| Entry |
|
| Symbol |
Plcb2
|
| Name |
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1
|
| KO |
|
| Organism |
mcoc Mastomys coucha (southern multimammate mouse)
|
| Pathway |
| mcoc04070 | Phosphatidylinositol signaling system |
| mcoc04261 | Adrenergic signaling in cardiomyocytes |
| mcoc04613 | Neutrophil extracellular trap formation |
| mcoc04621 | NOD-like receptor signaling pathway |
| mcoc04723 | Retrograde endocannabinoid signaling |
| mcoc04750 | Inflammatory mediator regulation of TRP channels |
| mcoc04925 | Aldosterone synthesis and secretion |
| mcoc04928 | Parathyroid hormone synthesis, secretion and action |
| mcoc04933 | AGE-RAGE signaling pathway in diabetic complications |
| mcoc04935 | Growth hormone synthesis, secretion and action |
| mcoc04961 | Endocrine and other factor-regulated calcium reabsorption |
| mcoc04973 | Carbohydrate digestion and absorption |
| mcoc05022 | Pathways of neurodegeneration - multiple diseases |
|
| Module |
| mcoc_M00130 | Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4 |
|
| Brite |
KEGG Orthology (KO) [BR:mcoc00001]
09100 Metabolism
09101 Carbohydrate metabolism
00562 Inositol phosphate metabolism
116090695 (Plcb2)
09130 Environmental Information Processing
09132 Signal transduction
04015 Rap1 signaling pathway
116090695 (Plcb2)
04310 Wnt signaling pathway
116090695 (Plcb2)
04371 Apelin signaling pathway
116090695 (Plcb2)
04020 Calcium signaling pathway
116090695 (Plcb2)
04070 Phosphatidylinositol signaling system
116090695 (Plcb2)
04072 Phospholipase D signaling pathway
116090695 (Plcb2)
04071 Sphingolipid signaling pathway
116090695 (Plcb2)
04022 cGMP-PKG signaling pathway
116090695 (Plcb2)
09133 Signaling molecules and interaction
04082 Neuroactive ligand signaling
116090695 (Plcb2)
04081 Hormone signaling
116090695 (Plcb2)
09140 Cellular Processes
09144 Cellular community - eukaryotes
04540 Gap junction
116090695 (Plcb2)
09150 Organismal Systems
09151 Immune system
04611 Platelet activation
116090695 (Plcb2)
04613 Neutrophil extracellular trap formation
116090695 (Plcb2)
04621 NOD-like receptor signaling pathway
116090695 (Plcb2)
04062 Chemokine signaling pathway
116090695 (Plcb2)
09152 Endocrine system
04911 Insulin secretion
116090695 (Plcb2)
04922 Glucagon signaling pathway
116090695 (Plcb2)
04929 GnRH secretion
116090695 (Plcb2)
04912 GnRH signaling pathway
116090695 (Plcb2)
04915 Estrogen signaling pathway
116090695 (Plcb2)
04921 Oxytocin signaling pathway
116090695 (Plcb2)
04926 Relaxin signaling pathway
116090695 (Plcb2)
04935 Growth hormone synthesis, secretion and action
