEQEQSIYRRVLPVDYLCFLTRDLGTPECQRSLPCLKASISASILTTQNGEHNALEDLVM
RFNEVSSWVTWLILTAGSMEEKREVFSYLVHVAKCCWNMGNYNAVMEFLAGLRSRKVLKM
WQFMDQSDIETMRSLKDAMAQHESSCEYRKVVTRALHIPGCKVVPFCGVFLKELCEVLDG
ASGLMKICPRYNSQEETLEFVADYSGQDNFLQRVGQNGLKNSEKESTVNSIFQVIRSCSR
SLETDEEDSPSEGNSSRKSSLKDKSRWQFIIGDLLDSDNDIFEQSKEYDSHGSEDSQKAF
DHGTELIPWYVLSIQADVHQFLLQGATVIHYDQDTHLSARCFLQLQPDNSTLTWVKPTTA
SPASTKAKLGVLNNTAEPGKFPLLGNAGLSGLTEGVLDLFAVKAVYMGHPGIDIHTVCVQ
NKLGSMFLSETGVTLLYGLQTTDNRLLHFVAPKHTAKMLFSGLLELTRAVRKMRKFPDQR
QQWLRKQYVSLYQEDGRYEGPTLAHAVELFGGRRWSARNPSPGTSAKNAEKPSMQRNNTL
GISTTKKKKKILMRGESGEATDDEMATRKAKMHKECRSRSGSDPQDINEQEESEANTIAS
PPNPLPSRRAHSLTTAGSPNLAAGTSSPIRPVSSPVLPSSNKSPSSAWSSSSWHGRIKGG
MKGFQSFMVSDSNMSFVEFVELFKSFSVRSRKDLKDLFDVYAVPCSRSGSESAPLYTNLM
IDENTSDLQPDLDLLTRNVSDLGLFIKSKQQLSDNQRQISDAIAAASIVTNGTGIESTSL
GIFGVGILQLNDFLVNCQGEHCTYDEILSIIQKFEPNISMCHQGLMSFEGFARFLMDKEN
FASKNDESQENIKELQLPLSYYYIESSHNTYLTGHQLKGESSVELYSQVLLQGCRSVELD
CWDGDDGMPIIYHGHTLTTKIPFKEVVEAIDRSAFINSDLPIIISIENHCSLPQQRKMAE
IFKTVFGEKLVAKFLFETDFSDDPMLPSPDQLRRKVLLKNKKLKAHQTPVDILKQKAHQL
ASMQAQAYNGGNANPPPANNEEEEDEEDEYDYDYESLSDADVLTASPAPNGQEDNILEDR
PENKSCNDKLQFEYSEEIPKRIKKADNSACNKGKVYDMELGEEFYLDQNKKESRQIAPEL
SDLVIYCQAVKFPGLSTLNASGSNRGKERKSRKSIFGNNPGRMSPGETASFNKTSGKSSC
EGIRQTWEESSSPLNPTTSLSAIIRTPKCYHISSLNENAAKRLCRRYSQKLIQHTACQLL
RTYPAATRIDSSNPNPIMFWLHGIQLVALNYQTDDLPLHLNAAMFEANGGCGYVLKPPVL
WDKNCPMYQKFSPLERDLDSMDPVVYSLTIVSGQNVCPSNSTGSPCIEVDVLGMPLDSCH
FRTKPIHRNTLNPMWNEQFLFRVHFEDLVFLRFAVVENNSSAVTAQRIIPLKALKRGYRH
LQLRNLHNEVLEISSLFINSRRMEENSSGSPMSASSMFTTEERKCLQTHRVTVHGVPGPE
PFTVFTINGGTKAKQLLQQILTTEQDIKPVTTDYFLMEEKYFISKEKNECRKQPFQRAIG
PEEEIVQILSSWFPEEGYVGRILLKTQQENLEEKNIVQDDKEVILSSEEESFFVQVHDVS
PEQPRTVIKAPRVSTAQDVIQQTLCKAKYSYSILSNPNPSDYVLLEEVVKDTTNKKSTTP
KSSQRVLLDQECVFQAQSKWKGAGKFILKLKEQVQASREDKKKGISFASELKKLTKSTKQ
PRGLTSPSQLLTSESIQTKEEKPVGGLSSSDTMDYRQ
NT seq 6954 nt   +upstreamnt  +downstreamnt
atgacttctgaagaaattacagcttctgttctcatacctgtgactcagagaaaagtggtt
tctgcccagtcagctgcagatgaaagtagtgaaaaggtctcagacatcaatatttcaaaa
gcacatactgtcagacaaagtggggagacttctcataccatctcacgactgaacaaactt
aaagaagaaccttctggaagcaacttgccaaagattctctcaataacaagggagaaaata
gtgagtgatgagaacagtaatgaaaaatgctgggagaaaagcatgccagattctgtgaaa
aaccttaacattaactgcaacaacatattgagaaaccatcagcatggccttcctcaaaga
