KEGG   Mastomys coucha (southern multimammate mouse): 116095058
Entry
116095058         CDS       T07224                                 
Symbol
Pik3ca
Name
(RefSeq) phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform isoform X1
  KO
K00922  phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
Organism
mcoc  Mastomys coucha (southern multimammate mouse)
Pathway
mcoc00562  Inositol phosphate metabolism
mcoc01100  Metabolic pathways
mcoc01521  EGFR tyrosine kinase inhibitor resistance
mcoc01522  Endocrine resistance
mcoc01524  Platinum drug resistance
mcoc04012  ErbB signaling pathway
mcoc04014  Ras signaling pathway
mcoc04015  Rap1 signaling pathway
mcoc04024  cAMP signaling pathway
mcoc04062  Chemokine signaling pathway
mcoc04066  HIF-1 signaling pathway
mcoc04068  FoxO signaling pathway
mcoc04070  Phosphatidylinositol signaling system
mcoc04071  Sphingolipid signaling pathway
mcoc04072  Phospholipase D signaling pathway
mcoc04081  Hormone signaling
mcoc04140  Autophagy - animal
mcoc04150  mTOR signaling pathway
mcoc04151  PI3K-Akt signaling pathway
mcoc04152  AMPK signaling pathway
mcoc04210  Apoptosis
mcoc04211  Longevity regulating pathway
mcoc04213  Longevity regulating pathway - multiple species
mcoc04218  Cellular senescence
mcoc04360  Axon guidance
mcoc04370  VEGF signaling pathway
mcoc04380  Osteoclast differentiation
mcoc04510  Focal adhesion
mcoc04550  Signaling pathways regulating pluripotency of stem cells
mcoc04611  Platelet activation
mcoc04613  Neutrophil extracellular trap formation
mcoc04620  Toll-like receptor signaling pathway
mcoc04625  C-type lectin receptor signaling pathway
mcoc04630  JAK-STAT signaling pathway
mcoc04650  Natural killer cell mediated cytotoxicity
mcoc04660  T cell receptor signaling pathway
mcoc04662  B cell receptor signaling pathway
mcoc04664  Fc epsilon RI signaling pathway
mcoc04666  Fc gamma R-mediated phagocytosis
mcoc04668  TNF signaling pathway
mcoc04670  Leukocyte transendothelial migration
mcoc04722  Neurotrophin signaling pathway
mcoc04725  Cholinergic synapse
mcoc04750  Inflammatory mediator regulation of TRP channels
mcoc04810  Regulation of actin cytoskeleton
mcoc04910  Insulin signaling pathway
mcoc04914  Progesterone-mediated oocyte maturation
mcoc04915  Estrogen signaling pathway
mcoc04917  Prolactin signaling pathway
mcoc04919  Thyroid hormone signaling pathway
mcoc04923  Regulation of lipolysis in adipocytes
mcoc04926  Relaxin signaling pathway
mcoc04929  GnRH secretion
mcoc04930  Type II diabetes mellitus
mcoc04931  Insulin resistance
mcoc04932  Non-alcoholic fatty liver disease
mcoc04933  AGE-RAGE signaling pathway in diabetic complications
mcoc04935  Growth hormone synthesis, secretion and action
mcoc04960  Aldosterone-regulated sodium reabsorption
mcoc04973  Carbohydrate digestion and absorption
mcoc05010  Alzheimer disease
mcoc05017  Spinocerebellar ataxia
mcoc05020  Prion disease
mcoc05100  Bacterial invasion of epithelial cells
mcoc05132  Salmonella infection
mcoc05135  Yersinia infection
mcoc05142  Chagas disease
mcoc05146  Amoebiasis
mcoc05160  Hepatitis C
mcoc05161  Hepatitis B
mcoc05162  Measles
mcoc05163  Human cytomegalovirus infection
mcoc05164  Influenza A
mcoc05165  Human papillomavirus infection