116090695 (Plcb2)
04918 Thyroid hormone synthesis
116090695 (Plcb2)
04919 Thyroid hormone signaling pathway
116090695 (Plcb2)
04928 Parathyroid hormone synthesis, secretion and action
116090695 (Plcb2)
04916 Melanogenesis
116090695 (Plcb2)
04924 Renin secretion
116090695 (Plcb2)
04925 Aldosterone synthesis and secretion
116090695 (Plcb2)
04927 Cortisol synthesis and secretion
116090695 (Plcb2)
09153 Circulatory system
04261 Adrenergic signaling in cardiomyocytes
116090695 (Plcb2)
04270 Vascular smooth muscle contraction
116090695 (Plcb2)
09154 Digestive system
04970 Salivary secretion
116090695 (Plcb2)
04971 Gastric acid secretion
116090695 (Plcb2)
04972 Pancreatic secretion
116090695 (Plcb2)
04973 Carbohydrate digestion and absorption
116090695 (Plcb2)
09155 Excretory system
04961 Endocrine and other factor-regulated calcium reabsorption
116090695 (Plcb2)
09156 Nervous system
04724 Glutamatergic synapse
116090695 (Plcb2)
04725 Cholinergic synapse
116090695 (Plcb2)
04728 Dopaminergic synapse
116090695 (Plcb2)
04726 Serotonergic synapse
116090695 (Plcb2)
04720 Long-term potentiation
116090695 (Plcb2)
04730 Long-term depression
116090695 (Plcb2)
04723 Retrograde endocannabinoid signaling
116090695 (Plcb2)
09157 Sensory system
04742 Taste transduction
116090695 (Plcb2)
04750 Inflammatory mediator regulation of TRP channels
116090695 (Plcb2)
09159 Environmental adaptation
04713 Circadian entrainment
116090695 (Plcb2)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
116090695 (Plcb2)
09172 Infectious disease: viral
05163 Human cytomegalovirus infection
116090695 (Plcb2)
09174 Infectious disease: parasitic
05146 Amoebiasis
116090695 (Plcb2)
05142 Chagas disease
116090695 (Plcb2)
05143 African trypanosomiasis
116090695 (Plcb2)
09164 Neurodegenerative disease
05010 Alzheimer disease
116090695 (Plcb2)
05016 Huntington disease
116090695 (Plcb2)
05017 Spinocerebellar ataxia
116090695 (Plcb2)
05022 Pathways of neurodegeneration - multiple diseases
116090695 (Plcb2)
09166 Cardiovascular disease
05417 Lipid and atherosclerosis
116090695 (Plcb2)
05415 Diabetic cardiomyopathy
116090695 (Plcb2)
09167 Endocrine and metabolic disease
04933 AGE-RAGE signaling pathway in diabetic complications
116090695 (Plcb2)
04934 Cushing syndrome
116090695 (Plcb2)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
04131 Membrane trafficking [BR:mcoc04131]
116090695 (Plcb2)
Enzymes [BR:mcoc01000]
3. Hydrolases
3.1 Acting on ester bonds
3.1.4 Phosphoric-diester hydrolases
3.1.4.11 phosphoinositide phospholipase C
116090695 (Plcb2)
