KEGG   Mastomys coucha (southern multimammate mouse): 116073820
Entry
116073820         CDS       T07224                                 
Symbol
Araf
Name
(RefSeq) serine/threonine-protein kinase A-Raf
  KO
K08845  A-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
Organism
mcoc  Mastomys coucha (southern multimammate mouse)
Pathway
mcoc01521  EGFR tyrosine kinase inhibitor resistance
mcoc01522  Endocrine resistance
mcoc04010  MAPK signaling pathway
mcoc04012  ErbB signaling pathway
mcoc04068  FoxO signaling pathway
mcoc04270  Vascular smooth muscle contraction
mcoc04650  Natural killer cell mediated cytotoxicity
mcoc04720  Long-term potentiation
mcoc04726  Serotonergic synapse
mcoc04730  Long-term depression
mcoc04810  Regulation of actin cytoskeleton
mcoc04910  Insulin signaling pathway
mcoc04914  Progesterone-mediated oocyte maturation
mcoc04928  Parathyroid hormone synthesis, secretion and action
mcoc05010  Alzheimer disease
mcoc05022  Pathways of neurodegeneration - multiple diseases
mcoc05034  Alcoholism
mcoc05160  Hepatitis C
mcoc05161  Hepatitis B
mcoc05200  Pathways in cancer
mcoc05205  Proteoglycans in cancer
mcoc05208  Chemical carcinogenesis - reactive oxygen species
mcoc05210  Colorectal cancer
mcoc05211  Renal cell carcinoma
mcoc05212  Pancreatic cancer
mcoc05213  Endometrial cancer
mcoc05214  Glioma
mcoc05215  Prostate cancer
mcoc05218  Melanoma
mcoc05219  Bladder cancer
mcoc05220  Chronic myeloid leukemia
mcoc05221  Acute myeloid leukemia
mcoc05223  Non-small cell lung cancer
mcoc05224  Breast cancer
mcoc05225  Hepatocellular carcinoma
mcoc05226  Gastric cancer
Brite
KEGG Orthology (KO) [BR:mcoc00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    116073820 (Araf)
   04012 ErbB signaling pathway
    116073820 (Araf)
   04068 FoxO signaling pathway
    116073820 (Araf)
 09140 Cellular Processes
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    116073820 (Araf)
 09150 Organismal Systems
  09151 Immune system
   04650 Natural killer cell mediated cytotoxicity
    116073820 (Araf)
  09152 Endocrine system
   04910 Insulin signaling pathway
    116073820 (Araf)
   04914 Progesterone-mediated oocyte maturation
    116073820 (Araf)
   04928 Parathyroid hormone synthesis, secretion and action
    116073820 (Araf)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    116073820 (Araf)
  09156 Nervous system
   04726 Serotonergic synapse
    116073820 (Araf)
   04720 Long-term potentiation
    116073820 (Araf)
   04730 Long-term depression
    116073820 (Araf)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    116073820 (Araf)
   05205 Proteoglycans in cancer
    116073820 (Araf)
   05208 Chemical carcinogenesis - reactive oxygen species
    116073820 (Araf)
  09162 Cancer: specific types
   05210 Colorectal cancer
    116073820 (Araf)
   05212 Pancreatic cancer
    116073820 (Araf)
   05225 Hepatocellular carcinoma
    116073820 (Araf)
   05226 Gastric cancer
    116073820 (Araf)
   05214 Glioma
    116073820 (Araf)
   05221 Acute myeloid leukemia
    116073820 (Araf)
   05220 Chronic myeloid leukemia
    116073820 (Araf)
   05218 Melanoma
    116073820 (Araf)
   05211 Renal cell carcinoma
    116073820 (Araf)
   05219 Bladder cancer
    116073820 (Araf)
   05215 Prostate cancer
    116073820 (Araf)
   05213 Endometrial cancer
    116073820 (Araf)
   05224 Breast cancer
    116073820 (Araf)
   05223 Non-small cell lung cancer
    116073820 (Araf)
  09172 Infectious disease: viral
   05161 Hepatitis B