mcoc05166  Human T-cell leukemia virus 1 infection
mcoc05167  Kaposi sarcoma-associated herpesvirus infection
mcoc05168  Herpes simplex virus 1 infection
mcoc05169  Epstein-Barr virus infection
mcoc05170  Human immunodeficiency virus 1 infection
mcoc05171  Coronavirus disease - COVID-19
mcoc05200  Pathways in cancer
mcoc05203  Viral carcinogenesis
mcoc05205  Proteoglycans in cancer
mcoc05206  MicroRNAs in cancer
mcoc05207  Chemical carcinogenesis - receptor activation
mcoc05208  Chemical carcinogenesis - reactive oxygen species
mcoc05210  Colorectal cancer
mcoc05211  Renal cell carcinoma
mcoc05212  Pancreatic cancer
mcoc05213  Endometrial cancer
mcoc05214  Glioma
mcoc05215  Prostate cancer
mcoc05218  Melanoma
mcoc05220  Chronic myeloid leukemia
mcoc05221  Acute myeloid leukemia
mcoc05222  Small cell lung cancer
mcoc05223  Non-small cell lung cancer
mcoc05224  Breast cancer
mcoc05225  Hepatocellular carcinoma
mcoc05226  Gastric cancer
mcoc05230  Central carbon metabolism in cancer
mcoc05231  Choline metabolism in cancer
mcoc05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
mcoc05415  Diabetic cardiomyopathy
mcoc05417  Lipid and atherosclerosis
mcoc05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:mcoc00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    116095058 (Pik3ca)
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    116095058 (Pik3ca)
   04014 Ras signaling pathway
    116095058 (Pik3ca)
   04015 Rap1 signaling pathway
    116095058 (Pik3ca)
   04370 VEGF signaling pathway
    116095058 (Pik3ca)
   04630 JAK-STAT signaling pathway
    116095058 (Pik3ca)
   04668 TNF signaling pathway
    116095058 (Pik3ca)
   04066 HIF-1 signaling pathway
    116095058 (Pik3ca)
   04068 FoxO signaling pathway
    116095058 (Pik3ca)
   04070 Phosphatidylinositol signaling system
    116095058 (Pik3ca)
   04072 Phospholipase D signaling pathway
    116095058 (Pik3ca)
   04071 Sphingolipid signaling pathway
    116095058 (Pik3ca)
   04024 cAMP signaling pathway
    116095058 (Pik3ca)
   04151 PI3K-Akt signaling pathway
    116095058 (Pik3ca)
   04152 AMPK signaling pathway
    116095058 (Pik3ca)
   04150 mTOR signaling pathway
    116095058 (Pik3ca)
  09133 Signaling molecules and interaction
   04081 Hormone signaling
    116095058 (Pik3ca)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    116095058 (Pik3ca)
  09143 Cell growth and death
   04210 Apoptosis
    116095058 (Pik3ca)
   04218 Cellular senescence
    116095058 (Pik3ca)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    116095058 (Pik3ca)
   04550 Signaling pathways regulating pluripotency of stem cells
    116095058 (Pik3ca)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    116095058 (Pik3ca)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    116095058 (Pik3ca)
   04613 Neutrophil extracellular trap formation
    116095058 (Pik3ca)
   04620 Toll-like receptor signaling pathway
    116095058 (Pik3ca)
   04625 C-type lectin receptor signaling pathway
    116095058 (Pik3ca)
   04650 Natural killer cell mediated cytotoxicity
    116095058 (Pik3ca)
   04660 T cell receptor signaling pathway
    116095058 (Pik3ca)
   04662 B cell receptor signaling pathway
    116095058 (Pik3ca)
