KEGG   Mastomys coucha (southern multimammate mouse): 116099433
Entry
116099433         CDS       T07224                                 
Symbol
Raf1
Name
(RefSeq) RAF proto-oncogene serine/threonine-protein kinase isoform X1
  KO
K04366  RAF proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
Organism
mcoc  Mastomys coucha (southern multimammate mouse)
Pathway
mcoc01521  EGFR tyrosine kinase inhibitor resistance
mcoc01522  Endocrine resistance
mcoc04010  MAPK signaling pathway
mcoc04012  ErbB signaling pathway
mcoc04014  Ras signaling pathway
mcoc04015  Rap1 signaling pathway
mcoc04022  cGMP-PKG signaling pathway
mcoc04024  cAMP signaling pathway
mcoc04062  Chemokine signaling pathway
mcoc04068  FoxO signaling pathway
mcoc04071  Sphingolipid signaling pathway
mcoc04072  Phospholipase D signaling pathway
mcoc04140  Autophagy - animal
mcoc04150  mTOR signaling pathway
mcoc04151  PI3K-Akt signaling pathway
mcoc04210  Apoptosis
mcoc04218  Cellular senescence
mcoc04270  Vascular smooth muscle contraction
mcoc04360  Axon guidance
mcoc04370  VEGF signaling pathway
mcoc04371  Apelin signaling pathway
mcoc04510  Focal adhesion
mcoc04540  Gap junction
mcoc04550  Signaling pathways regulating pluripotency of stem cells
mcoc04613  Neutrophil extracellular trap formation
mcoc04625  C-type lectin receptor signaling pathway
mcoc04630  JAK-STAT signaling pathway
mcoc04650  Natural killer cell mediated cytotoxicity
mcoc04660  T cell receptor signaling pathway
mcoc04662  B cell receptor signaling pathway
mcoc04664  Fc epsilon RI signaling pathway
mcoc04666  Fc gamma R-mediated phagocytosis
mcoc04720  Long-term potentiation
mcoc04722  Neurotrophin signaling pathway
mcoc04726  Serotonergic synapse
mcoc04730  Long-term depression
mcoc04810  Regulation of actin cytoskeleton
mcoc04910  Insulin signaling pathway
mcoc04912  GnRH signaling pathway
mcoc04914  Progesterone-mediated oocyte maturation
mcoc04915  Estrogen signaling pathway
mcoc04916  Melanogenesis
mcoc04917  Prolactin signaling pathway
mcoc04919  Thyroid hormone signaling pathway
mcoc04921  Oxytocin signaling pathway
mcoc04926  Relaxin signaling pathway
mcoc04928  Parathyroid hormone synthesis, secretion and action
mcoc04929  GnRH secretion
mcoc04935  Growth hormone synthesis, secretion and action
mcoc05010  Alzheimer disease
mcoc05022  Pathways of neurodegeneration - multiple diseases
mcoc05034  Alcoholism
mcoc05132  Salmonella infection
mcoc05152  Tuberculosis
mcoc05160  Hepatitis C
mcoc05161  Hepatitis B
mcoc05163  Human cytomegalovirus infection
mcoc05164  Influenza A
mcoc05165  Human papillomavirus infection
mcoc05167  Kaposi sarcoma-associated herpesvirus infection
mcoc05170  Human immunodeficiency virus 1 infection
mcoc05200  Pathways in cancer
mcoc05205  Proteoglycans in cancer
mcoc05206  MicroRNAs in cancer
mcoc05207  Chemical carcinogenesis - receptor activation
mcoc05208  Chemical carcinogenesis - reactive oxygen species
mcoc05210  Colorectal cancer
mcoc05211  Renal cell carcinoma
mcoc05212  Pancreatic cancer
mcoc05213  Endometrial cancer
mcoc05214  Glioma
mcoc05215  Prostate cancer
mcoc05218  Melanoma
mcoc05219  Bladder cancer
mcoc05220  Chronic myeloid leukemia
mcoc05221  Acute myeloid leukemia
mcoc05223  Non-small cell lung cancer
mcoc05224  Breast cancer
mcoc05225  Hepatocellular carcinoma
mcoc05226  Gastric cancer
mcoc05230  Central carbon metabolism in cancer
mcoc05231  Choline metabolism in cancer
mcoc05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:mcoc00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    116099433 (Raf1)
   04012 ErbB signaling pathway
    116099433 (Raf1)
   04014 Ras signaling pathway
    116099433 (Raf1)
   04015 Rap1 signaling pathway
    116099433 (Raf1)
   04370 VEGF signaling pathway
    116099433 (Raf1)
   04371 Apelin signaling pathway
    116099433 (Raf1)
   04630 JAK-STAT signaling pathway
    116099433 (Raf1)
   04068 FoxO signaling pathway
    116099433 (Raf1)