Membrane trafficking [BR:mcoc04131]
Exocytosis
Calcium ion-dependent exocytosis
Phospholipases
116090695 (Plcb2)
Endocytosis
Macropinocytosis
Phospholipase C
116090695 (Plcb2)
|
| SSDB |
|
| Motif |
|
| Other DBs |
|
| LinkDB |
|
| Position |
Unknown
|
| AA seq |
1187 aa
MSLLNPVLLPPNVKAYLSQGERFIKWDDETSIASPVILRVDPKGYYLYWTHQNKEMEFLD
VTSIRDTRFGKFAKIPKSQKLREVFNMDFPDNHFLLKTLTVVSGPDMVDLTFHNFVSYKE
NVGKDWAEDVLALAKHPMTANAPRSTFLDKILVKLKMQLNPEGKIPVKNFFQMFPADRKR
VEAALSACHLAKGKNDAINPEDFPESVYKSFLMSLCPRPEIDEIFTSYHAKAKPYMTKEH
LTKFINQKQRDPRLNSLLFPPARPEQVQVLIDKYEPSGINVQRGQLSPEGMVWFLCGPEN
SVLAHDTLLIHQDMTQPLNHYFINSSHNTYLTAGQFSGLSSAEMYRQVLLSGCRCVELDC
WKGKPPDEEPIITHGFTMTTDILFKEAIEAIAESAFKTSPYPVILSFENHVDSPRQQAKM
AEYCRSMFGETLLTDPLENFPLKPGIPLPSPEDLRGKILIKNKKNQFSGPASPSKKPGGV
AEESFLSSVPVEEDTGWTAEDRTEVEEEVVVEEEEEEESGSLDEEEIKKMQSDEGTAGLE
VTAYEEMSSLVNYIQPTKFISFEFSAQKNRSYVVSSFTELKAYELLSKASMQFVDYNKRQ
MSRVYPKGTRMDSSNYMPQMFWNAGCQMVALNFQTMDLPMQQNMALFEFNGQSGYLLKHE
FMRRLDKQFNPFSVDRIDVVVATTLSITVISGQFLSERSVRTYVEVELFGLPGDPKRRYR
TKLSPTANSINPVWKEEPFIFEKILVPELASLRIAVMEEGGKFLGHRIIPINALHSGYHH
LCLRSESNMPLTMPALFVFLEMKDYVPDTWADLTVALANPIKYFNAHDKKKSVKLKEVTG
NLPEATLTQKLFSSGTPVASHSNGAPVSAGNGSTAPGTKAKEEATREVTEPQTTSLEELR
ELKGVVKLQRRHEKELRELERRGARRWEELLQRGAAQLAELQTPAAACKLRPGKGSRKKR
TVPCEETVVASSELPEGADPRVQELKDRLEQELQQQGEEQYRSVLKRKEQHVTEQIAKMM
ELAREKQAAELKTFKETSETDTKEMKKKLEAKRLERIQAMTKVTTDKVAQERLKREINSS
HIQEVVQAVKQMTETLERHQEKLEERQTACLEQIQAMEKQFQEKALAEYEAKMKGLEAEV
KESVRAYFKVCFRAEAENKPERLCEASEESCPQEPLVDRADTQESRL |
| NT seq |
3564 nt +upstreamnt +downstreamnt
atgtctttgctcaaccccgtgctgttgccccctaacgtgaaggcttatctaagccaaggg
gagcgcttcatcaagtgggacgacgaaacttcaatagcctctcctgttatcctccgtgtg
gatcccaagggctactacttatactggacacatcaaaataaggagatggagttcctggat
gtcacgagcatccgagacactcgctttgggaagtttgctaagatacccaagagccagaaa
ctccgggaggtcttcaacatggacttccctgacaaccacttcctgctgaagacactcacg
gtggtgtctggccccgacatggtggacctcaccttccacaactttgtctcttacaaggag
aatgtaggcaaggattgggctgaggatgtattggctctcgccaaacacccaatgacggcc
aatgctccccgaagcacattcctagacaagatcctggtgaagcttaaaatgcagctcaac
cctgaagggaagattcccgtgaagaattttttccagatgtttcctgcagatcgaaaacgt
gtggaagctgccctcagtgcctgtcaccttgcaaaaggcaagaatgatgctatcaatcca
gaggacttcccagaatctgtgtacaagagcttcctcatgagcctgtgtcctcggccagaa
attgatgagatctttacttcttaccatgctaaagctaaaccctacatgaccaaagagcac
ctgaccaaattcatcaatcagaagcagcgagaccctcgactcaactccttgctgttccca
ccagcccggcctgagcaggtgcaggtgctcattgacaagtacgagcccagtggcatcaat
gtgcagagaggccaactgtcaccagaggggatggtctggtttctctgtggaccagagaac
agtgtgctggcccatgatacactgctgatccaccaagacatgacccagccactaaatcac
tacttcatcaactcctcacacaatacctacctgacagctggccagttttcaggcctttcc