   04664 Fc epsilon RI signaling pathway
    116095058 (Pik3ca)
   04666 Fc gamma R-mediated phagocytosis
    116095058 (Pik3ca)
   04670 Leukocyte transendothelial migration
    116095058 (Pik3ca)
   04062 Chemokine signaling pathway
    116095058 (Pik3ca)
  09152 Endocrine system
   04910 Insulin signaling pathway
    116095058 (Pik3ca)
   04923 Regulation of lipolysis in adipocytes
    116095058 (Pik3ca)
   04929 GnRH secretion
    116095058 (Pik3ca)
   04915 Estrogen signaling pathway
    116095058 (Pik3ca)
   04914 Progesterone-mediated oocyte maturation
    116095058 (Pik3ca)
   04917 Prolactin signaling pathway
    116095058 (Pik3ca)
   04926 Relaxin signaling pathway
    116095058 (Pik3ca)
   04935 Growth hormone synthesis, secretion and action
    116095058 (Pik3ca)
   04919 Thyroid hormone signaling pathway
    116095058 (Pik3ca)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    116095058 (Pik3ca)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    116095058 (Pik3ca)
  09156 Nervous system
   04725 Cholinergic synapse
    116095058 (Pik3ca)
   04722 Neurotrophin signaling pathway
    116095058 (Pik3ca)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    116095058 (Pik3ca)
  09158 Development and regeneration
   04360 Axon guidance
    116095058 (Pik3ca)
   04380 Osteoclast differentiation
    116095058 (Pik3ca)
  09149 Aging
   04211 Longevity regulating pathway
    116095058 (Pik3ca)
   04213 Longevity regulating pathway - multiple species
    116095058 (Pik3ca)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    116095058 (Pik3ca)
   05206 MicroRNAs in cancer
    116095058 (Pik3ca)
   05205 Proteoglycans in cancer
    116095058 (Pik3ca)
   05207 Chemical carcinogenesis - receptor activation
    116095058 (Pik3ca)
   05208 Chemical carcinogenesis - reactive oxygen species
    116095058 (Pik3ca)
   05203 Viral carcinogenesis
    116095058 (Pik3ca)
   05230 Central carbon metabolism in cancer
    116095058 (Pik3ca)
   05231 Choline metabolism in cancer
    116095058 (Pik3ca)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    116095058 (Pik3ca)
  09162 Cancer: specific types
   05210 Colorectal cancer
    116095058 (Pik3ca)
   05212 Pancreatic cancer
    116095058 (Pik3ca)
   05225 Hepatocellular carcinoma
    116095058 (Pik3ca)
   05226 Gastric cancer
    116095058 (Pik3ca)
   05214 Glioma
    116095058 (Pik3ca)
   05221 Acute myeloid leukemia
    116095058 (Pik3ca)
   05220 Chronic myeloid leukemia
    116095058 (Pik3ca)
   05218 Melanoma
    116095058 (Pik3ca)
   05211 Renal cell carcinoma
    116095058 (Pik3ca)
   05215 Prostate cancer
    116095058 (Pik3ca)
   05213 Endometrial cancer
    116095058 (Pik3ca)
   05224 Breast cancer
    116095058 (Pik3ca)
   05222 Small cell lung cancer
    116095058 (Pik3ca)
   05223 Non-small cell lung cancer
    116095058 (Pik3ca)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    116095058 (Pik3ca)
   05170 Human immunodeficiency virus 1 infection
    116095058 (Pik3ca)
   05161 Hepatitis B
    116095058 (Pik3ca)
   05160 Hepatitis C
    116095058 (Pik3ca)
   05171 Coronavirus disease - COVID-19
    116095058 (Pik3ca)
   05164 Influenza A
    116095058 (Pik3ca)
   05162 Measles
    116095058 (Pik3ca)
