Mycobacterium canettii CIPT 140070017: BN45_110069
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Entry
BN45_110069 CDS
T02422
Symbol
leuA
Name
(GenBank) 2-isopropylmalate synthase LeuA (Alpha-Isopropylmalate Synthase) (alpha-IPM synthetase)
KO
K01649
2-isopropylmalate synthase [EC:
2.3.3.13
]
Organism
mcz
Mycobacterium canettii CIPT 140070017
Pathway
mcz00290
Valine, leucine and isoleucine biosynthesis
mcz00620
Pyruvate metabolism
mcz01100
Metabolic pathways
mcz01110
Biosynthesis of secondary metabolites
mcz01210
2-Oxocarboxylic acid metabolism
mcz01230
Biosynthesis of amino acids
Module
mcz_M00432
Leucine biosynthesis, 2-oxoisovalerate => 2-oxoisocaproate
Brite
KEGG Orthology (KO) [BR:
mcz00001
]
09100 Metabolism
09101 Carbohydrate metabolism
00620 Pyruvate metabolism
BN45_110069 (leuA)
09105 Amino acid metabolism
00290 Valine, leucine and isoleucine biosynthesis
BN45_110069 (leuA)
Enzymes [BR:
mcz01000
]
2. Transferases
2.3 Acyltransferases
2.3.3 Acyl groups converted into alkyl groups on transfer
2.3.3.13 2-isopropylmalate synthase
BN45_110069 (leuA)
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Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
HMGL-like
IPMS_D2
LeuA_dimer
Motif
Other DBs
NCBI-ProteinID:
CCK65946
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Position
4271639..4273396
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AA seq
585 aa
AA seq
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MPVNRYRPFAEEVEPVRLRNRTWPDRVIDRAPLWCAVDLRDGNQALIDPMSPARKRRMFD
LLVRMGYKEIEVGFPSASQTDFDFVREIIEQGAIPDDVTIQVLTQCRPELIERTFQACSG
APRAIVHFYNSTSILQRRVVFRADRAEVQAIATDGARKCVEQAAKYPGTLWRFEYSPESY
TGTELEYAKQVCDAVGEVIAPTPEHPIIFNLPATVEMTTPNVYADSIEWMSRNLANRESV
ILSLHPHNDRGTAVAAAELGFAAGADRIEGCLFGNGERTGNVCLVTLGLNLFSRGVDPQI
DFSNIDEIRRTVEYCNQLPVHERHPYGGDLVYTAFSGSHQDAINKGLDAMKFDADAADCD
VDDMLWQVPYLPIDPRDVGRTYEAVIRVNSQSGKGGVAYIMKTDHGLSLPRRLQIEFSQV
IQKIAEGTAGEGGEVSPKEMWDAFAEEYLAPVRPLERIRQHVDAADDDGGTTSITATVKI
NGVETEISGSGNGPLAAFVHALADVGFDVAVLDYYEHAMSAGDDAQAAAYVEASVRIASP
AQPGEAGRHASDPVTSKTVWGVGIAPSITTASLRAVVSAVNRAAR
NT seq
1758 nt
NT seq
+upstream
nt +downstream
nt
atgccggtcaaccgctaccggccgttcgccgaggaggtcgagcccgtccggctgagaaac
cgcacgtggcctgatcgcgtcatcgatcgcgcgccgctgtggtgcgcggtcgatttacgc
gacggcaaccaggcgctgatcgacccgatgagcccggcccgcaagcgccgcatgttcgac
ctgctggtccgcatgggctacaaggagattgaggtggggttcccctcggccagccagacc
gacttcgacttcgtcagagagatcatcgagcagggcgccattcccgacgacgtcaccatc
caggtgctcacccaatgccgtcccgagctgatcgagcgcaccttccaggcgtgttcgggc
gcgccccgggccatcgtgcacttctacaactcgacgtcaatcctgcagcgccgcgtggtc
tttcgcgccgaccgggctgaggtgcaggccatcgcgaccgacggggcgcgcaagtgcgtc
gagcaggccgccaaatacccgggcacactgtggcggttcgagtattccccggagtcctac
accggcaccgagctggaatacgccaaacaagtgtgcgacgccgtcggcgaggtcattgcg
ccgacgccggagcacccgatcatcttcaacctgcccgccacggtggagatgacgacgccc
aatgtctacgccgactcgatcgagtggatgagccgcaacctggccaaccgggagtcggtc
atcttgagcctgcacccgcacaatgaccgcggaaccgccgtcgccgcagcggaattgggt
ttcgcggcgggggcggatcggatcgagggctgcctgttcggcaacggcgagcgcaccggc
aacgtatgcctggtcacgctgggactcaacctgttctcccgaggtgtggacccgcagatc
gacttctccaatatcgacgagatccggcgcacggtggagtactgcaaccagctgccggtg
cacgaacgtcacccctatggcggcgacctggtgtacaccgcgttctccggtagccaccag
gacgccatcaacaagggcctagacgcgatgaagttcgacgccgacgccgccgactgtgac
gtcgacgacatgctgtggcaggtgccgtatctgcccatcgacccgcgcgatgtcgggcgc
acctacgaggcggtgatccgagtcaactcgcagtccggcaagggcggggtggcctacatc
atgaagaccgaccacggcctttccctgccgcggcggctgcagatcgagttttcccaggtg
atccagaagatcgcagagggtacagcaggcgagggtggcgaggtctcgcccaaggagatg
tgggatgcgttcgccgaggagtatctggccccggtgcggcctttggagcggataaggcaa
catgtggacgctgccgacgacgacggcggcacgaccagcatcacggcgaccgtcaagatc
aacggcgtggagaccgaaatcagcgggtccggtaacggtccgctggccgcgttcgtccat
gcgctggccgatgtcgggtttgacgtggccgtgctggactactacgagcacgcgatgagc
gccggcgacgacgctcaggccgccgcgtatgtggaggcctccgtgaggatcgcgagcccg
gcgcagccgggcgaagcgggtcggcacgcatccgaccccgtgacgagtaagacggtgtgg
ggtgtcggtatcgcgccgtcgatcaccaccgcgtcgctgcgcgccgtggtgtcggcggtc
aaccgggcggcacgctag
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