cagttttatgaaatgtacaactctgttgttgaggaagacctgtgtttagaaactggaatt
ctgtctccactggaaagaaaggtgttccctggaattcaactggaactagacagaccttcc
atgggcattaatcctttaggaaatcagtcagcaatcatagagacaggcagagcagaccct
gacagcagcacggcagtatttcattttcattatgaagttgacagaagaatgtcagacact
ttctgtaccctatcagaaaacttaattttagacgattgtggaaattgtgtaccactacct
gggggtgaggagaagcaaaaggaaaactacatggcatatacctgtaaactgatggaattg
gccaaaaattgtgataataagaatgaacagctgcagtgtgatcattgtgacaccttgaat
gataaatacttttgctttgaaggctcttgccagaaggtggacatggtatattcaagtcat
agtttttgtaaggaagattttactgacagtcaaactgccaagacctttttgagccatttt
gaggacttccctgataattgtgaagatgtagaagaagatgcttttaaaagcaaaaaggag
cggtccactttgttagtcaggagattctgtaaaaatgacagagaagttaagaaatctgtg
tataccggaacaagagcaattgtgaggactctgccttctggccacattgggctgattgca
tggagttacatagatcagaagagaaatggtcccttactgccttgtgggagagtaatggaa
cccctatcaacagtggagataaagcaaggtgggagccgacgtctgtcagaagcccagtgg
tatcctatctacaatgcagtgagaagaggagaagaaacagaaaatacagttggatctcta
ctccatttcttcaccaagctcccagcctccgagacagcccatggaagaataagtgttggt
ccatgcttaaagcaatgtgtccgagacactgtatatgagtatcgcgccaccctccaaagg
acttcaatatcgcagtacatcaccggttctctcctagaagcaaccacatctttgggagca
agaagtggccttctcagtacttttggaggatccactggacgaatgatgctgaaagaacgc
cagccaggcccctctgtggccaattccaacaccctcccttcaagttcagctgggatcagc
aaggagctgatcgatctgcagcctctcatccagttcccagaggaagtcgccagcatcctg
atggagcaggagcagagtatttaccgcagggtcttgccggtcgactacctttgcttctta
acacgggacttgggcactcccgaatgccagaggtccctgccctgcctcaaagcatccatc
tcagcgtcaattcttaccactcagaatggagagcacaatgcccttgaagatctggtgatg
aggtttaatgaggtgagctcctgggtgacgtggctgatcctcacggcaggctccatggag
gagaagcgagaagtcttttcatatttggtgcatgtggccaagtgctgctggaacatgggc
aactacaacgctgtcatggagttcttggctggcctcaggtcaagaaaagttttaaaaatg
tggcagtttatggaccagtctgatattgagaccatgaggagcctgaaggatgctatggcc
cagcatgagtcctcttgtgagtacagaaaggtggtgacacgtgccctgcacatccctggc
tgtaaggtggttccgttctgtggagtgtttcttaaggagctctgtgaagtgcttgacggc
gcctctggcctcatgaagatatgcccgcggtacaattcccaagaagaaactttagagttt
gtagcagattacagtggacaagataatttcttacaacgagtgggacaaaatggcttaaag
aattcggagaaggagtccactgtcaacagcatctttcaggtcatccggagctgcagtcga
agtctggagacagacgaggaggacagccccagtgaagggaacagctccaggaaaagttcc
ttgaaggataaaagccgatggcagtttataattggagatttgttggattcagacaatgat
atctttgagcaatccaaagaatacgactctcatggttcagaggactcacagaaggccttc
gaccatggaacggagctcatcccatggtatgtgctgtccatccaagccgatgtgcaccag