   05168 Herpes simplex virus 1 infection
    116095058 (Pik3ca)
   05163 Human cytomegalovirus infection
    116095058 (Pik3ca)
   05167 Kaposi sarcoma-associated herpesvirus infection
    116095058 (Pik3ca)
   05169 Epstein-Barr virus infection
    116095058 (Pik3ca)
   05165 Human papillomavirus infection
    116095058 (Pik3ca)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    116095058 (Pik3ca)
   05135 Yersinia infection
    116095058 (Pik3ca)
   05100 Bacterial invasion of epithelial cells
    116095058 (Pik3ca)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    116095058 (Pik3ca)
   05142 Chagas disease
    116095058 (Pik3ca)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    116095058 (Pik3ca)
   05017 Spinocerebellar ataxia
    116095058 (Pik3ca)
   05020 Prion disease
    116095058 (Pik3ca)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    116095058 (Pik3ca)
   05418 Fluid shear stress and atherosclerosis
    116095058 (Pik3ca)
   05415 Diabetic cardiomyopathy
    116095058 (Pik3ca)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    116095058 (Pik3ca)
   04932 Non-alcoholic fatty liver disease
    116095058 (Pik3ca)
   04931 Insulin resistance
    116095058 (Pik3ca)
   04933 AGE-RAGE signaling pathway in diabetic complications
    116095058 (Pik3ca)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    116095058 (Pik3ca)
   01524 Platinum drug resistance
    116095058 (Pik3ca)
   01522 Endocrine resistance
    116095058 (Pik3ca)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:mcoc04131]
    116095058 (Pik3ca)
Enzymes [BR:mcoc01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.153  phosphatidylinositol-4,5-bisphosphate 3-kinase
     116095058 (Pik3ca)
Membrane trafficking [BR:mcoc04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    116095058 (Pik3ca)
SSDB
Motif
Pfam: PI3Ka PI3_PI4_kinase PI3K_C2 PI3K_rbd PI3K_p85B DUF2321 ABC1 Ribosomal_S15
Other DBs
NCBI-GeneID: 116095058
NCBI-ProteinID: XP_031232425
LinkDB
Position
Unknown
AA seq 1068 aa
MPPRPSSGELWGIHLMPPRILVECLLPNGMIVTLECLREATLVTIKHELFKEARKYPLHQ
LLQDESSYIFVSVTQEAEREEFFDETRRLCDLRLFQPFLKVIEPVGNREEKILNREIGFV
IGMPVCEFDMVKDPEVQDFRRNILNVCKEAVDLRDLNSPHSRAMYVYPPNVESSPELPKH
IYNKLDKGQIIVVIWVIVSPNNDKQKYTLKINHDCVPEQVIAEAIRKKTRSMLLSSEQLK
LCVLEYQGKYILKVCGCDEYFLEKYPLSQYKYIRSCIMLGRMPNLMLMAKESLYSQLPID
SFTMPSYSRRISTATPYMNGETSTKSLWVINSALRIKILCATYVNVNIRDIDKIYVRTGI
YHGGEPLCDNVNTQRVPCSNPRWNEWLNYDIYIPDLPRAARLCLSICSVKGRKGAKEEHC
PLAWGNINLFDYTDTLVSGKMALNLWPVPHGLEDLLNPIGVTGSNPNKETPCLELEFDWF
SSVVKFPDMSVIEEHANWSVSREAGFSYSHTGLSNRLARDNELRENDKEQLRALCTRDPL
SEITEQEKDFLWSHRHYCVTIPEILPKLLLSVKWNSRDEVAQMYCLVKDWPPIKPEQAME
LLDCNYPDPMVRSFAVRCLEKYLTDDKLSQYLIQLVQVLKYEQYLDNLLVRFLLKKALTN
QRIGHFFFWHLKSEMHNKTVSQRFGLLLESYCRACGMYLKHLNRQVEAMEKLINLTDILK
QEKKDETQKVQMKFLVEQMRQPDFMDALQGFLSPLNPAHQLGNLRLEECRIMSSAKRPLW
LNWENPDIMSELLFQNNEIIFKNGDDLRQDMLTLQIIRIMENIWQNQGLDLRMLPYGCLS
IGDCVGLIEVVRNSHTIMQIQCKGGLKGALQFNSHTLHQWLKDKNKGEIYDAAIDLFTRS
CAGYCVATFILGIGDRHNSNIMVKDDGQLFHIDFGHFLDHKKKKFGYKRERVPFVLTQDF
LIVISKGAQEYTKTREFERFQEMCYKAYLAIRQHANLFINLFSMMLGSGMPELQSFDDIA
YIRKTLALDKTEQEALEYFTKQMNDAHHGGWTTKMDWIFHTIKQHALN
NT seq 3207 nt   +upstreamnt  +downstreamnt
atgcctccacgaccatcttcgggtgaactgtggggcatccacttgatgcccccacgaatc