tccgctgagatgtaccgccaggtgctgctgtctggctgccgttgtgtcgagttagactgt
tggaagggcaagccccccgatgaagagcccattatcacccatggtttcaccatgaccaca
gatatcttgttcaaggaagcaatcgaagccattgcagaaagtgcctttaagacctccccg
tatcctgtcatcctgtcatttgagaaccacgtggactcaccccgccaacaggctaagatg
gctgagtactgcaggtccatgtttggagagaccttgctcacagatcccctggaaaatttc
cctctgaaacctggcatccctctgcccagccccgaggacctccggggtaagatcctcatt
aagaataagaagaaccagttttctgggccagcatcccccagcaagaagcctggtggggtg
gccgaggaaagcttcctgtctagtgtccctgtagaagaggacacggggtggactgctgag
gaccggactgaggtggaagaggaggtggtggtggaagaggaggaagaggaggagtcagga
agcctggatgaagaagaaattaagaaaatgcagtcggatgagggcacagcaggcctggag
gtgacagcatatgaggaaatgtccagccttgtcaattacatccagcccaccaagtttatc
tccttcgagttctctgcacagaagaacagaagttatgttgtctcttccttcacggagctc
aaggcctacgagctgctctccaaggcctccatgcagtttgtggactataataaacgccag
atgagccgtgtgtaccccaagggcacacgcatggactcttccaactatatgccccagatg
ttctggaatgctggatgtcagatggttgccctcaatttccagacaatggacctgcccatg
cagcagaacatggcactgtttgagttcaacgggcagagtggctacctcctaaagcacgag
ttcatgcgcaggctggacaagcagttcaaccccttctcagtggaccgcattgatgtggtg
gtagccaccaccctttccattacggtcatctctgggcagttcctgtcagagcgcagtgtg
cgcacctatgtggaggtggaactgtttggcctcccaggagaccccaagaggcgctatcgt
accaagctgtcacccactgccaactccatcaatcctgtctggaaagaggagcctttcatc
tttgagaagatcttggtgcctgagctggcctccctcaggatagctgtgatggaagaaggc
ggcaaatttcttggacaccgcatcattcccatcaatgccttacattctggataccaccat
ctgtgcctgcgcagtgagagcaacatgcctcttaccatgcctgctctcttcgtcttcctg
gagatgaaggactacgtacctgacacgtgggcagatcttactgtggcccttgccaacccc
atcaagtatttcaacgcccacgataagaagaagtctgtgaagctcaaagaagtgacagga
aatctgcctgaggccaccctcacgcagaagctcttctcctctgggacgcctgttgccagc
cactccaatggggcgccagtctcagcaggcaatggatcaacagcacccgggaccaaggcc
aaggaggaagctacaagagaagtgacagagccacagacaaccagcttggaagagctgcga
gagctgaagggcgtggtgaagctgcagcgcagacacgagaaggagcttcgagagctggag
cggcgtggagcccggcgctgggaggagctgctgcagcgtggcgccgcacagctggcggag
ctccagaccccagcagcggcctgcaagctccgcccgggcaagggctcccgcaagaagagg
accgtgccctgtgaggagaccgtcgtggcgtctagcgagctccccgagggagcggaccca
cgcgtgcaggagctaaaggacaggctggagcaggagctgcagcagcaaggcgaggagcag
taccgctctgtcctcaagcgcaaggagcagcacgtgaccgagcaaatcgccaagatgatg
gagctggccagagagaaacaggctgccgaactcaagaccttcaaggagacctcggaaact
gacaccaaagagatgaagaaaaaactggaggccaagaggctggaacggatccaagccatg
accaaagtcaccacagacaaggtggcccaggagaggctcaagagagaaatcaatagctcc
cacatccaggaagtggtccaggctgtcaagcagatgacagaaaccctggagcgtcaccag
gaaaagctggaagagaggcagacagcctgcctggagcagatccaggcgatggaaaagcag
ttccaggagaaggcgctggcagagtatgaggccaagatgaagggcctggaggccgaagta
aaggagtcagtgcgggcctacttcaaggtctgcttccgcgctgaagcagaaaacaagcct
gagaggctctgtgaggcctccgaggagtcatgtccacaggaaccacttgtggacagggca
gacacccaggagagccgcctctga |