ttcctgctgcagggtgccacggtcatccactacgaccaggacacacacctctctgcccgc
tgcttcctccagcttcagcctgacaatagcaccttgacctgggtaaagcccacaactgcc
tccccagccagcactaaagcaaaacttggtgtacttaataacacagctgagcctggaaaa
ttcccactactgggcaatgctggattaagtggcctgacggaaggggtcttggatcttttt
gcagtgaaggctgtatacatgggccaccctggcattgatatacacactgtgtgtgttcaa
aacaaactgggtagcatgttcctgtcagagactggtgtgacactgctctatgggcttcag
accacggacaatagattattgcacttcgtggcaccaaagcacacagctaaaatgctcttc
agcggattgttggaactcactagagctgtgagaaagatgaggaaattccctgaccaaaga
cagcagtggctgcggaaacagtacgtcagcctctatcaggaggatggacggtatgaaggc
ccaactttggctcatgctgtggagttgtttggtggcagacgatggagtgctcgaaacccc
agccccggcacatctgcaaagaatgctgagaagcccagtatgcagagaaacaacaccctg
ggcataagcactaccaagaaaaagaagaaaatcctcatgaggggtgagagtggagaggca
actgacgacgagatggcaacccgaaaggccaagatgcacaaagagtgtcgaagccggagt
ggttctgatcctcaagacattaatgaacaagaagaatcagaggcgaataccatcgctagc
ccgccaaaccccctcccttccagaagagcccactctttgaccacagctgggtcccccaac
ttggctgccgggacgtcatctcccatcaggccagtgtcctcccctgtgctgccttcttca
aacaagagcccgtccagtgcttggagcagtagtagctggcacgggcggatcaaaggcggc
atgaagggatttcagagcttcatggtttcagacagcaacatgagttttgttgaatttgtt
gagctgttcaaatcgttcagtgtcaggagccgcaaggacctgaaggatctgtttgatgtc
tatgcagtgccctgcagccgatctggatccgagtcagccccgctctacaccaacttgatg
attgatgaaaacaccagcgatcttcagcctgacctagatctgttgaccagaaatgtctca
gatttggggttgttcatcaagagtaaacagcagctatcggacaaccagaggcagatatct
gatgccattgctgctgcaagcatcgtgacaaatggcactgggattgagagcacatctctg
ggcattttcggggtgggcatacttcagctcaacgatttcctcgtgaattgccaaggagaa
cactgcacttatgatgaaatcctcagcatcatccagaagtttgagcctaacatcagtatg
tgtcatcagggactaatgtcatttgaagggtttgcaaggtttctgatggataaagaaaat
tttgcctcaaaaaatgatgagtcacaggagaacattaaagaactgcagctacccctctca
tactattacatcgaatcttcgcacaatacctacctcacgggccatcagctcaaaggagaa
tcctcggtagaactctacagccaggtcctcttgcaaggctgtcgaagtgtagaattggac
tgctgggatggagacgatgggatgcccatcatttatcatggacatacactgacaaccaag
atccccttcaaggaagtggttgaagccattgatcgcagtgccttcatcaactctgacctg
ccaatcatcatatcgattgagaaccactgttcattgcctcagcaacgaaaaatggcagaa
attttcaagactgtgtttggagaaaagctggtggctaaattcttatttgagactgatttc
tcagatgatccaatgcttccttcacctgaccaactcagaaggaaagtgcttcttaaaaac
aagaaactaaaagcccatcagacgccagtggatatcttaaagcaaaaggctcatcagtta
gcatctatgcaagcgcaggcttataatggtgggaatgccaaccccccacctgccaataat
gaggaagaggaagatgaggaggacgaatatgattatgactatgaatccctttctgatgca