   04072 Phospholipase D signaling pathway
    116099433 (Raf1)
   04071 Sphingolipid signaling pathway
    116099433 (Raf1)
   04024 cAMP signaling pathway
    116099433 (Raf1)
   04022 cGMP-PKG signaling pathway
    116099433 (Raf1)
   04151 PI3K-Akt signaling pathway
    116099433 (Raf1)
   04150 mTOR signaling pathway
    116099433 (Raf1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    116099433 (Raf1)
  09143 Cell growth and death
   04210 Apoptosis
    116099433 (Raf1)
   04218 Cellular senescence
    116099433 (Raf1)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    116099433 (Raf1)
   04540 Gap junction
    116099433 (Raf1)
   04550 Signaling pathways regulating pluripotency of stem cells
    116099433 (Raf1)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    116099433 (Raf1)
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    116099433 (Raf1)
   04625 C-type lectin receptor signaling pathway
    116099433 (Raf1)
   04650 Natural killer cell mediated cytotoxicity
    116099433 (Raf1)
   04660 T cell receptor signaling pathway
    116099433 (Raf1)
   04662 B cell receptor signaling pathway
    116099433 (Raf1)
   04664 Fc epsilon RI signaling pathway
    116099433 (Raf1)
   04666 Fc gamma R-mediated phagocytosis
    116099433 (Raf1)
   04062 Chemokine signaling pathway
    116099433 (Raf1)
  09152 Endocrine system
   04910 Insulin signaling pathway
    116099433 (Raf1)
   04929 GnRH secretion
    116099433 (Raf1)
   04912 GnRH signaling pathway
    116099433 (Raf1)
   04915 Estrogen signaling pathway
    116099433 (Raf1)
   04914 Progesterone-mediated oocyte maturation
    116099433 (Raf1)
   04917 Prolactin signaling pathway
    116099433 (Raf1)
   04921 Oxytocin signaling pathway
    116099433 (Raf1)
   04926 Relaxin signaling pathway
    116099433 (Raf1)
   04935 Growth hormone synthesis, secretion and action
    116099433 (Raf1)
   04919 Thyroid hormone signaling pathway
    116099433 (Raf1)
   04928 Parathyroid hormone synthesis, secretion and action
    116099433 (Raf1)
   04916 Melanogenesis
    116099433 (Raf1)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    116099433 (Raf1)
  09156 Nervous system
   04726 Serotonergic synapse
    116099433 (Raf1)
   04720 Long-term potentiation
    116099433 (Raf1)
   04730 Long-term depression
    116099433 (Raf1)
   04722 Neurotrophin signaling pathway
    116099433 (Raf1)
  09158 Development and regeneration
   04360 Axon guidance
    116099433 (Raf1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    116099433 (Raf1)
   05206 MicroRNAs in cancer
    116099433 (Raf1)
   05205 Proteoglycans in cancer
    116099433 (Raf1)
   05207 Chemical carcinogenesis - receptor activation
    116099433 (Raf1)
   05208 Chemical carcinogenesis - reactive oxygen species
    116099433 (Raf1)
   05230 Central carbon metabolism in cancer
    116099433 (Raf1)
   05231 Choline metabolism in cancer
    116099433 (Raf1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    116099433 (Raf1)
  09162 Cancer: specific types
   05210 Colorectal cancer
    116099433 (Raf1)
   05212 Pancreatic cancer
    116099433 (Raf1)
   05225 Hepatocellular carcinoma
    116099433 (Raf1)
   05226 Gastric cancer
    116099433 (Raf1)
   05214 Glioma
    116099433 (Raf1)
   05221 Acute myeloid leukemia
    116099433 (Raf1)
   05220 Chronic myeloid leukemia
    116099433 (Raf1)
   05218 Melanoma
    116099433 (Raf1)
   05211 Renal cell carcinoma
    116099433 (Raf1)
   05219 Bladder cancer
    116099433 (Raf1)
   05215 Prostate cancer
    116099433 (Raf1)
   05213 Endometrial cancer
    116099433 (Raf1)
   05224 Breast cancer
    116099433 (Raf1)
   05223 Non-small cell lung cancer
    116099433 (Raf1)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    116099433 (Raf1)
   05161 Hepatitis B
    116099433 (Raf1)
   05160 Hepatitis C
    116099433 (Raf1)
   05164 Influenza A
    116099433 (Raf1)
   05163 Human cytomegalovirus infection