ctagtggaatgtttactccccaatggaatgatagtgactttggaatgcctccgtgaggcc
acgctagtcaccatcaaacatgagctgttcaaagaggccaggaagtaccctctgcaccag
ctgctgcaggatgagtcttcttacattttcgtaagtgttacccaggaagcagaaagggaa
gaattctttgatgaaacaagacggctttgtgaccttcggctttttcaaccctttttaaaa
gtaattgaaccagtaggcaaccgtgaagaaaagatcctcaatcgagaaattggttttgtt
attggcatgccagtgtgtgaatttgatatggttaaagatccagaagtccaagactttcga
aggaacattctgaatgtttgcaaagaagccgtggacttgcgggatctcaactcgcctcac
agcagagcaatgtatgtctaccctccaaatgtcgagtcttccccagaactgccaaagcac
atctacaacaagttagataaaggacaaatcatcgtggtgatttgggtaatagtctctcca
aacaatgacaagcagaagtacactctgaagatcaaccatgactgtgtgccagagcaagtc
attgctgaagccatcaggaagaagactcggagcatgttgttgtcctctgagcagctgaag
ctctgtgtcttagaataccagggcaagtatattctgaaggtgtgtggctgtgatgaatac
ttcctagaaaagtaccctctgagtcagtacaagtatataagaagctgtataatgctgggg
aggatgcccaacttgatgctgatggccaaggaaagcctatactctcagctgcctatcgat
agcttcacaatgccctcatactctaggcgcatctccacagccacaccctacatgaatgga
gagacatctacgaaatccctctgggttataaatagtgccctcagaataaaaattctttgt
gcaacctatgtaaatgtaaatattcgagacattgataagatctatgttcgaacaggtatc
taccatggaggagaacccttatgtgacaatgtgaacactcaaagagtaccttgttccaat
cctaggtggaatgaatggctgaattatgatatatacattcctgatcttcctcgtgctgcg
cgcctttgcctttcaatctgctctgttaaaggccgaaagggtgctaaggaggagcactgt
ccgttggcctggggaaacataaacttgtttgattatacagacaccctagtgtccgggaaa
atggctttgaatctctggcctgtaccacatgggttagaagatctgctgaaccctattggt
gttactggatcaaatccaaataaagaaactccatgcttagagttggagtttgattggttc
agcagtgtggtgaagtttccagacatgtctgtgattgaagagcatgctaattggtctgtg
tcccgagaagctggattcagttactctcatacaggcctgagtaacagactagccagagac
aatgagttaagagaaaatgacaaggaacagctccgagcactttgcacccgggatccactg
tctgaaatcactgaacaagagaaagacttcctatggagccacagacactactgtgtaact
attcctgaaatcctacccaaattgcttctgtctgtcaagtggaattccagagatgaagtg
gcccagatgtactgcttagtaaaagattggcctccaatcaaaccggagcaagccatggaa
ctcctggactgtaactatccagatcctatggttcggagttttgctgttcggtgcttggaa
aaatacttaacagatgacaaactttctcagtacctcattcagcttgtacaggtcttaaaa
tatgaacaatatttggataacctgcttgtgagatttttactcaagaaagcattgacaaat
caaaggattggccattttttcttttggcatttaaaatccgagatgcacaataagactgtc
agtcagaggtttggcctgctcttggagtcctactgccgtgcctgtgggatgtatctcaag
cacctgaacagacaagtagaggccatggagaagctcatcaacctaactgacatcctcaag
caggagaaaaaggatgagacacaaaaggtacagatgaagtttttggttgaacagatgaga
cagccagatttcatggatgctttgcagggttttctgtcccctctaaatcctgctcatcaa
ctaggaaacctcaggcttgaagaatgtcgaattatgtcctctgcaaaaaggccactgtgg
ttgaattgggagaacccagacatcatgtcagagctactgtttcagaacaatgagatcatc
tttaaaaatggtgacgacttacggcaagatatgttaacccttcagatcatccgaatcatg
gagaacatctggcaaaaccaaggccttgaccttcgcatgctaccttatggctgtctatcc
attggagactgtgtgggtctcatcgaggtggtaagaaactctcacaccatcatgcagatc
cagtgcaaaggaggcctgaagggggcgctgcaattcaacagccacacactgcatcagtgg
ctcaaggacaagaacaagggcgagatatatgatgcagccattgacctgttcactcggtcc
tgcgctgggtactgcgtggcaacctttatcttgggaattggagaccggcacaacagcaac
atcatggtgaaagatgacggacagctgtttcatatagattttgggcactttttggatcac
aagaagaaaaaatttggctataaacgggaacgtgtgccatttgttttgacgcaggatttc
ttgattgtgattagtaaaggagcacaagagtacacaaagaccagagagtttgagaggttt
caggagatgtgttacaaggcttacctagcaattcggcagcatgccaatctcttcatcaac
cttttttcaatgatgcttggctctggaatgccagaactgcagtcttttgatgacattgca
tatattcgaaagactctagccttggacaaaactgagcaagaggctttggaatatttcaca
aagcaaatgaatgatgcccatcatggtggctggacgacaaaaatggattggatcttccac
accatcaagcagcatgcattgaactga

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