gatgtccttactgcctcccctgctcctaacggtcaggaagacaacattctggaagacaga
cctgaaaataaatcatgtaatgacaagcttcagtttgagtatagtgaagaaatccccaag
aggataaagaaggcagataactctgcttgcaacaaaggaaaggtttatgatatggaactg
ggagaagaattttatcttgatcagaataaaaaggaaagcagacagattgcaccagagctt
tctgaccttgtaatctattgtcaagcagtaaaatttccaggactgtcaactctaaatgca
tctggctctaacagaggaaaggaaaggaaaagcaggaagtccatttttggcaacaatccg
ggcagaatgagcccaggggagacagcatcatttaacaaaacatctggaaaaagttcctgt
gaaggcattcgacagacctgggaggaatcttcttcccctctcaacccaaccacgtccctc
agtgctatcattagaactcctaaatgttatcatatctcgtcgctgaatgaaaatgccgcc
aaacgtctgtgtcgcaggtattctcagaaactgatccagcataccgcctgtcagctgctg
agaacttaccctgctgccactcgcatcgactcctccaacccgaaccccatcatgttctgg
ctccatgggatacagctcgtggcactcaactaccagaccgatgatctccctttacattta
aatgctgcaatgtttgaggcaaatggtggttgtggttatgttttgaaacctccagttctg
tgggacaagaactgcccgatgtatcagaagttttctccactggaaagagatttggacagc
atggatcctgtagtctattctttaactattgtctctggtcagaatgtgtgccccagtaac
agcacgggaagcccgtgcattgaagtcgacgtcctgggcatgcctctggacagctgccat
ttccgcacaaagcccatccatcgaaacaccctgaaccccatgtggaacgagcagtttctg
ttccgcgttcacttcgaagatcttgtatttcttcgttttgcagttgtggaaaacaacagt
tcagcggtaactgctcagagaatcattccactgaaagctttaaaacgaggctatcgacat
cttcagctgcgaaaccttcacaatgaagtcttggagatctctagtttattcattaacagc
agaaggatggaagaaaattcctctggcagtcccatgtcagcctcttcgatgtttactaca
gaagaaagaaaatgtttgcagactcacagagtcacggtgcatggggtcccagggccagag
ccctttactgttttcactattaatggaggcaccaaggcaaagcaacttctgcagcaaatt
ctgacaactgaacaagacatcaaacctgttaccacagactattttttgatggaagaaaaa
tattttatatctaaagaaaagaatgaatgcaggaaacaaccattccagagagccattggt
ccagaagaggagatcgtgcaaattttaagcagctggtttccagaagagggatatgtgggc
aggattctcttaaaaacccagcaggaaaacctagaagagaaaaacattgttcaagatgac
aaagaggtgatcttgagctcagaggaggagagtttctttgtccaagtgcatgatgtttct
ccagagcaacctcgaacagtcatcaaagcaccccgcgtcagcaccgcacaggatgtcatt
cagcagaccttatgcaaagccaaatattcctacagcatcctgagcaaccccaatccgagt
gactatgtgcttctggaagaggtggtgaaagacactaccaacaagaagtctaccacaccc
aagtcctctcagcgggtccttctggatcaagagtgtgtgtttcaagcccaaagcaagtgg
aaaggtgcaggaaaattcatccttaagctaaaggagcaggtgcaggcatctcgagaagac
aaaaagaaaggcatttcttttgcaagtgaactcaagaagctcaccaagtcaactaaacag
ccccgaggacttacatcaccttctcagctcttgacctcagaaagtatccaaaccaaggag
gagaaacctgtgggtggcttgtcctccagtgacacaatggattaccgacagtga

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