    116073820 (Araf)
   05160 Hepatitis C
    116073820 (Araf)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    116073820 (Araf)
   05022 Pathways of neurodegeneration - multiple diseases
    116073820 (Araf)
  09165 Substance dependence
   05034 Alcoholism
    116073820 (Araf)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    116073820 (Araf)
   01522 Endocrine resistance
    116073820 (Araf)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:mcoc01001]
    116073820 (Araf)
Enzymes [BR:mcoc01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     116073820 (Araf)
Protein kinases [BR:mcoc01001]
 Serine/threonine kinases: TKL group
  RAF family [OT]
   116073820 (Araf)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Pkinase RBD C1_1 Kinase-like zf-RING-like ABC1 Pkinase_fungal TUG-UBL1 Kdo
Other DBs
NCBI-GeneID: 116073820
NCBI-ProteinID: XP_031201846
LinkDB
Position
X
AA seq 604 aa
MEPPRGPPVGGAEPSRAVGTVKVYLPNKQRTVVTVREGMSVYDSLDKALKVRGLNQDCCV
VYRLIKGRKTVTAWDTAIAPLDGEELIVEVLEDVPLTMHNFVRKTFFSLAFCDFCLKFLF
HGFRCQTCGYKFHQHCSSKVPTVCVDMSTNRRQFYHSIQDLSGGSRQQEAPSNLSVNELL
TPQGPSSFTQQRDQEHFSFPAPANPPLQRIRSTSTPNVHMVSTTAPMDSSLMQFTAQSFS
TDAAGRSGDRAPRGSPSPASVSSGRKSPHSKLPSEQRERKSLADEKKKVKNLGYRDSGYY
WEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVAQPTAEQAQAFKNEMQVLRKTR
HVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTHFDMVQLIDVARQTAQGMDYLHA
KNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQD
PNPYSFQSDVYAYGVVLYELMTGSLPYSHIGSRDQIIFMVGRGYLSPDLSKIFSNCPKAM
RRLLTDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAA
RLVP
NT seq 1815 nt   +upstreamnt  +downstreamnt
atggaaccaccacgaggccctcctgttggtggggctgagccatctcgggcagttggcact
gtcaaagtgtacctgcctaacaagcagcgcacagtggtgactgtccgcgaaggcatgagt
gtctatgactctttggacaaggccctcaaggtgcggggtctcaatcaggactgctgcgtg
gtctacagactcatcaaaggaagaaagacagtcactgcctgggacacagccattgcgcct
ctggatggtgaggagctcattgtggaggtcctagaagatgtaccactgaccatgcacaat
tttgtacggaagacattcttcagcctggccttctgtgacttctgccttaagtttctgttc
catggattccgctgccagacctgtggctacaagttccaccagcattgttcctccaaggtc
cccaccgtctgcgttgacatgagtaccaaccgccgacagttctaccacagcatccaggat
ttgtctggaggctccaggcagcaggaggctccctcaaatctctctgtgaatgagctgcta
accccccagggtcccagctcctttacccagcaacgtgaccaggagcacttctcattccct
gcccctgccaatcccccactgcagcgcatccgctccacatctactcctaacgtccacatg
gtcagcaccacagctcccatggactccagcctcatgcagtttactgctcagagcttcagc
accgatgctgctggtagaagtggtgatcgagcccctcggggtagccctagcccagctagt
gtgtcttcagggaggaagtccccacattccaagttaccttcagaacagcgggagcggaag
tccttggcagatgaaaagaaaaaagtgaagaacctggggtaccgggactcaggctattac
tgggaggtgccacccagtgaggtacagctgttgaagaggatcgggacaggctcttttggc
actgtgtttcgggggcgttggcatggcgatgtagctgtgaaagtgctcaaggttgcccaa
cctaccgctgagcaggcccaggccttcaagaatgagatgcaggtgctcaggaagacacga
catgtcaacattttgctgttcatgggtttcatgactcggccagggtttgccatcatcaca
cagtggtgtgagggttccagcctctaccaccacctacatgtggctgacacgcactttgac
atggtccagctcattgatgtggcccggcagactgcccagggcatggactacctccacgcc
aagaacatcattcaccgagacctaaagtccaacaatatcttcctacatgaggggctcaca
gtcaagattggtgacttcggcctggccacagtgaagacacggtggagtggggcccagcct
ttagagcagccctcagggtctgtgctatggatggcagctgaggtgatccgtatgcaggac
ccgaacccctacagcttccagtcggatgtctatgcctatggtgttgtactctatgagcta
atgaccggctcactgccctacagccacattggcagccgtgaccagatcatctttatggtg
ggccgtggctatctatctccggacctcagcaaaatcttcagtaattgccccaaagccatg
aggcgcctgctgactgactgcctcaagttccagcgggaggagcggcccctatttccccag
attctggccacgatcgagctactgcagcggtcactccccaagattgagcggagtgcctcc
gaaccctccttgcaccgcacccaggctgatgagttgcctgcttgccttctcagcgcagcc
cgccttgtgccttag

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