    116099433 (Raf1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    116099433 (Raf1)
   05165 Human papillomavirus infection
    116099433 (Raf1)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    116099433 (Raf1)
   05152 Tuberculosis
    116099433 (Raf1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    116099433 (Raf1)
   05022 Pathways of neurodegeneration - multiple diseases
    116099433 (Raf1)
  09165 Substance dependence
   05034 Alcoholism
    116099433 (Raf1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    116099433 (Raf1)
   01522 Endocrine resistance
    116099433 (Raf1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:mcoc01001]
    116099433 (Raf1)
Enzymes [BR:mcoc01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     116099433 (Raf1)
Protein kinases [BR:mcoc01001]
 Serine/threonine kinases: TKL group
  RAF family [OT]
   116099433 (Raf1)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr RBD C1_1 Kinase-like ABC1 zf-RING-like Pkinase_fungal C1_2
Other DBs
NCBI-GeneID: 116099433
NCBI-ProteinID: XP_031238868
LinkDB
Position
Unknown
AA seq 668 aa
MDAELGHHGRQGISIVQIASMEHIQGAWKTISNGFGLKDAVFDGSSCISPTIVQQFGYQR
RASDDGKLTDSSKTSNTIRVFLPNKQRTVVNVRNGMSLHDCLMKALKVRGLQPECCAVFR
LLQEHKGKKARLDWNTDAASLIGEELQVDFLDHVPLTTHNFARKTFLKLAFCDICQKFLL
NGFRCQTCGYKFHEHCSTKVPTMCVDWSNIRQLLLFPNSTVGDIGVPAPPSFPMRRMRES
VSRMPASSQHRYSTPHAFTFNTSSPSSEGSLSQRQRSTSTPNVHIVSTTLPVDSRMIEDA
IRSHSESASPSALSSSPNNLSPTGWSQPKTPVPAQRERAPGPGTQEKNKIRPRGQRDSSY
YWEIEASEVMLSTRIGSGSFGTVYKGKWHGDVAVKILKVVDPTPEQLQAFRNEVAVLRKT
RHVNILLFMGYMTKDNLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLH
AKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQ
DNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMVGRGYASPDLSRLYKNCPKA
MKRLVADCVKKVKEERPLFPQILSSIELLQHSLPKINRSASEPSLHRAAHTEDINACTLT
TSPRLPVF
NT seq 2007 nt   +upstreamnt  +downstreamnt
atggatgcagagttgggacaccacgggaggcaaggtataagtattgttcaaattgcatca
atggagcacatacagggagcttggaagactatcagcaatggttttggactcaaagatgcg
gtgtttgatggctccagctgcatctcccctacaattgttcagcagtttggctatcagcgc
cgggcctcagatgatggcaaactcacggattcttctaagacaagcaatactatccgggtt
ttcttgccgaataagcaaaggactgtggtcaatgtgcggaatggaatgagcttgcatgac
tgccttatgaaagctctgaaggtgagaggcctgcagccagagtgctgtgcagtgttcaga
cttctccaggaacacaaaggtaagaaagcacgcttagattggaacaccgatgccgcctct
ctgattggagaagaactgcaagtggattttttggatcatgttccactcacaactcacaac
tttgctcggaaaacgttcctgaagcttgcattctgtgacatctgtcagaagttcctacta
aacggatttcgatgtcagacctgtggctacaagtttcatgagcactgtagcaccaaagta
cctactatgtgtgtggactggagtaatatcagacagctcttgctgtttccaaattctact
gttggtgacataggagtcccagcaccaccttctttcccgatgcgtcggatgcgagagtct
gtttctcggatgcctgctagttcccagcacagatactccacaccccatgccttcactttc
aacacctccagcccttcctctgaaggttccctgtcccagaggcagaggtcaacgtccact
cccaatgtccacattgtcagcaccaccctgcctgtggacagcaggatgattgaggatgca
attcgaagtcacagtgaatcagcctcaccttcagccctgtccagcagccctaacaacctg
agcccaacaggctggtcacagcccaaaacccctgtgccagcacaaagagagcgggcacca
ggacctgggacccaggaaaaaaacaaaattaggcctcgtgggcagagagattcaagctat
tactgggaaatagaagccagtgaggtgatgctgtctactcggatcgggtcaggctctttt
ggcactgtgtacaagggcaagtggcatggagatgttgcagtaaagatcctaaaggtggtt
gacccaactccagagcaacttcaggccttcaggaacgaggtggctgttttgcgcaaaaca
cggcatgttaatatcctgctgttcatggggtacatgacaaaggacaacctggcgattgtg
acccagtggtgtgagggcagcagtctctacaaacacctgcatgtccaggagaccaaattc
cagatgttccagctaattgacattgcccgacagacggctcagggaatggactatttgcat
gcaaagaacatcatccacagagacatgaaatccaacaatatatttcttcatgaaggcctc
acggtaaaaattggagattttggcttggcaacagtgaagtcacgctggagtggttctcag
caggttgaacagcccactggctctgtgctgtggatggcgccagaagtaatccgaatgcag
gataacaacccattcagcttccagtctgatgtctactcctacggcattgtgctgtacgag
ctgatgactggggagcttccctactcccacatcaacaaccgagaccagatcatcttcatg
gtaggccgtgggtatgcctctccagatcttagcaggctctacaagaactgtcccaaggca
atgaagagattggtggctgactgtgtgaagaaagtcaaagaagagagacctttgtttccc
cagatcctgtcttccattgagctgcttcagcactctctgccgaaaatcaacaggagcgcc
tctgagccttccctgcaccgggcagctcacactgaggacatcaatgcttgtacgctgact
acatccccgaggctaccagtcttctag

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